WEBVTT 1 00:00:04.080 --> 00:00:08.070 The Joe Rogan Experience. Train by day, Joe Rogan podcast 2 00:00:08.109 --> 00:00:09.509 by night, all day. 3 00:00:12.529 --> 00:00:15.130 Mr. Sinclair, good to see you again. 4 00:00:16.050 --> 00:00:16.769 Dr. Sinclair? 5 00:00:16.829 --> 00:00:17.230 Doctor. 6 00:00:17.449 --> 00:00:17.890 I'm kidding. 7 00:00:17.949 --> 00:00:20.500 It's better that way, right? Yeah, do you ever introduce 8 00:00:20.519 --> 00:00:21.320 yourself as doctor? 9 00:00:21.539 --> 00:00:21.780 Never. 10 00:00:22.500 --> 00:00:24.559 Yeah, that's a kind of a, it's a weird thing 11 00:00:24.600 --> 00:00:25.519 because you're allowed to. 12 00:00:25.539 --> 00:00:28.120 I'm actually a Sir David from Australia. 13 00:00:28.460 --> 00:00:29.140 Are you a sir? 14 00:00:29.519 --> 00:00:31.780 Yeah, but it's kind of a joke. I don't really. 15 00:00:31.839 --> 00:00:35.070 How does that work out? Did you get knighted or 16 00:00:35.109 --> 00:00:35.409 some shit? 17 00:00:35.450 --> 00:00:38.560 The Queen's representative gave me some Australian version of a knighthood. 18 00:00:39.820 --> 00:00:42.320 But I get to put AO at the end of 19 00:00:42.359 --> 00:00:42.719 my name. 20 00:00:43.219 --> 00:00:43.619 AO? 21 00:00:43.960 --> 00:00:45.159 Yeah, Order of Australia. 22 00:00:45.179 --> 00:00:46.079 Oh. 23 00:00:46.799 --> 00:00:48.700 But it actually makes no difference to my life. So 24 00:00:49.219 --> 00:00:50.359 it's just an extra couple of letters. 25 00:00:50.479 --> 00:00:51.229 It's kind of cool. 26 00:00:51.869 --> 00:00:57.850 I'm honored, for sure. But it's just a joke. 27 00:00:58.450 --> 00:01:01.149 Well, it's kind of anybody, sir. You meet a guy 28 00:01:01.170 --> 00:01:02.429 at the gas station. How you doing, sir? 29 00:01:03.490 --> 00:01:06.010 It's like, wow, how does he know? Right. 30 00:01:06.030 --> 00:01:08.750 You don't say how you're doing, King. Yeah. Right. 31 00:01:09.109 --> 00:01:12.109 Well, I'm David. I'm Australian. So in Australia, if you 32 00:01:12.650 --> 00:01:14.790 have any ego, you get beaten up in the playground. 33 00:01:14.870 --> 00:01:17.930 That is true. Australia is the land of the tall 34 00:01:17.969 --> 00:01:21.159 poppy syndrome. They don't they don't fuck around. They don't 35 00:01:21.170 --> 00:01:22.680 like you getting a big head in Australia. 36 00:01:23.260 --> 00:01:25.840 That is that is true. I like to go back there, though, 37 00:01:25.900 --> 00:01:28.719 because it's a level playing field. Nobody cares who you are. 38 00:01:29.019 --> 00:01:31.680 I love the people there. Australian people are some of 39 00:01:31.700 --> 00:01:35.900 my favorite people. They're awesome. They're very friendly and fun. 40 00:01:36.659 --> 00:01:38.439 It's a great place to be. It's just too far 41 00:01:38.480 --> 00:01:40.579 to get there. It's such a haul. Oh, no. 42 00:01:40.739 --> 00:01:43.079 If you just, you know, whiskey in an Ambien and 43 00:01:43.099 --> 00:01:43.750 you're there without. 44 00:01:43.890 --> 00:01:44.560 Is that what you do? 45 00:01:44.579 --> 00:01:47.890 I used to. I've gone clean. I don't drink much 46 00:01:48.170 --> 00:01:48.890 at all anymore. 47 00:01:48.909 --> 00:01:51.109 What does that mean? How often does he drink much 48 00:01:51.150 --> 00:01:54.209 at all? Celebrations. Do you want to drink right now? 49 00:01:54.230 --> 00:01:56.269 No, it would be a bad look. I've got the 50 00:01:56.310 --> 00:01:57.439 coffee that you gave me. 51 00:01:57.730 --> 00:02:03.000 Yeah, this is Laird Superfood Coffee. So Laird Hamilton. It's 52 00:02:03.060 --> 00:02:06.849 black rifle coffee mixed with his superfood stuff, which is– 53 00:02:07.079 --> 00:02:09.939 this one is turmeric. So it's turmeric and I think 54 00:02:09.979 --> 00:02:12.460 it has coconut milk in it and some other jazz. 55 00:02:12.620 --> 00:02:13.340 That's great. 56 00:02:13.439 --> 00:02:15.259 Anti-inflammatory. Yes. 57 00:02:15.979 --> 00:02:17.060 Which I know you're all about. 58 00:02:17.979 --> 00:02:22.360 Yes, as a prophet of longevity. Yes. 59 00:02:22.939 --> 00:02:24.960 Is that another title of you? 60 00:02:25.199 --> 00:02:27.599 Yes, you can call me Sir David the Prophet. How 61 00:02:27.620 --> 00:02:27.939 about that? 62 00:02:29.310 --> 00:02:33.030 Sir David, the prophet. Dr. Sir David, the prophet of longevity. 63 00:02:33.330 --> 00:02:34.050 That'll do. 64 00:02:34.430 --> 00:02:36.830 So there's a lot. Let's just jump right into it 65 00:02:36.849 --> 00:02:39.939 because there is a lot going on in the longevity space. 66 00:02:39.960 --> 00:02:41.289 Thank you for having me back on. 67 00:02:41.400 --> 00:02:41.840 My pleasure. 68 00:02:41.860 --> 00:02:44.939 And by the way, I also want to thank you for, 69 00:02:45.680 --> 00:02:47.960 I think this is fourth time on, which is amazing. 70 00:02:48.000 --> 00:02:50.419 Thank you. Congrats on all your success. Thank you. It's 71 00:02:50.439 --> 00:02:54.460 been wonderful to see. Also, the book that I wrote, 72 00:02:54.500 --> 00:02:56.349 which you first had me on to promote, has done 73 00:02:56.449 --> 00:02:59.990 so well. And it's really because of you. And the book, Lifespan, 74 00:03:00.509 --> 00:03:02.810 became a bestseller. Not just that, but it's now been 75 00:03:02.849 --> 00:03:05.039 read millions of times around the world. It's in 40 languages. 76 00:03:05.060 --> 00:03:06.759 Well, that's phenomenal, and it's my pleasure. 77 00:03:06.780 --> 00:03:09.139 And that's not a promo. As you know, you don't 78 00:03:09.180 --> 00:03:11.819 make any money from books really. But I'm just honored 79 00:03:11.879 --> 00:03:14.680 that it was read by so many people around the 80 00:03:14.699 --> 00:03:17.740 world because it wasn't an easy read. It was high-tech science. 81 00:03:18.099 --> 00:03:22.729 Well, people are very interested, especially nowadays. I think I've 82 00:03:22.849 --> 00:03:28.560 never– I can't recall a time– In my life where 83 00:03:28.780 --> 00:03:32.599 optimizing your health and longevity has been more of a 84 00:03:32.639 --> 00:03:34.060 subject that people are interested in. 85 00:03:34.719 --> 00:03:37.580 Well, I think that's largely because not to keep blowing 86 00:03:37.639 --> 00:03:41.409 smoke up your rear, but largely because of what you 87 00:03:41.449 --> 00:03:44.569 did in the book. So the book went global and 88 00:03:45.189 --> 00:03:50.090 it was right in 2019 and the pandemic hit. And 89 00:03:50.110 --> 00:03:52.469 I think most people saw their own mortality at that point. 90 00:03:53.229 --> 00:03:55.509 Most people under the age of about 70 didn't even 91 00:03:55.530 --> 00:03:59.849 think about dying, but then pandemics like shit, I could die. 92 00:03:59.870 --> 00:04:01.960 And I saw the book take off. You launched it. 93 00:04:03.189 --> 00:04:05.289 But yeah, since then, a lot of people have jumped 94 00:04:05.340 --> 00:04:07.740 on the bandwagon and now longevity is, I hear this 95 00:04:08.020 --> 00:04:09.360 everywhere I go. It's everything. 96 00:04:09.500 --> 00:04:13.639 It's everywhere. People are constantly talking about different modalities. How 97 00:04:13.740 --> 00:04:15.979 often do you cold plunge? Are you sauna? What about 98 00:04:16.000 --> 00:04:17.959 the red light? What do you think? Is this legit? 99 00:04:18.000 --> 00:04:21.600 Is that legit? Like this, everybody's optimizing everything constantly all 100 00:04:21.620 --> 00:04:23.879 the time, but The reason why it's caught on is 101 00:04:23.899 --> 00:04:26.819 because if you do follow some of the protocols, you 102 00:04:26.920 --> 00:04:31.089 will feel better. And so that's the ultimate goal. Longevity 103 00:04:31.110 --> 00:04:35.009 is wonderful, but feeling better in the moment currently, like 104 00:04:35.050 --> 00:04:38.829 living your life, should be primary. Longevity, I think, is 105 00:04:40.410 --> 00:04:44.300 if you're optimizing your life and you feel better, you 106 00:04:44.310 --> 00:04:47.449 will live longer. It's all part of it. So if 107 00:04:47.470 --> 00:04:50.769 you follow the longevity principles and the ideas behind it, 108 00:04:50.839 --> 00:04:52.939 you certainly will live better right now. 109 00:04:53.160 --> 00:04:54.839 You will and it's not even that hard. There are 110 00:04:54.860 --> 00:04:57.939 basic things, five basic things you can do or avoid 111 00:04:58.459 --> 00:05:00.620 and you can live another 15 years. It's really not 112 00:05:00.660 --> 00:05:02.819 that hard and that's what I'm excited about telling millions 113 00:05:02.860 --> 00:05:05.000 of people today is– and maybe we can go over 114 00:05:05.040 --> 00:05:06.899 the kind of things that people can do easily to 115 00:05:06.939 --> 00:05:07.399 live longer. 116 00:05:07.899 --> 00:05:09.939 Well, I definitely want to do that. But I also 117 00:05:09.990 --> 00:05:13.589 want to talk about like what is the current state 118 00:05:13.649 --> 00:05:18.779 of science today? uh, as applied to longevity treatments? Like, 119 00:05:19.040 --> 00:05:23.040 cause I know that there's some pretty groundbreaking stuff that's 120 00:05:23.160 --> 00:05:25.379 in the pipeline right now. Yeah. 121 00:05:25.500 --> 00:05:29.769 It's so since 2019, a lot of what we talked 122 00:05:29.810 --> 00:05:33.209 about has come true, which is the amazing thing. We, uh, 123 00:05:33.930 --> 00:05:38.600 we're speculating 2019 that we could potentially reverse aging. And 124 00:05:38.620 --> 00:05:40.620 that was a sin to say that as a scientist 125 00:05:41.339 --> 00:05:44.399 publicly in those days, I put it in the book. Um, 126 00:05:45.040 --> 00:05:48.379 And it's actually come true since then, certainly for the lab, 127 00:05:49.529 --> 00:05:52.870 for mice, monkeys. And now we have a human clinical trial, 128 00:05:53.089 --> 00:05:57.370 the first potential human age reversal technologies in people right now. 129 00:05:58.029 --> 00:06:01.629 Listen, it completely seems logical. The idea that that at 130 00:06:01.709 --> 00:06:04.319 one point in time would have been heresy in science 131 00:06:04.379 --> 00:06:09.139 to discuss it. That seems crazy. Like if people get 132 00:06:09.240 --> 00:06:12.740 old and we understand the mechanism, why couldn't we reverse it? 133 00:06:13.509 --> 00:06:14.769 Well, I think for a long time we had to 134 00:06:14.810 --> 00:06:17.230 accept it in the way that cancer used to be 135 00:06:17.290 --> 00:06:20.149 accepted 200 years ago probably. There was nothing you could 136 00:06:20.170 --> 00:06:22.750 do about it. And then my colleagues and I found 137 00:06:22.790 --> 00:06:24.870 that aging has a root cause that's the same in 138 00:06:25.009 --> 00:06:27.350 pretty much every cell in the body and that we 139 00:06:27.389 --> 00:06:29.709 could control that and that there were genes that not 140 00:06:29.769 --> 00:06:32.860 only slowed it down, but in 2020 we had a 141 00:06:32.860 --> 00:06:35.199 big publication that showed we could actually safely for the 142 00:06:35.240 --> 00:06:38.939 first time reverse that process like reinstalling software in the 143 00:06:38.980 --> 00:06:40.079 cell to make it work again. 144 00:06:41.579 --> 00:06:44.329 And so what is the– is that using CRISPR? Like 145 00:06:44.389 --> 00:06:46.949 what are you using to– Well. 146 00:06:46.970 --> 00:06:51.029 We deliver genes into the body like CRISPR. I have 147 00:06:51.050 --> 00:06:53.089 a little prop here I brought. 148 00:06:53.110 --> 00:06:53.449 What is that? 149 00:06:53.470 --> 00:06:55.800 In my pocket here. This is a representation of how 150 00:06:55.839 --> 00:07:00.459 we deliver the age reversal genes. It's a virus-like capsule 151 00:07:00.500 --> 00:07:02.839 that we make in the lab. And this is what's 152 00:07:02.860 --> 00:07:07.290 going into the patients right now, into their eyes initially. 153 00:07:07.310 --> 00:07:08.589 Whoa. 154 00:07:09.269 --> 00:07:10.490 The eye is a good place to start. 155 00:07:10.589 --> 00:07:12.730 How do you pick the people to get on these tests? 156 00:07:13.670 --> 00:07:18.699 They volunteer. I was really fortunate to see the first 157 00:07:18.720 --> 00:07:24.620 patient get dosed earlier this year. And that person bravely 158 00:07:24.839 --> 00:07:28.180 volunteered to be the first person to get trillions of 159 00:07:28.220 --> 00:07:31.019 these injected into his eye to see if it could 160 00:07:31.160 --> 00:07:33.000 cure his glaucoma loss of vision. 161 00:07:34.259 --> 00:07:36.860 I bet if you have glaucoma, you're probably like, listen, 162 00:07:36.920 --> 00:07:39.399 what's the worst that could happen? Well, exactly. 163 00:07:39.459 --> 00:07:42.029 He pretty much was totally blind in one eye, and 164 00:07:42.110 --> 00:07:45.350 so there's really nothing that he has to lose. There's 165 00:07:45.389 --> 00:07:49.009 a risk that something might go wrong, but not really. 166 00:07:51.089 --> 00:07:53.060 The good news is, and I can report to everybody 167 00:07:53.079 --> 00:07:57.060 around the world, that nothing's gone wrong so far. Everything's 168 00:07:57.120 --> 00:08:01.899 proceeding according to plan, and we're at a turning point, potentially, 169 00:08:02.180 --> 00:08:03.459 in human history, if it works. 