WEBVTT

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<v Speaker 1>You're on the bus an hour from home in bumper

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<v Speaker 1>to bumper traffic, creeping forward a few inches at a time,

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<v Speaker 1>someone's kids are screaming, and suddenly your back is too. Luckily,

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<v Speaker 1>Always read the label or.

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<v Speaker 2>Leaflet get value.

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<v Speaker 2>Tesco.

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<v Speaker 3>Every little helps available the most stores, prices very in express.

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<v Speaker 4>Oh hey, it's still the fountain at the mall that's

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<v Speaker 4>never on. Ali Ward, you are here for part two

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<v Speaker 4>of Nemnology Memory. Please tell me that you started with

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<v Speaker 4>part one. Even if you don't remember it, start with

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<v Speaker 4>part one because this is the thrilling conclusion with Professor

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<v Speaker 4>Researcher and the director of UC Irvine Center for the

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<v Speaker 4>Neurobiology of Learning and Memory.

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<v Speaker 2>He's amazing.

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<v Speaker 4>We're going to get into it, but first this is

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<v Speaker 4>a wall twell episode of questions from patrons, and if

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<v Speaker 4>you'd like to submit some time you two can join

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<v Speaker 4>for as low as a buck a month, and upper

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<v Speaker 4>tiers can submit audio questions. Thank you also to everyone

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<v Speaker 4>getting ologies merch from ologiesmarch dot com, and thanks to

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<v Speaker 4>everyone leaving us for reviews, which boosts the show so much.

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<v Speaker 4>And each week I remember to read them all and

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<v Speaker 4>I pick a just written one such as this one

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<v Speaker 4>from Sulasang, who wrote this podcast saved my life. It's

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<v Speaker 4>like spending an hour at the most amazing library ever

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<v Speaker 4>where you find exactly the right book that you didn't

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<v Speaker 4>know that you needed. Sula Sang and everyone who's ever

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<v Speaker 4>left review I've read it and thank you. Welcome to

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<v Speaker 4>the library. Okay, on to part two, where we answer

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<v Speaker 4>your questions about how to remember names and faces, what

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<v Speaker 4>causes Alzheimer's, photographic memory, short term versus long term memory,

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<v Speaker 4>how to prevent dementia, cannabis and memory, goldfish brains, and

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<v Speaker 4>why smelling sunscreen makes you want to cry sometimes with

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<v Speaker 4>neurobiologists professor researcher and memory expert neemnologist doctor Michael Yassa, Oh,

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<v Speaker 4>I have questions from listeners. Can I ask you one million?

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<v Speaker 4>Of course you're the best, Okay, So this question was

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<v Speaker 4>on the minds of patrons Esopardy, Elsa T. Who's a

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<v Speaker 4>first time question asker? And face name forgetter Diana's to

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<v Speaker 4>Red Nick Dean, LILLYB. And audio question submitter Summer wanted

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<v Speaker 4>to know.

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<v Speaker 5>Hi, Ellie. Some are from New Zealand here. What I

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<v Speaker 5>find really interesting is that I remember faces, but sometimes

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<v Speaker 5>I can't remember where I've seen that person before, even

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<v Speaker 5>in what country I've seen them. And I'm wondering why

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<v Speaker 5>we're so good at recognizing faces and remembering knowing a face,

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<v Speaker 5>but knowing none of the details around that face.

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<v Speaker 4>What is it about remembering certain aspects of a person

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<v Speaker 4>or a connection. I know some people have total face

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<v Speaker 4>blindness yep, as well, either evolutionarily or how do we

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<v Speaker 4>look at faces where we blank and say who is that?

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<v Speaker 6>Yeah, that's a fantastic question, Summer. So you've already mentioned

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<v Speaker 6>one version of this, which is face blindness, right, And

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<v Speaker 6>I'm not saying that Summer has face blindness at all.

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<v Speaker 6>In fact, I think all of us struggle with faces

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<v Speaker 6>to an extent.

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<v Speaker 4>So this condition is medically known as prosopagnasha. And a

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<v Speaker 4>twenty twenty three study in the journal Cortex titled what

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<v Speaker 4>is the Prevalence of Developmental Prosopagnasia An empirical assessment of

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<v Speaker 4>different diagnostic cutoffs, found that developmental prosopygnasha, meaning it's lifelong

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<v Speaker 4>and not caused by injury to the brain, is more

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<v Speaker 4>common than previously thought, and that it lies on a

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<v Speaker 4>spectrum of severity. And I was doing some reading on

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<v Speaker 4>it from people who have it to try to figure

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<v Speaker 4>out what it feels like. And I've read it described

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<v Speaker 4>as seeing a tree and then trying to pick out

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<v Speaker 4>that specific tree in a forest, or telling the difference

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<v Speaker 4>between two different cows in a field. And if this

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<v Speaker 4>sounds like you, and if you watch movies wondering, wait

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<v Speaker 4>is that the same guy or is that a different guy.

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<v Speaker 4>You may be one in thirty three people who have it,

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<v Speaker 4>which is cool but also awful, So don't let anyone

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<v Speaker 4>make you feel too.

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<v Speaker 2>Bad about it.

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<v Speaker 6>Now, faces are a very important piece of information. When

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<v Speaker 6>you look at somebody's face, you can tell by their

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<v Speaker 6>expression whether they're a threat to you, whether they're a

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<v Speaker 6>friendly person. You can choose to approach or avoid. You

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<v Speaker 6>can base a lot of your decision making based on

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<v Speaker 6>a face. If somebody's face has an expression of fear

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<v Speaker 6>and they're looking behind you, they might warn you to

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<v Speaker 6>something and you might react accordingly. So we evolved, and

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<v Speaker 6>not just our species. Many social species have evolved to

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<v Speaker 6>try to always interpret faces and facial expressions. But recognizing

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<v Speaker 6>a face and remembering whether a face belongs to a

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<v Speaker 6>certain name is this thing that happened much later in evolution.

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<v Speaker 6>And I don't think our brains are just very good

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<v Speaker 6>at it yet. I think we're developing that, but we're

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<v Speaker 6>still sort of half baked when it comes to connecting

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<v Speaker 6>names and faces. So number one complaints that I hear

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<v Speaker 6>from everybody is I remember faces, but I could never

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<v Speaker 6>connect them with when did I see this person? What

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<v Speaker 6>their name is, or sometimes I'll hear the name and

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<v Speaker 6>I can't recall the face, but then I connect when

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<v Speaker 6>I see it. So face names associations that they tend

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<v Speaker 6>to be the most challenging for us humans. But one

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<v Speaker 6>of the reasons why faces are really important is because

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<v Speaker 6>of this evolutionary survival sort of significance. Things around fear,

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<v Speaker 6>things around pleasure, reward, all of that. We get our

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<v Speaker 6>cues A lot of our cues from faces.

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<v Speaker 4>I learned a trick once on a film set where

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<v Speaker 4>one guy I worked with. It was Adam Savage from MythBusters.

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<v Speaker 4>He knew everyone's name on this huge set we were on.

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<v Speaker 4>It's like, how do you do that?

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<v Speaker 2>He was like, Okay, have this.

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<v Speaker 4>Trick where that woman's name is Dorothy and I think

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<v Speaker 4>of Dorothy from the Wizard of Us. That person's name

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<v Speaker 4>is Ben, and I have a brother in law named Ben,

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<v Speaker 4>And so as soon as they said their name, you

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<v Speaker 4>had to pay attention.

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<v Speaker 2>But then you made a connection.

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<v Speaker 6>Absolutely. You know, there's lots of folks out there who

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<v Speaker 6>try to train you on how to make your memory

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<v Speaker 6>system better, and many of them you might know. Their

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<v Speaker 6>memory champions out there. They're sort of memory grand masters

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<v Speaker 6>out there, and they've learned tricks that have been used

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<v Speaker 6>by the Greeks for a long time, ancient Greeks, I

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<v Speaker 6>should say, like mind palaces and so on, And all

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<v Speaker 6>of these methods are based on forming strong personal associations.

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<v Speaker 6>So if you have never seen The Wizard of Oz,

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<v Speaker 6>it wouldn't have made sense to you, Yes, associated, right,

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<v Speaker 6>But if you've seen it and you can picture the

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<v Speaker 6>dorith the in the exact movie, right, that makes it

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<v Speaker 6>much more personal. So they tell you to try to

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<v Speaker 6>be able to remember people's faces and names, make that

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<v Speaker 6>something that is emotionally significant to you. But making those

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<v Speaker 6>connections and making them as vivid as possible seems to

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<v Speaker 6>be the trick that works for most people.

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<v Speaker 4>So I hope that helps Clay Trover, Sarah mcckeacher, and

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<v Speaker 4>Eric Kidzeg, Jennifer Frow at least we will Hannah Nowen,

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<v Speaker 4>Jacqueline Church, Nomes, lorm Or, Bennett van der Bosch, Eleen

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<v Speaker 4>lands Ken, Termine Lists, Zulika Pevic, Kelli Fon, Kelly Larson,

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<v Speaker 4>Carleen dh and Connor. They them, all of whom say

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<v Speaker 4>that they are garbage at remembering names. It's okay obviously,

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<v Speaker 4>based on that list, you are not alone, and patron

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<v Speaker 4>Jackie G said that a tour guide shared this tip

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<v Speaker 4>with them that you introduce yourself first. Then you can

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<v Speaker 4>actually listen when other people say their names instead of

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<v Speaker 4>mentally rehearsing your own introduction, and Jackie G says it's

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<v Speaker 4>amazing and has worked wonders for me, So perhaps that'll

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<v Speaker 4>make some of you less anxious. Oh, speaking of anxiety

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<v Speaker 4>and trauma and emotions in general, many many of you

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<v Speaker 4>Little miss particular Camilli Gimino, Susan Singley, Mattie Cake's Popsicle Emperor,

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<v Speaker 4>Joshua Tals and Sarah Argueta, Rowan Tree, Michelle Gregos, Ali Brown,

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<v Speaker 4>Patricia Evans, Katie Hammont and Rachel Persco wanted to know

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<v Speaker 4>how emotions affect pretension, and Nick Allston asked what's the

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<v Speaker 4>chemistry behind emotional memories? And also patron Ryan asked, Hi.

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<v Speaker 7>This is Ryan from Los Angeles. I was wondering if

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<v Speaker 7>you could speak to the effects that negative emotions such

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<v Speaker 7>as shame and guilt have on working memory and long

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<v Speaker 7>term memory.

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<v Speaker 4>Are people who experience heightened emotions, either with anxiety or

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<v Speaker 4>pretty happy people, do they keep those memories more because

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<v Speaker 4>there is more of an emotional connection.

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<v Speaker 6>There's no doubt that having an emotional connection strengthens the

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<v Speaker 6>way that you store on memory. So certainly, if you

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<v Speaker 6>tend to have much more emotional reactions to things or

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<v Speaker 6>the experience that you're having are much more emotional, they

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<v Speaker 6>will have the capacity to be stored for longer, to

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<v Speaker 6>be able to influence your actions and decisions for longer.

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<v Speaker 6>And again there's the evolutionary significance for that. Of course,

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<v Speaker 6>more emotional things may be a little bit more involved

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<v Speaker 6>in your survival. Right that said, emotion doesn't always improve

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<v Speaker 6>your ability to store things. It colors the experience, for sure,

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<v Speaker 6>but it also kind of zooms in on certain aspects

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<v Speaker 6>of the experience and zooms out from others. So you

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<v Speaker 6>may recall certain details incredibly well, but there may be

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<v Speaker 6>other things that are kind of lost on you because

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<v Speaker 6>of the emotionality. So it creates this competition between some

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<v Speaker 6>central features of the experience, and then a lot of

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<v Speaker 6>the peripheral stuff doesn't win out in that competition, and

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<v Speaker 6>that can be forgotten.

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<v Speaker 4>Many of you wondered about what is normal given our

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<v Speaker 4>very chaotic and technological world, such as pologist from the

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<v Speaker 4>Carobology episode, Meghan lynch Amelia Frank, Jinny Bateman, Katie brick Klein,

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<v Speaker 4>Margaret and Nuskum Randapana Regular k Waspsologist, Eric are Eaton,

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<v Speaker 4>Rachel m Meghan Walker, Tiny Nature and first time question

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<v Speaker 4>askers Julie Williams, Chelsea Loves Chocolate, Theo Klin, Tara Villanova,

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<v Speaker 4>and some folks who are distracted by Struus don ewelld

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<v Speaker 4>Holly Coole, Eric Masterson, and Helen Langale. I wonder if

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<v Speaker 4>our lack of presence, because we were distracted a lot

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<v Speaker 4>with our phones and internet stuff, I wonder if that

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<v Speaker 4>lack of presence is making our memories a little bit

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<v Speaker 4>more Swiss cheesy.

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<v Speaker 6>I like this Swiss cheesy. It's a good way to

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<v Speaker 6>think about it. Certainly, every time that I've lifted up

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<v Speaker 6>my phone and tried to record a video of my

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<v Speaker 6>daughter playing basketball, as opposed to put the phone down

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<v Speaker 6>and actually watch her play, I feel like I have

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<v Speaker 6>Swiss cheese in my brain. Yeah, so one percent. I

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<v Speaker 6>think that you're right when we replace actually experiencing something

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<v Speaker 6>in its full glory, three dimensional and all of that

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<v Speaker 6>with some two D version of what we're recording on

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<v Speaker 6>the phone, or being distracted by looking at something at

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<v Speaker 6>the same time and not being fully aware, fully cognizant

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<v Speaker 6>of what's happening. Of course, it's going to change how

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<v Speaker 6>these memories are stored and how they're represented, and I

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<v Speaker 6>do worry about that. I think that, you know, there's

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<v Speaker 6>no doubt that there's value to having the electronics and

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<v Speaker 6>having I mean, look at us, we have our devices

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<v Speaker 6>are out all the time, and that's just the nature

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<v Speaker 6>of what we have to do to be able to

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<v Speaker 6>deal with the situations around us and the rapidly kind

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<v Speaker 6>of evolving world and all of the stimulation. But I

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<v Speaker 6>think it misses something about experiencing something fully and truly

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<v Speaker 6>with all of its three dimension at four dimensionality, i

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<v Speaker 6>should say, and with all the emotional contexts that come

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<v Speaker 6>with it, right, and to be able to have that

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<v Speaker 6>genuinely you have to be there. So immersion, I think

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<v Speaker 6>is really key for good memory storage.

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<v Speaker 4>So those four dimensions are like a three D object

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<v Speaker 4>on the x, y, and Z axis, but with the

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<v Speaker 4>added dimension of time. It's interesting because we're experiencing it

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<v Speaker 4>less in the moment, but we're able to recall it

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<v Speaker 4>more With that video footage, and it's such a weird

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<v Speaker 4>trade off that it's like, well, I can remember it

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<v Speaker 4>later as long as I don't fully experience it now.

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<v Speaker 6>It is a weird trade off because what you remember

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<v Speaker 6>based on the video is this weird sort of you know,

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<v Speaker 6>two dimensional version on a screen, and you're never able

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<v Speaker 6>to piece back being there fully in three dimensions. But

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<v Speaker 6>if that was your experience, that's what you piece back,

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<v Speaker 6>So it comes back with all of the pleasure, the

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<v Speaker 6>sensory experience that came with it, as opposed to if

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<v Speaker 6>you're looking at the screen, that's your version of that reality,

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<v Speaker 6>and that's what comes back. It's just that two dimensional,

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<v Speaker 6>more impoverished version. Yeah, and that, to me, I think

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<v Speaker 6>is the big concern.

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<v Speaker 4>That's funny because I my husband and I got married

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<v Speaker 4>three years ago and a good friend of mine was like,

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<v Speaker 4>let's watch the video on your first anniversary. My husband

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<v Speaker 4>and I can't watch the video. What we remember from

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<v Speaker 4>it is what we remember, and both of us have

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<v Speaker 4>like the ick when it comes to watching it.

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<v Speaker 2>For some reason.

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<v Speaker 4>We're like, I don't want to remember it any differently

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<v Speaker 4>because we are kind of always, like you said, reconstructing

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<v Speaker 4>those memories based on input right.

