WEBVTT 1 00:00:30.719 --> 00:00:32.759 Welcome to Destiny. 2 00:00:33.799 --> 00:00:36.560 Now here's your host, Cliff dunning. 3 00:00:37.880 --> 00:00:42.240 Well. I have news. I have very, very very good news. 4 00:00:42.280 --> 00:00:46.359 If you're a fan of Destiny. I love Destiny. I've 5 00:00:46.520 --> 00:00:50.960 enjoyed the work and the interviews and continue to enjoy 6 00:00:51.320 --> 00:00:58.119 interviewing people on a variety of topics that are personal growth, spirituality, 7 00:00:58.200 --> 00:01:03.119 wellness and in between, and the topics that are not 8 00:01:03.439 --> 00:01:09.280 necessarily suitable for Earth agents but are comparable and compatible. 9 00:01:09.640 --> 00:01:13.079 There you go. Hey, this is clip your host of Destiny, 10 00:01:13.519 --> 00:01:16.079 and I hope you are doing well today. My news 11 00:01:16.280 --> 00:01:21.680 is this, I have this amazing team in Pakistan headed 12 00:01:21.760 --> 00:01:27.079 up by Face Soul Parves and he has decided to 13 00:01:27.319 --> 00:01:34.560 create a YouTube channel for Destiny. And this means for 14 00:01:34.640 --> 00:01:38.719 the last five years, we're going to slowly edit and 15 00:01:39.519 --> 00:01:43.920 put up the variety of wonderful guests that we've had 16 00:01:44.000 --> 00:01:47.920 on this program and post it on YouTube. There will 17 00:01:47.959 --> 00:01:49.760 be a chance. It will be a chance for you 18 00:01:49.879 --> 00:01:54.719 to see many of your favorite authors on hundreds of 19 00:01:54.799 --> 00:02:03.239 different topics, including ayahuasca, the Akashik Records, psychic development, paranormal studies, 20 00:02:04.000 --> 00:02:06.480 and the list goes on and on and on. Even 21 00:02:06.920 --> 00:02:12.919 people like doctor Avy Love from Harvard working on alien probes, 22 00:02:14.280 --> 00:02:18.039 and it really opens the door for a lot more content. 23 00:02:19.280 --> 00:02:20.879 Not to say that we don't have enough. We have 24 00:02:20.919 --> 00:02:22.919 a ton of content. It's going to take him and 25 00:02:22.960 --> 00:02:27.560 his team several months to ramp up, but I am 26 00:02:27.599 --> 00:02:31.360 happy to announce that I just sent him a series 27 00:02:31.479 --> 00:02:35.719 of videos from twenty twenty three on a number of 28 00:02:35.719 --> 00:02:40.719 topics to get things started. So when he has that 29 00:02:40.840 --> 00:02:42.680 channel up, which is only going to be in a 30 00:02:42.680 --> 00:02:47.319 couple of lessen ten days, I will make that announcement. 31 00:02:47.360 --> 00:02:50.360 And then you can see many of the guests that 32 00:02:50.360 --> 00:02:54.439 we've had in a number of on a number of occasions, 33 00:02:55.520 --> 00:02:59.319 these guests have had graphs, have had photographs, have had 34 00:02:59.360 --> 00:03:05.159 illustration that you have missed. So what a great, great 35 00:03:05.400 --> 00:03:10.520 treat for me and obviously for you, because this adds 36 00:03:10.520 --> 00:03:14.719 is a dimension YouTube channel. Being able to see these 37 00:03:14.759 --> 00:03:20.479 guests in that channel adds a dimension as a yeah, 38 00:03:20.599 --> 00:03:25.400 adds much much more to the simple interview than I 39 00:03:25.439 --> 00:03:29.439 could ever ask. So now I don't know how successful 40 00:03:29.599 --> 00:03:33.439 the YouTube channel is, but I'm not launching it necessarily 41 00:03:33.479 --> 00:03:36.120 to have hundreds of thousands of people. That would be 42 00:03:36.240 --> 00:03:40.319 nice because then people will get a sense of exactly 43 00:03:40.360 --> 00:03:44.960 what is happening and see firsthand what is the story 44 00:03:45.159 --> 00:03:48.639 on many of these topics. But it's a benefit, it's 45 00:03:48.639 --> 00:03:54.759 a benefit, and it's fun. And heck, we record most 46 00:03:54.800 --> 00:03:59.080 of these interviews that you hear on video. We record 47 00:03:59.199 --> 00:04:03.199 audio and there's a video component as well, so stay 48 00:04:03.240 --> 00:04:07.479 tuned for that. Wow. Wow's that's a great announcement now 49 00:04:08.120 --> 00:04:10.520 if you are if you're a fan of Earth Ancients, 50 00:04:10.599 --> 00:04:17.000 remember we had a big announcement the relodge of Earth 51 00:04:17.040 --> 00:04:20.639 Ancients after a year and a half. So here we go. 52 00:04:20.759 --> 00:04:24.920 This is a fun addition for you and it makes 53 00:04:26.279 --> 00:04:31.439 it may, It gives uh a needed it elevates destiny 54 00:04:32.079 --> 00:04:35.160 and I appreciate it and I think the energy behind 55 00:04:35.279 --> 00:04:40.399 destiny is served. It's well served. So make sure you 56 00:04:40.480 --> 00:04:43.160 check it out. And again I'll make an announcement when 57 00:04:43.680 --> 00:04:51.360 you can go to YouTube and see these uh these videos. 