170 00:08:04.290 --> 00:08:08.870 So I interrupted you, but explain this little virus transport system. 171 00:08:08.990 --> 00:08:10.769 For those of you listening, I've got a little rubber 172 00:08:10.810 --> 00:08:12.769 ball with spikes on it. It looks a bit like COVID, 173 00:08:12.790 --> 00:08:17.110 but don't be scared of it. It's not a pathogenic virus. 174 00:08:17.209 --> 00:08:19.810 It's actually a domesticated version of a virus. And this 175 00:08:19.829 --> 00:08:23.550 little plastic ball has little adapters. These red balls on 176 00:08:23.589 --> 00:08:26.949 the surface of the big ball target it to the 177 00:08:27.009 --> 00:08:28.720 cells in the back of the eye. And you can 178 00:08:28.759 --> 00:08:31.259 change the balls to target different tissues. We could change 179 00:08:31.300 --> 00:08:34.620 that outside. little spike and target it to the liver, 180 00:08:34.679 --> 00:08:37.379 which we've done, and cured mice of their fatty liver 181 00:08:37.399 --> 00:08:40.019 disease as well. But this one's for the eye. And 182 00:08:40.059 --> 00:08:44.379 within that big ball is a protein capsule. And inside 183 00:08:44.399 --> 00:08:50.129 the protein capsule is our DNA special delivery, which we 184 00:08:50.169 --> 00:08:56.210 call OSK or ER100. ER100 is epigenetic reprogramming 100, the 185 00:08:56.250 --> 00:08:59.049 drug that we know when we put it into human cells, 186 00:08:59.490 --> 00:09:02.059 it makes them younger. And then they work like they 187 00:09:02.080 --> 00:09:02.539 were young again. 188 00:09:05.220 --> 00:09:08.259 This sounds like the beginning of a horror movie. You 189 00:09:08.279 --> 00:09:10.299 know what I mean? Like the scientist is on a 190 00:09:10.340 --> 00:09:13.899 talk show. The scientist is explaining it. And everyone's at 191 00:09:13.940 --> 00:09:18.299 home like with their coffee like, wow. This is wonderful. 192 00:09:18.360 --> 00:09:21.230 We're going to get younger again. Don't worry. 193 00:09:21.250 --> 00:09:22.490 It's all going to work out. 194 00:09:22.490 --> 00:09:26.129 28 days later, garbage in the streets, cars on fire. 195 00:09:26.190 --> 00:09:29.129 The guy's waking up from a coma, doesn't know what happened. 196 00:09:29.470 --> 00:09:30.450 He goes outside. 197 00:09:30.490 --> 00:09:33.820 These optimized humans are eating each other. I admit. I admit. 198 00:09:33.899 --> 00:09:36.120 It is science fiction. And I even have to pinch 199 00:09:36.159 --> 00:09:38.500 myself that it's actually happening. But we've done a lot 200 00:09:38.519 --> 00:09:41.320 of safety studies and this trial is FDA approved because 201 00:09:41.340 --> 00:09:42.299 they've looked at all the data. 202 00:09:42.450 --> 00:09:44.210 Well, God knows they never fuck anything up. 203 00:09:44.799 --> 00:09:46.129 I figured you might say that. 204 00:09:46.450 --> 00:09:47.769 Perfect. Yeah. 205 00:09:48.230 --> 00:09:50.090 Well, it's in the eye. So that's why we start 206 00:09:50.110 --> 00:09:52.289 with the eye. It's enclosed. It's not going to spread. 207 00:09:53.330 --> 00:09:54.309 Nobody's going to grow another eye. 208 00:09:54.350 --> 00:09:59.190 And so these trillions of cells that you're putting. 209 00:09:59.110 --> 00:10:01.960 Into the eyes the little capsule the virus. 210 00:10:02.440 --> 00:10:06.940 I shouldn't call them cells trillions of capsules that you're 211 00:10:06.960 --> 00:10:11.360 putting into the eye what are they doing for glaucoma. 212 00:10:12.240 --> 00:10:14.419 Well what they're doing is there are three genes in 213 00:10:14.460 --> 00:10:20.610 this DNA package and I called them OSK OSK are 214 00:10:20.789 --> 00:10:25.830 three special genes that we found safely reprogram cells and 215 00:10:25.870 --> 00:10:29.169 reboot the backup copy of youth, which we now believe 216 00:10:29.220 --> 00:10:32.360 exists in our body. That's a big deal, that there's 217 00:10:32.379 --> 00:10:34.639 a backup copy of youth. Even an old person, I 218 00:10:34.679 --> 00:10:37.120 don't see an old person anymore on the street. I 219 00:10:37.159 --> 00:10:40.059 just see a person that needs to be rebooted. These 220 00:10:40.179 --> 00:10:41.799 OSK genes... You just see. 221 00:10:41.860 --> 00:10:45.169 Wait a minute, hold on. When you see old people, 222 00:10:45.210 --> 00:10:47.559 you don't see old people, you just say, Oh, that 223 00:10:47.580 --> 00:10:49.500 poor person needs to be rebooted. 224 00:10:49.519 --> 00:10:49.799 Yeah. 225 00:10:50.279 --> 00:10:53.639 You're doing the perfect job for you. Like your personality 226 00:10:53.720 --> 00:10:57.000 is perfectly suited for your occupation if that's how you 227 00:10:57.059 --> 00:10:57.960 actually look at people. 228 00:10:58.539 --> 00:11:03.899 Well, I do. And the reason is that we all 229 00:11:03.960 --> 00:11:07.929 have this backup copy that the DNA, the instructions to 230 00:11:07.950 --> 00:11:10.450 be young that made us into who we are as 231 00:11:10.490 --> 00:11:14.990 kids is still in our bodies, almost largely intact. You 232 00:11:15.009 --> 00:11:18.019 just need to read it again. And that's why reinstalling 233 00:11:18.059 --> 00:11:20.919 software or– I used to use the analogy of a CD. 234 00:11:22.500 --> 00:11:24.860 Kids these days probably don't know what a CD is. 235 00:11:24.919 --> 00:11:27.639 It's a little plastic circle like a record that we 236 00:11:27.679 --> 00:11:29.690 used to put 20 songs on. It was awesome at 237 00:11:29.710 --> 00:11:29.950 the time. 238 00:11:29.990 --> 00:11:30.750 I think most people know. 239 00:11:31.029 --> 00:11:33.330 I'm kidding. I'm kidding. It's a bit of a silly joke. 240 00:11:33.370 --> 00:11:34.669 Maybe a 10-year-old does it. 241 00:11:34.730 --> 00:11:37.110 When I teach kids at Harvard, most of them have 242 00:11:37.129 --> 00:11:38.090 never held a CD. 243 00:11:38.169 --> 00:11:39.289 Isn't that wild? 244 00:11:40.129 --> 00:11:44.340 Yeah. They're not coming back but albums definitely. So think 245 00:11:44.360 --> 00:11:46.080 of it like an album that you scratch and the 246 00:11:46.120 --> 00:11:50.159 scratch is– like aging, and we are getting rid of 247 00:11:50.179 --> 00:11:53.590 the scratches with these three genes, OSK. So let me 248 00:11:53.610 --> 00:11:56.769 tell you how these three genes work, we found. There 249 00:11:56.789 --> 00:11:59.929 was a person whose name is well known in science 250 00:11:59.970 --> 00:12:05.389 circles called Shinya Yamanaka, from Japan, obviously. And he discovered 251 00:12:05.429 --> 00:12:08.019 that there was a set of four genes that could 252 00:12:08.059 --> 00:12:12.919 reliably make adult cells, like skin cells, into stem cells. 253 00:12:13.600 --> 00:12:17.639 And he deservedly won the Nobel Prize for that in 2006. 254 00:12:17.639 --> 00:12:20.460 But that wouldn't be useful here. If I turned you 255 00:12:20.500 --> 00:12:23.279 into a bunch of stem cells, you'd probably die within 256 00:12:23.299 --> 00:12:25.350 a few minutes. So we don't want to do that. 257 00:12:25.610 --> 00:12:30.289 And cancer is also a potential. So it took us about, well, 258 00:12:30.409 --> 00:12:33.490 from 2019, it took us a while to figure out 259 00:12:33.549 --> 00:12:36.379 that if we leave out one of the Aminoka genes 260 00:12:36.460 --> 00:12:39.759 and just use three, OSK, leave out the other one 261 00:12:39.779 --> 00:12:42.779 called M, we'd get safe age reversal, about 75%, 80% 262 00:12:42.779 --> 00:12:46.389 back to youth. but no further. We don't go back 263 00:12:46.429 --> 00:12:49.389 to zero, which is what Yamanaka did. And instead of 264 00:12:49.429 --> 00:12:51.490 cells losing their identity, which is what a stem cell 265 00:12:51.789 --> 00:12:55.789 has no identity, we regain identity. So it's actually, I 266 00:12:55.830 --> 00:12:59.210 could draw graphs, but it doesn't really help listeners. But basically, 267 00:12:59.450 --> 00:13:02.250 old age is losing identity of your cells. So they 268 00:13:02.269 --> 00:13:04.549 don't work. They forget how to work. That's what we 269 00:13:04.570 --> 00:13:07.250 think old age is in my lab. And stem cells 270 00:13:07.269 --> 00:13:10.139 have no identity. It was like a very early embryo. 271 00:13:10.950 --> 00:13:13.509 In between, our cells have a lot of identity. They 272 00:13:13.549 --> 00:13:17.360 function beautifully. We're in our 20s. We're at peak. And 273 00:13:17.399 --> 00:13:18.759 what we've done is we've figured out how to go 274 00:13:18.799 --> 00:13:23.379 back towards youth, get these cells to work like they 275 00:13:23.399 --> 00:13:27.519 did again, get the backup copy somewhere it exists. We're 276 00:13:27.539 --> 00:13:30.659 looking for it. And now cells actually behave like they 277 00:13:30.679 --> 00:13:33.850 did when we were 20. And if it works, we're 278 00:13:33.870 --> 00:13:36.029 going to have glaucoma patients seeing for the first time. 279 00:13:36.750 --> 00:13:39.649 And that's the beginning of a whole cascade of drugs 280 00:13:39.710 --> 00:13:42.450 that I want to develop for diseases of aging and 281 00:13:42.490 --> 00:13:43.970 eventually whole body rejuvenation. 282 00:13:44.929 --> 00:13:48.409 So the initial experiments are on glaucoma because it's a 283 00:13:48.470 --> 00:13:52.149 contained thing. The eyeball is a contained thing and you 284 00:13:52.169 --> 00:13:52.850 could do it that way? 285 00:13:53.009 --> 00:13:55.909 Yeah. My student, Wan Cheng Lu, who was doing this 286 00:13:56.250 --> 00:13:59.340 in 2017, I said, let's do the liver. Let's rejuvenate 287 00:13:59.379 --> 00:14:00.519 the liver. And he said, no, the eye is a 288 00:14:00.539 --> 00:14:03.200 good idea. And he was right. So that's exactly why 289 00:14:03.220 --> 00:14:04.000 we chose that first. 290 00:14:04.700 --> 00:14:06.960 But just think about how many people have vision problems. 291 00:14:07.299 --> 00:14:11.149 It's 40 million just in the U.S. for glaucoma. Macular 292 00:14:11.169 --> 00:14:13.750 degeneration is even more. And in the lab, we can 293 00:14:14.269 --> 00:14:15.889 cure that as well in the mice. 294 00:14:16.450 --> 00:14:22.029 Now, macular degeneration and glaucoma, these are diseases of aging, right, 295 00:14:22.169 --> 00:14:24.830 you would say? Or glaucoma is a disease? 296 00:14:25.009 --> 00:14:25.629 Oh, yeah. 297 00:14:25.669 --> 00:14:29.070 What about people that have had eyeball injuries and things 298 00:14:29.110 --> 00:14:31.850 like that? Is there a backup copy of the eyeball 299 00:14:31.909 --> 00:14:34.889 where you could sort of reformat the eyeball structure? 300 00:14:35.740 --> 00:14:38.100 You should come work in my lab. at least come visit. 301 00:14:38.320 --> 00:14:39.080 I would love to visit. 302 00:14:39.159 --> 00:14:40.850 And the reason I say that is that's the exact 303 00:14:40.879 --> 00:14:43.990 question that we're asking. Hmm. We showed that even if 304 00:14:44.029 --> 00:14:48.250 you injure, say a nerve, uh, whether it's peripheral on, 305 00:14:48.370 --> 00:14:51.509 in your arm or in your brain or in the eye, 306 00:14:51.669 --> 00:14:55.009 like the optic nerve, we can regrow those back to 307 00:14:55.029 --> 00:14:57.919 where they were. And actually in 2020 on the cover 308 00:14:57.940 --> 00:15:00.879 of nature magazine, there was the picture of an eye. 309 00:15:01.419 --> 00:15:03.580 And in the, in the paper we published, you could 310 00:15:03.620 --> 00:15:07.929 see the nerves regrowing back. Um, And so we think 311 00:15:07.950 --> 00:15:11.389 that injury is also treatable. Actually, a group in China 312 00:15:11.429 --> 00:15:14.529 just took our technology, this OSK stuff, put it into 313 00:15:14.629 --> 00:15:17.789 mice that had bad joints, and it regrew their muscle 314 00:15:17.950 --> 00:15:19.269 and their bone back to normal. 315 00:15:19.929 --> 00:15:20.230 Whoa. 316 00:15:20.549 --> 00:15:26.720 And so we're also looking at treating injury, back injury, joints, osteoarthritis. 317 00:15:27.289 --> 00:15:31.759 That would be phenomenal because there are so many people 318 00:15:31.779 --> 00:15:34.429 that are suffering from arthritis and so many. I know 319 00:15:34.590 --> 00:15:37.649 so many people with injuries, like martial arts injuries. I 320 00:15:37.669 --> 00:15:40.799 have one. My left knee is fucked up. It's annoying. 321 00:15:40.860 --> 00:15:44.870 I keep it together. I've got it like– I maintain it, 322 00:15:45.220 --> 00:15:47.259 but it's always an issue. I have to stay on it. 323 00:15:47.659 --> 00:15:49.600 And there's little you can do, like stem cells, a 324 00:15:49.639 --> 00:15:50.840 little bit of relief. 325 00:15:51.259 --> 00:15:55.179 Stem cells give you relief, but not– once you're dealing 326 00:15:55.220 --> 00:15:58.519 with cartilage damage and you're dealing with the– I had 327 00:15:58.570 --> 00:16:00.669 a meniscus surgery where they took out a piece of 328 00:16:00.710 --> 00:16:03.860 my meniscus. And I had my ACL reconstructed on that 329 00:16:03.919 --> 00:16:06.320 knee as well. So it's just an issue. But it 330 00:16:06.440 --> 00:16:10.100 works pretty good for like what it should be. Like 331 00:16:10.139 --> 00:16:13.539 if we were living in the 1930s, I'd be a cripple. 