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<v Speaker 6>And you don't want to change the version that you

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<v Speaker 6>have in your brain, especially if that version was beautiful

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<v Speaker 6>and something that you want to hold on to. Now.

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<v Speaker 6>I have the anytime anybody tells me to watch a

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<v Speaker 6>video of myself, So I just can't do it. Categorically,

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<v Speaker 6>that's just something I don't want to do. But I

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<v Speaker 6>can totally resonate with what you're saying. If you've experienced

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<v Speaker 6>it fully being there, being able to piece it back

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<v Speaker 6>together in this two dimensional version, and looking at it

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<v Speaker 6>on a video, it's just never the same and it

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<v Speaker 6>kind of alters your actual recollection of that experience.

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<v Speaker 4>And a University of Chicago study recently recruited users of

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<v Speaker 4>this app called One Second every Day to hop it

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<v Speaker 4>an MRI and look at quick videos of strangers lives

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<v Speaker 4>versus one second clips that they had recorded themselves using

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<v Speaker 4>that app, and this study found that different parts of

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<v Speaker 4>the brain light up if it was their own memory

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<v Speaker 4>versus just intaking a stranger's video. And other neurobiologists at

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<v Speaker 4>the University of Toronto are exploring how video diaries like

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<v Speaker 4>that could help Alzheimer's patients connect more to their own past,

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<v Speaker 4>so to patrons Antifa and Rosalie de Laforet, who recall

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<v Speaker 4>more when prompted by photos and videos. That's some real

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<v Speaker 4>science right there for you everyone else. That app was

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<v Speaker 4>called one Second every Day If you want to log

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<v Speaker 4>little chunks of your whole life. Now, what if you

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<v Speaker 4>don't need physical memorabilia or pixels to jog your memory?

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<v Speaker 4>What if your mind is a camera? So Alia Myers

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<v Speaker 4>and Erica Perryandre, among others, had questions about that.

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<v Speaker 7>Well.

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<v Speaker 4>On the topic of photographic memory, many people asked. Mariah

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<v Speaker 4>Kay said, this question has been on my mind for

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<v Speaker 4>so long, all caps. I know there's photographic memory, but

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<v Speaker 4>are there different versions or levels of it? Read Berry

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<v Speaker 4>wants to know what actually is photographic memory? This question

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<v Speaker 4>was us why Cyberman's, Erica Harry Andre, Rachel McGill Arla Gramlkin,

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<v Speaker 4>what is photographic memory exactly?

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<v Speaker 6>Okay, fellas, this is mythbust in time. Okay, ready, yeah,

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<v Speaker 6>photographic memory does not exist. Hell, and it's so uncomfortable

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<v Speaker 6>to hear that. Well, So photographic memory is or what

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<v Speaker 6>we sometimes referred to as idetic memory. And you know

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<v Speaker 6>the way that it's defined, it's that you have this

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<v Speaker 6>perfect recall, perfect recollection of something that you've seen potentially

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<v Speaker 6>only once, right, and if it's in the context of

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<v Speaker 6>say reading, you're talking about like a remembering page numbers and

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<v Speaker 6>all of that. The evidence that that exists historically is

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<v Speaker 6>slim to none. We've been led to there's maybe a

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<v Speaker 6>very small handful of cases of savant syndrome where somebody

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<v Speaker 6>could legitimately make the claim for true photographic memory, But

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<v Speaker 6>aside from that, there's no real evidence that photographic memory

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<v Speaker 6>to this sense exists. That said, there's really really really

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<v Speaker 6>good memory, and this really really really bad memory. There's

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<v Speaker 6>a whole spectrum and a lot of times when we're

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<v Speaker 6>thinking about photographic memory, it's not exactly that, but it's close.

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<v Speaker 6>It's really good memory where you're memorizing where things are

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<v Speaker 6>laid out on the page, where you may be memorizing

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<v Speaker 6>things like you know, the page numbers and where the

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<v Speaker 6>figures were, where the pictures were, all that kind of stuff,

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<v Speaker 6>to the extent that we can tell whether or not

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<v Speaker 6>you know that that's actually helpful in a day to

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<v Speaker 6>day learning, it's not clear whether or not that actually

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<v Speaker 6>helps you.

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<v Speaker 4>And well, a true photographic memory is at this point

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<v Speaker 4>just flim flam. There is such a thing as idetic memory,

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<v Speaker 4>where someone can see a visual and look at it

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<v Speaker 4>or sometimes hear something, and once it's removed, they can

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<v Speaker 4>recall it in great detail. It's as if visually they're

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<v Speaker 4>still looking at it, but it's not one hundred percent faithful,

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<v Speaker 4>and it does not last a lifetime. Your brain's like,

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<v Speaker 4>I don't really need that fancy of a feature.

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<v Speaker 6>Because remember, what we're trying to learn and remember on

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<v Speaker 6>a day to day basis is not necessarily the details

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<v Speaker 6>of the exact words on a page or the exact

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<v Speaker 6>details of what happened. It's the gist. It's sort of

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<v Speaker 6>the overall is kind of abstracted. It's whatever knowledge it

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<v Speaker 6>can abstract from that experience and be able to use

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<v Speaker 6>it to guide my future decision making. So, if you

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<v Speaker 6>start to think about memory a little bit differently, that

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<v Speaker 6>it's not really about the past, it's all about the future,

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<v Speaker 6>this is no longer uncomfortable. It's okay to sit with

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<v Speaker 6>that that there's no photographic memory because there's no rationale,

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<v Speaker 6>there's no reason for it to exists.

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<v Speaker 4>So though we debunked learning styles in part one, what

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<v Speaker 4>about people who don't retain things as well visually but

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<v Speaker 4>through sound. Hey, first time question askers Kimberly, Kirston Cornell,

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<v Speaker 4>as well as E Jordan Sewn, Thomas k Matthew Walcher,

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<v Speaker 4>Lisa Gorman, Maria Kay, Josh Walden, sonny As, Vanessa Adams,

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<v Speaker 4>Daniel van Voren, Jennifer Frow, Debda Science, Alicia Clarkson and

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<v Speaker 4>Sam wanted to know about sound and memory, including song lyrics. Well,

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<v Speaker 4>I know because we have obviously a lot of listeners

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<v Speaker 4>who learn by auditory memory. Are some people better at

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<v Speaker 4>recalling things that they hear it?

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<v Speaker 6>Yes? Okay, yes, so, and this takes us back to

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<v Speaker 6>a COmON station about learning styles. So I want to

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<v Speaker 6>be very clear, right, it is a myth. Learning styles

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<v Speaker 6>is a myth. There is no one way to be

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<v Speaker 6>able to get to your brain, and it could be

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<v Speaker 6>visual for you or auditory for you. That said, people

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<v Speaker 6>do have individual differences in how much they learn visually

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<v Speaker 6>and how much they learn through their ears auditorily, and

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<v Speaker 6>how much they learn through other senses. But at the

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<v Speaker 6>end of the day, the most effective learning is the

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<v Speaker 6>one that combines the most senses. Ah So as a species,

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<v Speaker 6>we are far more visual as a species collectively. If

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<v Speaker 6>you look at rodents, for example, rats, they have a

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<v Speaker 6>much stronger sense of smell than we ever would be

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<v Speaker 6>motivated by. Right, that does not diminish our sense of smell,

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<v Speaker 6>does not diminish our other senses, But it says that

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<v Speaker 6>primarily because we are not nocturnal, we operate usually in daylight,

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<v Speaker 6>and the sunlight visual information seems to be really important

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<v Speaker 6>to us. We tend to kind of prioritize that we

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<v Speaker 6>have a lot more real estate in our brain dedicated

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<v Speaker 6>to processing of the visual sense and to other senses.

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<v Speaker 6>So when somebody says, well, I learned better if I

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<v Speaker 6>hear it, I'll say I'm willing to bet that you'd

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<v Speaker 6>learn better if you heard it and saw it at

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<v Speaker 6>the same time. Ah, So don't just rely on oh,

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<v Speaker 6>I just want to hear it if you can. So,

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<v Speaker 6>for example, if you're reading and you say I'm just

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<v Speaker 6>not a reader, we'll try reading out loud so you're

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<v Speaker 6>also hearing it and listening to yourself say the words,

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<v Speaker 6>and you'll notice that that is a bimodal kind of learning,

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<v Speaker 6>and things will stick a lot more.

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<v Speaker 4>We did a reading episode recently and there was a

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<v Speaker 4>big question as to whether or not audiobooks were reading,

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<v Speaker 4>whether they count, whether you can count them in your book.

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<v Speaker 6>Oh, I sure hope they count.

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<v Speaker 2>Yeah.

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<v Speaker 4>So we talked about this in the recent Anagnosology episode

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<v Speaker 4>all about Reading, and I'll just give you an excerpt

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<v Speaker 4>from that with doctor Adrian Johns, who is a professor

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<v Speaker 4>and a historian and who authored the book The Science

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<v Speaker 4>of Reading.

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<v Speaker 8>It's actually interesting that e books or actually audiobooks more

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<v Speaker 8>the idea that you could, as it well, read a

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<v Speaker 8>novel or something by having it read to you by machine.

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<v Speaker 8>There are schemes for those going back as far as

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<v Speaker 8>the pretty much the origin of recording, so the late

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<v Speaker 8>nineteen thirty twentieth century, there were visionary schemes for having

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<v Speaker 8>things like, oh, you know, vending machines where you could

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<v Speaker 8>put your money in and there would be a speaker,

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<v Speaker 8>you know, like a speaking trumpet that would speak a book.

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<v Speaker 8>It's not like there's something that is that radically new

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<v Speaker 8>about audiobooks per se. Having said that, I mean my

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<v Speaker 8>own sense of it kind of crudely is that I

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<v Speaker 8>think with audiobooks it's really that you're having something read

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<v Speaker 8>to you rather than reading. And part of that has

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<v Speaker 8>to do with the control of the pace of it,

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<v Speaker 8>you know, so you can slow down recordings, you can

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<v Speaker 8>pause it, and all of that kind of thing. But

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<v Speaker 8>it's not the same as doing what mon does with

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<v Speaker 8>one's mind's eye all the time in reading a page,

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<v Speaker 8>where you're constantly shifting the speed and considering things and

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<v Speaker 8>going back, you know, without necessarily thinking about it. You

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<v Speaker 8>don't have to press a button or something. Ebooks, on

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<v Speaker 8>the other hand, I think are just reading. I mean,

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<v Speaker 8>I don't have any issue with those at all.

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<v Speaker 4>So doctor John's is a reading scholar, and I am

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<v Speaker 4>a lady recording this while not wearing a bra, but

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<v Speaker 4>whose entire life revolves around reading to people. So we'll

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<v Speaker 4>have to arm wrestle for dominance. But I will say

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<v Speaker 4>that per an ancient study from the late nineteen sixties

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<v Speaker 4>titled Retention and Recall Incidental Learning of visual and auditory

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<v Speaker 4>material in the Journal of Genetic Psychology, that visual memories tend.

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<v Speaker 2>To be better for recall.

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<v Speaker 4>But there is quote a decline with age for recall

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<v Speaker 4>of visual material, but virtually no deterioration in performance on

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<v Speaker 4>the auditory task. So I'm going to amplify that data

418
00:21:34.559 --> 00:21:37.720
<v Speaker 4>in my favor now what about smell? Cody bardoc Vanessa Adams,

419
00:21:37.799 --> 00:21:40.400
<v Speaker 4>Christine Hurley, The Dork next door a, Manda Regan, Guy

420
00:21:40.480 --> 00:21:43.640
<v Speaker 4>Hutchinson eating dark hair for a Living Renee Vandenhoven, Jess

421
00:21:43.799 --> 00:21:47.160
<v Speaker 4>h Fiona, Elizabeth Karro Young Anastasia press All wanted to

422
00:21:47.200 --> 00:21:50.359
<v Speaker 4>know about smell and memory, and Susan Singley asked, why

423
00:21:50.359 --> 00:21:54.640
<v Speaker 4>do some aromas bring back such clear and nostalgic memories

424
00:21:54.920 --> 00:21:59.480
<v Speaker 4>like cut grass, old books, coconut sunscreen, ocean waves, and

425
00:21:59.519 --> 00:22:00.799
<v Speaker 4>that smell after rain.

426
00:22:01.119 --> 00:22:02.480
<v Speaker 2>But yeah, earlier Mike.

427
00:22:02.400 --> 00:22:05.920
<v Speaker 4>Mentioned that rodents have a much stronger sense of smell

428
00:22:05.960 --> 00:22:08.279
<v Speaker 4>than us, and I wonder if they feel nostalgic for

429
00:22:08.319 --> 00:22:09.400
<v Speaker 4>smelling certain garbage.

430
00:22:09.440 --> 00:22:09.960
<v Speaker 2>I bet they do.

431
00:22:10.480 --> 00:22:10.640
<v Speaker 4>Well.

432
00:22:10.680 --> 00:22:12.559
<v Speaker 2>You mentioned smell and rats.

433
00:22:13.079 --> 00:22:16.839
<v Speaker 4>We have an excellent Urban Rodentology episode about rats that

434
00:22:16.960 --> 00:22:20.319
<v Speaker 4>made me cry with affection for rats. But Amanda Regan

435
00:22:20.359 --> 00:22:24.720
<v Speaker 4>wanted to know why do smells or sounds trigger memories sometimes?

436
00:22:24.880 --> 00:22:26.279
<v Speaker 2>And I have.

437
00:22:26.319 --> 00:22:30.240
<v Speaker 4>Heard that it's difficult to really know what a smell is.

438
00:22:30.319 --> 00:22:31.920
<v Speaker 4>You have to have a memory of that smell that

439
00:22:31.960 --> 00:22:34.160
<v Speaker 4>it goes straight to some memory center.

440
00:22:34.480 --> 00:22:37.359
<v Speaker 2>Ye, what's up with that couple things?

441
00:22:37.440 --> 00:22:39.160
<v Speaker 6>So let me break this down, because you asked a

442
00:22:39.160 --> 00:22:41.240
<v Speaker 6>couple of really really interesting questions, but they're a little

443
00:22:41.240 --> 00:22:43.319
<v Speaker 6>bit different from each other. So the first one is

444
00:22:43.400 --> 00:22:46.359
<v Speaker 6>maybe whether or not we can sort of label smells.

445
00:22:46.519 --> 00:22:48.720
<v Speaker 6>You can label a sound, and people that have perfect

446
00:22:48.720 --> 00:22:50.440
<v Speaker 6>pitch can tell you exactly what note it is and

447
00:22:50.480 --> 00:22:53.200
<v Speaker 6>so on, and you can certainly label visual things. We

448
00:22:53.240 --> 00:22:56.759
<v Speaker 6>have objects, we have things colors, right, but with smells,

449
00:22:56.759 --> 00:22:59.079
<v Speaker 6>it's a little bit different, and we don't have a

450
00:22:59.079 --> 00:23:01.680
<v Speaker 6>great lexicon for ss smells. A lot of times we're

451
00:23:01.680 --> 00:23:04.880
<v Speaker 6>relegated to kind of like lavender, kind of like and

452
00:23:04.920 --> 00:23:06.960
<v Speaker 6>fill in the blank, right, something that you're familiar with,

453
00:23:07.359 --> 00:23:09.000
<v Speaker 6>But that's the rob You have to go back to

454
00:23:09.039 --> 00:23:11.920
<v Speaker 6>something that you're familiar with, so it reminds you of

455
00:23:11.960 --> 00:23:14.319
<v Speaker 6>something else. It reminds me of something that you might

456
00:23:14.319 --> 00:23:17.200
<v Speaker 6>have smelled or since before, and that maybe just that

457
00:23:17.279 --> 00:23:20.880
<v Speaker 6>evolutionary thing, like we haven't really evolved to prioritize this

458
00:23:21.039 --> 00:23:24.640
<v Speaker 6>kind of information, smell information. We don't use it typically

459
00:23:24.720 --> 00:23:27.160
<v Speaker 6>to navigate around the world, although if you've got a

460
00:23:27.319 --> 00:23:29.839
<v Speaker 6>nice baking cake in a kitchen, you might navigate your

461
00:23:29.880 --> 00:23:32.839
<v Speaker 6>way there. So in some situations maybe it's helpful, but

462
00:23:32.880 --> 00:23:35.200
<v Speaker 6>we tend to navigate mostly based on visual information.