58 00:04:52.560 --> 00:04:57.800 My guest today is a neuroscientist. She has herself suffered 59 00:04:58.040 --> 00:05:02.920 such a very young age of with migraines chronic migraines, 60 00:05:03.879 --> 00:05:08.800 to the point where she was basically having a migraine 61 00:05:08.839 --> 00:05:14.240 almost every day, and after years of suffering, she finally 62 00:05:14.399 --> 00:05:19.399 decided that she was gonna do some significant research over 63 00:05:19.439 --> 00:05:26.199 a decade's worth of research on understanding migraines and what 64 00:05:26.759 --> 00:05:31.720 the body does basically shuts down during one of these attacks, 65 00:05:32.879 --> 00:05:39.160 and she has made some groundbreaking discoveries which reveals a 66 00:05:39.360 --> 00:05:44.600 nutritional aspect of migraines. Now, the other thing, and this 67 00:05:44.680 --> 00:05:47.839 is what will come out in this interview today, is 68 00:05:47.879 --> 00:05:53.279 that her research has culminated in a nutritional supplement that 69 00:05:53.399 --> 00:05:59.680 is so effective it actually can be considered a biohacking tool. 70 00:06:00.040 --> 00:06:05.480 Only does it help people who have migraines, it appears 71 00:06:05.519 --> 00:06:11.959 to have potential health ramifications for people with dementia, Alzheimer's 72 00:06:12.519 --> 00:06:17.319 brain fog, which can be caused by a number of 73 00:06:17.399 --> 00:06:23.519 different topics, and most importantly help people relieve themselves of 74 00:06:23.720 --> 00:06:30.199 pharmacological remedies. The allopathic community does not have anything like this. 75 00:06:30.360 --> 00:06:35.680 In fact, their approach is to is to medicate rather 76 00:06:35.759 --> 00:06:41.600 than holistically innovate with different types of herbs, supplements nutritional 77 00:06:42.160 --> 00:06:48.560 remedies over drugs. And I was so impressed with this 78 00:06:49.439 --> 00:06:52.720 nutritional supplement that I am going to promote it as 79 00:06:52.759 --> 00:06:54.639 soon as possible, as soon as I get the information, 80 00:06:55.279 --> 00:06:57.959 and in the near future we'll talk more about it. 81 00:06:58.439 --> 00:07:00.399 I'm going to be kind of a guinea pig on 82 00:07:00.439 --> 00:07:04.959 my own and start taking the supplement, and I'll report 83 00:07:05.000 --> 00:07:08.279 on the benefits I have. I don't have I don't 84 00:07:08.319 --> 00:07:12.319 have headaches, I don't have migraines, but I do have 85 00:07:12.480 --> 00:07:17.040 brain fog occasionally. I am, like most of us, you know, 86 00:07:17.199 --> 00:07:21.000 under a certain amount of stress, and I need to 87 00:07:21.040 --> 00:07:27.240 stay creative. I need to have enough support mentally to 88 00:07:27.360 --> 00:07:33.240 write articles, trying to finish some books, and work with 89 00:07:33.319 --> 00:07:41.240 my team to produce Destiny, produce Earth Ancients, and on occasion, 90 00:07:41.759 --> 00:07:46.000 produce Earth Ancients Special edition, either the Archives or a 91 00:07:46.040 --> 00:07:50.560 special program, depending on who the topic or who the 92 00:07:50.680 --> 00:07:54.160 guest is, or what the topic is. So stay tuned 93 00:07:54.199 --> 00:07:59.560 for that. And the product is called brain Ritual. If 94 00:07:59.560 --> 00:08:03.120 you do suffer from debilitating migraines. And by the way, 95 00:08:04.120 --> 00:08:07.399 I was blown away to discover that over a billion 96 00:08:07.720 --> 00:08:12.399 people suffer from migraines. A billion, that is one in 97 00:08:12.519 --> 00:08:18.480 seven people suffer from migraines. It's just amazing. So listen closely. 98 00:08:18.800 --> 00:08:22.720 I think you're gonna find today's program intriguing. So today's 99 00:08:22.759 --> 00:08:28.680 program is overcoming chronic migraines and the Brain Ritual solution 100 00:08:29.439 --> 00:09:13.320 with my guests, Doctor Elena Gross. I didn't know that 101 00:09:13.879 --> 00:09:17.039 the world suffers from migraines. I just discovered. And by 102 00:09:17.080 --> 00:09:19.879 the way, our program today is on migraines. That a 103 00:09:19.919 --> 00:09:26.200 billion people on our planet suffer from migraines, and that's amazing. 