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Speaker 1: Oh hey, it's the half a cookie you forgot you
Speaker 1: saved from lunch ally ward, and we're here with asmologies episode.
Speaker 1: If you don't know what somologies is. Smologies are shorter,
Speaker 1: kid friendly episodes that we have cut together and put
Speaker 1: out parental requests for some cleaner versions that they can
Speaker 1: listen to with the whole fam So these are for
Speaker 1: smologites for the small people in your life, or if
Speaker 1: you've just got to listen to something shorter with a
Speaker 1: wide audience who doesn't want to hear me swearing. Okay,
Speaker 1: this episode is great. I loved it. Let's get right
Speaker 1: into it. Molecular biology so molecule comes from the Latin
Speaker 1: for mass or moles or extremely minute particle, and biology,
Speaker 1: of course, is the study of life. So molecular biology
Speaker 1: is the study of the little, itty, bitty, squiggly intricate
Speaker 1: structures that keep us alive and breathing and finding off
Speaker 1: illnesses and falling in love and digesting a pisa. So
Speaker 1: molecular biology is how molecules interact with each other to
Speaker 1: form life processes and how proteins do a lot of
Speaker 1: our dirty work. This ologist has been an assistant professor
Speaker 1: of biology and a Stem College coordinator for high school students,
Speaker 1: has worked in a private lab researching cancer cures, and
Speaker 1: has done a ted X talk and been recognized by
Speaker 1: Fortunes forty under forty Now. I have been a fan
Speaker 1: of hers for quite a while, so we hopped on
Speaker 1: a call to talk about what a molecular biologist does,
Speaker 1: the grossest parts of her lab work, protein folding, DNA strands,
Speaker 1: and more with science communicator and molecular biologist, doctor Raven
Speaker 1: the Science Maven Baxter. Knowlogies, ALOGI pology.
Speaker 4: Knowledge is Raven Baxter and my pronouns are she her.
Speaker 1: You're not the only Raven Baxter that people may have
Speaker 1: heard of. Such a good.
Speaker 4: Name, you know, and I loved having it until the
Speaker 4: Disney Channel came in and just decided they were going
Speaker 4: to do do their own thing.
Speaker 1: I think a lot of people think of you as
Speaker 1: Raven the Science Maven Like a lot of times, I
Speaker 1: don't even think about you having a last name. I
Speaker 1: just think of you as Raven the Science may Ben.
Speaker 1: Have you always been kind of science minded?
Speaker 4: Absolutely? Quite often I would find that I just get
Speaker 4: drawn to the natural environment and looking at the clouds
Speaker 4: or digging in the dirt things that kids do, you know,
Speaker 4: But I was very I feel like I engaged in
Speaker 4: scientific inquiry from a very young age. When I went
Speaker 4: to college, I had tried different majors out and as
Speaker 4: I transitioned in my academic journey, found genetics and was
Speaker 4: so thrilled to learn that our bodies are so cool
Speaker 4: that they speak their own language, which is the genetic code.
Speaker 4: And I'm sitting in this class like, oh my gosh,
Speaker 4: you know, none of my friends are in this class.
Speaker 4: They have to they have to learn about this. This
Speaker 4: is so cool. Our bodies are speaking a language, and
Speaker 4: and like we're the only ones that are taking a
Speaker 4: class on it, right, So like, not only did I
Speaker 4: think it was super cool, but I wanted to share
Speaker 4: that with everyone that I knew. But I just went
Speaker 4: down that rabbit hole of genetics and molecular biology and
Speaker 4: I never came out. So the language is our DNA,
Speaker 4: the genetic code, and it is a sequence of nucleotides
Speaker 4: that contain instructions for proteins. Yes, and those proteins are
Speaker 4: doing the work inside of ourselves to generate our life processes.
Speaker 4: So the way that I like to see it is
Speaker 4: just a scale bound version of how cities work, where
Speaker 4: you have the mayor, you know, and he's at city hall,
Speaker 4: and that's that's off than like the central point of
Speaker 4: a city. And the mayor has like his staff that
Speaker 4: he talks to and you know, he tells so and
Speaker 4: so to do this, and then they go do that.
Speaker 4: So it tells another person to do another thing, and
Speaker 4: they go do that job. And everything that happens out
Speaker 4: from city hall affects the entire city. And that's how
Speaker 4: I think about molecular biology. It's a super simplified version
Speaker 4: of it. And where your DNA is, the mayor and
Speaker 4: the mayor's staff are like proteins that are carrying out
Speaker 4: different functions.