332 00:16:13.620 --> 00:16:15.490 Hang in there because we're going to be in a 333 00:16:15.539 --> 00:16:18.419 world where we can rebuild parts of the body, including joints. 334 00:16:19.029 --> 00:16:21.649 The problem with that is like how does that apply 335 00:16:21.669 --> 00:16:25.669 to athletics? We're going to have fucking super soldiers in 336 00:16:25.769 --> 00:16:27.690 every sport. There's going to be people in every sport 337 00:16:27.730 --> 00:16:30.169 that could. Do what Michael Jordan did and like leap 338 00:16:30.190 --> 00:16:32.669 from halfway across the basketball court and dunk. 339 00:16:33.490 --> 00:16:36.830 That's probably coming and there may be DNA tests to 340 00:16:36.850 --> 00:16:40.029 see if you've got these OSK genes inserted. And we're 341 00:16:40.049 --> 00:16:41.870 working on it, working on a drink and a pill. 342 00:16:41.710 --> 00:16:43.509 As well for– A drink and a pill? 343 00:16:43.960 --> 00:16:46.200 Yeah. I mean we're now eight years ahead of what 344 00:16:46.299 --> 00:16:47.200 the public realizes. 345 00:16:48.100 --> 00:16:48.440 Really? 346 00:16:48.639 --> 00:16:49.639 In my lab at Harvard, yeah. 347 00:16:50.200 --> 00:16:51.419 A drink and a pill and what's a drink and 348 00:16:51.440 --> 00:16:52.059 a pill going to do? 349 00:16:53.039 --> 00:16:55.879 Well, right now it's in mice so we've still got 350 00:16:55.899 --> 00:16:58.809 a ways to go. But when we give– the drink 351 00:16:58.950 --> 00:17:00.470 to mice, they get rejuvenated. 352 00:17:00.669 --> 00:17:03.190 You just give it to 80 year olds. If you're 353 00:17:03.250 --> 00:17:05.490 on the way out, like let's fucking go. Like give 354 00:17:05.539 --> 00:17:06.039 it a chance. 355 00:17:06.059 --> 00:17:08.299 This is what the FDA is for. They forbid that. 356 00:17:08.799 --> 00:17:10.039 Yeah. That's what we need to get rid of them. 357 00:17:10.420 --> 00:17:12.240 Get rid of the FDA and just give it to 358 00:17:12.299 --> 00:17:15.240 old people. If I was an old guy and I 359 00:17:15.359 --> 00:17:18.819 was like hanging in there and I'm walking around with a, 360 00:17:19.289 --> 00:17:22.369 and you're like, look, this drink and a pill might 361 00:17:22.430 --> 00:17:24.890 kill you or you might be like a 30 year 362 00:17:24.930 --> 00:17:26.869 old again. I'm like, let's fucking go. 363 00:17:27.279 --> 00:17:29.839 Well, I get emails a lot. I've had to take 364 00:17:29.900 --> 00:17:32.160 my emails off public access because there's a lot of 365 00:17:32.180 --> 00:17:33.259 people that want this. 366 00:17:33.599 --> 00:17:34.119 Oh, I'm sure. 367 00:17:34.559 --> 00:17:37.460 There was one guy that wouldn't leave the building until 368 00:17:37.500 --> 00:17:39.950 he saw me. So it's getting to that point. 369 00:17:40.289 --> 00:17:42.029 Yeah, there's a little bit of that, right? People get 370 00:17:42.049 --> 00:17:43.670 a little selfish like it's all about them. 371 00:17:44.089 --> 00:17:47.970 Yeah, and actually the U.S. government blocked an investment from 372 00:17:47.990 --> 00:17:50.859 a foreign country into one of my companies because they 373 00:17:50.880 --> 00:17:52.359 were afraid of super soldiers. 374 00:17:53.220 --> 00:17:54.099 Ooh, what country? 375 00:17:54.140 --> 00:17:58.289 Well, they were afraid of technology getting out. Which country? 376 00:17:58.589 --> 00:18:00.190 Could I guess? Sure. 377 00:18:00.730 --> 00:18:02.309 China. It wasn't. 378 00:18:02.650 --> 00:18:02.980 Was it? 379 00:18:03.210 --> 00:18:03.529 No, no. 380 00:18:03.569 --> 00:18:03.890 Russia? 381 00:18:04.190 --> 00:18:07.049 It was somewhere in between here and China. Oh, well, 382 00:18:07.170 --> 00:18:12.440 that's pretty vague. It's a little sensitive. But, yeah, the U.S. 383 00:18:12.460 --> 00:18:15.099 government does have the ability to block foreign investment, and 384 00:18:15.119 --> 00:18:17.279 they did in this case. $ 160 million they blocked. 385 00:18:17.460 --> 00:18:18.180 Wow. 386 00:18:18.480 --> 00:18:19.980 That was a painful episode. 387 00:18:20.180 --> 00:18:22.279 So they were worried that people were going to actually 388 00:18:22.400 --> 00:18:25.119 engineer super soldiers, right? This episode is brought to you 389 00:18:25.170 --> 00:18:28.579 by superpower. Your doctor spends eight minutes with you and 390 00:18:28.599 --> 00:18:32.319 your insurance company decides what blood work you're allowed to get. 391 00:18:32.640 --> 00:18:36.670 That's not healthcare. It's a broken system with superpower. You 392 00:18:36.710 --> 00:18:42.750 have control over your health for $ 199. You get all 393 00:18:42.829 --> 00:18:46.279 the tools you need to understand your body. It starts 394 00:18:46.359 --> 00:18:51.019 with one blood test measuring over 100 100 biomarkers. Then 395 00:18:51.299 --> 00:18:55.400 they give you detailed insights and a personalized plan built 396 00:18:55.519 --> 00:19:01.099 around you, your labs, health history, genetics, wearable data, and goals. 397 00:19:01.420 --> 00:19:06.990 Go to superpower.com slash Rogan and take control of your health. 398 00:19:07.910 --> 00:19:08.509 Yeah. 399 00:19:08.529 --> 00:19:12.329 Do you know about the Russian experiments that they did 400 00:19:12.549 --> 00:19:14.569 during World War II where they were trying to come 401 00:19:14.609 --> 00:19:16.390 up with a chimpanzee-human hybrid? 402 00:19:17.710 --> 00:19:18.059 Tell us. 403 00:19:18.890 --> 00:19:23.049 Yes. So it's very difficult obviously to get information out 404 00:19:23.089 --> 00:19:25.470 of the former Soviet Union as to what their top 405 00:19:25.490 --> 00:19:28.720 secret programs were. But there seems to be an indication 406 00:19:28.759 --> 00:19:32.279 that there was actual real research to try to– because 407 00:19:32.380 --> 00:19:36.859 obviously Russia lost an incredible amount of people in World 408 00:19:36.900 --> 00:19:40.519 War II. I mean tens of millions of soldiers died 409 00:19:40.599 --> 00:19:44.210 in World War II from Russia. And I think they said, 410 00:19:44.410 --> 00:19:47.220 wouldn't it be great if it wasn't people? And so 411 00:19:47.259 --> 00:19:51.039 they were doing experiments with hybridization. And they were trying 412 00:19:51.099 --> 00:19:56.220 to combine human beings and chimpanzees to create a, you know, 413 00:19:56.460 --> 00:20:01.660 a stable of super soldiers that were like some hybrid hominin. 414 00:20:02.119 --> 00:20:04.269 Yeah, there's a scientist in New York who does this 415 00:20:04.309 --> 00:20:04.789 for a living. 416 00:20:05.049 --> 00:20:06.509 What? He does that for a living? 417 00:20:06.529 --> 00:20:09.160 Well, he's not creating them, but I've seen... I was 418 00:20:09.200 --> 00:20:13.359 on stage with him. He made hybrid embryos. They didn't 419 00:20:14.140 --> 00:20:14.720 reach birth rate. 420 00:20:14.740 --> 00:20:16.559 See, the thing is if that guy is doing that 421 00:20:16.599 --> 00:20:18.519 and he's ethical and he lives in America and we 422 00:20:18.539 --> 00:20:20.619 have rules and regulations and the FDA and all that 423 00:20:20.640 --> 00:20:23.029 good stuff, what the fuck is going on in other 424 00:20:23.069 --> 00:20:24.369 countries where they don't have that? 425 00:20:24.490 --> 00:20:28.509 Right, right. Well, there's genetic engineering of humans already and 426 00:20:28.529 --> 00:20:29.269 certainly selection. 427 00:20:29.710 --> 00:20:30.190 Yes. 428 00:20:30.289 --> 00:20:32.769 Even parents today in the US can– if they have 429 00:20:32.789 --> 00:20:33.750 the money, they can select. 430 00:20:33.769 --> 00:20:34.670 Well, people select. 431 00:20:34.869 --> 00:20:35.730 Even based on intelligence. 432 00:20:35.750 --> 00:20:39.380 People select for hotness. They select for tallness. They select 433 00:20:39.440 --> 00:20:40.599 for intelligence. 434 00:20:40.900 --> 00:20:41.700 It's like Gattaca. 435 00:20:41.920 --> 00:20:42.210 Yes. 436 00:20:42.230 --> 00:20:43.319 It's a great movie if you haven't seen it. 437 00:20:43.849 --> 00:20:46.250 It is a great movie. Yeah. So see if you 438 00:20:46.269 --> 00:20:51.490 could find that Russian hybridization program. It never happened, I 439 00:20:51.529 --> 00:20:55.710 don't think. I don't think they did it. But there's 440 00:20:55.779 --> 00:20:59.359 actually a guy who was also involved in a gigantic 441 00:20:59.440 --> 00:21:03.759 fertility scam. Not a scam per se, but he was 442 00:21:03.819 --> 00:21:07.410 a doctor. that was supposed to be doing fertility treatments 443 00:21:07.670 --> 00:21:10.069 with women. Like, you know, like if you went with 444 00:21:10.109 --> 00:21:12.690 your wife to a doctor and said, hey, we're having 445 00:21:12.710 --> 00:21:15.940 a hard time getting pregnant. And well, David, I just 446 00:21:15.980 --> 00:21:18.180 need some of your sperm and I'll take your wife's egg. 447 00:21:18.200 --> 00:21:19.880 We'll make you a nice baby. And he was using 448 00:21:19.920 --> 00:21:23.900 his sperm on everybody, on everybody. Everybody gets mine. 449 00:21:24.000 --> 00:21:27.960 One of my kids partners is from someone in the 450 00:21:28.039 --> 00:21:30.180 US who had hundreds of babies. 451 00:21:30.220 --> 00:21:32.839 Dude, there is a ton of those guys. As I 452 00:21:32.859 --> 00:21:35.730 was doing research for this, I started looking up all 453 00:21:35.769 --> 00:21:37.750 these stories and I said, wait, this is a different story? 454 00:21:37.809 --> 00:21:40.430 The same thing? There's been a ton of these doctors 455 00:21:40.769 --> 00:21:43.490 from fertility clinics that use their own sperm. Just insane. 456 00:21:43.750 --> 00:21:47.130 But this one doctor that did that also claimed that 457 00:21:47.190 --> 00:21:51.799 he impregnated an orangutan. Yeah. Like how? How did you 458 00:21:51.819 --> 00:21:59.400 do that? Soviet doctor Joseph Stalin. Dictator. Dictator. Obviously. Wanted 459 00:21:59.420 --> 00:22:02.440 to rebuild the Red Army in the mid-1920s. With Planet 460 00:22:02.480 --> 00:22:05.039 of the Apes-style troops by crossing humans with apes, Stalin 461 00:22:05.059 --> 00:22:07.819 is said to have told Ivanov, I want a new, 462 00:22:07.980 --> 00:22:11.750 invincible human being, insensitive to pain, resistant and indifferent about 463 00:22:11.769 --> 00:22:14.910 the quality of the food they ate. Which is crazy. 464 00:22:15.509 --> 00:22:17.549 The only legitimate source of the claim comes from a 465 00:22:17.529 --> 00:22:21.970 2002 paper in the academic journal Science in Context. by 466 00:22:21.990 --> 00:22:28.900 the Russian historian of science, uh, Kirill Rassianov. Rassianov's, uh, 467 00:22:29.000 --> 00:22:32.500 study follows the ill-fated attempt by the Russian psychologist or 468 00:22:32.539 --> 00:22:36.549 physiologist rather, uh, Ooh, that was that word. Ilya Ivanov 469 00:22:36.650 --> 00:22:41.309 to crossbreed humans with anthropoid apes. His research offers an 470 00:22:41.329 --> 00:22:45.069 important warning about the ethical abuses. Did you do it? 471 00:22:45.670 --> 00:22:49.730 What happened? Um, The alleged quote from Stalin is not 472 00:22:49.789 --> 00:22:51.789 found in the paper and there's no evidence of Stalin 473 00:22:51.910 --> 00:22:59.460 ever made such a statement. Yeah. I don't know. However, 474 00:22:59.579 --> 00:23:03.480 why the Soviets would find such a human chimp hybridization 475 00:23:03.559 --> 00:23:05.420 program in the first place and what could be learned 476 00:23:05.440 --> 00:23:08.880 from this sordid tale of ethical misconduct is an important 477 00:23:08.920 --> 00:23:11.970 topic and fascinating in its own right. That's an interesting 478 00:23:12.470 --> 00:23:15.970 way of phrasing it, like a sordid tale of ethical misconduct. 479 00:23:16.630 --> 00:23:20.890 However– If you are going to go to war, would 480 00:23:20.970 --> 00:23:30.140 you rather have human-made orcs fight for us or Johnny Robinson, 481 00:23:30.279 --> 00:23:32.059 who grew up down the street, who's a nice kid, 482 00:23:32.539 --> 00:23:35.539 who just really wanted money for college, and so he 483 00:23:35.579 --> 00:23:38.599 signed up for military service, and you're going to fly 484 00:23:38.619 --> 00:23:41.660 him over to fight this war that maybe he doesn't 485 00:23:41.680 --> 00:23:44.039 need to die in when you can have these monsters 486 00:23:44.059 --> 00:23:45.240 that you made in a lab fight? 487 00:23:45.420 --> 00:23:48.380 Yep, and the average ape can kill a human with 488 00:23:48.460 --> 00:23:51.029 one punch. Easy. So they're much stronger than we realize. 489 00:23:51.049 --> 00:23:52.529 That's what I'm talking about. Let's go. 490 00:23:52.640 --> 00:23:56.470 Well, we're in the process of building, you know, anthropoid 491 00:23:56.509 --> 00:23:58.789 robots that I think will be recruited to the army. 492 00:23:59.589 --> 00:24:01.769 Yeah. That's going to be weird. Like our robots beat 493 00:24:01.829 --> 00:24:04.150 your robots. So give us your oil. How's that going 494 00:24:04.190 --> 00:24:04.410 to work? 495 00:24:04.690 --> 00:24:06.230 And if we all have one at home, what stops 496 00:24:06.269 --> 00:24:07.349 the government recruiting them all? 497 00:24:07.730 --> 00:24:11.710 Right. And also what's the real problem is going to be? 498 00:24:11.859 --> 00:24:13.480 We both know the real problem is going to be 499 00:24:13.519 --> 00:24:14.200 sex robots. 