WEBVTT 1 00:00:03.919 --> 00:00:07.679 Step right up, ladies and gents. Tickets your tickets. The 2 00:00:07.719 --> 00:00:09.240 wild and materre about to begin. 3 00:00:09.480 --> 00:00:13.439 Tikets, tickets, get them here on the Greatest show. 4 00:00:15.080 --> 00:00:21.519 Welcome to Deplorable Cult Nation, Act Cloth Conspiracy Side Show Tent, 5 00:00:22.280 --> 00:00:26.359 the greatest freak show on Earth, where the stranger it gets, 6 00:00:26.879 --> 00:00:31.839 the more that it's worth. See the Curious and the Absurd, 7 00:00:33.119 --> 00:00:38.399 Every act you've never seen or heard. Tickets tickets against 8 00:00:38.439 --> 00:00:39.200 your tickets here. 9 00:01:02.520 --> 00:01:07.599 See the curious and the absurd, Every act you've never 10 00:01:07.680 --> 00:01:09.079 seen or heard. 11 00:01:10.400 --> 00:01:12.400 Tickets tickets tickets here. 12 00:01:14.359 --> 00:01:17.640 Hi, and welcome back to another episode of Deplorable Nation. 13 00:01:17.879 --> 00:01:21.879 I'm your host, Deplorable Janna, and today, ladies and gents, 14 00:01:21.959 --> 00:01:27.560 we have another banger in the Sideshow Attraction series. This 15 00:01:27.760 --> 00:01:30.480 is what's age got to do with it? And we're 16 00:01:30.480 --> 00:01:34.239 going to talk about all things wild and weird that 17 00:01:34.439 --> 00:01:41.719 make people rapidly age and change their appearance to like 18 00:01:41.799 --> 00:01:45.680 little kids or even babies looking like really old people, 19 00:01:45.920 --> 00:01:50.239 very wrinkly, saggy skin, the whole nine yards. This one 20 00:01:50.359 --> 00:01:56.719 is very odd and different. But welcome that to my 21 00:01:57.000 --> 00:02:01.719 wonderful bestie from the West e, my lovely other have 22 00:02:02.400 --> 00:02:06.079 the darling Miss Heidi from Unfiltered Rise, How are you love? 23 00:02:06.879 --> 00:02:09.840 Wonderful? Wonderful, Thank you for having me. Always fun to 24 00:02:09.840 --> 00:02:13.280 collaborate with Miss Janet. She is awesome and you guys 25 00:02:13.319 --> 00:02:15.159 always have to check out her work if you're watching 26 00:02:15.159 --> 00:02:18.759 on my show. We do some amazing things, I feel, 27 00:02:18.879 --> 00:02:21.479 and I think that this series has really brought to 28 00:02:21.599 --> 00:02:23.680 light a lot of things that really need to be 29 00:02:23.879 --> 00:02:24.400 in the light. 30 00:02:24.599 --> 00:02:26.879 Like I mean, we can't just shove. 31 00:02:26.639 --> 00:02:29.159 Everything under a rug and be like that never happened, 32 00:02:29.560 --> 00:02:32.520 Like this one's still pretty out there. 33 00:02:32.680 --> 00:02:33.560 It's still around. 34 00:02:33.639 --> 00:02:37.199 It is, it is very out there, and for the 35 00:02:37.199 --> 00:02:40.919 most part, I will say that the things that we're 36 00:02:40.960 --> 00:02:46.039 going to discuss today, they're unusual in a lot of 37 00:02:46.080 --> 00:02:51.719 different ways. But I've literally only seen one person in 38 00:02:51.759 --> 00:02:54.520 my lifetime that had any of the things that we're 39 00:02:54.520 --> 00:02:56.639 going to discuss it. Yes, yeah, so. 40 00:02:57.039 --> 00:02:59.759 Once, and I think they were just I didn't see 41 00:02:59.759 --> 00:03:01.000 them in the clinical aspect. 42 00:03:01.000 --> 00:03:04.199 They were just at the hospital, like going the other way. 43 00:03:04.400 --> 00:03:07.520 So yeah, it's a weird one. And I of course 44 00:03:07.560 --> 00:03:10.240 brought you some slides so we can and I have. 45 00:03:10.240 --> 00:03:10.879 Them at an order. 46 00:03:10.919 --> 00:03:16.479 I hope and prays, oh well, if it, if it happens, 47 00:03:16.680 --> 00:03:19.240 it happens. If it does, I'm good with that too. 48 00:03:19.319 --> 00:03:23.759 Whatever, right, we try to collaborate so this is an 49 00:03:23.840 --> 00:03:26.560 easier time, so Janet doesn't have to go all over 50 00:03:26.599 --> 00:03:30.280 the universe with her stuff because it's a little daunting. 