Speaker 1: Oh, that's amazing. They look, from what I've seen, kind
Speaker 1: of like gift wrap. Right, are there a lot of
Speaker 1: spirals happening? What are these proteins shaped like?
Speaker 4: Ah, that's hilarious. So proteins. Proteins are really interesting. They
Speaker 4: have different shapes and sizes. They fold into these different
Speaker 4: shapes that determine their functions. But they don't start folded.
Speaker 1: Okay, let's back up a little.
Speaker 4: We can just start from the beginning. Right, we have
Speaker 4: our DNA, which is inside of our nucleus, and it's
Speaker 4: very neatly packaged in the nucleus, and it gets read
Speaker 4: by other proteins right inside of your nucleus into a
Speaker 4: different code called RNA, which is almost the same as DNA,
Speaker 4: but it uses a slightly different code. And then the
Speaker 4: RNA is read by proteins called polymerases, and the polymerases
Speaker 4: then translate the information from your RNA to create a protein.
Speaker 4: As the protein's being made, it's basically like a spaghetti
Speaker 4: noodle as it comes out of this polymerase, and then
Speaker 4: as it's coming out, it folds into these different shapes.
Speaker 4: But the two basic shapes are beta sheets, which kind
Speaker 4: of look like a brick of ramen noodles, or alpha helices,
Speaker 4: which are those curly pieces that look like, I don't know,
Speaker 4: RIGATONI actually don't know, is RIGATONI even the curly one?
Speaker 4: Oh no, it's few, silly, few silly, Okay, you're.
Speaker 1: Right, Okay, So then they're in those two different beta
Speaker 1: or alpha helix shapes, and then what do they do
Speaker 1: from there?
Speaker 4: From there, all of these shapes and structures are determined
Speaker 4: by the protein's amino acid composition, and so depending on
Speaker 4: the composition of the protein itself, it'll fold and shape
Speaker 4: into different levels of protein folding. So there's primary structure,
Speaker 4: secondary structure, tertiary structure, and quaternary structure.
Speaker 1: And those different proteins, the complicated ones or the simpler ones,
Speaker 1: are they bouncing around in our bloodstream to send messages
Speaker 1: or are they packaged to form different organelles and different
Speaker 1: organs like what happens to those curly folded, very specific proteins.
Speaker 4: I mean, they do so many different things. Where do
Speaker 4: we even start. They get packaged in the golgi apparatus
Speaker 4: and shipped out to different parts of the cells. One
Speaker 4: place where they can go is they can get packaged
Speaker 4: out in a vesicle, which is basically just a little
Speaker 4: you can call it, maybe like a little fat bubble,
Speaker 4: you know. The proteins can get packaged into vesicles and
Speaker 4: sent to the cell membrane where they can release proteins
Speaker 4: out into the extracellular environment or present the proteins onto
Speaker 4: the cell surface.
Speaker 1: Okay, so right now, no matter what you're doing, there
Speaker 1: are tiny proteins cruising around your cytosol, which is the
Speaker 1: ooze that makes up the cytoplasm in your cells, and
Speaker 1: a gold gee apparatus is sorting some of them and
Speaker 1: just popping them into fat envelopes. And you just have
Speaker 1: no idea how hard they're working in trillions of tiny factories,
Speaker 1: just attaching labels to things and passing chemical notes back
Speaker 1: and forth like two teenage lovers in an after school detention.
Speaker 4: So cells use molecules to communicate, for example, there are
Speaker 4: certain cell pathways that cause cancer, or there's certain cell
Speaker 4: pathways that we can study to risk, to understand, like
Speaker 4: cellular responses to immunity, things like that.
Speaker 1: And now you have worked in cancer research, You've worked
Speaker 1: around big vats of E. Coli. You have done some
Speaker 1: really awesome work. What was it like studying this, getting
Speaker 1: your masters and then studying this on a corporate level?
Speaker 1: What types of things were you looking at? How does
Speaker 1: the molecular biologist do their work. Do you need like
Speaker 1: the most gargantuan microscopes to look at these curly cue
Speaker 1: proteins out?