104 00:09:26.279 --> 00:09:30.360 When I read that, I was a bit shocked. And 105 00:09:30.480 --> 00:09:32.919 migraines are different than headaches. We're going to find out 106 00:09:32.960 --> 00:09:35.639 the details here shortly. But my guest today is Elena, 107 00:09:35.759 --> 00:09:39.720 doctor Elena Gross. She is a specialist on this. She 108 00:09:39.919 --> 00:09:45.080 is the founder and CEO of a company, and she 109 00:09:45.240 --> 00:09:51.320 is a passionate neuroscientist, clinical researcher, and former chronic migraine suffering. 110 00:09:51.399 --> 00:09:54.399 I mean, if anyone could become passionate about it as 111 00:09:54.399 --> 00:09:57.399 somebody who suffers from migraines. So today we're going to 112 00:09:57.480 --> 00:10:03.360 discover not only the causation of migraines, but solutions for 113 00:10:03.399 --> 00:10:06.480 those of you who have chronic migraines. We're going to 114 00:10:06.600 --> 00:10:10.840 have a solution for you. So Elena, welcome to Destiny. 115 00:10:10.879 --> 00:10:12.120 Great to have you on the program. 116 00:10:13.320 --> 00:10:15.360 Thank you so much for having me. It's exciting to 117 00:10:15.399 --> 00:10:15.799 be here. 118 00:10:16.440 --> 00:10:19.639 Let's talk about you. In your work, you say that 119 00:10:19.720 --> 00:10:24.960 you were suffering from a young age with migraines. That 120 00:10:25.039 --> 00:10:28.320 must have been really a challenge because because the people 121 00:10:28.320 --> 00:10:32.320 that I know who have migraines, there is stabilitating. You 122 00:10:32.360 --> 00:10:34.720 can't really do a lot when you have a severe migraine. 123 00:10:35.080 --> 00:10:37.000 And what I've read about and I've only read a 124 00:10:37.039 --> 00:10:40.519 little bit, the suggestions are, of course, take your meds, 125 00:10:40.919 --> 00:10:44.080 but also go to a room, be quiet, shut the 126 00:10:44.120 --> 00:10:48.720 world off, and if you can, try to sleep, which 127 00:10:48.759 --> 00:10:51.919 I thought was kind of interesting. Talk a little bit 128 00:10:51.919 --> 00:10:55.519 about migraines. What's the what's the what's the background on migraines? 129 00:10:55.559 --> 00:10:59.440 How are they? How are they formed? Yeah? 130 00:10:59.440 --> 00:11:02.679 Thank you. So My backstory is, as you already just 131 00:11:02.759 --> 00:11:06.559 quickly mentioned, is that I started getting this very debilitating 132 00:11:06.679 --> 00:11:10.759 headaches with some other associated in terms such as a 133 00:11:10.799 --> 00:11:14.120 lot of light sensitivity, so light would heard, noises would heard, 134 00:11:14.639 --> 00:11:18.679 I would get six or nausea. Moving would make it worse, 135 00:11:19.240 --> 00:11:21.720 and I would actually wake up from it. So there 136 00:11:21.799 --> 00:11:23.759 was no way I could go to sleep and just 137 00:11:23.799 --> 00:11:25.720 sleep it off because the pain was so bad that 138 00:11:25.759 --> 00:11:27.639 it would wake me up. So there's no way of 139 00:11:27.720 --> 00:11:30.080 sleeping through it. And when I was waking up with 140 00:11:30.120 --> 00:11:35.879 this terrible headaches and everything was like spinning, it was 141 00:11:35.960 --> 00:11:41.080 basically the moment for taking painkillers that would maybe work 142 00:11:41.120 --> 00:11:44.559 had passed because it was already so bad. So yeah, 143 00:11:44.600 --> 00:11:47.000 some of this advice they go to bed, sleep it off. 144 00:11:47.039 --> 00:11:48.440 You know, you can do that with a headache, with 145 00:11:48.480 --> 00:11:51.559 a tension, take hebaite, not with the micraine. Microines are 146 00:11:51.600 --> 00:11:54.440 typically half sided, so that's a good sign that only 147 00:11:54.480 --> 00:11:59.000 half of the phase or the skull the brain is affected. 