51 00:03:31.520 --> 00:03:35.120 May she has a couple of pages of notes on this. 52 00:03:36.360 --> 00:03:39.280 Yes, she's like, hold on a minute, hold on a second, 53 00:03:39.879 --> 00:03:41.280 and then I mess her all up. 54 00:03:41.360 --> 00:03:42.439 And maybe I've. 55 00:03:42.360 --> 00:03:44.680 Witched a page twenty seven in my notes. 56 00:03:45.599 --> 00:03:48.360 My gosh, and I tried to do these a little 57 00:03:48.400 --> 00:03:50.680 bit in order, and I'm so can you see this. 58 00:03:52.759 --> 00:03:56.960 Baby? And this is the cutest little old man I've 59 00:03:56.960 --> 00:03:57.560 ever seen. 60 00:03:59.039 --> 00:04:03.280 Yeah, and some of these things are going to be crazy. 61 00:04:03.439 --> 00:04:07.280 Some of the pictures may or may not be upsetting 62 00:04:07.280 --> 00:04:11.080 to people. Again, disclaimer at the top of the show, 63 00:04:11.199 --> 00:04:15.000 we are not making fun. Even if we make silly 64 00:04:15.039 --> 00:04:20.199 comments or say a stupid joke, we are not making fun. 65 00:04:20.319 --> 00:04:24.279 We are trying to shed light on conditions that not 66 00:04:24.439 --> 00:04:27.680 only were in the sideshows and the freak shows back 67 00:04:27.800 --> 00:04:31.639 in the day when it was popular, but also people 68 00:04:31.680 --> 00:04:35.519 that you may encounter out in public. And if you 69 00:04:35.720 --> 00:04:39.879 have the knowledge of what something could be, then maybe 70 00:04:40.519 --> 00:04:43.079 your face won't say at all if you know what 71 00:04:43.120 --> 00:04:43.959 I'm saying. 72 00:04:44.120 --> 00:04:46.199 Because if you've seen a little baby that looked like 73 00:04:46.240 --> 00:04:50.000 a wrinkly old man, you might be startled unless you 74 00:04:50.040 --> 00:04:50.680 know what it is. 75 00:04:50.720 --> 00:04:52.759 And that's what we're here to tell you about today. 76 00:04:54.319 --> 00:04:56.519 So the first thing that we're going to talk about 77 00:04:56.519 --> 00:05:02.040 today is called progeria. This to me is such a 78 00:05:02.199 --> 00:05:12.000 fascinating topic to cover because it is rare genetic thing 79 00:05:12.160 --> 00:05:17.079 that you don't see very often. It's like one and 80 00:05:17.240 --> 00:05:20.879 twenty million births, so uber rare that you see this. 81 00:05:21.079 --> 00:05:26.000 That's why I've never seen anybody with this condition in person. 82 00:05:26.639 --> 00:05:30.560 Have I seen them in shows, yes, but in person no. 83 00:05:30.800 --> 00:05:38.439 So what progeria is. It's also called Hutchinson Guilford progeria syndrome, 84 00:05:39.439 --> 00:05:44.199 and it is the thing that's closely linked to very 85 00:05:44.319 --> 00:05:49.040 untimely aging and so, like I said, it's a very 86 00:05:49.120 --> 00:05:52.879 rare genetic thing. And it has to do with the 87 00:05:52.959 --> 00:05:57.600 gene that makes a protein called lamon A, and that 88 00:05:57.720 --> 00:06:02.759 is important for maintaining the cell's nuclear structure. So like 89 00:06:02.839 --> 00:06:07.160 the roundness of the structure of the cell, and so 90 00:06:07.639 --> 00:06:13.800 because the cell can't maintain you know, size, shape, things 91 00:06:13.879 --> 00:06:22.399 like that, it has mutated proteins that make the cells unstable, 92 00:06:22.480 --> 00:06:26.319 which is what leads to the weird like aging things. 93 00:06:26.720 --> 00:06:31.920 Doesn't this baby look like a little nymph for something cosmute? 94 00:06:32.439 --> 00:06:35.800 This is the I know, we I know, we're talking 95 00:06:35.839 --> 00:06:37.639 about sad things, but this baby's darling. 96 00:06:38.720 --> 00:06:42.279 And that's the one of the things on this that 97 00:06:42.560 --> 00:06:45.439 a lot of babies we're going to talk about different 98 00:06:45.519 --> 00:06:50.639 kinds of uh. They're called progerroid syndromes. So progeria is 99 00:06:50.680 --> 00:06:54.959 the first one, but there is one that affects babies. 