Speaker 4: Yeah, you do really Okay. The kind of work that
Speaker 4: I was doing looked a lot different. Almost on a
Speaker 4: weekly basis or monthly basis. I was doing cell transfections,
Speaker 4: which is a fancy word for running experiments to insert
Speaker 4: DNA into cells, or I was doing crisper projects, or
Speaker 4: I was trying to generate a new cell line that
Speaker 4: expresses a particular protein that we're interested in, or isolating
Speaker 4: DNA from bacteria by the gallons, which is why I
Speaker 4: had to make, you know, basically gallons of poop, like
Speaker 4: you just said, because I was using E. Coli as
Speaker 4: an expression post for the DNA and had to get
Speaker 4: the DNA out of them. And it was really interesting,
Speaker 4: you know. I was working with different types of cell lines,
Speaker 4: breast cancer cell lines, skin cancer cell lines, and even
Speaker 4: neuronal cell lines, which is really cool. I did some
Speaker 4: work on trying to understand or find the best drugs
Speaker 4: to treat Parkinson's disease or brain diseases like Alzheimer's as well,
Speaker 4: and that involves some really interesting and fun work using
Speaker 4: neuronal cells.
Speaker 1: Neuronal cells side note, are types of neurons in the brain.
Speaker 1: And now, when we think of a neuron, you might
Speaker 1: picture like a kind of hand at the end of
Speaker 1: a long arm that has a bulbous other end, or
Speaker 1: maybe it looks like a tree, hence the word dendrite
Speaker 1: from its root tree. But some research estimates there may
Speaker 1: be up to a thousand different types of the cells
Speaker 1: in our nervous system, depending on their structure and function
Speaker 1: or location. So okay, what my point is, our brains
Speaker 1: don't know everything about our brains, and studying our brains
Speaker 1: with our brains requires machines devised by our brains to
Speaker 1: study themselves, which is creepy and also not cheap.
Speaker 4: The equipment that we use can is often very expensive.
Speaker 4: I had the pleasure of working with a super cool
Speaker 4: machine called the Perkin Elmer Opera I think it's.
Speaker 1: Called introducing the Opera Phoenix high Content screening system from
Speaker 1: Perkin Elmer. For the speed and sensitivity you need no compromise.
Speaker 4: It was super cool because it's a high content screening system.
Speaker 4: So we were able to test hundreds and thousands of
Speaker 4: drug compounds on different cell lines to find out, you know,
Speaker 4: what drugs work the best against a certain type of cancer,
Speaker 4: and then we would formulate the drug.
Speaker 1: And so you're just like low key care and cancer
Speaker 1: when you go into work. So how it gets done, right.
Speaker 4: Yeah, that's the very beginning part of it. Like when
Speaker 4: you talk about clinical trials, that's where it starts with
Speaker 4: the molecular biologists trying to find what drugs you should
Speaker 4: even be looking at in the first place.
Speaker 1: I have so many questions from patrons. Can I just
Speaker 1: lob some at you? Ooh yes, okay, But before we
Speaker 1: pepper her with curiosities, we will of course donate to
Speaker 1: a cause of the ologists choosing. And Raven said she
Speaker 1: didn't have a preference, She just like the money to
Speaker 1: go to whomever needs it. And as it happened, our
Speaker 1: mutual buddy Hank Green's Project for Awesome happened to be
Speaker 1: at the final couple of seconds as they reached the
Speaker 1: two million dollar mark, so we made a donation in
Speaker 1: Raven's name. Project for Awesome is a project of the
Speaker 1: Foundation to decrease World Suck, and you can learn more
Speaker 1: about them at projectfoawesome dot com. And that donation was
Speaker 1: made possible by sponsors of the show, whom I shall
Speaker 1: now yammer about very briefly.
Speaker 2: Get value you can't argue with at Tesco with their
Speaker 2: amazing cloak card prices. Have the perfect night in with
Speaker 2: their finest frozen pizza meal deal. Get the finest frozen pizza,
Speaker 2: chips and ice cream all for six euro Like our
Speaker 2: delicious spicy salami, hot honey, and do you or Margarito
Speaker 2: wood fired pizzas served up with their crispy chunkie chips
Speaker 2: and ice cream like sea salta caramel or pistatio for dessert.
Speaker 2: Can't argue with that shop in store or online tesco.
Speaker 2: Every little helps available in most stories, Prices varying. Express.