148 00:11:59.279 --> 00:12:01.879 Mine used to be predominantly right sided, but it can 149 00:12:01.919 --> 00:12:05.679 be both as well. It's more rare. They're pulsating and 150 00:12:05.720 --> 00:12:09.320 burning in quality, and they come with light noise, even 151 00:12:09.360 --> 00:12:12.360 smell sensitivity, so people get really sick when they smell 152 00:12:12.399 --> 00:12:16.519 perfumes and all of that. Sometimes even touch sensitivity and 153 00:12:17.039 --> 00:12:20.519 moving makes it worse. You get sick. And also in 154 00:12:20.559 --> 00:12:23.679 a third of sufferers you have this so called aura face, 155 00:12:23.759 --> 00:12:27.360 which precedes the headache face, and there you get kind 156 00:12:27.399 --> 00:12:29.759 of blackening out of the visual field. You get visual 157 00:12:29.759 --> 00:12:34.320 disturbances or sensory disturbances. So this goes from like blacking 158 00:12:34.320 --> 00:12:36.320 in our parts of the visual field, people think they 159 00:12:36.360 --> 00:12:39.360 have a stroke all the way to like paralysis or 160 00:12:39.399 --> 00:12:44.679 numbness of body, so almost like seizure like symptoms, and 161 00:12:44.720 --> 00:12:48.039 it's transient but still, and then you get this crushing fatigue. 162 00:12:48.080 --> 00:12:51.519 So even before you get yawning, frequent urination, you have 163 00:12:51.559 --> 00:12:56.840 this craving for foods, You get irritable, and afterwards you 164 00:12:56.919 --> 00:12:59.200 get this kind of like a hangover phase where your 165 00:12:59.200 --> 00:13:02.360 body is just rained, right, you just feel so exhausted. 166 00:13:02.679 --> 00:13:05.399 And these are kind of phases of the migraine. And 167 00:13:05.559 --> 00:13:07.639 this goes all the way from like I have one 168 00:13:07.679 --> 00:13:10.840 attack year to I have an attack every day or 169 00:13:10.879 --> 00:13:12.759 at least fifty percent of the time than you're in 170 00:13:12.840 --> 00:13:16.440 chronic migraine, which means very difficult. So this is where 171 00:13:16.519 --> 00:13:19.440 I ended up in. I started having these headaches when 172 00:13:19.480 --> 00:13:24.039 I was fourteen. Interestingly enough, half a year after I 173 00:13:24.240 --> 00:13:28.840 was prescribed the contraceptive pill for hormone deficiency, so they 174 00:13:28.879 --> 00:13:30.879 figured out I don't have enough hormones and then they 175 00:13:30.879 --> 00:13:34.200 gave me artificial hormones, which probably made everything worse. And 176 00:13:34.240 --> 00:13:37.240 the pill actually raises ooxitive stress, which are these free 177 00:13:37.320 --> 00:13:41.200 radicals that destroy parts of the body by fifty percent, 178 00:13:41.720 --> 00:13:45.519 so you're more inflamed. And this oxitive stress that we 179 00:13:45.559 --> 00:13:49.279 will talk about more, these like free radical bombs. They 180 00:13:49.279 --> 00:13:52.159 are also the common denominator of all migraine triggers, but 181 00:13:52.279 --> 00:13:55.320 basically for me, it only went downhill from there. I 182 00:13:55.360 --> 00:13:59.000 tried everything pharmacological, all the different drugs that they give you, 183 00:13:59.080 --> 00:14:02.919 like convolves in drugs, entity pressants that may work for 184 00:14:03.039 --> 00:14:06.759 migraine or not. I tried all the alternative stuff, Chinese, 185 00:14:06.879 --> 00:14:11.240 urbal medicine, acupuncture, but it only kept getting worse. So 186 00:14:11.279 --> 00:14:14.120 by the time I was halfways through my bachelor's degree 187 00:14:14.159 --> 00:14:18.480 in psychology, I had chronic migraine despite trying everything, despite 188 00:14:18.720 --> 00:14:21.320 leaving all the food triggers and going to bed and 189 00:14:21.840 --> 00:14:24.720 at a regular time, and taking all the drugs and 190 00:14:24.759 --> 00:14:28.919 trying everything right. And then I was thinking, well, I'm 191 00:14:28.960 --> 00:14:31.600 never gonna lead a normal life anyway. I will never 192 00:14:31.639 --> 00:14:33.919 be able to hold a normal jaw, so I might 193 00:14:33.960 --> 00:14:36.320 as well dedicate my life for a little bit of 194 00:14:36.720 --> 00:14:40.759 workforce and energy. I have left research, so I switched 195 00:14:40.759 --> 00:14:44.039 into neuroscience. I was lucky enough to get a stipend 196 00:14:44.080 --> 00:14:48.360 at Oxford in England and a medical doctor who was 197 00:14:48.399 --> 00:14:50.799 a migraine expert took me under his wings and I 198 00:14:50.840 --> 00:14:54.200 did both of my master projects in migraine research and 199 00:14:54.360 --> 00:14:58.559 stumped across the fact or the evidence that migraine could 200 00:14:58.639 --> 00:15:02.919 be as much a match ofolic disease as a neurological one. 201 00:15:03.519 --> 00:15:07.159 And the beauty of this finding is metabolism. So the 202 00:15:07.200 --> 00:15:11.240 way we make energy from food, in very simple terms, 203 00:15:12.320 --> 00:15:15.559 is something that you might know from diabetes, right, metabolic 204 00:15:15.600 --> 00:15:18.399 disease one of the most known one. But it's something 205 00:15:18.440 --> 00:15:22.159 that we can change. We cannot change the neurological heart 206 00:15:22.200 --> 00:15:25.120 wiring of our brain, right, the neural connections whatever, not yet, 207 00:15:25.159 --> 00:15:29.039 you cannot change our genetics, but we can influence metabolism. 