100 00:06:55.199 --> 00:07:03.120 So if you have like the progeria, it's Babies usually 101 00:07:03.279 --> 00:07:06.639 look normal when they're born and then by age one 102 00:07:06.680 --> 00:07:10.120 to two that's when their symptoms appear. They have a 103 00:07:10.120 --> 00:07:13.199 lot of growth failure, so they're very short in stature, 104 00:07:13.319 --> 00:07:18.120 very low in weight, loss of body fat and muscle, 105 00:07:18.959 --> 00:07:22.079 lots of hair loss, and it's not uncommon to see 106 00:07:22.079 --> 00:07:30.839 them bald. Even eyelashes and eyebrows are gone. Like this 107 00:07:31.000 --> 00:07:34.560 boy that we're looking at now completely bald head. You 108 00:07:34.600 --> 00:07:37.759 can see the indentation where the eyebrows were, but there 109 00:07:37.839 --> 00:07:43.720 are no eyebrows at all. So because the protein structure 110 00:07:43.959 --> 00:07:48.720 and the cell is abnormal is what causes them to 111 00:07:48.800 --> 00:07:51.759 have age looking skin. So it's either going to be 112 00:07:51.839 --> 00:07:54.720 really thin so you can see through it. You can 113 00:07:54.800 --> 00:07:59.000 see all the veins and arteries through the skin, which 114 00:08:01.360 --> 00:08:04.240 kind of creepy, kind of be off putting for some people. 115 00:08:04.279 --> 00:08:07.279 If you've never looked closely at an old person with 116 00:08:07.560 --> 00:08:08.800 paper thun skin. 117 00:08:10.920 --> 00:08:14.279 Shows those beings so good in the saginal area. 118 00:08:14.319 --> 00:08:19.160 Yeah, one hundred percent, and that's it kind of becomes 119 00:08:19.199 --> 00:08:22.199 like transparent skin, which, like I said, I've had a 120 00:08:22.199 --> 00:08:26.279 lot of elderly patients that have the very transparent skin. 121 00:08:26.519 --> 00:08:30.040 But along with this, they get really stiff joints, they 122 00:08:30.079 --> 00:08:35.320 get hyptose locations all of the time. They have a 123 00:08:35.399 --> 00:08:39.320 really small jaw, so the jaw is disproportionate to the 124 00:08:39.360 --> 00:08:42.440 rest of the face. They have a what they call 125 00:08:42.519 --> 00:08:46.360 a pinched nose, so it looks like somebody just like 126 00:08:46.759 --> 00:08:49.759 had an extra heavy duty breath right strip on the nose. 127 00:08:49.840 --> 00:08:50.960 And like you look at. 128 00:08:52.120 --> 00:08:57.480 Live cuey dolls if anybody remembers Qby dolls, Yes, yeah, 129 00:08:57.559 --> 00:09:00.759 they look and not in a derogatory way way and 130 00:09:00.879 --> 00:09:01.600 not being made. 131 00:09:02.039 --> 00:09:10.840 So people that get progeria, the main progeria as a child, unfortunately, 132 00:09:10.960 --> 00:09:15.159 life expectancy for them is fourteen to fifteen years old, 133 00:09:15.279 --> 00:09:20.960 so not a super long time if they're lucky to 134 00:09:21.080 --> 00:09:27.360 their twenties. But that's with exceptional medical care. And I'm 135 00:09:27.399 --> 00:09:30.120 just going to throw this out there. With the quote 136 00:09:30.200 --> 00:09:35.960 unquote practice of medicine that we have, I can see 137 00:09:36.039 --> 00:09:43.919 a progeria patient being grossly misdiagnosed a lot before they 138 00:09:43.919 --> 00:09:48.360 finally actually figure out what it is because a lot 139 00:09:48.399 --> 00:09:51.559 of the symptoms that they get closely mimics some of 140 00:09:51.600 --> 00:09:55.840 the things that we've talked about on previous shows. So 141 00:09:56.039 --> 00:09:58.799 for them to you know, narrow that down. 142 00:09:58.600 --> 00:10:01.879 Here, especially in a mild case, because this doesn't always 143 00:10:01.960 --> 00:10:04.559 look like this. This can sometimes like some of these 144 00:10:04.600 --> 00:10:07.879 other kids in this one right here, right like this 145 00:10:07.919 --> 00:10:10.799 little girl looks like she may have looked semi I 146 00:10:10.799 --> 00:10:14.279 don't want to say normal, but like baseline, okay, yeah 147 00:10:14.399 --> 00:10:16.120 for a while, like she does. 148 00:10:16.240 --> 00:10:19.720 I mean, you know, it's not that severe and so. 149 00:10:20.120 --> 00:10:24.639 Yeah, yeah, and so some of these some of these children, 150 00:10:25.440 --> 00:10:32.519 they're they're definitely like progressive stages of this and how 151 00:10:32.639 --> 00:10:35.600 severe each one of them has. One of the things 152 00:10:35.639 --> 00:10:39.600 that they have a really hard time with is they 153 00:10:39.720 --> 00:10:44.919 developed arterial schulerosis, which is hardening other arteries like really 154 00:10:45.120 --> 00:10:50.480 early in life, so infancy or even childhood. And so 155 00:10:50.759 --> 00:10:54.519 it says that most of these kids, while their life 156 00:10:54.559 --> 00:11:00.919 expectancy is fourteen to fifteen years old, that's because they 157 00:11:01.000 --> 00:11:04.240 die of heart attacks and strokes more than any other 158 00:11:04.399 --> 00:11:08.759 population on the planet, which is frightening if you think 159 00:11:08.799 --> 00:11:10.559 about that, you would. 