Speaker 3: You're on the bus an hour from home, in bumper
Speaker 3: to bumper traffic, creeping forward a few inches at a time,
Speaker 3: someone's kids are screaming, and suddenly your back is too. Luckily,
Speaker 3: Panadal extra film coated tablets are boosted by caffeine and
Speaker 3: they get to work in as little as ten minutes
Speaker 3: for powerful relief. That's more than just paracetamol. That's one
Speaker 3: for Pana doll speed based on absorption data contains paracetamol.
Speaker 3: Always read the label or leaflet.
Speaker 5: Bantoma got boga the hatanir, the hola, the Cayman he
Speaker 5: call ah ers, where as lance la Dani detained nudovshu
Speaker 5: willarhu la hula shomparod and lance is phaser lat Gan's
Speaker 5: throw Tasha tapa seraanashka aga is FuGO more h i
Speaker 5: a punk ie is called on tudoros or raslanse if
Speaker 5: we real this Naharan.
Speaker 1: Okay, you had questions for raven. A lot of folks
Speaker 1: had questions, including Brendan Butler and Ashley Emmanuel. Is the
Speaker 1: mitochondria actually the powerhouse of the cell? What is the
Speaker 1: mitochondria doing?
Speaker 4: So yeah, it definitely is the mitochandria of you eu
Speaker 4: carriotic cells, meaning not bacteria basically, And what mitochondria do
Speaker 4: is they break down sugars and turn them into energy.
Speaker 1: It's almost like something that breaks down gasoline in our car.
Speaker 4: Honestly, yeah, it's pretty much.
Speaker 1: Okay, I look this up and wouldn't you know it.
Speaker 1: Molecular biology happens to be a little bit more complicated
Speaker 1: than a Honda Civic engine, but still mitochondria do sort
Speaker 1: of burn our food fuel and produce a source of energy.
Speaker 1: This whole process is called oxidative phosphorylation, and it does
Speaker 1: require oxygen, just like a combustion engine. Also, there can
Speaker 1: be a bunch of mitochondria shoved into one cell. Your
Speaker 1: hard working heart muscles right now are really jam packed
Speaker 1: with mitochondria. So, yes, mitochondria is the powerhouse of the cell.
Speaker 1: It is useful information to know if you're into breathing
Speaker 1: and being alive and stuff. Now, as long as we
Speaker 1: are gossiping about spiral structures, let's get into the heroic helix,
Speaker 1: shall we. Keanu Spinelli asks, I was told several times
Speaker 1: when I was younger that there were six plus feet
Speaker 1: of a DNA strand in just one cell. Is this
Speaker 1: true or is that flim flam?
Speaker 4: Oh my gosh. So I don't know the exact answer
Speaker 4: to this, but I would not be surprised because DNA
Speaker 4: is super coiled inside of your nucleus. I mean, it's
Speaker 4: it doesn't just hang out in there like spaghetti. It's
Speaker 4: wrapped around itself. It's wrapped around things called his stones,
Speaker 4: and it's very tightly and neatly packaged inside of your nucleus.
Speaker 4: So I wouldn't be surprised if you stretched it all
Speaker 4: out that it did that it did end up being
Speaker 4: six feet or six and a half feet.
Speaker 1: Okay, I was so curious. I had to double check this,
Speaker 1: and geneticist doctor Barry Starr does confirm that it's about
Speaker 1: six feet or two meters of DNA strands inside each cell,
Speaker 1: and then he calculated that each human being has around
Speaker 1: ten billion miles of DNA in them, meaning that your DNA,
Speaker 1: your DNA right now, just as you're sitting here eating
Speaker 1: pirate's booty or whatever, your DNA could stretch to the
Speaker 1: sun and back. Sucks. What you beautiful freak, You just
Speaker 1: living pooping work of magic, all of us. A few
Speaker 1: people asked about motor proteins. Honey wants to know. Can
Speaker 1: you tell us about motor proteins? How the heck do
Speaker 1: they work?
Speaker 4: They carry cargo, basically the cargo that are containing molecules, proteins,
Speaker 4: whatever it could be. Anything it could be. They could
Speaker 4: be carrying organelles. They can carry different structures within the cell.
Speaker 4: They can move chromosomes. They're just they're working hard. Okay,
Speaker 4: they're working hard, and they move in particular ways. Think
Speaker 4: of this as a highway, and one end of the
Speaker 4: highway is a negative side and the other side is positive.