208 00:15:29.080 --> 00:15:33.240 That's called epigenetics. We can totally change this. That's in 209 00:15:33.320 --> 00:15:37.320 our control even today. So this is very powerful. Took 210 00:15:37.360 --> 00:15:39.279 me a decade to figure out what you need to do. 211 00:15:39.320 --> 00:15:40.039 And I guess that's what. 212 00:15:40.000 --> 00:15:42.840 A horrible sad story though, because some people will just 213 00:15:42.960 --> 00:15:48.480 like go nuts without my pain, that my discomfort. Before 214 00:15:48.519 --> 00:15:50.759 we get into more details, can you give us the 215 00:15:50.799 --> 00:15:57.159 fundamentals of what is happening physiologically that is creating migrance? 216 00:15:57.200 --> 00:16:01.639 What is it expanded blood vessels? Is it something in 217 00:16:01.679 --> 00:16:05.120 the brain? Talk about the specific so that our listeners 218 00:16:05.120 --> 00:16:07.080 have an idea exactly what a migraine is. 219 00:16:07.799 --> 00:16:10.480 Yeah, that's great, So I wish we would know too. 220 00:16:10.679 --> 00:16:15.320 One hundred percent certainty. But we published this quite highly 221 00:16:15.320 --> 00:16:18.279 what we think how the migraine is actually happening all 222 00:16:18.279 --> 00:16:21.200 the way from new genetics to the resolution of the attack. 223 00:16:21.279 --> 00:16:23.720 So let's quickly walk through this. So for a long 224 00:16:23.759 --> 00:16:26.960 time they thought migraine was a vascular problem, well for 225 00:16:27.000 --> 00:16:29.600 a long time, I say, for like the last fifty years, 226 00:16:29.919 --> 00:16:32.639 where they thought there was some vessels expanding and that 227 00:16:32.720 --> 00:16:35.720 presses against the skull and that hurts. But in the 228 00:16:35.759 --> 00:16:38.639 meantime this theory has been mainly debunked because we know 229 00:16:38.759 --> 00:16:42.360 that the dilation of the vessels is not in time 230 00:16:42.600 --> 00:16:47.200 coherence with the event, so it happens not before so after. 231 00:16:47.440 --> 00:16:50.480 So that doesn't really match. So no, I think there's 232 00:16:50.480 --> 00:16:55.480 a different explanation. We know that the physiological underlyking not 233 00:16:55.559 --> 00:17:01.559 the pain, is certain neuropeptides, certain molecules being released, and 234 00:17:01.600 --> 00:17:04.640 they hurt when they're around. They activate neurons, and that 235 00:17:04.799 --> 00:17:07.319 is pain. Right, So we know that, But why are 236 00:17:07.359 --> 00:17:11.519 these neural let's say, inflammatory molecules released in the first place. 237 00:17:12.160 --> 00:17:15.599 That's the question. And we can already say in my 238 00:17:15.759 --> 00:17:19.119 theory migraine. You already said a billion people in the 239 00:17:19.160 --> 00:17:22.720 world have migrained This cannot be an accident of nature. 240 00:17:23.279 --> 00:17:27.680 This is not a small nuisance mutation that is accidentally 241 00:17:27.759 --> 00:17:33.279 happening in every seventh person in the world. That's extremely unlikely. 242 00:17:33.440 --> 00:17:36.839 So that means, coming back to the ancient wisdom, that 243 00:17:37.000 --> 00:17:42.279 means migraine genetics must have had an evolutionary purpose an advantage. 244 00:17:42.440 --> 00:17:45.519 Otherwise those genes would have never been passed on to 245 00:17:45.680 --> 00:17:48.920 such a big degree. Right, Okay, so here we go. 246 00:17:49.160 --> 00:17:54.160 What is the advantage? Now? We know mechanistically migrainers' brains 247 00:17:54.240 --> 00:17:58.799 are hyperactive, so they are basically not habituating. And in 248 00:17:58.880 --> 00:18:02.000 simple terms, there's means if you without migraine were to 249 00:18:02.039 --> 00:18:05.000 look at a white wall or some stimulus that isn't changing, 250 00:18:06.039 --> 00:18:10.480 your brain at some point would drastically reduce firing because 251 00:18:10.519 --> 00:18:14.160 it only encodes for change. A miganus brain doesn't stop 252 00:18:14.160 --> 