160 00:11:10.399 --> 00:11:15.519 Think with our extensive like changes in cardio and everything, 161 00:11:15.559 --> 00:11:18.080 they would have like be able to put in stents 162 00:11:18.279 --> 00:11:20.120 or you know, filters or whatever. 163 00:11:20.200 --> 00:11:22.240 But I mean, it just doesn't seem like it's changed 164 00:11:22.360 --> 00:11:22.919 much for these. 165 00:11:23.000 --> 00:11:25.440 Yeah, And I don't. And that's a good point. And 166 00:11:25.519 --> 00:11:30.120 I don't think because it talks about like different types 167 00:11:30.159 --> 00:11:35.720 of treatments that they're experimenting with or looking at or whatever. 168 00:11:35.960 --> 00:11:40.320 But if you have something where your genes are mutated 169 00:11:40.519 --> 00:11:48.159 and it's you know, affecting the nuclear structure of the cells, 170 00:11:48.240 --> 00:11:51.759 and it's causing you know, plaque to build up and 171 00:11:51.799 --> 00:11:54.559 the arteries and all of those kind of things, would 172 00:11:54.559 --> 00:11:59.519 a stent or any kind of cardiothoracic surgery even hold 173 00:11:59.559 --> 00:12:00.399 what it any? 174 00:12:00.440 --> 00:12:04.679 Good? Right? Right? With such thin thin Yeah? Maybe not? 175 00:12:04.960 --> 00:12:09.159 Yeah, they said, And that's why, like the sad thing 176 00:12:09.200 --> 00:12:14.159 about this is there's no cure for it. So everything 177 00:12:14.200 --> 00:12:17.960 that they give is just too slow progression so it 178 00:12:18.080 --> 00:12:22.840 doesn't get progressively worse. One of the things that they 179 00:12:23.120 --> 00:12:26.159 give them used to be it was marketed as a 180 00:12:26.240 --> 00:12:33.120 cancer drug. They do nutrition therapy, physical therapy, cardiac monitoring 181 00:12:33.159 --> 00:12:36.440 of course like all of the time, but it said 182 00:12:36.679 --> 00:12:39.440 one of the things that they're experimenting with, and you 183 00:12:39.480 --> 00:12:43.279 and I talked about this technology on on another episode 184 00:12:44.360 --> 00:12:51.639 outside of the sideshow episodes, they're doing crisper technology to 185 00:12:51.799 --> 00:12:56.639 see if they can take out or cut out that 186 00:12:56.840 --> 00:12:59.120 gene mutation that's causing. 187 00:12:58.759 --> 00:13:01.759 This, and we are going to fuck around and find out, 188 00:13:01.840 --> 00:13:04.240 you know, with all the studying I do this last week, 189 00:13:04.399 --> 00:13:08.039 I ran into something where somebody was saying, and this 190 00:13:08.240 --> 00:13:12.360 was like in a white supremacist type comment, that they 191 00:13:12.480 --> 00:13:19.960 almost have it figured out how to restock their race. WHOA. 192 00:13:21.159 --> 00:13:25.200 And like we talked about before on the Christopher episode 193 00:13:25.279 --> 00:13:29.399 that we did, it is gene splicing or gene editing. 194 00:13:30.600 --> 00:13:33.720 It started a long time ago with like dog breeders 195 00:13:33.799 --> 00:13:37.240 and stuff like that, where certain types of dogs like 196 00:13:37.279 --> 00:13:42.679 German shepherds get hip dysplasia all the time, and so 197 00:13:42.799 --> 00:13:46.200 the breeders can go in and can cut out that 198 00:13:46.320 --> 00:13:51.799 gene or whatever and make a pure line of German shepherds. 199 00:13:52.440 --> 00:13:56.279 So you don't think they're doing that to human beings. 