500 00:24:16.079 --> 00:24:16.480 Is it a problem? 501 00:24:16.930 --> 00:24:19.009 It's going to be a problem for people that don't 502 00:24:19.049 --> 00:24:21.130 have a sex robot. People won't leave home. It's going 503 00:24:21.150 --> 00:24:23.309 to be a problem with people that want a regular person, 504 00:24:23.869 --> 00:24:26.390 and there's none available because everybody's got a sex robot. 505 00:24:26.839 --> 00:24:29.259 Yeah, well, it comes with fewer strings attached. 506 00:24:29.720 --> 00:24:32.799 It also comes with the same problems that AI comes with, right, 507 00:24:32.819 --> 00:24:36.359 where AI says, David, you're amazing. Everything you do is wonderful. 508 00:24:36.839 --> 00:24:38.839 You should be so proud of yourself. I love that. 509 00:24:39.019 --> 00:24:43.339 No real– we would all love that. But that's not healthy, right? 510 00:24:43.400 --> 00:24:44.180 You're so big. 511 00:24:44.279 --> 00:24:49.079 This is one of the reasons why actual real relationships 512 00:24:49.099 --> 00:24:51.299 between human beings are good. It's because you do things 513 00:24:51.319 --> 00:24:53.799 that are annoying. You don't realize they're annoying. And then 514 00:24:53.940 --> 00:24:57.369 your wife or your husband or whatever it is tells you, hey, 515 00:24:57.400 --> 00:25:01.109 you're fucking annoying. And you're like, I'm sorry. I'll– I'll 516 00:25:01.150 --> 00:25:03.609 fix that. I didn't mean to. I didn't. That's not 517 00:25:03.630 --> 00:25:05.230 what I was trying to do. I was in my 518 00:25:05.250 --> 00:25:06.869 own head. I was thinking about myself. You're right. I 519 00:25:06.890 --> 00:25:09.829 was selfish. You get better. It's like how people grow. 520 00:25:10.170 --> 00:25:13.430 Like relationships are important to help people grow. Not with AI. 521 00:25:13.849 --> 00:25:16.109 Like you can fart in my face any day, David. 522 00:25:16.250 --> 00:25:19.430 I don't mind at all. Your farts are amazing. 523 00:25:19.730 --> 00:25:21.109 I know the problem is they're going to be way 524 00:25:21.150 --> 00:25:21.950 smarter than us too. 525 00:25:22.170 --> 00:25:22.309 Right. 526 00:25:23.119 --> 00:25:24.740 I don't know how people are going to say, go 527 00:25:24.759 --> 00:25:27.480 stack the dishwasher to one of these robots. They're smarter 528 00:25:27.509 --> 00:25:28.420 than all humans combined. 529 00:25:28.440 --> 00:25:30.849 Yeah, but they're not going to mind stacking. They're smart 530 00:25:30.890 --> 00:25:31.549 enough to– They're going to. 531 00:25:31.529 --> 00:25:32.609 Be bored out of hell and they're going to beat 532 00:25:32.670 --> 00:25:32.930 us up. 533 00:25:33.069 --> 00:25:36.109 They don't care. They're not going to mind doing like 534 00:25:36.190 --> 00:25:39.869 menial tasks. But while you're doing it, you can go, 535 00:25:40.609 --> 00:25:47.269 explain to me quantum entanglement. So while they're filling up 536 00:25:47.289 --> 00:25:49.230 the dishwasher– They're going to go F you one day. 537 00:25:49.390 --> 00:25:53.759 Well– If you have a particle and the particles– Yeah. 538 00:25:53.799 --> 00:25:55.559 I just invented a cure for aging. 539 00:25:55.980 --> 00:25:59.160 Right. Well, look at what it's done with mathematics. Like 540 00:25:59.299 --> 00:26:03.349 just over the last couple weeks, they've solved more than 541 00:26:03.349 --> 00:26:08.089 50 program or 50 mathematical equations that they have struggled 542 00:26:08.410 --> 00:26:11.549 for decade upon decade to try to solve. And AI 543 00:26:11.630 --> 00:26:13.529 is like, oh, I got it. Yeah. 544 00:26:13.589 --> 00:26:16.470 Well, biology is a little bit more complicated, but already 545 00:26:16.589 --> 00:26:18.710 AI is doing a lot of the science that we 546 00:26:18.769 --> 00:26:21.079 used to do in my lab. In fact, what we 547 00:26:21.099 --> 00:26:23.380 just recently did in a couple of months would have 548 00:26:23.400 --> 00:26:25.210 taken about 160 years to complete. 549 00:26:25.990 --> 00:26:26.269 What? 550 00:26:26.529 --> 00:26:28.529 And it's only getting faster. Eventually someone can make a 551 00:26:28.549 --> 00:26:29.049 drug on their phone. 552 00:26:29.069 --> 00:26:29.609 Say that again. 553 00:26:30.809 --> 00:26:32.849 Two months instead of 160 years. 554 00:26:33.529 --> 00:26:35.690 Well, what exactly was it that you had to do? 555 00:26:35.910 --> 00:26:38.900 Oh, so this drink and the pill that we're looking for, 556 00:26:39.799 --> 00:26:42.859 that's not easy. So we have some candidate molecules. We 557 00:26:42.880 --> 00:26:45.700 have a cocktail that works. Are you taking this stuff? 558 00:26:46.960 --> 00:26:50.549 Not yet. You're thinking about it? Yeah. No one could 559 00:26:50.569 --> 00:26:50.970 stop you. 560 00:26:51.490 --> 00:26:54.529 Well, that is true. That is true. But it would 561 00:26:54.549 --> 00:26:56.890 be a bad look if I died. So maybe I 562 00:26:56.910 --> 00:26:58.710 wouldn't do it. What? You're not going to die. Come on. 563 00:26:58.839 --> 00:27:00.200 I don't think so. We've done a lot of safety 564 00:27:00.220 --> 00:27:03.799 tests and it looks really safe. But I'm not going 565 00:27:03.819 --> 00:27:05.779 to publicly do anything against the law. 566 00:27:06.259 --> 00:27:06.900 Of course. 567 00:27:06.920 --> 00:27:07.859 It would be in private, of course. 568 00:27:08.079 --> 00:27:08.799 Of course. 569 00:27:08.940 --> 00:27:11.690 Not publicly. I'm at a stage where I have to 570 00:27:11.730 --> 00:27:14.349 be a good boy because I've got the world watching. 571 00:27:14.450 --> 00:27:14.690 Yes. 572 00:27:15.109 --> 00:27:15.890 A lot is at stake. 573 00:27:16.069 --> 00:27:17.730 Yes. A lot is at stake. 574 00:27:17.750 --> 00:27:20.900 And if this trial– If there's any issues, it's not good. 575 00:27:20.920 --> 00:27:22.920 You've got to dot your I's and cross your T's 576 00:27:23.000 --> 00:27:26.319 and follow every– I understand that. But please explain again 577 00:27:26.339 --> 00:27:29.140 because I'm being rude. I interrupted you. When you're telling 578 00:27:29.180 --> 00:27:31.740 me that in two months it did something that would 579 00:27:31.769 --> 00:27:34.430 have required 160 years of work, like what do you 580 00:27:34.549 --> 00:27:35.529 exactly mean by that? 581 00:27:35.609 --> 00:27:40.930 Yeah, and now it would probably be impossible in thousands 582 00:27:40.950 --> 00:27:44.009 of years because what we do is we're looking for molecules, 583 00:27:44.690 --> 00:27:47.549 a single molecule that can replace this cocktail. So you 584 00:27:47.630 --> 00:27:49.990 need a molecule to do three or four activities in 585 00:27:50.009 --> 00:27:53.309 the cell. Finding one activity is what pharmaceutical companies do. 586 00:27:53.859 --> 00:27:57.180 It takes hundreds of millions, if not billions, to make 587 00:27:57.240 --> 00:28:00.660 a drug. We know that, right? My little lab of 588 00:28:00.660 --> 00:28:05.680 20 people and students, young kids, are trying to make 589 00:28:05.940 --> 00:28:10.769 one drug do three or four different things. That's beyond 590 00:28:10.789 --> 00:28:13.809 the reach of pharmaceutical experience at least five years ago. 591 00:28:14.420 --> 00:28:15.839 So what we do is we've teamed up with a 592 00:28:15.859 --> 00:28:18.779 group at St. Jude's Hospital where they can take– it 593 00:28:18.819 --> 00:28:23.710 was $ 10 billion. Now it's a trillion theoretical and also 594 00:28:23.789 --> 00:28:28.029 drug– known drugs. With my hands, I'm showing a big funnel. 595 00:28:29.069 --> 00:28:31.609 You're really good at podcasts. You're like helping out the 596 00:28:31.690 --> 00:28:33.519 audio people and everything. I love it. 597 00:28:33.529 --> 00:28:35.369 I relaunched my podcast. That's why. 598 00:28:35.390 --> 00:28:36.390 Oh, that's why. Yeah. 599 00:28:37.029 --> 00:28:42.569 Lifespan, David Sinclair. Shameless plug. So this funnel– is full 600 00:28:42.589 --> 00:28:44.009 of a trillion molecules and we have to come down 601 00:28:44.029 --> 00:28:45.930 to one. How do we do that? Well, we don't 602 00:28:46.490 --> 00:28:48.529 look for a trillion molecules at the bench. That would 603 00:28:48.549 --> 00:28:51.890 take 160 or thousands of years with the case of 604 00:28:51.910 --> 00:28:54.730 a trillion molecules, even with robots, even with a lot 605 00:28:54.750 --> 00:28:58.279 of graduate students. So we do it inside the computer. 606 00:28:58.579 --> 00:29:00.970 We just use a lot of compute and we dock 607 00:29:01.539 --> 00:29:04.740 each of these molecules against the enzymes that we now 608 00:29:04.799 --> 00:29:08.720 know how they work, thanks to Google DeepMind solved the 609 00:29:08.900 --> 00:29:11.759 problem of how do all our proteins look, 20,000 of them. 610 00:29:12.720 --> 00:29:14.700 And there's a lot of compute. But out the other end, 611 00:29:14.720 --> 00:29:21.380 a couple of months later, we have 200 molecules that 612 00:29:21.440 --> 00:29:25.390 we can now test in the lab within a few weeks. Actually, 613 00:29:25.430 --> 00:29:29.910 next week, we're testing these 200 against human cells. And 614 00:29:29.950 --> 00:29:32.250 we've also got AI helping us to tell us if 615 00:29:32.289 --> 00:29:35.880 the human cells go from 92 years old back to 20. 616 00:29:35.880 --> 00:29:38.019 We can tell that just by looking at them, thanks 617 00:29:38.059 --> 00:29:38.559 to the AI. 618 00:29:38.940 --> 00:29:40.730 Is there a way to stop that? from turning you 619 00:29:40.769 --> 00:29:42.619 into a baby? Because that's what I would worry about. 620 00:29:42.630 --> 00:29:42.759 Yes. 621 00:29:43.450 --> 00:29:46.980 Yes. I don't want to be a baby again. Right. 622 00:29:47.019 --> 00:29:47.819 Some people are already there. 623 00:29:47.859 --> 00:29:49.180 I'd like to cut it off at like– I was 624 00:29:49.240 --> 00:29:50.160 pretty good at 25. 625 00:29:50.160 --> 00:29:53.579 I'm going to get attacked for saying this, but that 626 00:29:53.619 --> 00:29:56.599 is what we do in the lab. We take 92-year-old 627 00:29:56.619 --> 00:29:58.410 cells and they stop at 20-something. Wow. 628 00:29:58.700 --> 00:30:00.170 Why would you get attacked for that? 629 00:30:00.190 --> 00:30:03.950 Because on the internet, people take a clip and they say, 630 00:30:04.029 --> 00:30:06.430 Sinclair says we can all go back to being 20 again. 631 00:30:07.369 --> 00:30:09.210 You suffer from this too, right? They take a clip 632 00:30:09.250 --> 00:30:13.910 and it's out of context. And I'm just saying cells 633 00:30:13.930 --> 00:30:16.890 from humans, skin cells, we take them back to 25. 634 00:30:16.890 --> 00:30:18.759 All my students can do this. In fact, if you 635 00:30:18.799 --> 00:30:21.339 had these little genes, OSK, in your garage, you could 636 00:30:21.359 --> 00:30:24.019 do this experiment. It's not hard at all to reverse aging. 637 00:30:24.500 --> 00:30:26.519 The question is, how do you safely make it a drug? 638 00:30:26.940 --> 00:30:28.740 And that's been the hard part over the last 10 years. 639 00:30:29.900 --> 00:30:36.140 So how would it be able to regulate this reduction 640 00:30:36.259 --> 00:30:41.660 or reversal of aging and stop it at 20-something years old? 641 00:30:42.380 --> 00:30:45.180 Well, that's what took so long. It wasn't obvious that 642 00:30:45.700 --> 00:30:49.750 these three Yamanaka genes called OSK were the right cocktail. 643 00:30:50.410 --> 00:30:53.430 My student, who I mentioned, Wen Cheng, he was struggling. 644 00:30:53.470 --> 00:30:56.690 He was trying a lot of different genes. Most of 645 00:30:56.710 --> 00:30:59.390 them from embryos because we know embryos have to do 646 00:30:59.410 --> 00:31:01.630 a reset in the first week of life. Otherwise, they 647 00:31:01.650 --> 00:31:06.349 stay the age of the parents. And he found that 648 00:31:07.109 --> 00:31:09.170 leaving out one of the Aminaka genes was the trick. 649 00:31:09.529 --> 00:31:11.230 And now that we know it, it's super easy. But 650 00:31:11.579 --> 00:31:13.170 in those days, he was ready to quit. 651 00:31:13.410 --> 00:31:14.240 How did he find that out? 652 00:31:15.339 --> 00:31:18.180 Well, he tried lots of different combinations, hundreds in human cells. 653 00:31:18.220 --> 00:31:19.680 And you look at the cells to see if they 654 00:31:19.720 --> 00:31:22.240 get younger. And then we can measure molecularly that they 655 00:31:22.279 --> 00:31:22.660 get younger. 656 00:31:22.799 --> 00:31:25.420 And are you measuring them by the length of their telomeres? 657 00:31:26.000 --> 00:31:30.920 Yeah. Partly, but actually a better measure is the chemicals 658 00:31:30.940 --> 00:31:34.900 that are added and subtracted off DNA itself called methyls. 