00:18:17.799 firing even if the stimulus isn't changing. It's hyperactive, so 253 00:18:17.839 --> 00:18:21.839 it uses more energy. And we know that even from 254 00:18:21.920 --> 00:18:25.519 your imaging studies, even between migrant attacks and Migan's brain 255 00:18:25.559 --> 00:18:29.200 on average has sixteen percent less atp or less energy 256 00:18:29.240 --> 00:18:32.359 currency in the brain. That's a lot sixteen percent less, 257 00:18:32.599 --> 00:18:35.519 so they use more energy. And again if we go 258 00:18:35.640 --> 00:18:39.519 back to ten thousand plus years people were maybe living 259 00:18:39.599 --> 00:18:42.720 in tribes around the campfire. Now you can imagine every 260 00:18:42.799 --> 00:18:46.599 seventh person lying around that campfire has this hyperactive brains. 261 00:18:47.359 --> 00:18:50.599 Those are the ones that wake up very easily and 262 00:18:50.640 --> 00:18:53.519 would save the tribe from the tiger approaching or whatever 263 00:18:53.640 --> 00:18:55.519 threat it could be, right an immigration. 264 00:18:55.720 --> 00:19:00.839 So you're looking at evolutionary wise as to certain people 265 00:19:00.920 --> 00:19:04.640 have this tendency because they have this chemistry in their 266 00:19:04.680 --> 00:19:08.880 brain that is hypersensitive. It's hyperactive. 267 00:19:08.920 --> 00:19:12.880 Excuse me, hyperactive, hyperactive, right, hyperactive. Yes, you need their 268 00:19:12.880 --> 00:19:13.599 brains fire. 269 00:19:13.440 --> 00:19:15.160 Me very fascinating price. 270 00:19:15.319 --> 00:19:17.759 It comes at a price. Now you have a hyperactive brain, 271 00:19:18.160 --> 00:19:22.079 it needs more energy. Now, ten thousand plus years ago, 272 00:19:22.599 --> 00:19:25.400 our salts would have been full of nutrients and minerals, 273 00:19:25.519 --> 00:19:29.359 our plants, and even a lot of meat and fat. 274 00:19:29.799 --> 00:19:33.799 It would have had a very energy dense diet. Genet 275 00:19:33.799 --> 00:19:37.200 takes from ten thousandlous years ago into the modern world 276 00:19:37.240 --> 00:19:40.920 where we are eating foods that is deprived of minerals nutrients. 277 00:19:41.240 --> 00:19:44.440 We are constantly having quick carbs and like fast food, 278 00:19:44.960 --> 00:19:48.480 and that cannot sustain those migraine brains anymore. Now you 279 00:19:48.559 --> 00:19:51.799 have a ferrari brain. Let's say, but you have a 280 00:19:51.920 --> 00:19:55.440 very small engine and it's just not sustaining it anymore. Now, 281 00:19:55.480 --> 00:19:59.599 what does the brain do. It has to warn us, right, 282 00:19:59.640 --> 00:20:02.319 it has tell us, look, slow down, it's not working. 283 00:20:02.359 --> 00:20:05.079 We're lacking something. But the brain cannot really talk to us, 284 00:20:05.920 --> 00:20:08.920 but it can warn us. So the migraine is the 285 00:20:09.000 --> 00:20:11.680 warning signal. The migraine is the fire alarm that there's 286 00:20:11.680 --> 00:20:15.160 a fire ongoing, that we're out of energy. And what 287 00:20:15.240 --> 00:20:18.599 does the migraine do. The migraine, as you already said, 288 00:20:18.799 --> 00:20:22.519 the migraine forces us to lie down, close our eyes, 289 00:20:23.039 --> 00:20:26.000 not move because all of that makes it worse. So 290 00:20:26.200 --> 00:20:31.359 it's an energy conserving behavior. The migraine tells us whoe. 291 00:20:31.480 --> 00:20:34.759 The pain is always a warning signal something is wrong, 292 00:20:35.400 --> 00:20:38.799 and it forces us to rest. So mechanistically we can 293 00:20:38.880 --> 00:20:42.279 explain all this. How you know the genetics hyper excitability, 294 00:20:43.240 --> 00:20:45.960 bad metabolism. Now this is where another part comes in. 295 00:20:46.000 --> 00:20:49.200 So the Miburner typically is not very adapted to our 296 00:20:49.240 --> 00:20:52.640 glucose or carbohydrate rich diets. So they have this more 297 00:20:52.680 --> 00:20:57.960 ancient maybe Pavio, let's say genetics just in simple terms, right, 298 00:20:58.000 --> 00:21:01.599 So metabolism is not wid or functioning so they have 299 00:21:01.759 --> 00:21:06.000 more energy demand met with less energy supply. It's a 300 00:21:06.039 --> 00:21:09.680 perfect storm in order to force us to rest to 301 00:21:09.720 --> 00:21:15.000 restore energy than these neuropeptides are released that hurt, and 302 00:21:15.079 --> 00:21:19.440 at the same time, the signals are