200 00:13:56.320 --> 00:13:58.559 They've been doing that for a long time. 201 00:13:59.200 --> 00:14:02.399 Well, with what we were talking about before we came 202 00:14:02.440 --> 00:14:04.919 on Live, with the genealogy stuff they trace you know, 203 00:14:04.960 --> 00:14:05.440 who's up. 204 00:14:05.440 --> 00:14:06.159 To no good with that. 205 00:14:06.440 --> 00:14:10.200 And the Howard Hughes Medical Center was continued on by 206 00:14:10.240 --> 00:14:15.000 the Mormon mafia after Howard's death through Gay. His name 207 00:14:15.039 --> 00:14:19.279 is Bill Gay, And you know, it's it's very concerning 208 00:14:19.399 --> 00:14:22.320 knowing what we know, because why the money is there 209 00:14:22.360 --> 00:14:24.440 to back it, not only through grants, but the more 210 00:14:24.480 --> 00:14:25.600 our church is loaded. 211 00:14:26.399 --> 00:14:28.519 So and they were very racial. 212 00:14:29.440 --> 00:14:31.519 Like the other day, I was telling somebody, I said, 213 00:14:31.519 --> 00:14:34.200 the stuff that I'm reading here tells me that the 214 00:14:34.320 --> 00:14:36.360 Church didn't support the Nazis. 215 00:14:36.440 --> 00:14:38.720 The Church are Nazis. And I can't prove that claim. 216 00:14:38.759 --> 00:14:41.639 I'm just saying from what I was reading, it was 217 00:14:41.679 --> 00:14:42.519 a little scary. 218 00:14:42.799 --> 00:14:46.840 So well, and that goes to make sense because one 219 00:14:46.879 --> 00:14:49.360 of our episodes that we did like a really long 220 00:14:49.440 --> 00:14:54.440 time ago, when we were talking about like Margaret Sanger 221 00:14:54.480 --> 00:14:57.679 and stuff like that, you know, and and all of 222 00:14:57.720 --> 00:15:02.320 the com munes that they used to have like back 223 00:15:02.360 --> 00:15:08.960 in the day that we're breeding other too, you know, 224 00:15:09.840 --> 00:15:14.200 weed out basically the lesser thans of society or what 225 00:15:14.279 --> 00:15:18.320 they deem to be lesser society, you know, and they're 226 00:15:18.360 --> 00:15:24.000 wanting all white race and you know, certain eye color, 227 00:15:24.080 --> 00:15:26.840 certain hair color, you know, the whole nine yards. And 228 00:15:26.919 --> 00:15:31.440 so that kind of stuff has been not just in 229 00:15:31.600 --> 00:15:37.639 American culture, but every culture around the world has some 230 00:15:38.000 --> 00:15:46.159 type of colony commune people they push more people scientists, 231 00:15:46.600 --> 00:15:50.840 you know, the scientists trust the science type people that 232 00:15:50.960 --> 00:15:55.840 are working to eradicate things they don't agree with. 233 00:15:56.639 --> 00:15:59.320 And to your point, if people want to take a 234 00:15:59.320 --> 00:16:03.679 look see speaking of Singer, there was a big eugenics 235 00:16:03.720 --> 00:16:06.399 program here in Utah of all places, where they're like, 236 00:16:06.519 --> 00:16:08.600 have all the kids, have as many kids as you 237 00:16:08.639 --> 00:16:12.799 possibly can, but only certain people, right, and then they 238 00:16:12.840 --> 00:16:16.559 were sterilizing people that had problems and that there was 239 00:16:16.600 --> 00:16:20.000 this huge eugenics pilot program that took place here in 240 00:16:20.080 --> 00:16:22.679 Utah of all places, where it's like very you know, 241 00:16:22.799 --> 00:16:25.840 pro babies and not for everyone. 242 00:16:26.000 --> 00:16:32.960 Apparently selective pro baby yep, kind of like selective hearing. 243 00:16:33.039 --> 00:16:34.120 Oh did I say all that? 244 00:16:35.639 --> 00:16:37.960 And with people like this like this guy, he had 245 00:16:37.960 --> 00:16:40.159 a little documentary. It may still be out there called 246 00:16:40.200 --> 00:16:42.399 life according to Sam. But like if I had a 247 00:16:42.440 --> 00:16:44.440 baby like this, this isn't the worst thing, or like 248 00:16:44.480 --> 00:16:48.279 down syndrome, like they're sweet, Like they have such a 249 00:16:48.320 --> 00:16:50.879 limited time frame, you would be so happy for each 250 00:16:50.919 --> 00:16:52.080 and every day you had with them. 251 00:16:52.200 --> 00:16:53.799 At least that's how I would look at it. 252 00:16:54.399 --> 00:17:00.120 Yeah, but there are some people that couldn't do