463
00:23:35.599 --> 00:23:38.440
<v Speaker 4>So our sense of smell isn't keen enough to save

464
00:23:38.559 --> 00:23:42.039
<v Speaker 4>us essentially, so it remains pretty mid. And think back

465
00:23:42.079 --> 00:23:44.759
<v Speaker 4>to any time you've tried to describe a smell, You've

466
00:23:44.759 --> 00:23:47.440
<v Speaker 4>probably said it smells like and thought of the last

467
00:23:47.480 --> 00:23:51.720
<v Speaker 4>instance or the strongest instance of smelling something like that thing.

468
00:23:52.200 --> 00:23:53.559
<v Speaker 6>We tend to kind of know what we need to

469
00:23:53.559 --> 00:23:56.880
<v Speaker 6>do based on visual information. So because it was never prioritized,

470
00:23:57.240 --> 00:24:00.680
<v Speaker 6>we never sort of bothered to create robustly lab for it.

471
00:24:01.079 --> 00:24:04.000
<v Speaker 6>And when you don't have labels for things, your brain

472
00:24:04.200 --> 00:24:06.440
<v Speaker 6>sort of struggle to kind of store it with that

473
00:24:06.440 --> 00:24:08.480
<v Speaker 6>fidelity because you don't have that verbal thing that you

474
00:24:08.519 --> 00:24:10.640
<v Speaker 6>can attach to it. I know what a coffee monk

475
00:24:10.680 --> 00:24:13.640
<v Speaker 6>is because I have a verbal label for those coffee monks, right,

476
00:24:13.799 --> 00:24:16.200
<v Speaker 6>So that's one piece. The other piece, which I think

477
00:24:16.279 --> 00:24:21.839
<v Speaker 6>is fascinating, is that especially smells can trigger memories, sometimes

478
00:24:21.920 --> 00:24:25.359
<v Speaker 6>long lost memories. There's a certain smells that will remind

479
00:24:25.400 --> 00:24:27.839
<v Speaker 6>me of my grandmother's house, certain smells that remind me

480
00:24:27.880 --> 00:24:31.000
<v Speaker 6>of specific people in my past because that might have

481
00:24:31.039 --> 00:24:33.000
<v Speaker 6>been the perfume or clone they wear or something like

482
00:24:33.039 --> 00:24:36.079
<v Speaker 6>that or similar to it. And then the experience of

483
00:24:36.319 --> 00:24:39.319
<v Speaker 6>going back sort of it like washes over you. You

484
00:24:39.440 --> 00:24:42.079
<v Speaker 6>kind of go back in time, immersed your exactly in

485
00:24:42.119 --> 00:24:47.200
<v Speaker 6>that moment. The sense of smell almost has this incredibly

486
00:24:47.240 --> 00:24:50.079
<v Speaker 6>privileged capacity to do this, And we don't know why

487
00:24:50.119 --> 00:24:54.039
<v Speaker 6>this happens, but we suspect that it's possible. Part of

488
00:24:54.079 --> 00:24:57.279
<v Speaker 6>it is the fact that your sense of smell, unlike

489
00:24:57.359 --> 00:25:00.519
<v Speaker 6>all of the other senses, it has direct access to

490
00:25:00.519 --> 00:25:03.960
<v Speaker 6>your hippocampus, your memory bits of the brain. And it's

491
00:25:03.960 --> 00:25:06.039
<v Speaker 6>not clear why that is, but it's sort of co

492
00:25:06.160 --> 00:25:09.839
<v Speaker 6>evolved that way. The sensory systems in the brain that

493
00:25:09.880 --> 00:25:12.680
<v Speaker 6>are outside of smell, so vision, audition, all have to

494
00:25:12.720 --> 00:25:15.079
<v Speaker 6>go through the thalamus, which is this sort of major

495
00:25:15.160 --> 00:25:17.279
<v Speaker 6>hub in the brain before they get to the memory

496
00:25:17.279 --> 00:25:20.160
<v Speaker 6>parts of the brain. There isn't like this direct access,

497
00:25:20.599 --> 00:25:25.240
<v Speaker 6>whereas everywhere else this happens. For our sense of smell,

498
00:25:25.440 --> 00:25:28.319
<v Speaker 6>it doesn't happen. Our sense smell doesn't go through the thalamus.

499
00:25:28.480 --> 00:25:31.759
<v Speaker 6>It like directly has this you know, revolving door straight

500
00:25:31.799 --> 00:25:33.640
<v Speaker 6>into our memory bits of the brain. And we have

501
00:25:33.759 --> 00:25:36.519
<v Speaker 6>no clue why the hell that is. It's just this weird,

502
00:25:36.599 --> 00:25:39.400
<v Speaker 6>quizzical thing. And I don't know to what extents that

503
00:25:39.480 --> 00:25:41.640
<v Speaker 6>means it's truly privileged, and that's the reason why we

504
00:25:41.720 --> 00:25:44.720
<v Speaker 6>remember thinks so vividly. But it seems plausible that it's

505
00:25:44.720 --> 00:25:47.400
<v Speaker 6>at least a contributing factor that you don't have to

506
00:25:47.799 --> 00:25:50.359
<v Speaker 6>gate through somewhere else before you get to the hippocampus

507
00:25:50.519 --> 00:25:50.960
<v Speaker 6>right there.

508
00:25:51.160 --> 00:25:55.079
<v Speaker 4>It's like an express train. Yeah, so exciting. What about

509
00:25:55.599 --> 00:25:59.480
<v Speaker 4>as someone who has had a nasty concussion Hope Lauren

510
00:25:59.519 --> 00:26:03.119
<v Speaker 4>Galia Well at a capello Adam Foot's wife Anna, a

511
00:26:03.160 --> 00:26:07.680
<v Speaker 4>bunch of people wanted to know how studying concussions or

512
00:26:07.720 --> 00:26:11.480
<v Speaker 4>TBI has influenced work or influences our memory.

513
00:26:12.000 --> 00:26:15.480
<v Speaker 6>You know, it's challenging with concussions or TBI traumatic brain

514
00:26:15.519 --> 00:26:17.720
<v Speaker 6>injury because there's no two injuries that are the same,

515
00:26:18.279 --> 00:26:21.359
<v Speaker 6>so that is a particularly difficult set of conditions. It

516
00:26:21.359 --> 00:26:24.079
<v Speaker 6>depends on the severity of the concussion, the location, all

517
00:26:24.119 --> 00:26:27.039
<v Speaker 6>sorts of things, and we're learning a lot more about this.

518
00:26:27.200 --> 00:26:30.119
<v Speaker 6>Clearly it impacts a variety of different memory systems, memory

519
00:26:30.160 --> 00:26:33.000
<v Speaker 6>being one of the key ones that gets impacted. But

520
00:26:33.160 --> 00:26:36.039
<v Speaker 6>depending on the kind of injury, whether it's a coup

521
00:26:36.079 --> 00:26:38.680
<v Speaker 6>contrac coup kind of injury where they're sort of stretching

522
00:26:38.720 --> 00:26:42.480
<v Speaker 6>and shearing of some of the brains, white matter pathways,

523
00:26:42.559 --> 00:26:46.000
<v Speaker 6>the connections between different regions. All of those things tend

524
00:26:46.000 --> 00:26:49.799
<v Speaker 6>to happen. There's inflammation, there's sometimes franc injury. You can

525
00:26:49.839 --> 00:26:53.559
<v Speaker 6>actually see evidence of that, but it's not clear how

526
00:26:53.640 --> 00:26:56.720
<v Speaker 6>much of that is, first of all, common across individuals,

527
00:26:56.759 --> 00:26:59.640
<v Speaker 6>because again the extent of the injury is different, the ideology,

528
00:26:59.680 --> 00:27:01.759
<v Speaker 6>the rooms of the injury, the cause it can be very,

529
00:27:01.839 --> 00:27:04.759
<v Speaker 6>very different. But the fact that memory is impacted almost

530
00:27:04.799 --> 00:27:11.079
<v Speaker 6>in all concussive injuries is an interesting phenomenon, and I

531
00:27:11.079 --> 00:27:13.960
<v Speaker 6>always go back to our memory system is, or at

532
00:27:14.000 --> 00:27:16.359
<v Speaker 6>least the hippocampal memory system, is one of the most

533
00:27:16.519 --> 00:27:19.680
<v Speaker 6>vulnerable systems in the brain. It tends to feel the

534
00:27:19.720 --> 00:27:21.079
<v Speaker 6>brunt of pretty much anything.

535
00:27:21.519 --> 00:27:25.039
<v Speaker 4>Patrons Rye of the Tiger, Heidi Brina Palencia and Christine

536
00:27:25.079 --> 00:27:29.799
<v Speaker 4>Hurley asked about what is loathsomely called mom brain, or

537
00:27:29.839 --> 00:27:32.240
<v Speaker 4>in Tim Farr's words, I don't feel like I know

538
00:27:32.400 --> 00:27:35.920
<v Speaker 4>things anymore, and it's horrible. I myself do not have kids,

539
00:27:36.000 --> 00:27:39.240
<v Speaker 4>but I have damaged my brain with a hospital grade

540
00:27:39.279 --> 00:27:40.039
<v Speaker 4>below to the head.

541
00:27:40.160 --> 00:27:42.640
<v Speaker 6>I feel for you, and not just concussions, but even

542
00:27:42.640 --> 00:27:47.079
<v Speaker 6>if we're sleep deprived, even if we're anxious or depressed,

543
00:27:47.160 --> 00:27:50.960
<v Speaker 6>or anything that's happening to us tends to impact the system.

544
00:27:51.480 --> 00:27:54.039
<v Speaker 6>It is one of our most primitive systems in the brain.

545
00:27:54.119 --> 00:27:56.839
<v Speaker 6>It's one that we shared with all the mammalian species

546
00:27:56.880 --> 00:27:59.480
<v Speaker 6>and many others. Even though it's tucked in the middle

547
00:27:59.519 --> 00:28:01.160
<v Speaker 6>of the brain, it seems like it would be like

548
00:28:01.240 --> 00:28:04.160
<v Speaker 6>nice and enveloped and covered up. It has kind of

549
00:28:04.200 --> 00:28:07.400
<v Speaker 6>weird positioning. The vasculature around it is quite vulnerable. The

550
00:28:07.440 --> 00:28:11.039
<v Speaker 6>white matter is quite vulnerable. It's also very close to

551
00:28:11.319 --> 00:28:14.400
<v Speaker 6>the most porous parts of the blood brain barrier, so

552
00:28:14.839 --> 00:28:18.720
<v Speaker 6>toxins can get into those limbic structures much more easily

553
00:28:18.759 --> 00:28:20.079
<v Speaker 6>than in other places in the brain.

554
00:28:20.400 --> 00:28:23.519
<v Speaker 4>So remember from part one that memories are stored all

555
00:28:23.599 --> 00:28:26.720
<v Speaker 4>over the brain, kind of like coins hidden in the sand.

556
00:28:26.960 --> 00:28:31.400
<v Speaker 4>But the hippocampus, that seahorse shaped organ, acts as a

557
00:28:31.440 --> 00:28:35.039
<v Speaker 4>sort of metal detector to find and retrieve those memories.

558
00:28:35.400 --> 00:28:39.160
<v Speaker 4>So the hippocampus is this wicked combination of really important

559
00:28:39.519 --> 00:28:40.759
<v Speaker 4>and very delicate.

560
00:28:41.480 --> 00:28:45.000
<v Speaker 6>Just be careful. So it's just the hub of vulnerability,

561
00:28:45.440 --> 00:28:46.960
<v Speaker 6>and it's one of the reasons why we studied so

562
00:28:47.000 --> 00:28:49.640
<v Speaker 6>excessively in my lab across a variety of different conditions

563
00:28:49.960 --> 00:28:52.920
<v Speaker 6>because we believe that it is very vulnerable and if

564
00:28:52.960 --> 00:28:55.319
<v Speaker 6>we develop ways to be able to protect it or

565
00:28:55.359 --> 00:28:58.279
<v Speaker 6>treat it, that will generalize across a number of different conditions.

566
00:28:58.759 --> 00:29:02.319
<v Speaker 4>And is it rather knew that we even know that

567
00:29:02.359 --> 00:29:05.200
<v Speaker 4>the blood brain barrier is permeable at all?

568
00:29:05.960 --> 00:29:08.279
<v Speaker 6>Yeah, I would think. I mean, we've always known that

569
00:29:08.319 --> 00:29:10.880
<v Speaker 6>it's permeable to some things. We know this because there's

570
00:29:10.960 --> 00:29:12.440
<v Speaker 6>a lot of things that are in our blood that

571
00:29:12.480 --> 00:29:14.319
<v Speaker 6>get through the blood brain barrier very quickly and get

572
00:29:14.359 --> 00:29:16.839
<v Speaker 6>into our brain easily. Alcohol is one of those, right

573
00:29:16.880 --> 00:29:19.079
<v Speaker 6>that gets straight from the blood to the brain. So

574
00:29:19.119 --> 00:29:21.200
<v Speaker 6>there are things that we've known about for quite some

575
00:29:21.319 --> 00:29:25.200
<v Speaker 6>time that can traverse that barrier with great ease. But

576
00:29:25.720 --> 00:29:28.039
<v Speaker 6>there are new things that we're learning about now that

577
00:29:28.119 --> 00:29:31.119
<v Speaker 6>we didn't realize can get through the blood brain barrier easily,

578
00:29:31.480 --> 00:29:33.839
<v Speaker 6>that seem to get through. And some of these things

579
00:29:33.880 --> 00:29:37.240
<v Speaker 6>maybe inflammatory in nature, some of them may be toxins.

580
00:29:37.599 --> 00:29:39.839
<v Speaker 6>So when we talk about the connection between the body

581
00:29:39.839 --> 00:29:43.079
<v Speaker 6>and the brain, that is real and it's always been there,

582
00:29:43.119 --> 00:29:45.559
<v Speaker 6>but we've only really started to study the sort of

583
00:29:45.799 --> 00:29:49.079
<v Speaker 6>mind body or brain body connection much more in recent

584
00:29:49.160 --> 00:29:52.160
<v Speaker 6>years and trying to understand how our gut, for example,

585
00:29:52.200 --> 00:29:54.880
<v Speaker 6>influences our brain, how our brain influences our gut, this

586
00:29:55.000 --> 00:29:57.119
<v Speaker 6>back and forth, which has to be able to kind

587
00:29:57.160 --> 00:29:59.119
<v Speaker 6>of get through some of those barriers, and the blood

588
00:29:59.119 --> 00:30:02.119
<v Speaker 6>brain barrier being the one. One of the most interesting

589
00:30:02.160 --> 00:30:05.160
<v Speaker 6>things that happened in terms of technology recently is there

590
00:30:05.200 --> 00:30:09.039
<v Speaker 6>is actually an approach technique using what's called focused ultrasound

591
00:30:09.359 --> 00:30:12.359
<v Speaker 6>to open up the blood brain barrier to be able

592
00:30:12.400 --> 00:30:14.759
<v Speaker 6>to transmit things through. Because it's always been a challenge

593
00:30:14.799 --> 00:30:19.319
<v Speaker 6>for us in developing drugs and interventions, sort of pharmacological interventions,

594
00:30:19.599 --> 00:30:21.480
<v Speaker 6>how to package something just right to get it through

595
00:30:21.519 --> 00:30:24.279
<v Speaker 6>the blood brain barrier. And this may be this other approach.