being released to 303 00:21:19.480 --> 00:21:24.759 set off an ancient metabolism pathway which is keton body production, 304 00:21:24.880 --> 00:21:28.640 which will come into as well. So it's trying to 305 00:21:28.720 --> 00:21:32.319 make an alternative energy source to glucose for the brain 306 00:21:32.920 --> 00:21:36.000 to rest energy situation while you're lying down right, and 307 00:21:36.039 --> 00:21:38.920 then it's through the pain forcing you to basically rest 308 00:21:39.039 --> 00:21:42.599 until energy home mistakes has been restored and these very 309 00:21:43.359 --> 00:21:46.720 dangerous free radicals have been neutralized. So it's also trying 310 00:21:46.720 --> 00:21:49.759 to reduce this oxiative stress at the same time. So 311 00:21:50.680 --> 00:21:55.160 in an upshell, my brain is an evolutionary preserve, ancient 312 00:21:55.279 --> 00:21:58.880 warning signal that we need that we have too much 313 00:21:59.119 --> 00:22:03.720 oxi of stress or too little energy. And basically migrain 314 00:22:03.799 --> 00:22:06.839 has to be of evolutionary advantage otherwise it wouldn't be 315 00:22:06.880 --> 00:22:11.119 around today. So if we turn back to look at 316 00:22:11.160 --> 00:22:13.480 more like what life was like ten thousand years back, 317 00:22:13.519 --> 00:22:17.119 when people weren't crippled by migraines all the time, maybe 318 00:22:17.160 --> 00:22:18.839 we can help figure out. 319 00:22:18.880 --> 00:22:21.279 I love that. I think that's fantastic. I think the 320 00:22:21.319 --> 00:22:24.839 big problem though, is, and this is obvious to me, 321 00:22:24.960 --> 00:22:28.400 is the allopathic solution is just not happening, you know, 322 00:22:28.599 --> 00:22:34.480 to drug to mask it to cover, and I. 323 00:22:34.400 --> 00:22:37.240 Don't want to live without painkillers, right, But the modern 324 00:22:37.279 --> 00:22:39.920 medicine is turning off the warning signal. They're turning off 325 00:22:39.920 --> 00:22:43.079 the fire alarm because it's anoint but they're not ditinguishing 326 00:22:43.160 --> 00:22:46.920 the fire. So we've completely moved away from root cause treatments. 327 00:22:47.000 --> 00:22:49.240 A doctor doesn't have the time to drill down in 328 00:22:49.319 --> 00:22:53.960 any potential root causes, it's symptoms, and then they give 329 00:22:54.039 --> 00:22:59.319 you a treatment for this symptom. Now, everything around migraine 330 00:22:59.359 --> 00:23:02.319 apart from these antidepressants or anti convulsions that are off 331 00:23:02.319 --> 00:23:05.599 a migraine, but they work accidentally a little bit. They 332 00:23:05.680 --> 00:23:08.799 all impact metabolism by the way, all of them. But 333 00:23:09.440 --> 00:23:14.079 really migrant specific stuff is all painkillers, whether it's tonic 334 00:23:14.400 --> 00:23:18.799 or cute or whatever. The pain which is the most 335 00:23:18.799 --> 00:23:23.240 annoying symptom, but it's a symptom and it's a warning signal. 336 00:23:23.359 --> 00:23:26.359 Right, ask you about this. I love your your research 337 00:23:26.599 --> 00:23:29.519 and looking at an evolutionary approach. 338 00:23:29.200 --> 00:23:32.720 To this, especially for your podcast rights, Yeah. 339 00:23:32.880 --> 00:23:36.200 I love it. What do you think in your studies 340 00:23:36.519 --> 00:23:39.559 was unique about these people that get migrants, was it? 341 00:23:39.680 --> 00:23:43.200 I mean you're saying they had early warning sensibilities, they 342 00:23:43.200 --> 00:23:46.079 could tell when some maybe they had a sixth sense. 343 00:23:46.440 --> 00:23:48.720 Do you think it's possible that it crosses over into 344 00:23:49.160 --> 00:23:51.680 high intuition high psychic ability. 345 00:23:52.640 --> 00:23:55.599 Now, a lot of I don't know too much about, 346 00:23:55.680 --> 00:23:59.359 let's say, autism or ADHD or these hyper sensitive people. 347 00:23:59.599 --> 00:24:01.279 But what I do know that a lot of these 348 00:24:01.519 --> 00:24:07.920 neuropsychiatric issues, they all have this hyper sensitivity component where light, doors, 349 00:24:08.359 --> 00:24:13.960 light noise, anything, sensory signals seems to be too strong. Right. 