it 253 00:17:00.200 --> 00:17:03.919 because the looks that other people would shoot at you 254 00:17:04.200 --> 00:17:09.160 or whatever. And again that's just selfishness. That's your own ego, 255 00:17:10.319 --> 00:17:14.559 you know, getting in the way of what could be 256 00:17:14.799 --> 00:17:16.960 the greatest love of your life. You know what I mean. 257 00:17:17.039 --> 00:17:19.200 God did not give me any handicapped children because I 258 00:17:19.200 --> 00:17:20.119 would have gone to jail. 259 00:17:20.880 --> 00:17:24.200 We'll just say that some may you mean to my 260 00:17:24.319 --> 00:17:26.240 kid once and that would be about all. 261 00:17:26.480 --> 00:17:32.039 So it's the mama bear thing. It happens. Yeah. So 262 00:17:32.079 --> 00:17:36.039 the next thing we have is called cocaine syndrome, and 263 00:17:36.079 --> 00:17:42.480 that is where it's also another type of pro gyroid syndrome, 264 00:17:42.599 --> 00:17:49.279 but it is also neuro degenerative and has multisystems included. 265 00:17:49.519 --> 00:17:54.960 It affects the DNA repair of our body, so excess 266 00:17:55.079 --> 00:17:58.519 mutations and then you're not able to repair it from 267 00:17:59.559 --> 00:18:06.480 the the damage from the DNA, and so they it 268 00:18:06.559 --> 00:18:10.039 has to do with UV light and oxidative stress. 269 00:18:10.200 --> 00:18:12.119 Okay, I was just going to ask you. I'm like, 270 00:18:12.359 --> 00:18:13.440 which I have it? 271 00:18:13.519 --> 00:18:17.400 But I find which. You know, if you think about 272 00:18:17.680 --> 00:18:22.200 UV light is light outside, it's like from you know, 273 00:18:22.359 --> 00:18:26.839 fluorescent lights, it's literally all kinds of stuff. And oxidative 274 00:18:26.880 --> 00:18:29.640 stress is literally every day wear and tear on your 275 00:18:29.640 --> 00:18:35.400 body from environmental factors, the whole nine yards. And so 276 00:18:36.240 --> 00:18:41.240 because they can't repair anything, the cells die off at 277 00:18:41.240 --> 00:18:45.119 a much more rapid rate than what we normally do, 278 00:18:45.640 --> 00:18:49.319 which is what causes their their aging. This is the 279 00:18:49.359 --> 00:18:50.960 one that starts in the infants. 280 00:18:52.000 --> 00:18:53.119 Okay, okay, yep. 281 00:18:53.759 --> 00:18:58.240 And so some of the pictures if people google this 282 00:18:58.519 --> 00:18:59.880 and again it's called cocka. 283 00:19:00.799 --> 00:19:03.519 Some of them are super cute, look right, but they 284 00:19:03.559 --> 00:19:05.720 have weird thumbs. This is the one with the weird 285 00:19:05.759 --> 00:19:08.160 thumbs right sometimes. 286 00:19:07.880 --> 00:19:16.519 Okay, Because because this is neurodegenerative and multi system, of course, 287 00:19:16.519 --> 00:19:19.960 it can affect anything in your body. This picture that 288 00:19:19.960 --> 00:19:23.599 we're looking at right now is two sisters. One's holding 289 00:19:23.640 --> 00:19:26.160 the other one on her lap, and the one that 290 00:19:26.200 --> 00:19:31.480 she's holding on her lap literally looks like, do you 291 00:19:31.480 --> 00:19:32.559 ever see beetlejuice? 292 00:19:32.680 --> 00:19:33.039 Solly? 293 00:19:33.519 --> 00:19:35.640 Yeah, oh yeah, yeah, uh huh. 294 00:19:36.119 --> 00:19:39.559 And so this girl has a very very tiny head 295 00:19:39.720 --> 00:19:43.880 and her legs are bigger than you. 296 00:19:43.759 --> 00:19:46.720 Know, it looks like she has lymphedema. Almost doesn't. 297 00:19:46.839 --> 00:19:51.640 Yes, And that's it. That's pretty common as well. And 298 00:19:51.720 --> 00:19:55.039 so this one, like I said, it starts in infancy 299 00:19:55.200 --> 00:19:59.079 to early childhood, so a lot of babies can be 300 00:19:59.200 --> 00:20:03.599 born with this and when they're born, some of the 301 00:20:03.640 --> 00:20:08.000 pictures are disturbing to look at. I ran across some 302 00:20:08.160 --> 00:20:13.839 and I'm like, wow, that's like they look like prunes 303 00:20:13.960 --> 00:20:20.079 or raisins because they're so you know whatever. 