659 00:31:35.559 --> 00:31:39.380 And it's just a carbon molecule with three hydrogens. Very 660 00:31:39.420 --> 00:31:42.509 simple molecule. But what cells do is they use these 661 00:31:42.970 --> 00:31:46.369 methyls to tag genes to be switched off. So when 662 00:31:46.410 --> 00:31:49.329 we're growing as an embryo, the cells that want to 663 00:31:49.369 --> 00:31:52.930 become neurons will shut off all these other unwanted genes 664 00:31:52.950 --> 00:31:56.359 like liver genes and skin genes. And the ones that 665 00:31:56.440 --> 00:31:59.339 don't get this methyl chemical stay on for our life. 666 00:31:59.440 --> 00:32:02.200 And that's how nerve cells develop and stay healthy. But 667 00:32:02.240 --> 00:32:05.440 what happens during aging– a friend of mine, Steve Horvath, 668 00:32:05.460 --> 00:32:08.819 discovered that you can use this as a clock. These chemicals, 669 00:32:08.839 --> 00:32:11.650 they change over time. And we found that that happens 670 00:32:12.230 --> 00:32:15.089 largely due to DNA damage going in the sun, these 671 00:32:15.130 --> 00:32:17.630 kind of things. We could use this to rapidly age 672 00:32:17.670 --> 00:32:20.490 a mouse, which we published in 2023. 673 00:32:20.470 --> 00:32:24.670 Oh, so like maybe like some nefarious state actor, like 674 00:32:24.750 --> 00:32:28.259 some– Russian spy could, like, inject something in your coffee 675 00:32:28.640 --> 00:32:30.339 and you would turn 99 overnight? 676 00:32:30.380 --> 00:32:31.180 We know how to do that. 677 00:32:31.660 --> 00:32:35.069 Whoa. Yeah. That's the dark side of this. It is. 678 00:32:35.170 --> 00:32:38.109 You could spike your husband's drink. Fuck that dude. And 679 00:32:38.190 --> 00:32:39.250 turn him into an old man. 680 00:32:39.289 --> 00:32:41.470 Hey, what did you do? 681 00:32:42.210 --> 00:32:43.650 Yeah. 682 00:32:43.789 --> 00:32:47.309 Someone tweeted the other day, if a 92-year-old could be 683 00:32:47.309 --> 00:32:49.259 25 again, would you have sex with them? 684 00:32:50.460 --> 00:32:53.019 And my response was– Imagine how much they know. 685 00:32:53.140 --> 00:32:54.680 But would they have sex with you? Right. 686 00:32:54.700 --> 00:32:54.900 Right. 687 00:32:55.319 --> 00:32:56.460 That's the better question. 688 00:32:56.480 --> 00:32:59.180 That's the question. They'd be looking for another 20-year-old. 689 00:32:59.500 --> 00:33:01.819 Right. So anyway, how do we do it? We can 690 00:33:01.880 --> 00:33:04.859 measure those chemicals and determine how old a cell is 691 00:33:05.400 --> 00:33:06.980 or a human. I could take your skin cells from 692 00:33:07.000 --> 00:33:08.539 your mouth or your blood and tell you. 693 00:33:08.509 --> 00:33:09.769 How old you are. I wonder if people would be 694 00:33:09.829 --> 00:33:13.910 so disturbed by like old rich guys dating young women 695 00:33:14.609 --> 00:33:17.430 if that was the case. You couldn't tell if they 696 00:33:17.470 --> 00:33:20.730 looked young. Because people get very mad at that. You 697 00:33:20.750 --> 00:33:21.130 ever notice? 698 00:33:21.430 --> 00:33:21.890 Yeah, yeah, yeah. 699 00:33:22.119 --> 00:33:24.299 You see some real old decrepit dude with a hot 700 00:33:24.339 --> 00:33:26.559 young wife and people are like, God damn it. They 701 00:33:26.579 --> 00:33:28.680 get really mad. Right. 702 00:33:28.759 --> 00:33:30.460 Right now the best way to do that is to 703 00:33:30.500 --> 00:33:32.759 have a big bank account, but eventually you'll actually. 704 00:33:32.619 --> 00:33:34.400 Look young again. Right, but people still get grossed out. 705 00:33:34.480 --> 00:33:36.150 I wonder if they would get grossed out if he 706 00:33:36.170 --> 00:33:38.970 looked 20. They'd be like, he's praying. He has so 707 00:33:39.009 --> 00:33:41.369 much more years of knowledge and information. It's not fair. 708 00:33:41.390 --> 00:33:45.900 I don't care if he looks 20. That's a 99-year-old man. 709 00:33:46.119 --> 00:33:48.450 That day will come. That day will come where you 710 00:33:48.490 --> 00:33:49.950 will not be able to tell how old somebody is 711 00:33:49.990 --> 00:33:52.369 by looking at them. You'll have to do a test 712 00:33:52.430 --> 00:33:54.190 for these genes. Wow. 713 00:33:54.329 --> 00:33:55.950 I wonder if people still lie about their age if 714 00:33:55.970 --> 00:33:58.869 that's the case. I wonder if no one will care. 715 00:33:58.930 --> 00:34:03.829 Like you would probably lie the other way. Like I'm 80. 716 00:34:03.829 --> 00:34:04.150 It's right. 717 00:34:04.190 --> 00:34:05.849 Tom's over there telling everybody he's 80. 718 00:34:05.849 --> 00:34:08.269 That's right. Well, when we live for hundreds of years, 719 00:34:08.389 --> 00:34:10.090 people will do that. They'll be proud of their age. 720 00:34:10.559 --> 00:34:15.739 Do you know anything about ancient civilizations and some of 721 00:34:15.760 --> 00:34:19.969 the weirdness of the records of like ancient Sumer? 722 00:34:20.949 --> 00:34:23.409 Well, only really what I've learned from listening to you. 723 00:34:23.909 --> 00:34:28.190 Well, it's– there's– what's really weird is the ancient king's 724 00:34:28.269 --> 00:34:30.650 lists because– so– OK. 725 00:34:31.510 --> 00:34:31.630 OK. 726 00:34:33.590 --> 00:34:39.010 The theory, the theory among these alternative archaeologist types is 727 00:34:39.110 --> 00:34:42.590 that there was a very advanced civilization that existed on 728 00:34:42.690 --> 00:34:46.030 Earth tens of thousands of years ago and we're probably 729 00:34:46.210 --> 00:34:50.280 wiped out by comet impact. And what we have today 730 00:34:50.460 --> 00:34:54.460 is a rebuild of civilization. There's not a linear progression 731 00:34:54.519 --> 00:34:57.039 from caveman to us and that at one point in 732 00:34:57.059 --> 00:34:59.900 time we had reached great heights. This explains the pyramids. 733 00:35:00.300 --> 00:35:05.920 This explains Machu Picchu, Sacsayhuaman, some megalithic structures that don't 734 00:35:05.940 --> 00:35:10.219 make any sense, the Trilithon stones in Baalbek Lemadon that 735 00:35:10.260 --> 00:35:13.900 are hundreds and hundreds of tons, that are massive, that 736 00:35:13.920 --> 00:35:18.179 are nine meters off the ground. No one understands exactly 737 00:35:18.219 --> 00:35:22.900 how they placed them. When you look at the Sumerian 738 00:35:23.019 --> 00:35:27.219 kings list, it gets very weird because there's kings that 739 00:35:27.320 --> 00:35:31.269 reigned for thousands of years. And then you have the flood. 740 00:35:31.849 --> 00:35:35.469 And then after the flood, the age of these people 741 00:35:35.730 --> 00:35:40.309 drops pretty dramatically. And the rains are– after a few 742 00:35:40.369 --> 00:35:43.800 hundred years become normal, become like a normal person, like 743 00:35:43.800 --> 00:35:47.719 50 years, 30 years, like that. But thousands of years before. 744 00:35:48.179 --> 00:35:50.460 And then people are looking at it like, OK, is 745 00:35:50.480 --> 00:35:54.019 this just myth? Is this poor record keeping? Do they 746 00:35:54.059 --> 00:35:59.610 have just these hyperbolic– elevated stories about these kings. They 747 00:35:59.630 --> 00:36:04.670 were so amazing. They reigned for 30,000 years. Or had 748 00:36:04.769 --> 00:36:09.139 they achieved, not just in building, because in building, we 749 00:36:09.159 --> 00:36:13.960 know they'd achieve incredibly complex structure, like the pyramid, for instance, 750 00:36:14.000 --> 00:36:18.000 like they had insane engineering somehow or another, the ability 751 00:36:18.019 --> 00:36:22.980 to move these 500 ton stones from hundreds of miles away. Like, 752 00:36:23.039 --> 00:36:24.980 how did they do this? We don't really know, but 753 00:36:25.019 --> 00:36:29.500 we know that they did it. Did they also have 754 00:36:29.559 --> 00:36:32.019 the kind of technology that you're talking about right now? 755 00:36:32.559 --> 00:36:35.599 Because if it's possible today– and if that is– I 756 00:36:35.599 --> 00:36:38.760 mean it makes it very difficult because it goes against 757 00:36:39.400 --> 00:36:43.219 what you would call like the modern narrative that they're 758 00:36:43.239 --> 00:36:45.980 teaching in universities in terms of the timeline of human history. 759 00:36:46.360 --> 00:36:49.980 But if that changes and we have undeniable evidence, well, 760 00:36:50.099 --> 00:36:52.880 it looks like these people were far more advanced than 761 00:36:52.920 --> 00:36:54.900 we thought and there probably was some sort of a 762 00:36:54.949 --> 00:36:58.489 reset of civilization. What else had they accomplished and had 763 00:36:58.550 --> 00:37:02.329 they gotten involved in genetic engineering? Had they figured out 764 00:37:02.369 --> 00:37:06.190 a way to extend lifespan? And if they did, imagine 765 00:37:06.670 --> 00:37:10.679 all the work that you've accomplished in your– you're 57 now? 766 00:37:10.719 --> 00:37:13.639 About to be 57? You look great by the way. 767 00:37:14.179 --> 00:37:16.119 You really do. Look at your hair. It's so dark. 768 00:37:16.539 --> 00:37:17.099 It's incredible. 769 00:37:17.420 --> 00:37:19.900 People speculate it's all fake but it's actually– it's not. 770 00:37:19.920 --> 00:37:22.679 But anyway, happy birthday to you. 771 00:37:22.699 --> 00:37:23.300 Thank you very much. 772 00:37:23.349 --> 00:37:23.969 Yeah. 773 00:37:24.150 --> 00:37:25.130 I don't look as good as you though. 774 00:37:26.090 --> 00:37:29.389 Yes, you do. Physically, you're way better than me. 775 00:37:29.550 --> 00:37:32.969 That's different though. My face looks older. You look very 776 00:37:33.030 --> 00:37:35.090 young for your age. You know why? Why? 777 00:37:35.170 --> 00:37:36.969 Because I've spent all my time in a lab and 778 00:37:36.989 --> 00:37:38.329 I haven't gone outdoors for a while. 779 00:37:38.630 --> 00:37:41.530 I'm sure that helps. That does help. But my point is, 780 00:37:41.989 --> 00:37:48.219 imagine if you had 500 years to do research, not 781 00:37:48.280 --> 00:37:53.300 just 57 years. Imagine if you could continue learning and 782 00:37:53.380 --> 00:37:57.010 growing and they did develop some sort of a life 783 00:37:57.050 --> 00:38:00.440 extension technology where you could not just be older but 784 00:38:00.519 --> 00:38:03.420 be healthier than you've ever been before and live for 785 00:38:03.440 --> 00:38:07.039 a thousand years, you would get so much done. I 786 00:38:07.099 --> 00:38:10.960 mean the exponential increase in technological innovation that we would 787 00:38:11.000 --> 00:38:14.199 have in this society would be absolutely mind-blowing. 788 00:38:14.219 --> 00:38:16.429 Exactly, exactly, exactly. This is a really important point. 789 00:38:16.469 --> 00:38:19.409 And that might be what these alternative history people think. 790 00:38:19.630 --> 00:38:22.630 That might be what had taken place tens of thousands 791 00:38:22.670 --> 00:38:23.130 of years ago. 792 00:38:23.489 --> 00:38:25.400 Yeah. Well, I'm a Harvard scientist, so I'm not going 793 00:38:25.420 --> 00:38:26.579 to say anything that isn't. 794 00:38:26.980 --> 00:38:28.800 Of course. That's for me. 795 00:38:29.389 --> 00:38:29.639 Yes. 796 00:38:29.760 --> 00:38:30.550 That's where I live. 797 00:38:30.570 --> 00:38:33.250 That's why I shut up. But you did make some 798 00:38:33.269 --> 00:38:36.610 really important points. One is that ancient civilizations have always 799 00:38:36.630 --> 00:38:38.250 been way more advanced than we think. 800 00:38:38.909 --> 00:38:39.130 Yes. 801 00:38:39.190 --> 00:38:42.369 Dinosaurs are a lot more real than we make them look. 802 00:38:42.429 --> 00:38:44.809 We always get things wrong looking back in time and 803 00:38:44.829 --> 00:38:47.269 looking forward in time. But the other thing that you said, 804 00:38:47.309 --> 00:38:49.230 which is really important, is that if we do have 805 00:38:49.289 --> 00:38:52.530 extension of human lifespan like the Bible and these civilizations 806 00:38:52.860 --> 00:38:57.190 suggest– then how will you think about your life if 807 00:38:57.869 --> 00:39:00.130 being 100 is, you know, you're still in your prime? 808 00:39:01.050 --> 00:39:04.309 You do things very differently. Who would you marry? What 809 00:39:04.369 --> 00:39:08.050 career would you think about? You might have multiple lifetimes, 810 00:39:08.130 --> 00:39:12.780 multiple marriages, multiple families. And that will happen. It's not 811 00:39:12.909 --> 00:39:15.780 really a question of if anymore. It's like asking the 812 00:39:15.800 --> 00:39:18.199 Wright brothers, will we fly? Yeah, we built the glider. 813 00:39:18.219 --> 00:39:20.820 We're going to fly around. The question is, will we 814 00:39:20.860 --> 00:39:22.739 build a Concorde? Will we go to space? And I 815 00:39:22.760 --> 00:39:23.559 think that will happen. 816 00:39:24.019 --> 00:39:27.909 Yeah. No, I think so too. I think– well, certainly 817 00:39:28.230 --> 00:39:30.900 one thing that we know is there's a giant difference 818 00:39:30.940 --> 00:39:34.699 between people who are 57 years old today versus 57 819 00:39:34.699 --> 00:39:38.219 years old in the 1930s. It's just a giant difference, 820 00:39:38.380 --> 00:39:41.099 a giant difference in your physical ability, your health. 