350 00:24:14.000 --> 00:24:16.839 They all seem to have this in common. And in 351 00:24:16.880 --> 00:24:19.759 a way, they're all connected to energy metabolism as well, 352 00:24:19.839 --> 00:24:23.440 So you can find mitochondrial dysfunction in almost all of them. 353 00:24:23.559 --> 00:24:26.039 That's one thing. So the powerhouses of the cells are 354 00:24:26.079 --> 00:24:29.319 not working as well anymore, and if they're not, Actually 355 00:24:29.599 --> 00:24:32.960 a bit more about neuroscience is one of the things 356 00:24:32.960 --> 00:24:36.200 that is the most energy demanding in the brain is 357 00:24:36.240 --> 00:24:41.039 actually filtering information. It's and you know this probably you 358 00:24:41.039 --> 00:24:43.640 know the cocktail party effect. Right, You're in a party 359 00:24:43.880 --> 00:24:46.759 or a room full of people and you can still 360 00:24:46.799 --> 00:24:49.519 listen to that one conversation even though there's like a 361 00:24:49.559 --> 00:24:52.839 million conversations around you. You can filter out all the 362 00:24:52.920 --> 00:24:56.559 unnecessary information but focus on the conversation you are having 363 00:24:56.599 --> 00:24:59.240 with a person in front of you. But if somebody 364 00:24:59.319 --> 00:25:03.079 else calls you your name across the room, suddenly you 365 00:25:03.160 --> 00:25:06.759 are stopping to filter and you can unfilter and listen 366 00:25:06.799 --> 00:25:08.960 to that again. Right, So this whole thing of like 367 00:25:09.039 --> 00:25:12.480 deciding what are we filtering, what are we focusing on? 368 00:25:12.799 --> 00:25:16.119 For example, you probably don't notice the chair under your 369 00:25:16.200 --> 00:25:19.400 bottom right now until I've mentioned it, and then you 370 00:25:19.519 --> 00:25:23.440 notice it, right, So you've constantly filtering and sitting on 371 00:25:23.480 --> 00:25:26.759 that chair and sitting here there's the air or noise 372 00:25:26.839 --> 00:25:29.359 or whatever. You're filtering everything out when you're listening to me, 373 00:25:29.640 --> 00:25:32.240 unless you focus your attention elsewhere. And this takes a 374 00:25:32.279 --> 00:25:35.720 lot of energy. Now, also something that is too bright, 375 00:25:35.759 --> 00:25:37.920 like filtering these things out take a lot of energy. 376 00:25:38.039 --> 00:25:42.920 So any kind of disease, neuropsychiatric disease, I would say condition, 377 00:25:43.119 --> 00:25:46.680 if it's a disease, well, it's debatable, right, Yeah, maybe 378 00:25:46.720 --> 00:25:50.480 all of these have solutionary advantage to them, but they 379 00:25:50.480 --> 00:25:53.599 have a problem with filtering and energy metabolism, and if 380 00:25:53.599 --> 00:25:57.440 these brains would have more energy and less inflammation, then 381 00:25:57.640 --> 00:26:01.880 these problems or issues, those symptoms may not express as 382 00:26:01.960 --> 00:26:05.119 much anymore. Now, what I said about migraine is really 383 00:26:05.640 --> 00:26:10.240 the migrainer having this brains that don't habituate, meaning they 384 00:26:10.319 --> 00:26:14.880 don't slow down firing when something doesn't change, so they 385 00:26:14.880 --> 00:26:17.960 don't have this energy conserving mechanism, which in today's world 386 00:26:18.000 --> 00:26:21.079 is shit because you want to sleep deep even with 387 00:26:21.200 --> 00:26:23.960 all the distractions going on. Right, So somebody who just 388 00:26:24.559 --> 00:26:29.720 sleeps deep and is filtering out everything intoday's world is adaptive. 389 00:26:30.079 --> 00:26:31.839 But if you go ten thousand years back and you 390 00:26:31.880 --> 00:26:34.599 have the deepest sleep, right, you probably don't survive the night. 391 00:26:34.799 --> 00:26:39.000 So it's depending on which environment you put the genetics 392 00:26:39.000 --> 00:26:42.880 into whether they are expressing let's say positively or negatively. Right. 393 00:26:43.960 --> 00:26:47.920 And maybe one last thing, because this doesn't have to 394 00:26:47.960 --> 00:26:52.039 be all about migraine. For example, depression. Take depression super 395 00:26:52.039 --> 00:26:55.359 common increasingly more common in today's world, Like people are 396 00:26:55.400 --> 00:26:58.920 so depressed left, right and center? Why right? Again, it's 397 00:26:58.960 --> 00:27:03.640 so frequent, it's not an accident of nature. These mechanisms 398 00:27:03.880 --> 00:27:06.599 must have had an advantage and when is there a 399 00:27:06.680 --> 00:27:09.480 moment that we are all kind of depressed in a 400 00:27:09.519 --> 00:27:12.400 sense that we withdraw. We don't want to meet people, 401 00:27:12.480 --> 00:27:16.640