596
00:30:24.480 --> 00:30:26.799
<v Speaker 6>It seems a little scary, I know, but with focused

597
00:30:26.839 --> 00:30:29.880
<v Speaker 6>ultrasounds and what's called microbubbles, we can actually open up

598
00:30:29.960 --> 00:30:32.359
<v Speaker 6>the blood brain barrier and get some things that maybe

599
00:30:32.359 --> 00:30:35.480
<v Speaker 6>are larger macromolecules that normally wouldn't get through actually to

600
00:30:35.759 --> 00:30:38.519
<v Speaker 6>go through the blood brain barrier. So lots of fun

601
00:30:38.599 --> 00:30:40.720
<v Speaker 6>activity these days in research on the blood brain barrier.

602
00:30:41.000 --> 00:30:43.319
<v Speaker 4>Well, you mentioned something about the gut connection to people

603
00:30:43.359 --> 00:30:44.519
<v Speaker 4>are talking a lot about.

604
00:30:44.279 --> 00:30:45.039
<v Speaker 2>The vagus nerve.

605
00:30:45.160 --> 00:30:47.720
<v Speaker 4>Yes, just a quick background on that vegas nerve so

606
00:30:47.759 --> 00:30:49.559
<v Speaker 4>it's the longest nerve in your body, and it plays

607
00:30:49.599 --> 00:30:53.039
<v Speaker 4>this key role in your parasympathetic nervous system, which is

608
00:30:53.119 --> 00:30:56.799
<v Speaker 4>the chill side, the rest and digest as the vagus

609
00:30:56.839 --> 00:30:59.400
<v Speaker 4>nerve carries messages between your heart and your brain and

610
00:30:59.440 --> 00:31:02.799
<v Speaker 4>your guts. And according to this twenty seventeen study, childhood

611
00:31:02.799 --> 00:31:07.119
<v Speaker 4>trauma and lifetime syncopy burden among older adults. Researchers say

612
00:31:07.119 --> 00:31:10.599
<v Speaker 4>that vasovagal syncope where your heart rate and blood pressure

613
00:31:10.799 --> 00:31:14.160
<v Speaker 4>fall suddenly, which can cause dizziness and sweating or fainting.

614
00:31:14.480 --> 00:31:17.680
<v Speaker 4>According to the study, it's governed by the autonomic nervous

615
00:31:17.720 --> 00:31:22.680
<v Speaker 4>system and it's often precipitated by a highly salient emotional situation.

616
00:31:23.160 --> 00:31:26.559
<v Speaker 4>And researchers found that the report of childhood abuse was

617
00:31:26.680 --> 00:31:31.039
<v Speaker 4>independently associated with frequent syncope in youth. So what role

618
00:31:31.240 --> 00:31:34.640
<v Speaker 4>does this physiology have. Does that vegus nerve play a

619
00:31:34.720 --> 00:31:35.839
<v Speaker 4>role in memory at all?

620
00:31:36.319 --> 00:31:39.519
<v Speaker 6>It certainly does. One easy way to think about that,

621
00:31:39.759 --> 00:31:41.680
<v Speaker 6>and it's been known for quite some time, is that

622
00:31:41.720 --> 00:31:44.559
<v Speaker 6>this is one of the ways by which the adrenal

623
00:31:44.599 --> 00:31:47.640
<v Speaker 6>hormones can impact the brain. So when we think about

624
00:31:47.640 --> 00:31:51.599
<v Speaker 6>cortisol and cortisol release, when we think about epinephrine. Those

625
00:31:51.720 --> 00:31:53.880
<v Speaker 6>kinds of things do have a way to be able

626
00:31:53.880 --> 00:31:56.400
<v Speaker 6>to impact the brain through its impact on the vegus nerve,

627
00:31:56.599 --> 00:31:59.000
<v Speaker 6>but it's way beyond that. Now. There's a lot of

628
00:31:59.079 --> 00:32:03.119
<v Speaker 6>literature now such as that vagual stimulation, for example, could

629
00:32:03.160 --> 00:32:07.200
<v Speaker 6>have some really interesting effects therapeutic in some ways, and

630
00:32:07.680 --> 00:32:10.079
<v Speaker 6>we're starting to understand a little bit more about how

631
00:32:10.119 --> 00:32:13.640
<v Speaker 6>that mode of communication is operating. But it's certainly there,

632
00:32:13.759 --> 00:32:15.920
<v Speaker 6>and it's again one that we stend to learn a

633
00:32:15.920 --> 00:32:16.559
<v Speaker 6>lot more about.

634
00:32:16.720 --> 00:32:19.440
<v Speaker 4>I feel like this is all a really good endorsement

635
00:32:19.519 --> 00:32:22.720
<v Speaker 4>for meditation and deep breathing all well, I.

636
00:32:22.640 --> 00:32:25.079
<v Speaker 6>Mean that should be endorsed right off the bat, all

637
00:32:25.200 --> 00:32:25.640
<v Speaker 6>the time.

638
00:32:25.880 --> 00:32:29.039
<v Speaker 4>Yeah, yeah, yeah, you know you're mentioning toxicity in the

639
00:32:29.079 --> 00:32:31.279
<v Speaker 4>brain blood brain barrier alcohol.

640
00:32:31.640 --> 00:32:32.839
<v Speaker 2>Many people wanted to know.

641
00:32:33.160 --> 00:32:36.240
<v Speaker 4>Matthew Welker, Ali and Julian and Neil Anderson asked about

642
00:32:36.240 --> 00:32:40.400
<v Speaker 4>different opinions of alcohol affecting memory, but others have more

643
00:32:40.440 --> 00:32:44.319
<v Speaker 4>herbal questions, such as Alia Myers, Adam Michael James, Storm,

644
00:32:44.440 --> 00:32:47.920
<v Speaker 4>Sericity and Olympia Rymple, and first time question askers Craig

645
00:32:47.920 --> 00:32:51.640
<v Speaker 4>Steinberg and Zach Gary and Chris bullagas why does marijuana

646
00:32:51.680 --> 00:32:52.960
<v Speaker 4>make memory so shitty?

647
00:32:53.079 --> 00:32:55.319
<v Speaker 2>Asking for a friend? Winky face?

648
00:32:55.680 --> 00:32:59.599
<v Speaker 6>Okay, ask you for a friend? I see, well, answering

649
00:32:59.640 --> 00:33:03.680
<v Speaker 6>for a friend. I can't say that I've had firsthand

650
00:33:03.680 --> 00:33:06.920
<v Speaker 6>experience of this, but I can say that, first of all,

651
00:33:07.119 --> 00:33:09.839
<v Speaker 6>there's different kinds of memory that are made shitty to

652
00:33:09.839 --> 00:33:13.440
<v Speaker 6>different extents by marijuana. So it doesn't impact all kinds

653
00:33:13.440 --> 00:33:16.720
<v Speaker 6>of memory. It might impact your recollection for things that

654
00:33:16.799 --> 00:33:19.160
<v Speaker 6>you were doing, you know, previously or sort of around

655
00:33:19.240 --> 00:33:23.160
<v Speaker 6>that same time. Not exactly clear why that happens, but

656
00:33:23.200 --> 00:33:25.480
<v Speaker 6>I can tell you that one of the things that's

657
00:33:25.519 --> 00:33:28.640
<v Speaker 6>really interesting about marijuana is that when you think about

658
00:33:29.000 --> 00:33:32.559
<v Speaker 6>how it impacts the brain, there are particular receptors in

659
00:33:32.599 --> 00:33:37.119
<v Speaker 6>the brain what we call endocannabinoid receptors that are specifically

660
00:33:37.200 --> 00:33:41.039
<v Speaker 6>geared to responding to cannabinoids, which is essentially the active

661
00:33:41.319 --> 00:33:45.359
<v Speaker 6>species in marijuana. But the interesting thing is that endocannabinoid

662
00:33:45.359 --> 00:33:50.039
<v Speaker 6>receptors are involved in long term potentiation in memory, in plasticity.

663
00:33:50.119 --> 00:33:52.640
<v Speaker 6>So in some ways, it's not surprising that it impacts

664
00:33:52.720 --> 00:33:56.160
<v Speaker 6>your memory. It's surprising if it's always shitty, because I

665
00:33:56.160 --> 00:33:58.480
<v Speaker 6>think there's probably an optimality. I'm not telling you should

666
00:33:58.519 --> 00:34:01.160
<v Speaker 6>use it to improve memory, but there may be some

667
00:34:01.319 --> 00:34:04.680
<v Speaker 6>realm in which you can actually improve plasticity as opposed

668
00:34:04.680 --> 00:34:06.960
<v Speaker 6>to make it worse. That's very difficult to get at

669
00:34:06.960 --> 00:34:10.079
<v Speaker 6>at an individual level. But the fact that you have

670
00:34:10.119 --> 00:34:13.119
<v Speaker 6>receptors in your brain and especially in your memory systems

671
00:34:13.239 --> 00:34:16.320
<v Speaker 6>that are specifically geared to responding to the impact of marijuana,

672
00:34:16.360 --> 00:34:18.679
<v Speaker 6>I think is a very very cool thing. And it

673
00:34:18.719 --> 00:34:20.880
<v Speaker 6>also tells us that we need to invest a lot

674
00:34:20.920 --> 00:34:22.920
<v Speaker 6>more energy and a lot more time and a lot

675
00:34:22.960 --> 00:34:26.800
<v Speaker 6>more resources in understanding exactly how it's impacting the brain,

676
00:34:27.000 --> 00:34:29.559
<v Speaker 6>how that changes from individual to individual, on what background

677
00:34:29.559 --> 00:34:32.320
<v Speaker 6>and what context with everything else is happening in the brain.

678
00:34:32.440 --> 00:34:36.519
<v Speaker 6>So recreational use versus use for depression and anxiety, other things,

679
00:34:37.079 --> 00:34:39.719
<v Speaker 6>some more sort of therapeutic uses, all of those are

680
00:34:39.719 --> 00:34:43.480
<v Speaker 6>really interesting questions. And now that we are seeing the

681
00:34:43.599 --> 00:34:46.960
<v Speaker 6>legalization sort of, you know, across many states and a

682
00:34:47.039 --> 00:34:49.639
<v Speaker 6>desire from the National Institutes of Health to really support

683
00:34:49.920 --> 00:34:52.159
<v Speaker 6>research on this front, I'm hopeful that we'll be able

684
00:34:52.199 --> 00:34:53.639
<v Speaker 6>to have a lot more answers. A lot of my

685
00:34:53.639 --> 00:34:55.519
<v Speaker 6>colleagues here actually are studying this exact thing.

686
00:34:56.119 --> 00:34:58.400
<v Speaker 4>Would there be a difference between the CBD component and

687
00:34:58.440 --> 00:35:00.559
<v Speaker 4>the THHD component definitely.

688
00:35:00.679 --> 00:35:03.960
<v Speaker 6>So they're different chemicals and they have different potency and

689
00:35:04.000 --> 00:35:07.000
<v Speaker 6>different binding properties and so on. I don't know that

690
00:35:07.039 --> 00:35:11.480
<v Speaker 6>there's as much evidence for CBD in terms of brain

691
00:35:11.599 --> 00:35:14.519
<v Speaker 6>active kinds of things or psychoactive kinds of things. There

692
00:35:14.559 --> 00:35:16.599
<v Speaker 6>may be a little bit out there, but certainly the

693
00:35:16.599 --> 00:35:19.639
<v Speaker 6>impact of THC has been the one that studied much more,

694
00:35:20.000 --> 00:35:21.599
<v Speaker 6>and there's a lot more literature on that.

695
00:35:22.159 --> 00:35:25.360
<v Speaker 4>So a twenty twenty three paper in the journal Biomolecules

696
00:35:25.519 --> 00:35:29.880
<v Speaker 4>titled Effective Cannabis on Memory, Consolidation, learning and Retrieval and

697
00:35:29.920 --> 00:35:33.199
<v Speaker 4>its current legal status in India acknowledges that quote the

698
00:35:33.320 --> 00:35:36.880
<v Speaker 4>role of cannabis on cognitive functions is a matter of

699
00:35:36.920 --> 00:35:42.000
<v Speaker 4>long debate, but that generally THHC is responsible for cognition

700
00:35:42.280 --> 00:35:47.480
<v Speaker 4>related deficits, while non psychoactive CBD has been shown to

701
00:35:47.679 --> 00:35:53.800
<v Speaker 4>elicit neuroprotective activity. However, because it's a restricted substance, there's

702
00:35:53.840 --> 00:35:57.599
<v Speaker 4>not enough research on it, they say, and contradictions exist,

703
00:35:57.679 --> 00:36:01.920
<v Speaker 4>and some reports showed low t SEA dose improved learning

704
00:36:02.000 --> 00:36:04.440
<v Speaker 4>in cognition. So I guess keep an eye out for

705
00:36:04.679 --> 00:36:09.239
<v Speaker 4>emerging studies, and as discussed in the recent surgical Angiology episode,

706
00:36:09.239 --> 00:36:12.920
<v Speaker 4>on veins and arteries. Smoking is not the best way

707
00:36:12.960 --> 00:36:15.760
<v Speaker 4>to ingest it if you're going to, so remember to

708
00:36:15.840 --> 00:36:18.679
<v Speaker 4>protect your blood plumbing for the long term.

709
00:36:18.840 --> 00:36:19.039
<v Speaker 6>Oh.

710
00:36:19.199 --> 00:36:23.679
<v Speaker 4>Patrons Lila Weller, Carleen dh and Barb Miller had questions

711
00:36:23.760 --> 00:36:26.280
<v Speaker 4>about the long and the short of it all.

712
00:36:26.559 --> 00:36:27.159
<v Speaker 2>Well, you know, I.

713
00:36:27.159 --> 00:36:30.199
<v Speaker 4>Feel like some people talk about short term versus long

714
00:36:30.280 --> 00:36:33.159
<v Speaker 4>term when it comes to that, But the difference between

715
00:36:33.320 --> 00:36:35.440
<v Speaker 4>short term memory and long term when does it become

716
00:36:35.480 --> 00:36:36.480
<v Speaker 4>a long term memory?

717
00:36:36.559 --> 00:36:37.639
<v Speaker 2>When does it get filed?

718
00:36:38.039 --> 00:36:40.880
<v Speaker 6>Yeah, great question, Carleen. I'm gonna get ready to bust

719
00:36:40.920 --> 00:36:43.559
<v Speaker 6>another myth. Okay, when I talk to people about long

720
00:36:43.639 --> 00:36:47.480
<v Speaker 6>term and short term memory, typically they're complaining about their

721
00:36:47.519 --> 00:36:49.559
<v Speaker 6>long term memory and they're saying, my short term memory

722
00:36:49.559 --> 00:36:51.760
<v Speaker 6>is okay, so I can remember things from yesterday or

723
00:36:51.800 --> 00:36:53.960
<v Speaker 6>the week before. But it's like, you know, long term

724
00:36:54.000 --> 00:36:57.000
<v Speaker 6>memory that's impaired, or my mother. If they're talking about

725
00:36:57.039 --> 00:37:01.559
<v Speaker 6>maybe their mother with developing Alzheimer's or early dementia, it's

726
00:37:01.559 --> 00:37:03.360
<v Speaker 6>the opposite. It's her long term memory is okay, so

727
00:37:03.360 --> 00:37:06.400
<v Speaker 6>she can remember her past, her childhood, but everything in

728
00:37:06.440 --> 00:37:09.000
<v Speaker 6>the last few years. Her short term memory is what's impaired.

729
00:37:09.599 --> 00:37:11.599
<v Speaker 6>And I kind of have to stop and say, okay,

730
00:37:11.679 --> 00:37:13.760
<v Speaker 6>let me just clear up the terminologies. Then when you're

731
00:37:13.760 --> 00:37:15.960
<v Speaker 6>talking to a physician or talking to somebody to understand

732
00:37:16.000 --> 00:37:18.960
<v Speaker 6>what you're talking about, both of those are long term memory.

733
00:37:19.199 --> 00:37:23.159
<v Speaker 6>You're talking about recent versus remote memories. Short term memory

734
00:37:23.239 --> 00:37:27.280
<v Speaker 6>is very very short. We're talking the span of seconds.

735
00:37:27.480 --> 00:37:30.159
<v Speaker 6>So that's at least the way that these things are

736
00:37:30.159 --> 00:37:34.800
<v Speaker 6>defined in psychology and neuroscience. Short term memory is extremely short.