821 00:39:41.179 --> 00:39:41.840 We'd be old men. 822 00:39:42.079 --> 00:39:45.469 Yeah, we would be old men. And what– I mean 823 00:39:45.550 --> 00:39:47.449 when I was a child, I thought of people– I'm 824 00:39:47.469 --> 00:39:50.480 almost 59. I'll be 59 in a week. I used 825 00:39:50.519 --> 00:39:55.300 to think of a 59-year-old as being basically dead. Like 826 00:39:56.019 --> 00:39:59.650 you're barely getting around. You're probably tired all the time. 827 00:39:59.690 --> 00:40:00.690 Looking to retire soon. 828 00:40:00.710 --> 00:40:04.369 Yeah, looking to retire. You got no energy. I'm filled 829 00:40:04.409 --> 00:40:07.610 with energy. I'm constantly doing– how old is he? 830 00:40:07.610 --> 00:40:07.750 60. 831 00:40:07.750 --> 00:40:10.170 That's what it says. Oh, no. I don't know if 832 00:40:10.190 --> 00:40:14.150 that's accurate. I bet that's accurate. They had no fucking vitamins. 833 00:40:14.670 --> 00:40:18.429 Nobody knew what the proper nutrients you should take were. 834 00:40:18.510 --> 00:40:21.559 Nobody knew the– What was really important in terms of 835 00:40:21.699 --> 00:40:25.099 like resistance training and sleep and red light therapy and 836 00:40:25.139 --> 00:40:25.639 all that jazz. 837 00:40:25.679 --> 00:40:29.199 And they were doing all the bad stuff like heavy smoking, drinking. 838 00:40:29.260 --> 00:40:32.110 Not sleeping a lot. Yep, not sleeping a lot. And 839 00:40:32.650 --> 00:40:36.920 pesticides and all kinds of terrible shit. 60-year-old. What? That 840 00:40:36.940 --> 00:40:40.039 guy's 60? That's crazy. No way. I don't know, man. 841 00:40:40.139 --> 00:40:43.559 Come on. Shut up. That guy's fucking 28 years old. 842 00:40:43.820 --> 00:40:46.639 There's no way. That guy's 60? Is that real? I 843 00:40:46.639 --> 00:40:47.190 will have to follow up. 844 00:40:47.239 --> 00:40:49.039 I doubt it. I doubt it. How about that guy 845 00:40:49.079 --> 00:40:52.360 that looks 50 and he says, everyone thinks I'm 18. Like, yeah, sure. 846 00:40:53.599 --> 00:40:53.940 What's that? 847 00:40:54.199 --> 00:40:58.019 There's a guy on Instagram, which I occasionally visit, and 848 00:40:58.380 --> 00:41:01.420 he obviously looks old. Like, he looks over 40. 849 00:41:01.400 --> 00:41:02.239 Oh, he's a crazy person. 850 00:41:02.400 --> 00:41:04.780 And he says... People think I look 18. It's like, 851 00:41:05.139 --> 00:41:05.800 are you crazy? 852 00:41:05.880 --> 00:41:08.340 Well, there's a lot of crazy people out there. Well, 853 00:41:08.380 --> 00:41:09.739 that's body dysmorphia. 854 00:41:10.340 --> 00:41:10.820 There must be. 855 00:41:11.059 --> 00:41:14.400 Bodybuilders, they think they're tiny. A lot of people are crazy. Yeah. 856 00:41:14.639 --> 00:41:16.340 A lot of people have a distorted perception of what 857 00:41:16.360 --> 00:41:16.860 they look like. 858 00:41:17.199 --> 00:41:20.960 Yeah. The plastic surgery industry is massive. It's just growing 859 00:41:21.000 --> 00:41:24.460 and growing. You can see it on the street, LA especially. 860 00:41:25.059 --> 00:41:28.980 But imagine a world where if I'm successful, you can 861 00:41:29.019 --> 00:41:31.619 take a pill. Your doctor could get it or eventually 862 00:41:31.659 --> 00:41:35.139 it's a cream. on your face and you literally get younger. 863 00:41:35.179 --> 00:41:37.480 We do this in mice already. The mice get younger. 864 00:41:38.519 --> 00:41:39.820 Is it going to work in humans? I think it's 865 00:41:39.840 --> 00:41:40.519 just a matter of time. 866 00:41:40.900 --> 00:41:44.880 So in the mice, uh, experiments, what have you achieved? 867 00:41:45.820 --> 00:41:48.789 Well, a lot, you know, I can reveal here, uh, 868 00:41:50.409 --> 00:41:53.250 some of it, uh, for the first time we, this, 869 00:41:53.449 --> 00:41:55.510 this pill that we give them to drink actually, cause 870 00:41:55.530 --> 00:41:59.380 they can't chew the mice within four weeks with this cocktail. 871 00:41:59.469 --> 00:42:02.429 It has three components, which are top secret, My lab 872 00:42:02.469 --> 00:42:05.750 is sworn to secrecy. After four weeks, we give it 873 00:42:05.769 --> 00:42:09.849 to them three days a week, Monday, Wednesday, Friday, weekends off. 874 00:42:10.570 --> 00:42:16.179 Within those four weeks, they get better physically, mentally. Excuse me. 875 00:42:16.599 --> 00:42:17.699 So we put them through tests. 876 00:42:17.780 --> 00:42:18.880 Just in a couple of days? 877 00:42:19.619 --> 00:42:20.780 No, three days a week for a month. 878 00:42:21.260 --> 00:42:23.400 Oh, okay. I found this guy's Instagram. This is the guy? 879 00:42:23.519 --> 00:42:27.320 He went viral last year. He's being 59 years old. What? 880 00:42:28.519 --> 00:42:30.000 It seems so not real. 881 00:42:31.099 --> 00:42:33.360 He looks like he's maybe 30. 882 00:42:33.360 --> 00:42:36.800 Exactly. He might have just amazing genetics. Well, look at 883 00:42:36.840 --> 00:42:40.900 Yoel Romero. There are people that are freaks. He's from Singapore. 884 00:42:40.960 --> 00:42:41.179 Yeah. 885 00:42:41.920 --> 00:42:46.110 Wow. Twando, Kwando Tan. And he's 60 years old? 886 00:42:46.190 --> 00:42:48.929 Yeah, he's been gone... Without facelifts? 887 00:42:48.969 --> 00:42:51.269 Yeah, I don't know. He certainly doesn't look like he's 888 00:42:51.329 --> 00:42:53.889 out of facelifts. Yeah, right. His skin is fucking incredible. 889 00:42:53.949 --> 00:42:56.250 Yeah. But he's probably never been in the sun. 890 00:42:56.050 --> 00:42:58.110 Except for this video. It could be a full AI 891 00:42:58.510 --> 00:43:03.090 account that's trolling everyone. I don't... No. That's possible, too. Like, 892 00:43:03.110 --> 00:43:04.769 look at that picture right there. Like, that looks a 893 00:43:04.769 --> 00:43:07.489 little AI-ish. Go back to that one again. Keep your 894 00:43:07.510 --> 00:43:12.309 pants on, Jamie. Relax, relax. That looks very AI, doesn't it? 895 00:43:12.309 --> 00:43:17.050 I'm just saying it could be. It's all. His 59th birthday. 896 00:43:17.230 --> 00:43:19.909 His whole thing is that he's young. 58 looks half 897 00:43:19.949 --> 00:43:22.880 his age. Wow. I mean. 898 00:43:23.199 --> 00:43:23.929 This will be normal. 899 00:43:24.659 --> 00:43:26.559 Yeah, this is 2024, so it's not. This has been 900 00:43:26.579 --> 00:43:29.019 going on for a while. Okay, so this is pre-AI. Yeah, 901 00:43:29.199 --> 00:43:31.789 if it's fake, then he would have been. called out now, 902 00:43:31.849 --> 00:43:32.409 I feel like. 903 00:43:32.449 --> 00:43:32.880 Right. 904 00:43:33.030 --> 00:43:35.340 So he might just be a genetic freak. Could be. Yep. 905 00:43:36.099 --> 00:43:39.900 Which is interesting, right? Like, do you guys study the different... Like, 906 00:43:39.960 --> 00:43:43.739 you know, unfortunately, certain people that have like pale people, 907 00:43:43.780 --> 00:43:47.469 for instance, with thin skin, they age hardcore. They go. 908 00:43:47.510 --> 00:43:49.489 And there are those kids that get old in their teens. 909 00:43:49.630 --> 00:43:49.889 Right. 910 00:43:49.909 --> 00:43:51.849 We study that as well. Yeah. 911 00:43:51.889 --> 00:43:51.969 Yeah. 912 00:43:52.050 --> 00:43:55.210 That's weird. We're reversing that too. But yeah, we do 913 00:43:55.250 --> 00:43:56.469 study the genetics of aging. 914 00:43:56.510 --> 00:44:00.030 That's the real... application for it where people are going 915 00:44:00.050 --> 00:44:01.909 to be excited about it. People that have that, what 916 00:44:01.949 --> 00:44:03.110 is it called? Progeria? 917 00:44:03.130 --> 00:44:03.869 Progeria, exactly. 918 00:44:03.929 --> 00:44:04.210 Yeah. 919 00:44:04.449 --> 00:44:06.610 Yeah. And so we have mice that have this same 920 00:44:06.670 --> 00:44:08.869 gene mutation and they get old really quickly and we're 921 00:44:09.190 --> 00:44:10.530 giving them the drink right now. 922 00:44:11.309 --> 00:44:13.269 And so in the drink, you give it to them 923 00:44:13.590 --> 00:44:14.989 how often and for a month? 924 00:44:15.449 --> 00:44:19.320 It's once a day, every other day, three days a 925 00:44:19.340 --> 00:44:24.059 week for a month. And yeah, in normal old mice, 926 00:44:24.099 --> 00:44:27.590 we see them fitter, stronger, better memory. They run around 927 00:44:27.610 --> 00:44:27.909 the cage. 928 00:44:27.929 --> 00:44:28.550 In just a month. 929 00:44:29.210 --> 00:44:31.730 It's amazing. We only did a month because it was 930 00:44:31.769 --> 00:44:34.829 Christmas holiday season. We didn't, we didn't want to go 931 00:44:34.869 --> 00:44:37.489 for longer, but, uh, it worked in four weeks. I'm shocked. 932 00:44:37.989 --> 00:44:40.630 Even these genes require six to eight weeks to work 933 00:44:40.949 --> 00:44:42.969 for revision, uh, recovery of vision. 934 00:44:44.409 --> 00:44:47.190 And so this, this is working on a different pathway. 935 00:44:47.989 --> 00:44:50.389 Well, here's the cool thing. We, we think it's working 936 00:44:50.409 --> 00:44:54.960 through the same mechanism, the reboot, the reinstallation of software. Um, 937 00:44:55.309 --> 00:44:58.889 the drink. Because there are genes called TETs. There are 938 00:44:58.929 --> 00:45:01.869 three of them in the body. And they do something... 939 00:45:01.809 --> 00:45:05.369 Spell that? T-E-T. Capital T-E-T. There's one, two, three. And 940 00:45:05.449 --> 00:45:09.480 these are genes that make enzymes that remove these methyls 941 00:45:09.679 --> 00:45:13.840 off the DNA. So they control the clock. And if 942 00:45:13.880 --> 00:45:17.860 we get rid of those genes, our system doesn't work. 943 00:45:18.000 --> 00:45:22.289 We cannot restore vision. And our pill doesn't work without 944 00:45:23.150 --> 00:45:26.210 removing and altering those chemicals. So In other words, it's 945 00:45:26.250 --> 00:45:28.949 not just because the chemicals make the cell healthier. It's 946 00:45:28.969 --> 00:45:31.789 actually resetting this clock on the DNA. 947 00:45:32.769 --> 00:45:33.050 Whoa. 948 00:45:33.710 --> 00:45:35.800 And that was the big deal. I said whoa when 949 00:45:35.840 --> 00:45:38.260 my student told me. And that's why I think it 950 00:45:38.300 --> 00:45:41.599 got the cover of Nature magazine, which is we're actually 951 00:45:41.860 --> 00:45:45.360 looking at the clock of life. And we've realized that 952 00:45:45.420 --> 00:45:49.250 this clock that goes around, this biological clock, isn't just 953 00:45:49.309 --> 00:45:51.710 a clock. When you move the hands of the clock, 954 00:45:52.070 --> 00:45:57.030 time goes backwards for the body. meaning the clock is aging, 955 00:45:58.170 --> 00:46:01.070 and aging is the clock. Wow. 956 00:46:01.449 --> 00:46:05.369 What is it? You don't really know in terms of humans, 957 00:46:05.730 --> 00:46:10.929 but is there any indication that improves cognitive function in mice? Yes. 958 00:46:11.570 --> 00:46:13.690 I can say without a doubt that other labs and 959 00:46:13.750 --> 00:46:16.110 ours have shown that when you reverse the age of 960 00:46:16.130 --> 00:46:19.170 the brain in a mouse, it gets better at learning. 961 00:46:19.730 --> 00:46:22.389 And we even have some hints, and we're going to 962 00:46:22.429 --> 00:46:24.849 publish this, that lost memories come back. 963 00:46:25.829 --> 00:46:26.170 Whoa. 964 00:46:26.489 --> 00:46:30.170 So Alzheimer's patients, I believe, still have memories. They just 965 00:46:30.190 --> 00:46:33.510 cannot access them. And that one day we can reverse 966 00:46:33.610 --> 00:46:37.829 Alzheimer's disease by making the brain young. And using that approach, 967 00:46:37.909 --> 00:46:41.070 making the whole body young, we can cure diseases that 968 00:46:41.090 --> 00:46:41.989 are currently incurable. 969 00:46:43.630 --> 00:46:44.469 Holy shit. 970 00:46:46.110 --> 00:46:47.449 Well, young people don't get Alzheimer's. 971 00:46:47.469 --> 00:46:47.659 Why? 972 00:46:47.679 --> 00:46:51.260 Because the body can tackle the problem. The young body 973 00:46:51.300 --> 00:46:54.059 can heal itself. So my approach is make the body young. 974 00:46:54.460 --> 00:46:55.780 It will heal itself in every way. 975 00:46:57.219 --> 00:46:57.980 Well, do you have children? 976 00:46:58.500 --> 00:46:58.719 Three. 977 00:46:59.099 --> 00:47:02.860 Yeah. One of the things that's just phenomenal is watching 978 00:47:02.880 --> 00:47:08.050 them heal. Yeah. I'm like it is so– it's so 979 00:47:08.170 --> 00:47:10.869 wild but also you envy them so much because they 980 00:47:10.889 --> 00:47:13.670 get cut and it's like two days later. Like where's 981 00:47:13.690 --> 00:47:17.510 your cut? It's fucking gone? Like that's crazy. My daughter 982 00:47:17.530 --> 00:47:20.630 had a cutter. She fell and knocked her head and 983 00:47:20.670 --> 00:47:22.769 she had this like dark spot on her head like 984 00:47:22.849 --> 00:47:26.000 where she got injured. It was like four or five days. 985 00:47:26.039 --> 00:47:27.639 It was gone. And I was like, that fucking thing 986 00:47:27.679 --> 00:47:29.639 would be with me for four months. Yeah. 987 00:47:30.420 --> 00:47:32.400 And the good thing is if we rub our cocktail 988 00:47:32.579 --> 00:47:34.469 on the skin of the mice, they heal like they're 989 00:47:34.489 --> 00:47:34.889 young again. 990 00:47:34.909 --> 00:47:37.849 Oh, so that would be like a great application for 991 00:47:37.909 --> 00:47:40.769 ladies who want the beauty treatment on the face, right? 992 00:47:40.909 --> 00:47:41.809 That's where we're headed. 