304 00:20:20.680 --> 00:20:27.400 Yeah, yeah, So they their thumb, holy moly, yeah. 305 00:20:26.000 --> 00:20:30.559 This thumb. Imagine pulling your thumb backwards, like down to 306 00:20:30.640 --> 00:20:35.400 your wrist. This child's thumb looks like it's actually broken 307 00:20:36.799 --> 00:20:40.519 backwards like that. So, of course, again they've got the 308 00:20:41.279 --> 00:20:45.880 short stature, very low birth weight or very low weight regardless, 309 00:20:46.519 --> 00:20:51.440 very small heads, so microcephaly they've got, of course, the 310 00:20:51.480 --> 00:20:57.400 aging appearance. They've got photosensitive skin, and so they can 311 00:20:57.480 --> 00:21:05.319 have lesions, rashes, burns, problems with like the picture you 312 00:21:05.440 --> 00:21:10.039 just showed, problems with the melanocytes in your skin that 313 00:21:10.119 --> 00:21:14.000 give you the pigmentation and the color. So this girl 314 00:21:14.160 --> 00:21:20.839 has like a very spotty appearance to her face dental problems. 315 00:21:21.680 --> 00:21:26.119 I was, yeah, there we go. And so this girl, 316 00:21:26.279 --> 00:21:28.799 it looks like she had some kind of really bad 317 00:21:29.079 --> 00:21:33.680 like photosensitive reaction on her face where she almost got 318 00:21:33.720 --> 00:21:39.640 like sun poisoning or something and it damaged the color 319 00:21:39.920 --> 00:21:41.240 cells in the skins. 320 00:21:41.319 --> 00:21:45.240 So sad like this one. I mean, I think it 321 00:21:45.359 --> 00:21:49.559 shows it pretty good in this one. You know he's older, 322 00:21:49.640 --> 00:21:52.119 but yeah, look at the feet and stuff. 323 00:21:52.079 --> 00:21:59.519 Like, Yeah, the the toes are like very strange, like 324 00:21:59.559 --> 00:22:04.240 that big toe it's pointing in towards the other toes, 325 00:22:04.279 --> 00:22:08.160 but it's like very long and very like the bones 326 00:22:08.160 --> 00:22:09.039 in the feet. 327 00:22:08.799 --> 00:22:14.160 Are very straight, kinder like long and skinny, skinny, skinny, skinny. 328 00:22:14.559 --> 00:22:19.680 So this particular thing has three different classifications. They have 329 00:22:19.799 --> 00:22:25.920 Type one, which is early onset and unfortunately, this one 330 00:22:26.119 --> 00:22:31.400 is pretty progressive and death usually occurs in the first 331 00:22:31.519 --> 00:22:35.160 or second decade of life, so the first ten twenty 332 00:22:35.240 --> 00:22:40.680 years of life happens. Type two is the most severe, 333 00:22:40.920 --> 00:22:45.880 and it's the severe congenital form. Symptoms appear at birth. 334 00:22:46.359 --> 00:22:50.960 There's little to no developmental progress in the child, and 335 00:22:51.000 --> 00:22:53.359 they typically die by age seven. 336 00:22:54.039 --> 00:22:56.799 Look at that hand deformity out. 337 00:22:58.880 --> 00:23:02.559 So type three is the most mild form that you 338 00:23:02.599 --> 00:23:06.720 can get. It occurs later on in life, has slower progression, 339 00:23:07.480 --> 00:23:13.720 and those are usually the children that can live into adulthood. 340 00:23:14.160 --> 00:23:18.200 So even though they're still young, they look very elderly. 341 00:23:18.400 --> 00:23:22.720 They're thin, they're frail, they have sunken faces, wrinkled skin 342 00:23:24.079 --> 00:23:28.880 of course, the loss of muscle and fat again, and 343 00:23:28.920 --> 00:23:32.799 then they have the neurological decline, so it's similar to 344 00:23:33.000 --> 00:23:40.359 Alzheimer's or Parkinson's. And because they have a problem with 345 00:23:41.240 --> 00:23:46.720 their skin, they can't absorb and synthesize vitamin D properly, 346 00:23:47.359 --> 00:23:52.680 which is what causes all the neurological complications. And so 347 00:23:53.839 --> 00:23:59.000 anything neurological, like pain receptors, things like that, especially pain, 348 00:23:59.119 --> 00:24:01.680 is going to be really heightened in these type of children. 