737
00:37:34.960 --> 00:37:37.880
<v Speaker 6>It's what we also call working memory. If I were

738
00:37:37.920 --> 00:37:39.519
<v Speaker 6>to give you a phone number, not that you would

739
00:37:39.519 --> 00:37:41.840
<v Speaker 6>have to dial a phone number these things, you know,

740
00:37:42.199 --> 00:37:43.679
<v Speaker 6>But if I were to give you a phone number

741
00:37:43.679 --> 00:37:46.000
<v Speaker 6>and say, hey, hold on to this phone number and

742
00:37:46.039 --> 00:37:47.960
<v Speaker 6>then you have to dial it, you might sort of

743
00:37:47.960 --> 00:37:50.159
<v Speaker 6>rehearse that phone number to yourself for a few seconds,

744
00:37:50.159 --> 00:37:51.559
<v Speaker 6>and then you dial it, and then what happens to

745
00:37:51.599 --> 00:37:55.400
<v Speaker 6>that number? Poof go all right, So you stored it

746
00:37:55.920 --> 00:37:59.639
<v Speaker 6>very briefly in your short term memory store, your working memory,

747
00:38:00.079 --> 00:38:02.440
<v Speaker 6>which is there to be able to help you store

748
00:38:02.440 --> 00:38:04.440
<v Speaker 6>things for a very short period of time. You can

749
00:38:04.480 --> 00:38:07.239
<v Speaker 6>get distracted out of it very quickly. And also I

750
00:38:07.239 --> 00:38:09.480
<v Speaker 6>can exceed your span very quickly if I just yell

751
00:38:09.480 --> 00:38:11.679
<v Speaker 6>out a whole bunch of numbers at you. Things are

752
00:38:11.719 --> 00:38:14.880
<v Speaker 6>going to fall out, right, So it's not intended to

753
00:38:14.880 --> 00:38:17.800
<v Speaker 6>store any more than just a few a handful of items.

754
00:38:18.039 --> 00:38:20.079
<v Speaker 6>People used to say seven plus or minus two, but

755
00:38:20.119 --> 00:38:21.880
<v Speaker 6>that number is likely closer to three or four.

756
00:38:22.079 --> 00:38:24.079
<v Speaker 4>Okay, he just threw a whole bunch of numbers at you,

757
00:38:24.199 --> 00:38:27.760
<v Speaker 4>But seven plus or minus two means that brain. Scientists

758
00:38:27.920 --> 00:38:30.760
<v Speaker 4>used to think we can hold five to nine items

759
00:38:30.800 --> 00:38:33.440
<v Speaker 4>in our short term memory, but turns out we don't

760
00:38:33.440 --> 00:38:35.480
<v Speaker 4>even have that much room. It's like three or four

761
00:38:35.519 --> 00:38:37.320
<v Speaker 4>things at a time, three or four things.

762
00:38:37.320 --> 00:38:38.840
<v Speaker 6>And the reason why phone numbers work is because we

763
00:38:38.920 --> 00:38:42.840
<v Speaker 6>chunk them into three bits yep. So then everything beyond

764
00:38:42.920 --> 00:38:45.480
<v Speaker 6>that is actually long term memory storage. But when we

765
00:38:45.519 --> 00:38:48.679
<v Speaker 6>think about memory for yesterday or last week or the

766
00:38:48.719 --> 00:38:52.000
<v Speaker 6>month before versus you know, years ago, we're talking about

767
00:38:52.039 --> 00:38:56.639
<v Speaker 6>recent long term memories versus remote long term memories. And

768
00:38:56.760 --> 00:39:00.440
<v Speaker 6>as we get older, our memory for things that happened

769
00:39:00.440 --> 00:39:02.960
<v Speaker 6>way in the past could be very preserved. Because we

770
00:39:03.000 --> 00:39:05.760
<v Speaker 6>talked about how memory over time gets strengthened and kind

771
00:39:05.800 --> 00:39:08.280
<v Speaker 6>of linked to a whole bunch of different regions of the brain,

772
00:39:08.320 --> 00:39:11.679
<v Speaker 6>so it becomes more robust, more resilient to forgetting. Those

773
00:39:11.719 --> 00:39:14.639
<v Speaker 6>are typically the last memories to go. Say for a

774
00:39:14.719 --> 00:39:19.480
<v Speaker 6>patient experiencing dementia, they're going to remember those memories much

775
00:39:19.599 --> 00:39:23.360
<v Speaker 6>later in the progression. But memories of the last few months,

776
00:39:23.400 --> 00:39:25.639
<v Speaker 6>the last year, the last few years, they're going to

777
00:39:25.679 --> 00:39:28.559
<v Speaker 6>be the ones that are the earliest to go because

778
00:39:28.599 --> 00:39:31.800
<v Speaker 6>they have not been solidified as much, they have not

779
00:39:31.960 --> 00:39:35.239
<v Speaker 6>been stored in all of these parallel networks in the

780
00:39:35.280 --> 00:39:38.280
<v Speaker 6>brain and made kind more resilient to forgetting. There's still

781
00:39:38.280 --> 00:39:41.039
<v Speaker 6>somewhat dependent on the Hippi campus, and the Hippi campus

782
00:39:41.079 --> 00:39:43.199
<v Speaker 6>is kind of the culprit in early dementia, right, It's

783
00:39:43.239 --> 00:39:46.599
<v Speaker 6>one of the places that's changing very early. So as

784
00:39:46.639 --> 00:39:48.679
<v Speaker 6>we think about long term versus short term, that's typically

785
00:39:48.719 --> 00:39:51.360
<v Speaker 6>what people are thinking about. Why am I not remembering

786
00:39:51.440 --> 00:39:53.519
<v Speaker 6>as much of the recent things, but I remember memories

787
00:39:53.519 --> 00:39:56.360
<v Speaker 6>in the past for longer. We experience that as we

788
00:39:56.360 --> 00:40:00.480
<v Speaker 6>get older, but much more dramatically in the context of dementia. Yeah,

789
00:40:00.519 --> 00:40:02.880
<v Speaker 6>so it's just a little bit of a misnomer, but

790
00:40:02.960 --> 00:40:06.119
<v Speaker 6>I think, you know, being able to kind of divide

791
00:40:06.119 --> 00:40:09.079
<v Speaker 6>it into recent versus remote covers the same question.

792
00:40:09.280 --> 00:40:09.920
<v Speaker 2>Yeah, Oh, I.

793
00:40:09.880 --> 00:40:12.199
<v Speaker 4>Had no idea, and I do want to ask about

794
00:40:12.199 --> 00:40:17.039
<v Speaker 4>dementia and Alzheimer's as well, but a quick detur with

795
00:40:17.199 --> 00:40:20.079
<v Speaker 4>short term memory. Many people mentioned having the memory of

796
00:40:20.079 --> 00:40:23.639
<v Speaker 4>a goldfish. Jasmine Patino, first time question asker whose dear

797
00:40:23.800 --> 00:40:28.320
<v Speaker 4>wonderful boyfriend is a goldfish in that capacity, and Caitlin Tindale,

798
00:40:28.400 --> 00:40:32.039
<v Speaker 4>who compared themselves to a fish cognitively.

799
00:40:31.920 --> 00:40:32.519
<v Speaker 2>True or false.

800
00:40:32.760 --> 00:40:35.360
<v Speaker 4>Goldfish remember for two minutes and then they don't know

801
00:40:35.599 --> 00:40:36.880
<v Speaker 4>why they're in a bowl.

802
00:40:37.440 --> 00:40:40.360
<v Speaker 6>You know, I'm trying to remember finding Nemo now and

803
00:40:40.440 --> 00:40:43.199
<v Speaker 6>think about whether it was truly two minutes. You know,

804
00:40:43.199 --> 00:40:44.960
<v Speaker 6>I don't know if it's exactly two minutes, but it

805
00:40:45.000 --> 00:40:47.880
<v Speaker 6>is very short. It is thought to be one of

806
00:40:47.920 --> 00:40:49.239
<v Speaker 6>the shortest memory spans.

807
00:40:49.760 --> 00:40:52.280
<v Speaker 2>How do they test that on a goldfish?

808
00:40:52.320 --> 00:40:55.400
<v Speaker 6>It's difficult. I think that whenever you're testing things with animals,

809
00:40:55.400 --> 00:40:57.519
<v Speaker 6>you have to be clever, right, So you have to

810
00:40:57.639 --> 00:40:59.840
<v Speaker 6>figure out a way that the animal can kind of

811
00:41:00.039 --> 00:41:03.199
<v Speaker 6>indicate to you whether or not they recognize something. Maybe

812
00:41:03.239 --> 00:41:06.000
<v Speaker 6>it's by the amount of exploration or the amount of

813
00:41:06.039 --> 00:41:08.280
<v Speaker 6>time they spend in the vicinity of that thing. If

814
00:41:08.320 --> 00:41:10.480
<v Speaker 6>they're more familiar with it, maybe they'll navigate to something

815
00:41:10.559 --> 00:41:13.360
<v Speaker 6>that's newer. So you can position things in the environment

816
00:41:13.400 --> 00:41:15.599
<v Speaker 6>in a way where you can see how much they

817
00:41:15.639 --> 00:41:18.559
<v Speaker 6>explorer went over the other and be able to tell oh, yeah,

818
00:41:18.639 --> 00:41:20.840
<v Speaker 6>their memory is shot, or maybe their memory is really good.

819
00:41:21.159 --> 00:41:23.079
<v Speaker 2>I love the idea. They're like, you know this guy,

820
00:41:23.199 --> 00:41:25.920
<v Speaker 2>and they're like, no, yep.

821
00:41:26.400 --> 00:41:28.000
<v Speaker 6>The name has not come into mind. I remember the

822
00:41:28.079 --> 00:41:29.239
<v Speaker 6>face though anywhere.

823
00:41:29.280 --> 00:41:31.960
<v Speaker 4>But yeah, we're in luck because yeah, people study this.

824
00:41:32.039 --> 00:41:34.119
<v Speaker 4>Of course they do. And according to a recent paper

825
00:41:34.239 --> 00:41:37.320
<v Speaker 4>Distance Estimation in the Goldfish in the Proceedings of the

826
00:41:37.400 --> 00:41:42.679
<v Speaker 4>Royal Society be of Biological Sciences Journal, goldfish can accurately

827
00:41:42.800 --> 00:41:46.440
<v Speaker 4>estimate distance after learning it. And another study in the

828
00:41:46.519 --> 00:41:50.280
<v Speaker 4>Journal Animals titled Visual Perception of Photographs of rotated three

829
00:41:50.320 --> 00:41:54.639
<v Speaker 4>D objects in Goldfish trained six goldfish to tap either

830
00:41:54.679 --> 00:41:58.159
<v Speaker 4>a photo of a frog or a turtle for a treat,

831
00:41:58.400 --> 00:42:02.840
<v Speaker 4>and researchers report that all the fish had successful performance,

832
00:42:03.119 --> 00:42:05.920
<v Speaker 4>showing that they were able to distinguish between the turtle

833
00:42:06.199 --> 00:42:10.159
<v Speaker 4>and the frog photographs, which is evidence of object constancy.

834
00:42:10.599 --> 00:42:14.360
<v Speaker 4>So flimflam goldfish memories are not trash. They can be

835
00:42:14.440 --> 00:42:16.320
<v Speaker 4>trained to do things, and it should be noted that

836
00:42:16.360 --> 00:42:19.559
<v Speaker 4>in five years of having my daughter, who's a poodle

837
00:42:19.599 --> 00:42:23.559
<v Speaker 4>mix named gremlin. I have never successfully trained her to

838
00:42:23.599 --> 00:42:27.119
<v Speaker 4>do anything, So lay off the goldfish and lay off yourselves.

839
00:42:27.360 --> 00:42:30.400
<v Speaker 4>Although when it comes to future fears and caring for

840
00:42:30.480 --> 00:42:34.480
<v Speaker 4>loved ones, many patrons had questions about Alzheimer's and dementia,

841
00:42:34.480 --> 00:42:38.119
<v Speaker 4>including Lisa Gorman, debdast Science, Stephanie Halfree, Matty Cakes, Two

842
00:42:38.119 --> 00:42:42.280
<v Speaker 4>Stones with One Check, Mia, Meg McDaniel, Ken Edmondson, Aaron White,

843
00:42:42.320 --> 00:42:46.239
<v Speaker 4>Camellia b Brian Reisinger, Sarah Crucker, and Stephanie, who wrote,

844
00:42:46.280 --> 00:42:49.280
<v Speaker 4>there are cases of dementia on both sides of my family.

845
00:42:49.480 --> 00:42:52.800
<v Speaker 4>Is there actually anything we can do to stop or

846
00:42:52.840 --> 00:42:56.559
<v Speaker 4>slow down this awful disease? A lot of people obviously

847
00:42:57.079 --> 00:43:00.199
<v Speaker 4>concerned about dementia concerned about Alzheimer's That deserves its own

848
00:43:00.920 --> 00:43:04.519
<v Speaker 4>two part episodes. Certainly, can you describe when it comes

849
00:43:04.559 --> 00:43:07.880
<v Speaker 4>to memory, the difference between dementia and Alzheimer's is Alzheimer's

850
00:43:07.920 --> 00:43:09.079
<v Speaker 4>a disease?

851
00:43:09.119 --> 00:43:12.679
<v Speaker 2>In dementia is the symptom of it? Or how does

852
00:43:12.719 --> 00:43:14.280
<v Speaker 2>it exactly what's happening?

853
00:43:14.480 --> 00:43:17.639
<v Speaker 6>Yeah, So the easiest way to think about it is

854
00:43:17.639 --> 00:43:21.719
<v Speaker 6>that dementia is a larger umbrella term and Alzheimer's disease

855
00:43:21.880 --> 00:43:24.880
<v Speaker 6>is one of the principal causes of dementia. Okay, you're

856
00:43:24.920 --> 00:43:27.400
<v Speaker 6>right that dementia is a set of symptoms and Alzheimer's

857
00:43:27.400 --> 00:43:29.239
<v Speaker 6>is a little bit more about the biology that leads

858
00:43:29.280 --> 00:43:32.480
<v Speaker 6>to those symptoms. And there are many other types of dementias.

859
00:43:32.559 --> 00:43:36.119
<v Speaker 6>So Parkinson's disease can lead to dementia. There's frontotemporal low

860
00:43:36.159 --> 00:43:40.039
<v Speaker 6>Bard degeneration or fronto temporal dementia. Huntington's disease can lead

861
00:43:40.039 --> 00:43:43.199
<v Speaker 6>to dementia. So there's a number of different causes for dementia,

862
00:43:43.519 --> 00:43:45.880
<v Speaker 6>but the most prevalent one, the one that most people

863
00:43:45.920 --> 00:43:49.320
<v Speaker 6>are really concerned about, is Alzheimer's dementia. So yeah, dementia

864
00:43:49.360 --> 00:43:51.880
<v Speaker 6>is the umbrella term. Alzheimer's is the subcategory or the

865
00:43:51.960 --> 00:43:54.920
<v Speaker 6>set of causes that lead down the path to dementia,

866
00:43:55.039 --> 00:43:57.840
<v Speaker 6>and it's among many others, but Alzheimer's is the chief one.