993 00:47:42.090 --> 00:47:42.369 Whoa. 994 00:47:42.630 --> 00:47:45.809 Yeah. And we're working on hair. We can grow human 995 00:47:45.849 --> 00:47:46.630 hair on mice now. 996 00:47:47.090 --> 00:47:47.389 Really? 997 00:47:47.429 --> 00:47:49.510 That took a few years. And now we can check 998 00:47:49.550 --> 00:47:52.250 if we can regrow hair and make it dark again. 999 00:47:52.329 --> 00:47:54.030 You can grow human hair on mice. 1000 00:47:54.369 --> 00:47:56.070 Yeah. I'm not allowed to– actually, I did post it 1001 00:47:56.130 --> 00:48:00.030 on Instagram and the university said get that down. But 1002 00:48:00.110 --> 00:48:02.869 it exists. We grow it from stem cells, from human 1003 00:48:03.289 --> 00:48:06.210 stem cells. We make little balls of hair. It takes 1004 00:48:06.250 --> 00:48:08.719 a few months. We open up the ball to make 1005 00:48:08.739 --> 00:48:11.920 a flat piece of skin, human skin, and we put 1006 00:48:11.940 --> 00:48:14.400 that in the back of a mouse that can accept 1007 00:48:14.460 --> 00:48:17.079 human skin. And then you get black tufts of hair 1008 00:48:17.099 --> 00:48:18.019 from humans in a mouse. 1009 00:48:18.039 --> 00:48:19.340 Could you get any kind of hair? Like could I 1010 00:48:19.360 --> 00:48:20.900 get an afro? I just want to get one that 1011 00:48:20.920 --> 00:48:23.400 pisses people off. I would love an afro, like a 1012 00:48:23.519 --> 00:48:26.320 Colin Kaepernick type, just a big crazy one. 1013 00:48:26.480 --> 00:48:29.559 Yeah, we can grow hair. We can do that. We're 1014 00:48:29.579 --> 00:48:30.960 one of the few labs that can grow this hair. 1015 00:48:31.840 --> 00:48:33.860 So I thought about doing that for a company, but 1016 00:48:33.880 --> 00:48:35.460 I think hair transplants would just be easier. 1017 00:48:36.480 --> 00:48:38.340 Oh, right. So you would grow hair in a lab 1018 00:48:38.380 --> 00:48:39.539 and then transplant those hairs? 1019 00:48:39.719 --> 00:48:40.559 We can do that, yeah. 1020 00:48:41.059 --> 00:48:43.039 Oh, well, that's the thing because I got a hair transplant. 1021 00:48:43.059 --> 00:48:47.809 But the way I describe it, it's like taking people 1022 00:48:48.130 --> 00:48:50.989 that are really healthy and moving them into a town 1023 00:48:51.010 --> 00:48:55.199 where everyone's dying. Because, like, you're taking hair from back 1024 00:48:55.260 --> 00:48:57.480 here where it's going to stay and you're putting it 1025 00:48:57.519 --> 00:48:58.739 up here where it's all falling out. 1026 00:48:59.199 --> 00:48:59.880 Oh, it didn't thrive? 1027 00:49:00.500 --> 00:49:00.860 What's that? 1028 00:49:00.900 --> 00:49:02.079 It doesn't thrive if you move it? 1029 00:49:02.320 --> 00:49:04.119 Oh, it thrives, but everybody else dies. 1030 00:49:04.239 --> 00:49:05.300 Oh, shit. 1031 00:49:05.340 --> 00:49:07.150 You know, you can only take so much from the 1032 00:49:07.190 --> 00:49:09.150 back of your head and move it to the top 1033 00:49:09.190 --> 00:49:10.550 of your head. That's why a lot of guys with 1034 00:49:10.590 --> 00:49:13.929 hair transplants look goofy because you have, like, this strong 1035 00:49:13.989 --> 00:49:16.710 hairline in the front and it goes back like that 1036 00:49:16.730 --> 00:49:18.309 and then everything else looks like chaos. 1037 00:49:18.550 --> 00:49:20.460 Oh, that sucks. You know what I take? for my hair? 1038 00:49:20.659 --> 00:49:21.039 What do you take? 1039 00:49:21.079 --> 00:49:24.179 Among other things. Viagra. 1040 00:49:25.199 --> 00:49:25.880 Viagra? 1041 00:49:26.800 --> 00:49:28.340 Yeah, actually. I shouldn't say the brand name. 1042 00:49:28.519 --> 00:49:30.699 That's why I take it for my hair. 1043 00:49:30.739 --> 00:49:33.619 That's what I tell everybody. That is true. It's low dose, 1044 00:49:33.619 --> 00:49:37.010 7 milligrams a day of Tadalafil. And it's good for 1045 00:49:37.110 --> 00:49:37.750 a lot of things. 1046 00:49:38.389 --> 00:49:41.710 I know it's good for endurance. Yeah. Yeah, because I 1047 00:49:41.730 --> 00:49:45.059 know athletes who take it for endurance, they probably take 1048 00:49:45.079 --> 00:49:47.719 it to fuck too. Let's not kid ourselves. 1049 00:49:48.519 --> 00:49:53.300 Well, it's a nice benefit. When a paper just came 1050 00:49:53.360 --> 00:49:57.619 out about its role in preventing cancer, I tweeted what's 1051 00:49:57.659 --> 00:50:01.010 not to love. People love that tweet. But the point 1052 00:50:01.289 --> 00:50:05.309 is actually last week they found that these drugs in 1053 00:50:05.349 --> 00:50:08.730 mice and seemingly in people who take these drugs are 1054 00:50:08.769 --> 00:50:11.849 actually resistant. certain types of cancer is like head and 1055 00:50:11.869 --> 00:50:12.389 neck cancer. 1056 00:50:13.110 --> 00:50:13.469 Interesting. 1057 00:50:13.510 --> 00:50:14.150 So they're turning out to. 1058 00:50:14.150 --> 00:50:15.889 Be really important. Because it improves blood flow? 1059 00:50:16.590 --> 00:50:19.170 Well, two reasons that are not related to blood flow, 1060 00:50:19.190 --> 00:50:22.300 but they're related to what's called nitric oxide signaling, which 1061 00:50:22.360 --> 00:50:24.599 is what helps dilate blood vessels in all your body, 1062 00:50:24.639 --> 00:50:28.719 including your penis. The other two mechanisms, one showed that 1063 00:50:29.260 --> 00:50:33.559 tadalafil is good for exposing the tumor to the immune system. 1064 00:50:34.260 --> 00:50:39.590 There are certain cells called MDSCs that protect the tumor 1065 00:50:39.630 --> 00:50:43.610 from getting attacked and the drug stops that. So now 1066 00:50:43.699 --> 00:50:47.980 the tumors shrink in mice and seemingly in people, in tumors. 1067 00:50:48.420 --> 00:50:51.320 And then the second mechanism is really interesting. It seems to, 1068 00:50:51.940 --> 00:50:55.059 this was Sedanafil, so this is now Viagra, found that 1069 00:50:55.340 --> 00:50:59.590 the cancer is, a lot of cancers thrive on cholesterol 1070 00:51:00.130 --> 00:51:02.869 and this blocks the ability of cancer cells to use cholesterol. 1071 00:51:03.210 --> 00:51:04.769 I thought they thrived on glucose. 1072 00:51:04.849 --> 00:51:08.250 That too, exactly. So you want to be in ketosis 1073 00:51:08.309 --> 00:51:12.690 if you've got The tumor in general. So fasting is good. 1074 00:51:13.130 --> 00:51:16.849 But now it looks like these ED drugs might be 1075 00:51:16.889 --> 00:51:17.719 good for it as well. 1076 00:51:18.030 --> 00:51:25.159 Fascinating. And wasn't– I think Viagra was a– it was 1077 00:51:25.199 --> 00:51:28.420 an accident, right? Wasn't it a blood pressure medication? 1078 00:51:28.440 --> 00:51:30.239 It's a good story. It was for angina, right? It 1079 00:51:30.280 --> 00:51:34.610 was for your heart. But the story goes that women 1080 00:51:34.650 --> 00:51:37.110 especially and the men didn't want to give up the 1081 00:51:37.150 --> 00:51:41.969 drugs that they had left over. It was amazing. I 1082 00:51:41.989 --> 00:51:45.230 think it was 75% had a positive reaction for erections 1083 00:51:45.289 --> 00:51:49.230 and without it, 22. So it's very clear that it 1084 00:51:49.269 --> 00:51:49.730 was working. 1085 00:51:50.550 --> 00:51:53.510 Interesting. And so how does it help hair? 1086 00:51:55.159 --> 00:51:57.840 Well, we don't know for sure, but there's a lot 1087 00:51:57.860 --> 00:52:00.900 of evidence that part of the reason hair dies out 1088 00:52:00.980 --> 00:52:03.719 and stops growing is a lack of blood flow. And 1089 00:52:03.739 --> 00:52:06.139 the minoxidil that people put on their hair helps with that. 1090 00:52:06.340 --> 00:52:10.059 Right. Interesting. And then DHT inhibitors. Yes. 1091 00:52:10.449 --> 00:52:10.929 Exactly. 1092 00:52:11.070 --> 00:52:11.909 Also help. 1093 00:52:11.929 --> 00:52:14.940 That B-dutesteride people can take orally. 1094 00:52:15.400 --> 00:52:18.840 The problem with that is my friend had severe depression 1095 00:52:18.880 --> 00:52:21.739 when he took that. Yeah. It really fucked him up. 1096 00:52:22.059 --> 00:52:25.329 And he didn't realize because he didn't understand that that 1097 00:52:25.369 --> 00:52:27.329 was– he was like, what is wrong with me? And 1098 00:52:27.389 --> 00:52:30.150 he was getting suicidal. And then he got off of 1099 00:52:30.230 --> 00:52:31.670 it and it just went away. And he's like, oh 1100 00:52:31.690 --> 00:52:34.710 my God, I can't believe that. This episode is sponsored 1101 00:52:34.750 --> 00:52:39.469 by BetterHelp. You've probably heard about BetterHelp before, but maybe 1102 00:52:39.530 --> 00:52:43.039 you haven't heard from those who have actually used BetterHelp. 1103 00:52:43.360 --> 00:52:46.219 That feedback can tell you everything you need to know. 1104 00:52:46.579 --> 00:52:50.969 Go to betterhelp.com slash reviews and check out the feedback 1105 00:52:51.010 --> 00:52:54.690 from hundreds of people saying how much they love this service. 1106 00:52:55.070 --> 00:52:58.059 It's easy to see why. To get started, all you 1107 00:52:58.099 --> 00:53:00.019 have to do is answer a few questions. You'll get 1108 00:53:00.099 --> 00:53:03.340 matched up with a therapist. based on your needs, and 1109 00:53:03.739 --> 00:53:06.199 if it's not the right fit, you can switch therapists 1110 00:53:06.300 --> 00:53:09.650 at any time. See the reviews, see what stands out, 1111 00:53:09.730 --> 00:53:13.650 and see if BetterHelp is right for you. Visit betterhelp.com 1112 00:53:14.010 --> 00:53:21.039 slash J-R-E. That's betterhelp.com slash J-R-E. Yeah. 1113 00:53:21.719 --> 00:53:25.780 Well, I'm taking it for a number of reasons, including 1114 00:53:25.800 --> 00:53:28.119 my hair and my prostate, to see if I can 1115 00:53:28.139 --> 00:53:31.190 keep it from growing. but fortunately I haven't had that 1116 00:53:31.230 --> 00:53:31.630 side effect. 1117 00:53:32.210 --> 00:53:35.530 It depends, right? It varies biologically depending on the person. 1118 00:53:35.739 --> 00:53:38.880 Yeah, it's important when either of us says that drug's good, 1119 00:53:38.920 --> 00:53:42.280 that drug's bad. People realize that you have to test 1120 00:53:42.340 --> 00:53:44.239 it with doctor's supervision. 1121 00:53:44.460 --> 00:53:46.340 Yeah, that was where I was going to get to. 1122 00:53:47.460 --> 00:53:51.489 Because different medications have different reactions or different people's reactions 1123 00:53:51.510 --> 00:53:56.489 to medications, they vary quite wildly. So before you make 1124 00:53:56.630 --> 00:54:01.190 this public, Like how do you determine whether or not 1125 00:54:01.230 --> 00:54:04.429 this is going to be safe for a wide variety 1126 00:54:04.469 --> 00:54:06.269 of people to reverse aging? 1127 00:54:06.750 --> 00:54:10.510 Oh, my drug, our drug that we're making. Well, we 1128 00:54:10.530 --> 00:54:13.139 will test it on a lot of people before it 1129 00:54:13.179 --> 00:54:15.090 goes out into the wide world. 1130 00:54:15.179 --> 00:54:17.199 And you've started testing it on people so far? Yeah. 1131 00:54:17.219 --> 00:54:20.780 There are people right now who have this– these genes 1132 00:54:20.820 --> 00:54:21.340 in their eye. 1133 00:54:21.820 --> 00:54:22.500 And how's it going? 1134 00:54:23.639 --> 00:54:24.480 I'm not allowed to say. 1135 00:54:24.500 --> 00:54:27.300 Can you wink twice if it's great? No. 1136 00:54:28.440 --> 00:54:31.320 I would say that everything's on target. 1137 00:54:32.000 --> 00:54:33.659 Okay. That's good to hear. 1138 00:54:34.070 --> 00:54:35.170 Nothing bad to report. 1139 00:54:35.530 --> 00:54:36.449 Nothing bad to report. 1140 00:54:36.469 --> 00:54:38.250 I think those might be the words I'm allowed to say. 1141 00:54:38.369 --> 00:54:40.829 And is that the only clinical trials you've used with 1142 00:54:40.889 --> 00:54:42.690 any of these applications for humans? 1143 00:54:43.210 --> 00:54:46.510 So far, that was the first. Glaucoma and also sudden blindness. 1144 00:54:46.989 --> 00:54:50.719 It's called Nyon, which is now twice as more prevalent 1145 00:54:50.800 --> 00:54:52.380 because of the GLP-1 drugs. 1146 00:54:53.639 --> 00:54:54.139 Really? 1147 00:54:54.420 --> 00:54:57.800 It's not well known. Obviously, companies don't want to Talk 1148 00:54:57.820 --> 00:55:02.530 about it. But yes, sudden blindness has doubled seemingly because 1149 00:55:02.590 --> 00:55:03.670 of these meds. 1150 00:55:04.190 --> 00:55:09.010 Holy shit. Sudden blindness has doubled because of GLP-1s? 1151 00:55:09.030 --> 00:55:11.449 Due to nion, which is like a stroke in your eye. 1152 00:55:12.489 --> 00:55:14.710 And then your other eye can go, which is pretty scary. 1153 00:55:15.489 --> 00:55:17.949 And there's nothing you can do about it. Hopefully our 1154 00:55:17.989 --> 00:55:19.409 drug does work for those people. 1155 00:55:20.469 --> 00:55:26.150 And obviously correlation does not equal causation, but it seems 1156 00:55:26.210 --> 00:55:28.010 to be. Yeah. 1157 00:55:28.030 --> 00:55:30.429 There's a scientist at Harvard. You could look up his work, 1158 00:55:31.159 --> 00:55:36.840 Joe Rizzo. It looks like it's repeatable across the planet. Wow. 1159 00:55:36.940 --> 00:55:39.059 That's terrible because there's so many people out there that 1160 00:55:39.079 --> 00:55:42.500 are just telling everyone they should get on GLP-1s. I've 1161 00:55:42.539 --> 00:55:47.690 seen that by online people, like online podcasters saying everyone 1162 00:55:47.710 --> 00:55:51.809 should get on GLP-1s. It's groundbreaking technology. This is amazing. 