Speaker 4: Dining walks towards the negative end, and they're carrying their
Speaker 4: cargo from the peripheral side of the cell to the
Speaker 4: center of the cell. And then Keynesen is like Dinine's sister,
Speaker 4: and they are walking in the opposite direction. So they're
Speaker 4: walking towards the positive side, and they carry their cargo
Speaker 4: from the center of the cell to the periphery of
Speaker 4: the cell. So in order to move their little feet
Speaker 4: they use ATP, which is the energy currency of the cell,
Speaker 4: which comes from the mitochondria. So now we've come full
Speaker 4: circle back to the mitochondria. They're going so fast.
Speaker 1: John Sanson has a question about where did DNA even
Speaker 1: come from, Like how did random bits of atoms and
Speaker 1: molecules know to build themselves into proteins and then assemble
Speaker 1: into DNA strands which now tell other things to build
Speaker 1: other DNA strands.
Speaker 4: This is something that I think about too much and
Speaker 4: it freaks me out. My brain is melting. But that's
Speaker 4: look great. That's a question about the origin of life
Speaker 4: because all living organisms on Earth use DNA to generate
Speaker 4: their life process, and we don't necessarily know exactly how
Speaker 4: this all started, and this will be a question that
Speaker 4: we're we are likely trying to answer for many many
Speaker 4: years to come. But I love thinking about it because
Speaker 4: of all the possibilities.
Speaker 1: So for years, the hypothesis has been that DNA started
Speaker 1: with the simpler single strand RNA, but in the past
Speaker 1: decade or so, other scientists are just begging to differ
Speaker 1: and say that DNA, which kind of has a trickier
Speaker 1: sugar molecule as well as that double helix shape, could
Speaker 1: have arisen at the same time. It's even possible that
Speaker 1: a hybrid RNA DNA molecule first arose and then split
Speaker 1: off into two forms. Who's to know? If you have
Speaker 1: a time machine, let us know now. One thing we
Speaker 1: are sure about is that these replicated codes have been
Speaker 1: encased in cellular goo and structures for billions of years,
Speaker 1: billions with a b okay a few people, Katrina NuGen,
Speaker 1: Adele Mison, Vie Francis, Davis Bourne, epigenetics, what's going on?
Speaker 1: How does it change DNA expression and pass it on
Speaker 1: to the next generation? Katrina ask will my children have
Speaker 1: my same weird quirks and habits?
Speaker 4: This is really interesting and something that I wish I
Speaker 4: had spent more time on when I was on my
Speaker 4: genetics cake. But epigenetics, it's a part of molecular bio
Speaker 4: that's looking at heredity, but not heredity that's caused by
Speaker 4: actual alterations in DNA itself. Right, the DNA has a code,
Speaker 4: and that set of code again codes for proteins and
Speaker 4: protein products. But epigenetics it's like they are changes on
Speaker 4: the DNA, like literally on it. But it's really cool.
Speaker 4: It's a different way of looking at heredity.
Speaker 1: So for a very very quick primer on epigenetics, your
Speaker 1: DNA is a big old long code, kind of like
Speaker 1: a recipe or an ingredients list, and that double helix
Speaker 1: is like a big old long scroll, just meters of
Speaker 1: it right in each cell. So how does a cell
Speaker 1: with all the instructions for all the other cells know
Speaker 1: to be a heart cell or groamy one, bristly mustache hair,
Speaker 1: or line my guts. So certain genes are turned on
Speaker 1: or off by signals or even protein according to the
Speaker 1: function of the cell. But the proteins can also turn
Speaker 1: on and off other expressions of the cell in response
Speaker 1: to environmental factors and then replicate from there, and that
Speaker 1: is called your epigenome. Now, speaking of hearts, many patrons
Speaker 1: wanted to know what was closest to Ravens and Katie
Speaker 1: matt Sicado, Earl of Gramulkin, Kathleen Sachs, Ira Gray, and
Speaker 1: Ashley Emmanuel all had favorite questions essentially favorite type of
Speaker 1: cell or protein or organelle or nitrogenous base, just normal
Speaker 1: questions you'd ask, really any celeb. George Powell wants to note,
Speaker 1: what's your favorite protein?
Speaker 4: Oh, you know what, that's a really good question. I
Speaker 4: personally am fascinated by how people name proteins. There is
Speaker 4: a protein called the pokemon protein.
Speaker 3: What.
Speaker 4: Yeah, There's a protein called sonic hedgehog, which is actually
Speaker 4: a critical involved in human development. And there's a Nemo one.