867
00:43:57.960 --> 00:44:01.880
<v Speaker 6>When we think about how do we DIFFERNI between dementia

868
00:44:01.920 --> 00:44:04.960
<v Speaker 6>and say, you know, healthy aging. That's another question that

869
00:44:04.960 --> 00:44:07.960
<v Speaker 6>pops up a lot is as I'm getting to a

870
00:44:07.960 --> 00:44:10.320
<v Speaker 6>certain age, i feel like I am losing my memory,

871
00:44:10.719 --> 00:44:13.360
<v Speaker 6>I'm starting to lose my way when I navigate, or

872
00:44:13.360 --> 00:44:16.239
<v Speaker 6>I'm having some memory issues and be forgetful. And some

873
00:44:16.320 --> 00:44:18.440
<v Speaker 6>of that happens as we all get older, and the

874
00:44:18.480 --> 00:44:21.159
<v Speaker 6>majority of it is okay, right, that's just the natural

875
00:44:21.159 --> 00:44:24.880
<v Speaker 6>part of a normal aging brain. But when it becomes

876
00:44:25.039 --> 00:44:29.159
<v Speaker 6>pervasive and noticeable to not just a person but to

877
00:44:29.239 --> 00:44:32.440
<v Speaker 6>others around them, and people are sort of missing doctor's

878
00:44:32.480 --> 00:44:35.559
<v Speaker 6>appointments or getting lost around their neighborhoods and their wandering,

879
00:44:35.639 --> 00:44:39.599
<v Speaker 6>and then it becomes a real concern. And when that's

880
00:44:39.639 --> 00:44:42.760
<v Speaker 6>happening already things have changed so much in the brain

881
00:44:43.679 --> 00:44:46.519
<v Speaker 6>that now it's really unable to compensate for it, because

882
00:44:46.519 --> 00:44:48.960
<v Speaker 6>we tend to compensate so much for any sort of

883
00:44:48.960 --> 00:44:51.639
<v Speaker 6>brain deficit for the longest time, So for many years,

884
00:44:52.199 --> 00:44:55.280
<v Speaker 6>a patient with Alzheimer's ease wouldn't technically be a patient

885
00:44:55.760 --> 00:44:59.679
<v Speaker 6>because they're not reporting symptoms, they're not experiencing anything. Neither

886
00:44:59.719 --> 00:45:02.480
<v Speaker 6>patient nor doctor can say anything is wrong with the brain.

887
00:45:03.079 --> 00:45:06.920
<v Speaker 6>But already the pathology is changing the brain. And one

888
00:45:06.960 --> 00:45:09.880
<v Speaker 6>of the challenges for us in research is trying to

889
00:45:09.920 --> 00:45:12.920
<v Speaker 6>develop ways that we can detect that pathology, maybe with

890
00:45:13.000 --> 00:45:15.679
<v Speaker 6>brain imaging, with brain scans and so on, very early,

891
00:45:16.079 --> 00:45:18.599
<v Speaker 6>even at a time when the patient and the doctor

892
00:45:18.639 --> 00:45:21.440
<v Speaker 6>don't really know that anything is wrong, But when it

893
00:45:21.440 --> 00:45:24.880
<v Speaker 6>comes to memory deficits experience that that older age, you know,

894
00:45:25.119 --> 00:45:27.400
<v Speaker 6>the question is always how do I know when it's

895
00:45:28.400 --> 00:45:29.960
<v Speaker 6>really kind of tipped over? How do I know when

896
00:45:29.960 --> 00:45:32.840
<v Speaker 6>it's really problematic? And a good rule of thumb to

897
00:45:32.840 --> 00:45:36.360
<v Speaker 6>think about is that if somebody's forgetting things, all natural

898
00:45:36.400 --> 00:45:38.559
<v Speaker 6>and fine, especially if they can remember it later on.

899
00:45:39.039 --> 00:45:41.239
<v Speaker 6>If they're reminded and they go, oh, now I remember,

900
00:45:41.320 --> 00:45:44.920
<v Speaker 6>so it's tracked somewhere, it's there, you know that it's okay.

901
00:45:45.039 --> 00:45:48.199
<v Speaker 6>Maybe that's challenge. As we're getting older, that just changes

902
00:45:48.239 --> 00:45:51.239
<v Speaker 6>to some extent. But if they're really never able to

903
00:45:51.239 --> 00:45:54.199
<v Speaker 6>piece it back together and no reminder is helping them,

904
00:45:54.599 --> 00:45:56.840
<v Speaker 6>that they may be kind of over that cliff and

905
00:45:56.880 --> 00:46:00.719
<v Speaker 6>they're going down the path to Alzheimer's disease. The somewhat

906
00:46:00.760 --> 00:46:03.360
<v Speaker 6>more cross example, if you forget where you placed your

907
00:46:03.360 --> 00:46:05.440
<v Speaker 6>car keys, it's okay, But if you forget that you

908
00:46:05.519 --> 00:46:08.199
<v Speaker 6>drove the car, then that may be a challenge.

909
00:46:08.559 --> 00:46:10.880
<v Speaker 4>Is that because of plaques in the brain, is that

910
00:46:10.960 --> 00:46:16.880
<v Speaker 4>parts of the brain atrophying into almost spaces where there

911
00:46:16.960 --> 00:46:18.920
<v Speaker 4>used to be more wider gray matter.

912
00:46:19.480 --> 00:46:20.800
<v Speaker 2>What's happening biologically?

913
00:46:21.480 --> 00:46:24.719
<v Speaker 6>We used to have this idea, and the idea took

914
00:46:24.760 --> 00:46:28.360
<v Speaker 6>the field by storm and actually resulted in, i think,

915
00:46:28.440 --> 00:46:32.920
<v Speaker 6>an overinvestment of resources into clinical trials that try to

916
00:46:32.960 --> 00:46:34.559
<v Speaker 6>get rid of those plaques. We used to think that

917
00:46:34.599 --> 00:46:38.039
<v Speaker 6>plaques were sort of the evil, right, and the two

918
00:46:38.079 --> 00:46:42.280
<v Speaker 6>pathologies of Alzheimer's disease are plaques and tangles. Plaques are

919
00:46:42.320 --> 00:46:45.360
<v Speaker 6>made up of amyloid protein. Tangles are made up of

920
00:46:45.400 --> 00:46:49.039
<v Speaker 6>what's called TAO protein. And for the longest time, people thought,

921
00:46:49.079 --> 00:46:51.440
<v Speaker 6>if you have amyloid and tao or plaques and tangles

922
00:46:51.440 --> 00:46:53.880
<v Speaker 6>in the brain, that's Alzheimer's disease, and we should be

923
00:46:53.920 --> 00:46:56.760
<v Speaker 6>trying to break up those pathologies somehow to restore the

924
00:46:56.760 --> 00:47:00.760
<v Speaker 6>brain or prevent it from getting worse. The reality is

925
00:47:00.800 --> 00:47:03.599
<v Speaker 6>the idea never really fully panned out, because just having

926
00:47:03.639 --> 00:47:05.440
<v Speaker 6>amyloid in the brain is not sufficient for you to

927
00:47:05.480 --> 00:47:08.920
<v Speaker 6>experience memory problems. It's not sufficient freeed have dementia. There's

928
00:47:09.039 --> 00:47:11.239
<v Speaker 6>about a third of everyone with amyloid in their brain

929
00:47:11.360 --> 00:47:15.239
<v Speaker 6>will likely never experience dementia. So clearly, by itself, it's

930
00:47:15.280 --> 00:47:18.840
<v Speaker 6>not sufficient. But something else that you mentioned turns out

931
00:47:18.840 --> 00:47:23.679
<v Speaker 6>to be sufficient and really important, which is neurodegeneration. Actual atrophy,

932
00:47:23.800 --> 00:47:28.679
<v Speaker 6>actual loss of cells. That doesn't happen naturally. As we age,

933
00:47:28.880 --> 00:47:31.760
<v Speaker 6>we lose synapses, we lose connections. As we get older,

934
00:47:31.800 --> 00:47:34.559
<v Speaker 6>it becomes more difficult to make them, difficult to maintain them.

935
00:47:34.880 --> 00:47:38.480
<v Speaker 6>That happens, for sure, But cell loss in these massive

936
00:47:38.519 --> 00:47:43.519
<v Speaker 6>amounts doesn't really happen unless there's a progressive neurodegenerative illness,

937
00:47:43.599 --> 00:47:46.880
<v Speaker 6>which is what Alzheimer's disease is. So when we find

938
00:47:46.960 --> 00:47:50.199
<v Speaker 6>evidence of neurodegenerations, say for example, on MRI scans, we

939
00:47:50.239 --> 00:47:53.280
<v Speaker 6>see a very close connection, a close link or our

940
00:47:53.280 --> 00:47:57.400
<v Speaker 6>relationship between the extent of that neurodegeneration and memory symptoms

941
00:47:57.519 --> 00:48:00.119
<v Speaker 6>or memory loss and cognitive symptoms down the line that

942
00:48:00.119 --> 00:48:04.280
<v Speaker 6>are not memory also, so executive function gets disrupted all

943
00:48:04.320 --> 00:48:08.000
<v Speaker 6>of our cognitive faculties right because it's progressive. But in

944
00:48:08.039 --> 00:48:11.320
<v Speaker 6>the absence of that neurodegenerative change, it's very difficult to

945
00:48:11.320 --> 00:48:15.760
<v Speaker 6>see associations with actual cognitive or clinical decline, which has

946
00:48:15.760 --> 00:48:17.840
<v Speaker 6>created a bit of a dilemma for the field. Even

947
00:48:17.880 --> 00:48:21.960
<v Speaker 6>though the FDA has been approving anti amyloid therapeutics, these

948
00:48:22.039 --> 00:48:25.320
<v Speaker 6>drugs have some nasty side effects and it's not clear

949
00:48:25.440 --> 00:48:29.840
<v Speaker 6>that clearing amyloid is going to be the solution in

950
00:48:29.880 --> 00:48:33.159
<v Speaker 6>the long run. Coupled with that also the complexity that

951
00:48:33.159 --> 00:48:37.239
<v Speaker 6>Alzheimer's disease is extremely heterogeneous. So if I were to

952
00:48:37.280 --> 00:48:39.320
<v Speaker 6>get it, and hopefully not, but if you were to

953
00:48:39.320 --> 00:48:41.480
<v Speaker 6>get it, it may look very different in your brain that

954
00:48:41.559 --> 00:48:43.719
<v Speaker 6>it does in my brain. We may have a lot

955
00:48:43.719 --> 00:48:46.559
<v Speaker 6>of variability, so that means you may respond to a

956
00:48:46.679 --> 00:48:48.559
<v Speaker 6>drug or therapy that I may not respond to, and

957
00:48:48.639 --> 00:48:51.800
<v Speaker 6>vice versa. So the idea of like a one size

958
00:48:51.800 --> 00:48:54.639
<v Speaker 6>fits all kind of solution is also kind of falling

959
00:48:54.639 --> 00:48:57.000
<v Speaker 6>away by the wayside and people thinking about the complexity

960
00:48:57.039 --> 00:49:00.960
<v Speaker 6>of maybe Alzheimer's disease is actually diseases it is, and

961
00:49:01.039 --> 00:49:03.599
<v Speaker 6>we need to be able to tailor therapeutic study individual.

962
00:49:03.800 --> 00:49:07.039
<v Speaker 4>Obviously, dementia once again deserves its own episode.

963
00:49:07.079 --> 00:49:08.679
<v Speaker 2>It's a complex.

964
00:49:08.119 --> 00:49:11.440
<v Speaker 4>Condition with a lot of emerging research. But there are

965
00:49:11.480 --> 00:49:16.320
<v Speaker 4>some pharmaceutical treatments that can involve modulating neurotransmitters in the

966
00:49:16.320 --> 00:49:20.639
<v Speaker 4>brain like glutamate. There are dietary modifications that can ease

967
00:49:20.719 --> 00:49:25.199
<v Speaker 4>some related symptoms, and psychopharmaceuticals that can help with depression

968
00:49:25.360 --> 00:49:28.159
<v Speaker 4>and anxiety related to the progression of dementia.

969
00:49:28.320 --> 00:49:29.079
<v Speaker 2>And Robert G.

970
00:49:29.239 --> 00:49:32.920
<v Speaker 4>Odey and Isabelle the Cleric mentioned Louis body dementia in

971
00:49:32.960 --> 00:49:35.840
<v Speaker 4>their questions and it is the second most common cause

972
00:49:35.840 --> 00:49:39.199
<v Speaker 4>of dementia after Alzheimer's and it's caused by aggregations of

973
00:49:39.280 --> 00:49:42.679
<v Speaker 4>proteins in the brain called Louis bodies, and some symptoms

974
00:49:42.679 --> 00:49:47.280
<v Speaker 4>of it can include visual hallucinations, trouble with sleep including sleepwalking,

975
00:49:47.480 --> 00:49:50.840
<v Speaker 4>mood changes, and stiffness. And Isabelle, whose mom had it,

976
00:49:50.960 --> 00:49:53.840
<v Speaker 4>asked why public awareness of Louis body dementia was low.

977
00:49:54.039 --> 00:49:55.920
<v Speaker 4>But there's a little bit of background on it, and

978
00:49:55.960 --> 00:49:57.719
<v Speaker 4>we're going to get to more questions about how you

979
00:49:57.840 --> 00:50:01.559
<v Speaker 4>can avoid dementia and memory loss and yourself per an expert.

980
00:50:01.599 --> 00:50:03.800
<v Speaker 4>But first, let's donate to a cause of his choosing,

981
00:50:03.800 --> 00:50:05.440
<v Speaker 4>and he opted to send it to a fund at

982
00:50:05.440 --> 00:50:08.320
<v Speaker 4>his center called the Junior Scholars Fund, which goes to

983
00:50:08.400 --> 00:50:12.119
<v Speaker 4>supporting graduate students and their professional development because he says

984
00:50:12.119 --> 00:50:14.360
<v Speaker 4>they are the next generation of talent and he wants

985
00:50:14.360 --> 00:50:16.559
<v Speaker 4>to do whatever he can to support them. And there's

986
00:50:16.599 --> 00:50:18.440
<v Speaker 4>a link in the show notes for more on the

987
00:50:18.519 --> 00:50:20.920
<v Speaker 4>Junior Scholars Fund at the UC Irvine Center for the

988
00:50:20.960 --> 00:50:23.840
<v Speaker 4>Neurobiology of Learning in Memory. So thanks to sponsors of

989
00:50:23.840 --> 00:50:25.840
<v Speaker 4>the show for making that donation possible.

990
00:50:27.920 --> 00:50:30.639
<v Speaker 1>You're on the bus an hour from home, in bumper

991
00:50:30.679 --> 00:50:33.960
<v Speaker 1>to bumper traffic, creeping forward a few inches at a time,

992
00:50:34.599 --> 00:50:39.840
<v Speaker 1>Someone's kids are screaming, and suddenly your back is too. Luckily,

993
00:50:39.960 --> 00:50:43.639
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994
00:50:43.719 --> 00:50:45.960
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995
00:50:46.360 --> 00:50:50.119
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996
00:50:50.199 --> 00:50:54.599
<v Speaker 1>for Panadal speed based on absorption data contains paracetamol. Always

997
00:50:54.599 --> 00:50:55.360
<v Speaker 1>read the label.

998
00:50:55.159 --> 00:50:56.079
<v Speaker 5>Or leaflet.

999
00:50:58.280 --> 00:50:58.880
<v Speaker 2>Get value.

1000
00:50:58.920 --> 00:51:02.159
<v Speaker 3>You can't argue with Tesco with their amazing club card prices.

1001
00:51:02.400 --> 00:51:04.760
<v Speaker 3>Have the perfect night in with their finest frozen pizza

1002
00:51:04.800 --> 00:51:07.519
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1003
00:51:07.559 --> 00:51:10.840
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1004
00:51:10.920 --> 00:51:14.320
<v Speaker 3>hot honey and Doya or Margarito wood fired pizzas, served

1005
00:51:14.360 --> 00:51:16.960
<v Speaker 3>up with their crispy chunkie chips and ice cream like

1006
00:51:17.000 --> 00:51:20.239
<v Speaker 3>se sil de caramel or Pistaggio for dessert. Can't argue

1007
00:51:20.239 --> 00:51:24.119
<v Speaker 3>with that shop in store or online. Tesco Every little

1008
00:51:24.119 --> 00:51:26.880
<v Speaker 3>helps available in most stores. Prices vary in express.