349 00:24:03.079 --> 00:24:07.279 No cure again, but again it's a genetic thing. They 350 00:24:07.319 --> 00:24:11.559 don't know why, so it says not any cure, but 351 00:24:12.160 --> 00:24:16.799 protect them from the sunlight because they're extremely photosensitive. And 352 00:24:16.880 --> 00:24:21.440 so if you see somebody that has a hat with 353 00:24:21.599 --> 00:24:24.880 a you know, the face and neck gator on long 354 00:24:24.960 --> 00:24:30.240 sleeve long pants, they probably have something. 355 00:24:30.000 --> 00:24:32.160 Don't just assume they're germaphobe in a. 356 00:24:32.079 --> 00:24:35.440 Week ago something related to this. So they're going to 357 00:24:35.559 --> 00:24:40.920 need extra and additional support again because they can't process 358 00:24:41.039 --> 00:24:43.279 vitamin D. So there's going to be all kinds of 359 00:24:43.319 --> 00:24:49.200 things that they need again because it's neurological hearing aids, 360 00:24:49.920 --> 00:24:54.480 visual aids, physical therapy because they can go deaf or 361 00:24:54.519 --> 00:24:58.799 blind because of that. Also have a lot of seizures 362 00:24:58.839 --> 00:25:03.599 because again NEURALI stuff is in play. And so it 363 00:25:03.680 --> 00:25:10.400 says again they're exploring DNA repair gene therapies for the 364 00:25:11.000 --> 00:25:12.400 christ technology. 365 00:25:12.920 --> 00:25:15.200 And here's what I love how the doctor was so 366 00:25:15.359 --> 00:25:18.319 nice and put a female sign on this kid right 367 00:25:18.440 --> 00:25:19.920 like what is wrong with you? 368 00:25:20.920 --> 00:25:25.000 Well, yeah, that was very nice of them too, you know, 369 00:25:25.119 --> 00:25:29.839 to do that. But these these kids like very sunken chest, 370 00:25:30.240 --> 00:25:37.240 very abnormal bones, joints, you know, all all of the things. 371 00:25:37.400 --> 00:25:42.559 And you know, if they're experimenting with gene therapy, and 372 00:25:42.720 --> 00:25:46.640 you know, gene therapy was a thing for a little while, 373 00:25:46.799 --> 00:25:53.880 like the monoclonal antibodies and stuff during the outbreak or 374 00:25:54.359 --> 00:26:02.720 planned break, but that's too like how would you give 375 00:26:02.880 --> 00:26:08.279 somebody something like that and have it take effect? Because 376 00:26:08.319 --> 00:26:11.799 they already have it. All of those cells are already damaged. 377 00:26:12.880 --> 00:26:15.079 How would that repair anything? 378 00:26:15.839 --> 00:26:16.559 I don't even know. 379 00:26:16.599 --> 00:26:18.559 You'd have to do it in utero at the time 380 00:26:18.599 --> 00:26:22.160 it's developing, I would think. And even then that's like 381 00:26:22.319 --> 00:26:25.440 such a high risk when you're doing in utero procedure. 382 00:26:25.559 --> 00:26:28.440 I just I don't know the risk for the mom, 383 00:26:29.039 --> 00:26:32.880 you know, let alone the baby would be tremendously off 384 00:26:33.039 --> 00:26:36.200 the charts. And then you don't know how the mom 385 00:26:36.519 --> 00:26:40.680 is going to react to injecting the baby with something. Yeah, 386 00:26:41.119 --> 00:26:42.599 they share it life. 387 00:26:43.440 --> 00:26:46.160 I mean, you know, it's not the worst thing ever, 388 00:26:46.359 --> 00:26:48.839 Like I mean, it's sad to watch your child go 389 00:26:48.960 --> 00:26:52.759 before you, But honestly, like I always think that people 390 00:26:53.079 --> 00:26:55.119 end up. And most of the time I see this 391 00:26:55.200 --> 00:26:58.240 with the parents, right that they're grateful and stuff like, 392 00:26:58.279 --> 00:27:01.119 they're not you know, well, most that I've ever seen 393 00:27:01.200 --> 00:27:06.400 with kids with issues where they're still cognitively there, it's 394 00:27:06.440 --> 00:27:09.640 a little bit different. Not saying the cognitive ones are 395 00:27:10.000 --> 00:27:11.920 worse or anything, but they're harder on people. 396 00:27:12.160 --> 00:27:14.279 So one hundred. 397 00:27:15.480 --> 00:27:18.079 And so, the next one that we're going to talk 398 00:27:18.119 --> 00:27:24.039 about is called Rothman Thompson syndrome. And this is another 399 00:27:24.440 --> 00:27:28.799 of course, rare genetic one. But this is also just 400 00:27:28.960 --> 00:27:35.799 in babies, and unfortunately, this is another thing that affects 401 00:27:35.880 --> 00:27:41.640