Speaker 4: There's a Cannon Barbie protein. There's scramble ace, which is
Speaker 4: an enzyme that scrambles fosphil lipids between the inside and
Speaker 4: the outside of this a cell membrane. There's pikachuran protein.
Speaker 4: There's spock one that's in zebrafish and it causes the
Speaker 4: fish to develop like pointy ears like spock.
Speaker 1: No, yeah, I mean earl of Gramblekin asked do you
Speaker 1: have a favorite protein or protein name? And I had
Speaker 1: no idea why. They asked about the name. Who gets
Speaker 1: to name these?
Speaker 4: The scientists that discover them get to name them?
Speaker 1: Oh my gosh, a lot of animation fans apparently.
Speaker 4: Yeah, yeah, I mean they these these are they're really funny.
Speaker 1: And what about the thing you love the most about
Speaker 1: what you do?
Speaker 4: I truly love building community, and I think that because
Speaker 4: I am who I am, I tend to build communities
Speaker 4: that are very diverse because I show a lot of
Speaker 4: different sides of myself that I feel like people from
Speaker 4: different walks of life and different backgrounds can relate to.
Speaker 4: And I try to be very transparent about who I
Speaker 4: am and what I'm interested in and what I'm passionate about,
Speaker 4: so that people who even aren't in science can latch
Speaker 4: onto something about a scientist that they see and maybe
Speaker 4: be more willing to listen and learn about science because
Speaker 4: they do relate. And I also love bringing these communities
Speaker 4: together in conversations about important things and watching people in
Speaker 4: my community learn from each other and teach each other.
Speaker 4: That's probably the best thing that I enjoy about what
Speaker 4: I do.
Speaker 1: So ask smart man's very simple, shameless questions. Because you
Speaker 1: only live once, and maybe your molecules may get rebuilt
Speaker 1: and refolded into proteins and become a frog. But why
Speaker 1: not learn while you're a person? So to follow or
Speaker 1: see Raven's videos or ted Talk, you can head to
Speaker 1: her website simevn dot com or find her on Instagram
Speaker 1: at raven Thescience. Maven or on Twitter at Ravensimevan. Those
Speaker 1: links plus links to her YouTube and her videos will
Speaker 1: be up also at aliwar dot com slash ologies slash
Speaker 1: Molecular Biology. You can follow me if you like on
Speaker 1: Instagram and Twitter. I'm at Aliward with one L on both.
Speaker 1: We're also at ologies on Twitter and Instagram. Also linked
Speaker 1: is aliward dot com slashsmologies, which has dozens more kids
Speaker 1: safe and shorter episodes you can blaze through and thank
Speaker 1: you Mercedes Maitland of Maitland Audio and Shared Sleeper of
Speaker 1: mindgm Media for editing those, as well as Zeke Rodriguez
Speaker 1: Thomas and says we like to keep things small around here.
Speaker 1: The rest of the credits are in the show notes
Speaker 1: and at the end of the episode, I give you
Speaker 1: a piece of advice, and this piece of advice is
Speaker 1: if you're not sure what to read, ask your friends
Speaker 1: or ask your parents or elders what books they liked reading.
Speaker 1: There are books that I never would have picked up
Speaker 1: unless I had asked, Hey, you guys like any books slightly?
Speaker 1: And then I got really great recommendations for books that
Speaker 1: I ended up loving. So sometimes you'll get out of
Speaker 1: your comfort zone a little bit. And you'll read something
Speaker 1: and learn something that you never knew that you liked.
Speaker 1: So yeah, ask for opinions from other people. You don't
Speaker 1: have to take all of the opinions, but sometimes it's
Speaker 1: nice to jump into someone else's head and see what
Speaker 1: they like reading. Okay, until next time, smologize, pervide knowledge,
Speaker 1: poling algy anology.
Speaker 2: Knowledgies get value you can't argue with. I'll Tesco with
Speaker 2: their amazing club card prices. Have the perfect night in
Speaker 2: with our finest frozen pizza meal deal. Get the finest
Speaker 2: frozen pizza, chips and ice cream all for six euro.
Speaker 2: Like our delicious spicy salami, hot honey and Doya or
Speaker 2: Margarito wood fired pizzas, served up with their crispy, chunky
Speaker 2: chips and ice cream like sea salta caramel or pistachio
Speaker 2: for dessert.
Speaker 1: Can't argue with that? Shop in store or online. Tesco.
Speaker 2: Every Little helps available in most stores, Prices varying. Express