1009
00:51:30.400 --> 00:51:33.239
<v Speaker 4>Okay, back to the million dollar question here, which honestly

1010
00:51:33.599 --> 00:51:36.360
<v Speaker 4>I think is eating away at everyone listening, But it

1011
00:51:36.400 --> 00:51:40.159
<v Speaker 4>was asked by Stephanie Christina Manuj who loves Saunas, Margaret

1012
00:51:40.159 --> 00:51:44.400
<v Speaker 4>and Nuska Carrat Singh, Shushanja Gettinger, Nicole dig Kara Young,

1013
00:51:44.440 --> 00:51:47.239
<v Speaker 4>and Jennie Hoover. So let's go well, I think, you know,

1014
00:51:47.519 --> 00:51:50.480
<v Speaker 4>last listener question that we got so much obviously is

1015
00:51:50.800 --> 00:51:53.840
<v Speaker 4>every day I feel like we're all getting older.

1016
00:51:54.159 --> 00:51:54.920
<v Speaker 2>It's nuts.

1017
00:51:54.960 --> 00:51:58.559
<v Speaker 4>Wow, time we're gonna get old eventually if we're lucky, right,

1018
00:51:59.199 --> 00:52:04.840
<v Speaker 4>what action does help us stay sharp and retain our memories?

1019
00:52:04.960 --> 00:52:08.119
<v Speaker 4>Is it sudoku? Is it going to zooma classes? Is

1020
00:52:08.159 --> 00:52:08.800
<v Speaker 4>it reading?

1021
00:52:09.920 --> 00:52:10.280
<v Speaker 1>Yeah?

1022
00:52:10.440 --> 00:52:13.320
<v Speaker 6>You know, the challenge of brain aging and sort of

1023
00:52:13.400 --> 00:52:16.760
<v Speaker 6>body aging is an interesting one. I think everybody wants to,

1024
00:52:17.159 --> 00:52:20.199
<v Speaker 6>you know, live longer and live happier and healthier lives

1025
00:52:20.280 --> 00:52:22.000
<v Speaker 6>and so on. And the trick is to make sure

1026
00:52:22.000 --> 00:52:24.800
<v Speaker 6>that our brain aging is sort of consistent with our

1027
00:52:24.800 --> 00:52:27.119
<v Speaker 6>body agent. You really want to kind of maintain health

1028
00:52:27.440 --> 00:52:30.280
<v Speaker 6>across both of those. So mind longevity is something that

1029
00:52:30.320 --> 00:52:32.639
<v Speaker 6>we think about a lot, and there are some answers.

1030
00:52:32.800 --> 00:52:36.719
<v Speaker 6>So we know, for example, that maintaining levels of physical

1031
00:52:36.760 --> 00:52:41.920
<v Speaker 6>activity regular physical activity hopefully not just undertaken when you're eighty, right,

1032
00:52:42.280 --> 00:52:45.760
<v Speaker 6>So starting kind of in midlife and continuing regular levels

1033
00:52:45.840 --> 00:52:49.000
<v Speaker 6>of moderate physical activity seems to be helpful, seem to

1034
00:52:49.000 --> 00:52:53.079
<v Speaker 6>be preventative. They are associated with reducedress for Alzheimer's disease.

1035
00:52:53.079 --> 00:52:54.639
<v Speaker 6>If people get it, they tend to get it later

1036
00:52:54.679 --> 00:52:57.039
<v Speaker 6>in life, but they're protected from it for some period

1037
00:52:57.079 --> 00:52:57.360
<v Speaker 6>of time.

1038
00:52:57.880 --> 00:53:01.920
<v Speaker 4>So exercise for more. You can see the paper Exercise

1039
00:53:02.039 --> 00:53:05.719
<v Speaker 4>and Dementia Prevention from the Journal Practical Neurology, which notes

1040
00:53:05.760 --> 00:53:09.760
<v Speaker 4>that around a third of dementia cases are attributable to

1041
00:53:10.000 --> 00:53:15.880
<v Speaker 4>modifiable risk factors such as physical inactivity, smoking, and hypertension.

1042
00:53:16.400 --> 00:53:18.960
<v Speaker 4>And they say that with the rising prevalence of dementia,

1043
00:53:19.280 --> 00:53:23.199
<v Speaker 4>there is a renewed focus on prevention strategies and exercise

1044
00:53:23.239 --> 00:53:27.920
<v Speaker 4>has emerged as a key intervention for influencing cognition positively,

1045
00:53:28.280 --> 00:53:33.519
<v Speaker 4>including reducing the risk of age related cognitive decline and dementia.

1046
00:53:34.000 --> 00:53:38.239
<v Speaker 4>So use ologies as walking time, dance around your kitchen,

1047
00:53:38.599 --> 00:53:41.800
<v Speaker 4>get a dog to walk, take a break dancing class,

1048
00:53:42.000 --> 00:53:45.400
<v Speaker 4>do some arm stretches. Just keep it moving, folks. Okay,

1049
00:53:45.440 --> 00:53:45.800
<v Speaker 4>what else?

1050
00:53:45.840 --> 00:53:49.079
<v Speaker 6>Dock The other thing that people have identified in these

1051
00:53:49.199 --> 00:53:53.119
<v Speaker 6>large scale not just trials, but also epedemiological studies. What

1052
00:53:53.239 --> 00:53:56.840
<v Speaker 6>seems to help while social activity and this was a

1053
00:53:56.960 --> 00:53:59.719
<v Speaker 6>challenge in the pandemic, actually, and I got to hear

1054
00:53:59.760 --> 00:54:01.960
<v Speaker 6>a lot about that from folks who felt that they

1055
00:54:02.000 --> 00:54:05.239
<v Speaker 6>had social structures and Zoom was no replacement for it.

1056
00:54:05.239 --> 00:54:07.320
<v Speaker 6>It just did not help as much. You really wanted

1057
00:54:07.360 --> 00:54:10.599
<v Speaker 6>to be around people, and being around people an older

1058
00:54:10.639 --> 00:54:13.639
<v Speaker 6>age is really key. Now we see this all the

1059
00:54:13.679 --> 00:54:15.880
<v Speaker 6>time when people retire. There's sort of a fork in

1060
00:54:15.920 --> 00:54:18.639
<v Speaker 6>the road. You are very socially engaged in your job

1061
00:54:18.800 --> 00:54:22.679
<v Speaker 6>and other settings, and then when people retire, in some cases,

1062
00:54:22.760 --> 00:54:26.000
<v Speaker 6>they become very isolated and they're spending a lot of

1063
00:54:26.000 --> 00:54:28.440
<v Speaker 6>time at home, maybe with just a twenty four hour

1064
00:54:28.480 --> 00:54:30.800
<v Speaker 6>news cycle and all that kind of stuff, and not

1065
00:54:30.880 --> 00:54:34.599
<v Speaker 6>going out and being around people. And others have planned

1066
00:54:34.639 --> 00:54:36.480
<v Speaker 6>appropriately and said, these are going to be my post

1067
00:54:36.519 --> 00:54:39.000
<v Speaker 6>retirement plans. I'm going to spend more time in my

1068
00:54:39.000 --> 00:54:41.400
<v Speaker 6>community center and my church and whatever it is to

1069
00:54:41.559 --> 00:54:45.199
<v Speaker 6>maintain that social level of activity. And those individuals tend

1070
00:54:45.199 --> 00:54:47.000
<v Speaker 6>to do better cognitively over time.

1071
00:54:48.039 --> 00:54:50.039
<v Speaker 4>And of course not everyone is able to get the

1072
00:54:50.079 --> 00:54:52.440
<v Speaker 4>same levels of physical activity. And we have an entire

1073
00:54:52.480 --> 00:54:58.280
<v Speaker 4>episode about disability sociology that discusses accommodations and attitudes toward disability.

1074
00:54:58.400 --> 00:55:00.920
<v Speaker 4>So talk to a doctor or a physical therapist about

1075
00:55:00.920 --> 00:55:03.400
<v Speaker 4>what you can do and how your activity level is.

1076
00:55:03.719 --> 00:55:05.880
<v Speaker 4>And we also have an episode on chronic pain with

1077
00:55:05.960 --> 00:55:10.119
<v Speaker 4>some biopsychosocial interventions that have helped some folks. And as

1078
00:55:10.159 --> 00:55:13.519
<v Speaker 4>this is being released right before the crush of holiday

1079
00:55:13.559 --> 00:55:17.559
<v Speaker 4>travel and flu season, likely a spike in more COVID cases,

1080
00:55:17.800 --> 00:55:21.400
<v Speaker 4>it's always good to take precautionary measures against infection.

1081
00:55:21.679 --> 00:55:23.920
<v Speaker 2>If I'm on a plane, I'm in a mask. So

1082
00:55:24.159 --> 00:55:24.960
<v Speaker 2>do what's right for you.

1083
00:55:25.199 --> 00:55:28.039
<v Speaker 4>But know that doing physical activity that works for you

1084
00:55:28.119 --> 00:55:31.280
<v Speaker 4>and staying social is incredibly important for your health and

1085
00:55:31.360 --> 00:55:34.880
<v Speaker 4>your brain, she said to herself in and aside.

1086
00:55:34.639 --> 00:55:37.199
<v Speaker 6>So maintaining a good level of physical activity and a

1087
00:55:37.199 --> 00:55:39.719
<v Speaker 6>good level of social activity. You know, a great exercise

1088
00:55:39.719 --> 00:55:42.400
<v Speaker 6>that do both simultaneously is dancing. So we tend to

1089
00:55:42.440 --> 00:55:43.920
<v Speaker 6>hear about that a lot. Like if somebody is in

1090
00:55:43.960 --> 00:55:46.920
<v Speaker 6>a dance group or does dance classes a couple times

1091
00:55:46.920 --> 00:55:49.480
<v Speaker 6>a week, they are much happier. You know, you get

1092
00:55:49.480 --> 00:55:52.079
<v Speaker 6>a lot of endogenous sort of dope mein boosts that

1093
00:55:52.119 --> 00:55:54.480
<v Speaker 6>happen when you do that, but the social exposure and

1094
00:55:54.519 --> 00:55:57.159
<v Speaker 6>the physical activity seem to be key. Then we go

1095
00:55:57.199 --> 00:55:59.199
<v Speaker 6>on to other things that people are really curious about.

1096
00:55:59.199 --> 00:56:02.159
<v Speaker 6>What about brain games, what about sudoku? What about this

1097
00:56:02.239 --> 00:56:05.440
<v Speaker 6>and this and that, and the evidence there is a

1098
00:56:05.440 --> 00:56:08.320
<v Speaker 6>little bit shaky, right, So there's some evidence to suggest

1099
00:56:08.360 --> 00:56:12.239
<v Speaker 6>that maintaining sort of cognitive engagement, of course is very helpful,

1100
00:56:12.719 --> 00:56:15.719
<v Speaker 6>but most of it is based on cognitive engagement again

1101
00:56:15.719 --> 00:56:19.000
<v Speaker 6>in a social setting. Right, So if you're playing chess

1102
00:56:19.079 --> 00:56:21.599
<v Speaker 6>out in the park with somebody and having discussions and

1103
00:56:21.639 --> 00:56:23.760
<v Speaker 6>all that, that seems to be more helpful than playing

1104
00:56:23.840 --> 00:56:27.920
<v Speaker 6>chess against the computer avatar at home. Right, you might think, well,

1105
00:56:27.920 --> 00:56:29.800
<v Speaker 6>cognitively it is the same, I'm playing chess, but it

1106
00:56:29.840 --> 00:56:31.719
<v Speaker 6>turns out to be different if you're doing it with

1107
00:56:31.760 --> 00:56:34.840
<v Speaker 6>a human, right, and actually having conversations and actually being

1108
00:56:34.880 --> 00:56:37.199
<v Speaker 6>out and about. So again I go back to the

1109
00:56:37.239 --> 00:56:38.880
<v Speaker 6>two things that are kind of tried and true and

1110
00:56:38.920 --> 00:56:41.039
<v Speaker 6>I think are very helpful. The third thing that seems

1111
00:56:41.039 --> 00:56:44.320
<v Speaker 6>to be helpful has to do with diet and being

1112
00:56:44.320 --> 00:56:46.719
<v Speaker 6>able to have sort of a heart healthy diet, because

1113
00:56:46.760 --> 00:56:49.280
<v Speaker 6>we know that heart health is really important for brain health.

1114
00:56:49.519 --> 00:56:52.360
<v Speaker 6>So maintaining something that looks close to something like the

1115
00:56:52.360 --> 00:56:56.000
<v Speaker 6>Mediterranean diet, smaller amounts of red meat and things like that,

1116
00:56:56.360 --> 00:56:59.360
<v Speaker 6>high levels of leafy greens and fruits and vegetables and

1117
00:56:59.360 --> 00:57:02.320
<v Speaker 6>those kinds of things that also seems to be associated

1118
00:57:02.360 --> 00:57:06.360
<v Speaker 6>with better longevity and higher levels of cognition into that longevity.

1119
00:57:06.599 --> 00:57:09.000
<v Speaker 6>Those are massive studies that were done where they randomize

1120
00:57:09.000 --> 00:57:11.360
<v Speaker 6>people to either the Mediterranean diet or so the typical

1121
00:57:11.400 --> 00:57:14.599
<v Speaker 6>American diet, and they see some really decent results for

1122
00:57:14.840 --> 00:57:17.559
<v Speaker 6>something like the Mediterranean diet. But the brain game stuff

1123
00:57:17.599 --> 00:57:19.760
<v Speaker 6>is the one that I'm sort of tentative about. It's like,

1124
00:57:19.840 --> 00:57:21.519
<v Speaker 6>I don't know if it'll hurt you, but I'm not

1125
00:57:21.519 --> 00:57:22.960
<v Speaker 6>sure it's helping you all that much.

1126
00:57:23.239 --> 00:57:26.559
<v Speaker 4>You know, my husband's grandfather played a lot of video

1127
00:57:26.599 --> 00:57:30.360
<v Speaker 4>games in his later years, and he would play multiplayers,

1128
00:57:30.360 --> 00:57:32.599
<v Speaker 4>so he would be on the headset with his grandkids

1129
00:57:32.639 --> 00:57:35.400
<v Speaker 4>across the country while he was playing like World of

1130
00:57:35.400 --> 00:57:37.199
<v Speaker 4>Warcraft or League of Legends or whatever.

1131
00:57:37.360 --> 00:57:39.400
<v Speaker 6>I mean, we've heard that from a number of folks

1132
00:57:39.519 --> 00:57:41.119
<v Speaker 6>were involved even in our studies, said you know, I

1133
00:57:41.119 --> 00:57:43.639
<v Speaker 6>started playing video games, and I started to and they

1134
00:57:43.639 --> 00:57:46.360
<v Speaker 6>felt like even the learning experience was a really good

1135
00:57:46.440 --> 00:57:48.800
<v Speaker 6>thing for them. And some others just said Nope, not

1136
00:57:48.800 --> 00:57:50.360
<v Speaker 6>for me. I don't know what you're talking. There's no

1137
00:57:50.360 --> 00:57:52.000
<v Speaker 6>way I could ever do that. There was just kind

1138
00:57:52.000 --> 00:57:55.679
<v Speaker 6>of a block. So while it's challenging, there's no doubt

1139
00:57:55.719 --> 00:57:58.920
<v Speaker 6>that incorporating the social aspects into this has made a

1140
00:57:59.000 --> 00:58:01.920
<v Speaker 6>huge difference. This is why also reluctant to tell my

1141
00:58:02.000 --> 00:58:04.480
<v Speaker 6>kids not to play games and do things, because I

1142
00:58:04.519 --> 00:58:06.679
<v Speaker 6>felt like, if they're doing it with their friends and

1143
00:58:06.719 --> 00:58:08.639
<v Speaker 6>it's sort of communal, then it's a little bit different

1144
00:58:08.679 --> 00:58:11.320
<v Speaker 6>than just droning in front of the computer and playing

1145
00:58:11.320 --> 00:58:12.880
<v Speaker 6>a game by yourself against the computer.

1146
00:58:13.159 --> 00:58:15.079
<v Speaker 2>Yeah. I love that you are.

1147
00:58:15.480 --> 00:58:18.360
<v Speaker 4>You're not only researching this on the daily, but also

1148
00:58:18.480 --> 00:58:21.880
<v Speaker 4>seeing it as your children are growing up and watching

1149
00:58:22.039 --> 00:58:25.280
<v Speaker 4>how memory might change. But I imagine there are some difficult

1150
00:58:25.280 --> 00:58:26.960
<v Speaker 4>things about your job or studying it.

1151
00:58:27.000 --> 00:58:30.760
<v Speaker 2>I always ask what sucks? What sucks the most about

1152
00:58:30.760 --> 00:58:31.239
<v Speaker 2>your job?

1153
00:58:32.280 --> 00:58:37.880
<v Speaker 6>Oh, what sucks the most? Let's see. I think sometimes

1154
00:58:37.920 --> 00:58:44.280
<v Speaker 6>the pace by which things move frustrates me. And in research,

1155
00:58:44.639 --> 00:58:47.119
<v Speaker 6>you know, I think in science in general, there's this

1156
00:58:47.199 --> 00:58:49.239
<v Speaker 6>notion that we're going to do the best science that

1157
00:58:49.280 --> 00:58:50.639
<v Speaker 6>we can. We're gonna put it out there, We're going

1158
00:58:50.679 --> 00:58:52.880
<v Speaker 6>to publish our work and then hope that somebody else

1159
00:58:52.960 --> 00:58:54.920
<v Speaker 6>is going to come and take that work and build

1160
00:58:54.960 --> 00:58:57.000
<v Speaker 6>on it and then be able to translate things and

1161
00:58:57.280 --> 00:58:59.079
<v Speaker 6>get them to be helpful to somebody out in the

1162
00:58:59.119 --> 00:59:03.880
<v Speaker 6>real world. That takes forever, and it's so frustrating that

1163
00:59:03.920 --> 00:59:06.320
<v Speaker 6>it takes forever. And so one of the things that

1164
00:59:06.360 --> 00:59:08.480
<v Speaker 6>I've started to do in recent years and get my

1165
00:59:08.639 --> 00:59:11.199
<v Speaker 6>lab more involved in, is say, to hell with that,

1166
00:59:11.400 --> 00:59:13.239
<v Speaker 6>We're not going to wait. We're actually going to try

1167
00:59:13.239 --> 00:59:16.280
<v Speaker 6>to do it ourselves. So I've started to bridge a

1168
00:59:16.320 --> 00:59:19.639
<v Speaker 6>little bit between sort of the academic environment and more

1169
00:59:19.679 --> 00:59:22.239
<v Speaker 6>of the industry. But for the longest time it sucked.

1170
00:59:22.639 --> 00:59:26.360
<v Speaker 6>It felt like it were so removed as academics doing

1171
00:59:26.400 --> 00:59:29.239
<v Speaker 6>the science, and there's not enough of that science that's

1172
00:59:29.280 --> 00:59:30.880
<v Speaker 6>getting out there and helping people, even though it has

1173
00:59:30.880 --> 00:59:34.360
<v Speaker 6>the potential to help people. And then the other thing

1174
00:59:34.400 --> 00:59:41.320
<v Speaker 6>that's frustrating, Well, I will say that you can change everything.

1175
00:59:41.760 --> 00:59:46.039
<v Speaker 6>You always want to do what you feel is scientifically

1176
00:59:46.119 --> 00:59:50.199
<v Speaker 6>very rigorous and also like morally and ethically right, and

1177
00:59:50.280 --> 00:59:52.400
<v Speaker 6>you have kind of a code by which you operate,

1178
00:59:53.079 --> 00:59:55.639
<v Speaker 6>But there are certain systems in place that are really

1179
00:59:55.679 --> 00:59:59.960
<v Speaker 6>really difficult to change and some of them you can change,

1180
01:00:00.039 --> 01:00:02.079
<v Speaker 6>and you have to kind of figure out who to

1181
01:00:02.119 --> 01:00:04.639
<v Speaker 6>work with to make sure the message is communicated very

1182
01:00:04.679 --> 01:00:07.519
<v Speaker 6>well outside of academia to be able to influence people.

1183
01:00:07.760 --> 01:00:10.679
<v Speaker 6>But I am very fortunate that I'm surrounded by people

1184
01:00:10.679 --> 01:00:14.079
<v Speaker 6>who are equally frustrated and also believe that that sucks.

1185
01:00:14.079 --> 01:00:15.559
<v Speaker 6>So at least we can kind of riff off of

1186
01:00:15.639 --> 01:00:18.480
<v Speaker 6>each other a little bit and commiserate slash come up

1187
01:00:18.519 --> 01:00:20.159
<v Speaker 6>with ways that we can try to address it.

1188
01:00:20.480 --> 01:00:24.280
<v Speaker 2>Well, there's a community aspect too, right, exactly helping your brand.

1189
01:00:24.079 --> 01:00:26.239
<v Speaker 6>And that's the thing also science. You know, when it

1190
01:00:26.320 --> 01:00:29.800
<v Speaker 6>started out hundreds of years ago, when people were doing science,

1191
01:00:30.039 --> 01:00:32.599
<v Speaker 6>it really was kind of a solo practice. When you

1192
01:00:32.639 --> 01:00:35.800
<v Speaker 6>look at Nobel laureates, was always sort of singular winners.

1193
01:00:35.880 --> 01:00:40.039
<v Speaker 6>And that's not a thing anymore. Science is so communal now.

1194
01:00:40.360 --> 01:00:43.840
<v Speaker 6>It really requires teams and communities of people that are

1195
01:00:43.840 --> 01:00:47.239
<v Speaker 6>dedicated to solving these big, you know, challenging questions. They're

1196
01:00:47.239 --> 01:00:51.079
<v Speaker 6>not very simple at all. They're extremely challenging, and I

1197
01:00:51.079 --> 01:00:52.840
<v Speaker 6>think that's one of the reasons why things have been

1198
01:00:52.880 --> 01:00:54.559
<v Speaker 6>exponentially growing in recent years.

1199
01:00:54.639 --> 01:00:54.800
<v Speaker 5>Right.

1200
01:00:54.840 --> 01:00:57.000
<v Speaker 6>It's not just that we have better technology, we have

1201
01:00:57.039 --> 01:01:00.559
<v Speaker 6>smarter people and hordes of them that are dedicated to

1202
01:01:00.559 --> 01:01:03.599
<v Speaker 6>answering these questions and doing it together. So when you

1203
01:01:03.639 --> 01:01:05.760
<v Speaker 6>look at the number of authors on a paper or

1204
01:01:05.760 --> 01:01:08.639
<v Speaker 6>the number of co investigators on a grant, those numbers

1205
01:01:08.679 --> 01:01:11.719
<v Speaker 6>have also shot up. So that community aspect of it,

1206
01:01:11.760 --> 01:01:13.400
<v Speaker 6>I think, is what keeps a lot of us at

1207
01:01:13.400 --> 01:01:16.599
<v Speaker 6>the table, and it's what makes it worthwhile despite the

1208
01:01:17.119 --> 01:01:18.119
<v Speaker 6>occasional sucking.

1209
01:01:18.960 --> 01:01:20.960
<v Speaker 4>Well, if someone wanted to go into this field or

1210
01:01:21.800 --> 01:01:25.599
<v Speaker 4>just just curious, what is the best thing about your job?

1211
01:01:26.000 --> 01:01:29.199
<v Speaker 6>Oh my gosh, there's so many things. I mean, I'm

1212
01:01:29.239 --> 01:01:31.079
<v Speaker 6>like a kid in a candy store most of a time.

1213
01:01:31.440 --> 01:01:33.960
<v Speaker 6>I can tell you that for someone who is naturally

1214
01:01:34.039 --> 01:01:37.199
<v Speaker 6>very curious and inquisitive, this is like heaven, right because

1215
01:01:37.239 --> 01:01:39.360
<v Speaker 6>you're learning new things every day and it never stops

1216
01:01:39.760 --> 01:01:42.840
<v Speaker 6>and there's no real retirement. Also for people like me,

1217
01:01:42.920 --> 01:01:45.360
<v Speaker 6>like you retire, but you're still on recall, You consult,

1218
01:01:45.400 --> 01:01:49.079
<v Speaker 6>you do things, you're constantly continuing to learn. So if

1219
01:01:49.159 --> 01:01:52.960
<v Speaker 6>that's something that appeals to you, being a constant student, man,

1220
01:01:53.119 --> 01:01:55.880
<v Speaker 6>science is like the best place to get into the

1221
01:01:55.960 --> 01:01:59.239
<v Speaker 6>other thing also is being an academic. I have incredible

1222
01:01:59.320 --> 01:02:02.400
<v Speaker 6>freedom to pursue the questions of my interests and my

1223
01:02:02.480 --> 01:02:05.320
<v Speaker 6>lab's interest. If tomorrow I decided I wanted to study

1224
01:02:05.320 --> 01:02:07.840
<v Speaker 6>fruit flies, I will not lose my job. I can

1225
01:02:07.880 --> 01:02:09.840
<v Speaker 6>do that. I have to go support that effort somehow.

1226
01:02:10.039 --> 01:02:12.440
<v Speaker 6>But no one tells me what to study, No one

1227
01:02:12.480 --> 01:02:15.400
<v Speaker 6>tells me what science to do. I get to decide that,

1228
01:02:15.440 --> 01:02:17.440
<v Speaker 6>and I do it communally with my lab because they

1229
01:02:17.440 --> 01:02:19.679
<v Speaker 6>we're all collectively, and so we get to decide on

1230
01:02:19.719 --> 01:02:21.039
<v Speaker 6>the science that we want to do. We get to

1231
01:02:21.039 --> 01:02:24.519
<v Speaker 6>write the grants and papers together. So that's liberating. And

1232
01:02:24.599 --> 01:02:27.920
<v Speaker 6>I don't know of any other job out there where

1233
01:02:27.960 --> 01:02:30.480
<v Speaker 6>you can decide what you want to do at any

1234
01:02:30.559 --> 01:02:32.920
<v Speaker 6>given day and just go do it.

1235
01:02:33.159 --> 01:02:33.440
<v Speaker 4>Yeah.

1236
01:02:33.559 --> 01:02:36.679
<v Speaker 6>Right, that's incredibly empowering. You can continue to do what

1237
01:02:36.679 --> 01:02:38.920
<v Speaker 6>you want to do and continue to be in love

1238
01:02:38.920 --> 01:02:41.119
<v Speaker 6>with it for as long as you want to.

1239
01:02:41.760 --> 01:02:45.760
<v Speaker 4>This has been such a journey into my own brain

1240
01:02:45.880 --> 01:02:49.360
<v Speaker 4>and anyone listening, so thank you for just inspiring us

1241
01:02:49.360 --> 01:02:50.920
<v Speaker 4>also to treat our brains a little better.

1242
01:02:51.159 --> 01:02:53.159
<v Speaker 6>You're very welcome. This was so much fun.

1243
01:02:53.519 --> 01:02:55.519
<v Speaker 2>Thank you so much, just a great.

1244
01:02:57.159 --> 01:03:01.000
<v Speaker 4>So once again, ask neuroscientist neuroticqiquestions if you are me,

1245
01:03:01.199 --> 01:03:03.679
<v Speaker 4>and thank you to doctor Michael Yasa and everyone down

1246
01:03:03.679 --> 01:03:06.559
<v Speaker 4>in Irvine for helping arrange this. There's more links to

1247
01:03:06.639 --> 01:03:09.159
<v Speaker 4>their lab and his work. They're in the show notes

1248
01:03:09.199 --> 01:03:12.679
<v Speaker 4>and up on our website at aliwar dot com, Slashnemnology,

1249
01:03:13.000 --> 01:03:15.480
<v Speaker 4>and we're at Ologies on Instagram and now blue Sky

1250
01:03:15.599 --> 01:03:17.800
<v Speaker 4>where everyone seems to be headed see you over there.

1251
01:03:17.840 --> 01:03:20.960
<v Speaker 4>We also have Smologies, which are shorter, kid friendly episodes

1252
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<v Speaker 4>that you can find anywhere you get podcasts.

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<v Speaker 2>We put them in a.

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01:03:23.480 --> 01:03:26.840
<v Speaker 4>New feed so it's easier for parents and teachers or

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<v Speaker 4>anyone who's looking for shorter, clean language versions of Ologies

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01:03:30.920 --> 01:03:32.760
<v Speaker 4>to find them. You can look for the new green

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01:03:32.920 --> 01:03:35.760
<v Speaker 4>artwork and the Smologies logo. Thank you also to Aaron

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01:03:35.840 --> 01:03:39.400
<v Speaker 4>Talbert for admitting Theologies podcast Facebook group. Aveline Mallick makes

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01:03:39.440 --> 01:03:42.599
<v Speaker 4>our professional transcripts. Kelly R. Dwyd is a website. Noelle

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01:03:42.639 --> 01:03:45.000
<v Speaker 4>Dilworth is our birthday girl this past week and she's

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01:03:45.039 --> 01:03:49.039
<v Speaker 4>our wonderful scheduling producer. Susan Hale Managing directsit All, Jack

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01:03:49.159 --> 01:03:52.159
<v Speaker 4>Chafy edits and lead editor. And another great brain is

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01:03:52.199 --> 01:03:54.000
<v Speaker 4>Mercedes Maitland of Maitland.

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<v Speaker 2>Audio with some assists the last couple weeks.

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01:03:55.760 --> 01:03:58.960
<v Speaker 4>From Jared Sleeper of mindjam media. When I'm late on things,

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01:03:59.119 --> 01:04:01.800
<v Speaker 4>Nick Thorburn the theme music, and if you stick around

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<v Speaker 4>until the end, I tell you a secret. And this

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01:04:04.280 --> 01:04:06.599
<v Speaker 4>week it's that I have a theory that if you

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01:04:06.679 --> 01:04:09.000
<v Speaker 4>have a good friend who has a party, like they're

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01:04:09.039 --> 01:04:11.719
<v Speaker 4>close buds, you should either be the first one there

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01:04:12.039 --> 01:04:14.280
<v Speaker 4>to help set up and just kind of like set

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01:04:14.320 --> 01:04:16.400
<v Speaker 4>the mood so they're not worried about when people are

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01:04:16.400 --> 01:04:18.599
<v Speaker 4>going to start showing up, or you should be the

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<v Speaker 4>last one standing to help tidy up and say, hey man,

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<v Speaker 4>great party. Relatedly, I love ice. I love having any

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01:04:25.800 --> 01:04:29.519
<v Speaker 4>cold beverage with an absolutely egregious amount of ice, so

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01:04:29.679 --> 01:04:32.719
<v Speaker 4>much so that our freezer could not keep up with

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01:04:32.760 --> 01:04:35.159
<v Speaker 4>my ice consumption. Our ice maker was like, I don't

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<v Speaker 4>know what to tell you.

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<v Speaker 7>Now.

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01:04:36.360 --> 01:04:38.960
<v Speaker 4>During early quarantine, there were a lot of cafes that

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<v Speaker 4>were closing, and Jarrett surprised me. When I was out

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01:04:40.960 --> 01:04:43.000
<v Speaker 4>of town, I was helping my dad and he bought

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01:04:43.039 --> 01:04:46.199
<v Speaker 4>an ice machine from a closing cafe. We have it

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01:04:46.239 --> 01:04:49.159
<v Speaker 4>in our garage and I use it every single day,

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<v Speaker 4>even in winter. Now, what does this have to do

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01:04:51.760 --> 01:04:52.320
<v Speaker 4>with parties?

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<v Speaker 1>So we have.

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<v Speaker 4>Become the friends who show up first with a giant

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01:04:56.519 --> 01:05:00.599
<v Speaker 4>bucket of ice and it feels heroic. You are someone

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01:05:00.639 --> 01:05:03.639
<v Speaker 4>who goes to bed early. Be the first to show

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01:05:03.719 --> 01:05:06.000
<v Speaker 4>up at a party, pick up some bags of ice

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01:05:06.039 --> 01:05:09.039
<v Speaker 4>on the way. Everyone will love you forever. You get

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<v Speaker 4>to bed early. Okay, just in general, be safe on there, Okay,

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<v Speaker 4>bye bye hacadermatology, homology or do zoology, lithology, new technology, meteorology, matteratology, ethnology, seriology, elidology.

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<v Speaker 8>Let's make some memories, huh.