1163 00:55:51.869 --> 00:55:55.659 It's going to transform society. I'm like, We just started 1164 00:55:55.719 --> 00:55:58.329 taking these. What the fuck are you saying? Yeah. 1165 00:55:58.730 --> 00:56:00.650 It's not risk-free. Same with ED drugs. 1166 00:56:00.829 --> 00:56:03.849 Here it goes. Recent studies suggest that a potential rare 1167 00:56:03.909 --> 00:56:09.650 link between GLP-1 receptor agonist medication such as Ozempic, Wagovi, blah, blah, blah, 1168 00:56:10.250 --> 00:56:17.519 and a condition called non-arteritic anterior– what's that word? Ischemic? Ischemic. 1169 00:56:17.679 --> 00:56:23.019 Ischemic optic neuropathy. An eye stroke can cause sudden painless 1170 00:56:23.079 --> 00:56:24.989 loss of vision– Well, very low is like– What does 1171 00:56:25.010 --> 00:56:26.440 that mean? More than 10,000 people. One in 10,000? Yeah. Yeah, 1172 00:56:26.469 --> 00:56:28.300 that's– No, total of 10,000. Oh, total of 10,000 so far. 1173 00:56:28.320 --> 00:56:29.500 How many people are taking this stuff? I think it's 1174 00:56:29.519 --> 00:56:50.769 pretty– the drugs were 68.6 times more likely to develop 1175 00:56:50.809 --> 00:56:54.650 this and eight times more likely to develop diabetic. What 1176 00:56:54.710 --> 00:57:08.030 is that? We only got the blurb. Oh my God. Then. Wow. Yeah, man, 1177 00:57:08.170 --> 00:57:11.510 these things are just, they're just rolling out. And the 1178 00:57:11.550 --> 00:57:15.449 people that are like super enthusiastic and also, uh, They 1179 00:57:15.489 --> 00:57:18.210 have some sort of a financial interest in promoting these things, 1180 00:57:18.269 --> 00:57:20.570 which oftentimes does seem to be the case with a 1181 00:57:20.610 --> 00:57:22.909 lot of these people. They have either stock in these 1182 00:57:22.969 --> 00:57:26.739 companies or some sort of a stake in them. Yeah, 1183 00:57:26.780 --> 00:57:27.659 it's true. 1184 00:57:27.739 --> 00:57:30.219 I will say to counter that, that the GLP-1 drugs 1185 00:57:30.260 --> 00:57:32.980 have probably saved millions of lives already and they're pretty common. 1186 00:57:33.019 --> 00:57:35.559 I think 10 percent of people are trying them and 1187 00:57:35.559 --> 00:57:36.400 25 percent want to. 1188 00:57:36.940 --> 00:57:38.889 Yeah. I mean they don't work for everybody. I have 1189 00:57:38.909 --> 00:57:40.690 a good friend of mine that had a terrible reaction 1190 00:57:40.730 --> 00:57:43.869 from it and he was hospitalized. Oh, no. Yeah. I 1191 00:57:43.909 --> 00:57:46.909 know other people where it's completely transformed their life and 1192 00:57:46.949 --> 00:57:50.079 they've lost a ton of weight, particularly people that just– 1193 00:57:50.650 --> 00:57:53.730 for whatever reason, the food addiction was so incredibly strong 1194 00:57:53.989 --> 00:57:58.750 that whatever– their constitution, the way they're designed, the way 1195 00:57:58.769 --> 00:58:01.309 they're built, the way they've evolved as a human being, 1196 00:58:01.630 --> 00:58:04.989 they weren't capable of overcoming it. They take the GLP-1s 1197 00:58:05.449 --> 00:58:08.780 and then they sort of start getting moving. And then 1198 00:58:08.820 --> 00:58:10.800 they lose all the weight. They start feeling better. They 1199 00:58:10.820 --> 00:58:13.139 start making a lot of other positive changes. You get 1200 00:58:13.179 --> 00:58:16.139 that momentum, which I always talk about, which is one 1201 00:58:16.159 --> 00:58:19.329 of the most important things for transforming your life. Everyone 1202 00:58:19.349 --> 00:58:22.329 wants to talk about discipline. I think discipline is the primary. 1203 00:58:22.590 --> 00:58:25.570 That's the main engine. But one of the things that 1204 00:58:25.630 --> 00:58:28.610 comes along with any kind of an exercise program or 1205 00:58:28.630 --> 00:58:31.840 a changing your life program, where you start getting positive results, 1206 00:58:32.159 --> 00:58:34.699 is momentum. And momentum is absolutely huge. 1207 00:58:34.780 --> 00:58:35.119 Thank you. 1208 00:58:35.219 --> 00:58:36.300 Because then you start feeling. 1209 00:58:36.320 --> 00:58:37.079 That's so important. 1210 00:58:37.099 --> 00:58:40.289 This is good. So I think GLP-1s are fantastic for 1211 00:58:40.329 --> 00:58:41.289 getting people going. 1212 00:58:41.329 --> 00:58:44.969 Yes. Everybody should hear this. It's really important. I'll give 1213 00:58:44.989 --> 00:58:49.269 you my example. It's a classic case. I couldn't fast 1214 00:58:49.309 --> 00:58:53.000 for more than about a day. I wanted to do more. 1215 00:58:53.059 --> 00:58:54.960 I know that three days fasting is good. A week 1216 00:58:54.980 --> 00:58:56.760 can be even better. But I couldn't do it. I 1217 00:58:57.360 --> 00:58:58.840 don't have a lot of willpower when it comes to 1218 00:58:58.880 --> 00:59:02.909 this kind of stuff. I tried a JLP1 receptor agonist, 1219 00:59:02.969 --> 00:59:04.909 I gave it, and it was easy. I didn't even 1220 00:59:05.429 --> 00:59:07.070 feel like I needed to snack at night, which is 1221 00:59:07.130 --> 00:59:08.829 one of the things that I and many people suffer from. 1222 00:59:09.599 --> 00:59:12.219 But the fact that I could do it, I went 1223 00:59:12.320 --> 00:59:15.030 off the drug. I didn't need it. But now I 1224 00:59:15.070 --> 00:59:18.829 can fast for– I went for two weeks a couple 1225 00:59:18.849 --> 00:59:21.550 of months ago. It's easy now. Now that I know 1226 00:59:21.570 --> 00:59:24.010 that I can do it mentally, it's not hard at all. 1227 00:59:24.289 --> 00:59:24.889 The momentum. 1228 00:59:25.269 --> 00:59:26.809 Exactly. I know what's possible. 1229 00:59:26.969 --> 00:59:36.619 Yeah. Yeah. That's fascinating. Are you still on a plant-based diet? Mostly. Yeah. 1230 00:59:36.739 --> 00:59:39.719 I just had a conversation with a friend of mine 1231 00:59:39.760 --> 00:59:41.920 about this. I don't know how much of the information 1232 00:59:41.940 --> 00:59:43.820 that he was telling me was totally accurate. But what 1233 00:59:43.860 --> 00:59:48.550 he was saying was that he was told before he 1234 00:59:48.590 --> 00:59:51.789 did fasting that one of the best– because he's a runner. 1235 00:59:52.190 --> 00:59:54.869 He said one of the best ways to get into 1236 00:59:54.949 --> 00:59:59.690 fasting is to get your body into ketosis first. He 1237 00:59:59.750 --> 01:00:03.210 said– and what he thinks is that a carnivore-based diet 1238 01:00:03.690 --> 01:00:05.929 and what he was told was a good way. If 1239 01:00:05.969 --> 01:00:08.469 you could do that for a few weeks, it mitigates 1240 01:00:08.489 --> 01:00:11.110 your appetite. Like one of the things that happens with 1241 01:00:11.170 --> 01:00:15.550 a lot of these diets that regulate insulin resistance is 1242 01:00:15.630 --> 01:00:20.269 that when you get used to consuming just fats and protein, 1243 01:00:20.690 --> 01:00:23.349 you don't have the kind of hunger pangs that you 1244 01:00:23.389 --> 01:00:27.050 have with carbohydrates. Like when I– if I go in 1245 01:00:27.070 --> 01:00:30.530 a bad streak and I'm eating pizza and pasta and 1246 01:00:31.230 --> 01:00:32.670 I've done that in the past, I don't really do 1247 01:00:32.710 --> 01:00:36.699 that much unless I'm on vacation. In the past though, 1248 01:00:37.239 --> 01:00:39.960 what I would get hungry, I would get crazy hungry. 1249 01:00:40.320 --> 01:00:42.940 Like I've got to eat now. I don't get that 1250 01:00:42.980 --> 01:00:46.260 at all anymore because I'm mostly on a carnivore-based diet. 1251 01:00:46.559 --> 01:00:49.139 Mostly what I eat– like you look at the bulk 1252 01:00:49.159 --> 01:00:53.159 of my diet. It's meat and fermented vegetables. It's meat 1253 01:00:53.280 --> 01:00:56.719 and like– Kimchi and sauerkraut and stuff along those lines. 1254 01:00:57.119 --> 01:01:00.480 And when I eat like that, my hunger is very 1255 01:01:00.559 --> 01:01:04.679 easy to control. And I've gone 24 hours like it's nothing, 1256 01:01:05.039 --> 01:01:07.300 not eating. It's like not a problem at all. But 1257 01:01:07.340 --> 01:01:09.440 that's the most I've ever fasted is 24 hours. 1258 01:01:09.579 --> 01:01:12.460 Okay. Well, see if you can go for three. It's 1259 01:01:12.500 --> 01:01:15.550 really worth it. You feel really great. Ketosis is wonderful. 1260 01:01:15.619 --> 01:01:16.949 That's what everybody says. Yeah. 1261 01:01:17.150 --> 01:01:19.389 And you go into what's called deep cleansing. It's called 1262 01:01:20.269 --> 01:01:23.989 chaperone-mediated autophagy or CMA. Okay. And a friend of mine 1263 01:01:24.010 --> 01:01:28.190 in New York, Maria Corvo, studies this. And it cleans 1264 01:01:28.269 --> 01:01:30.150 out a lot of the old proteins in your body. 1265 01:01:30.570 --> 01:01:33.050 So ketosis doesn't just make you feel good. You're actually 1266 01:01:33.429 --> 01:01:36.670 renewing your protein in your body and rebuilding it. And 1267 01:01:36.690 --> 01:01:38.929 so I do that as an anti-aging thing. 1268 01:01:39.010 --> 01:01:42.639 What I find is the biggest benefit is mental acuity. 1269 01:01:43.440 --> 01:01:46.239 It has a giant impact when I stick to the 1270 01:01:46.280 --> 01:01:52.159 diet in terms of my ability to form sentences, recall information, 1271 01:01:52.380 --> 01:01:55.199 and just be present in podcasts. 1272 01:01:55.500 --> 01:01:59.230 Yeah. So in my podcast, what you do is really 1273 01:01:59.349 --> 01:02:02.730 quite difficult. You make it look easy. So when I'm 1274 01:02:03.389 --> 01:02:06.190 doing my podcast, and often it's solo, so it's challenging, 1275 01:02:07.130 --> 01:02:09.269 I forget things. I have to remember hundreds of papers 1276 01:02:09.289 --> 01:02:12.190 for these things. They're quite hard. Either I'm going to fast, 1277 01:02:12.210 --> 01:02:15.269 and if I don't remember to fast, I did an experiment. 1278 01:02:15.409 --> 01:02:18.239 I took some ketones. You can drink these things, right? 1279 01:02:18.320 --> 01:02:18.500 Yeah. 1280 01:02:18.909 --> 01:02:20.829 There's the one– the little drink I think was. 1281 01:02:20.809 --> 01:02:21.409 Ketone IQ. 1282 01:02:21.449 --> 01:02:21.829 Ketone IQ. 1283 01:02:21.909 --> 01:02:23.190 Yeah, fantastic stuff. 1284 01:02:23.250 --> 01:02:24.110 Yeah, yeah. I use that. 1285 01:02:24.130 --> 01:02:25.809 I love that stuff. I do that. I take that 1286 01:02:25.849 --> 01:02:27.949 before I do UFC broadcasts. 1287 01:02:27.510 --> 01:02:28.289 A lot of times. 1288 01:02:28.309 --> 01:02:28.510 Yeah. 1289 01:02:29.369 --> 01:02:31.429 I actually took some before. 1290 01:02:31.710 --> 01:02:34.570 That's great for podcasts as well. One of the more 1291 01:02:34.639 --> 01:02:37.199 difficult things that I do is the UFC commentary because 1292 01:02:37.360 --> 01:02:42.360 it's six hours. It's six hours of talking on air live. Yeah, 1293 01:02:42.639 --> 01:02:45.900 and about fights. And I'm also recalling fights. And I'm 1294 01:02:45.940 --> 01:02:48.789 also– I'm seeing positions. So I have to remember in 1295 01:02:48.829 --> 01:02:51.949 my mind how this is finished because like in jiu-jitsu, 1296 01:02:51.969 --> 01:02:54.019 there might be– I don't know how many positions there are. 1297 01:02:54.030 --> 01:02:57.090 There's thousands. And there's moves where I'm like, what is 1298 01:02:57.110 --> 01:02:59.389 he doing? What is he doing? Oh, that's that. That's 1299 01:02:59.409 --> 01:03:03.340 the Peruvian necktie. I'm looking at his arms. Your brain 1300 01:03:03.460 --> 01:03:06.360 is– I am exhausted at the end of six hours 1301 01:03:06.699 --> 01:03:09.820 and fucking starving. Like after the UFC is over, I 1302 01:03:09.980 --> 01:03:12.820 can eat so much food. I'm so hungry. 1303 01:03:12.949 --> 01:03:13.909 But you take a little drink? 1304 01:03:14.130 --> 01:03:16.010 I take a little ketone. A little ketone IQ. Cool. 1305 01:03:16.380 --> 01:03:19.360 I take nootropics. I drink this stuff. My friend Derek 1306 01:03:19.400 --> 01:03:23.119 makes this. It's Gorilla Mind. It's a nootropic. 1307 01:03:23.500 --> 01:03:23.960 Oh, I got to try that. 1308 01:03:23.980 --> 01:03:28.289 So it's a nootropic cocktail with caffeine in it. This 1309 01:03:28.309 --> 01:03:30.329 stuff is really good for a podcast. I also take 1310 01:03:30.449 --> 01:03:33.320 Alpha Brain. Alpha Brain Black Label is phenomenal for that. 1311 01:03:33.820 --> 01:03:38.070 There's a bunch of different ones that I take. The gum, NeuroGum. 1312 01:03:38.210 --> 01:03:40.170 NeuroGum is excellent for that too. But I just do 1313 01:03:40.590 --> 01:03:42.469 fucking everything I can to maximize. 1314 01:03:42.190 --> 01:03:42.969 My– So that's how you do it. 1315 01:03:43.030 --> 01:03:43.510 All right. Yes. 1316 01:03:43.610 --> 01:03:44.590 Secret is now out. 1317 01:03:44.769 --> 01:03:45.050 All right. 1318 01:03:45.449 --> 01:03:47.570 But what you do is amazing. And I thought you 1319 01:03:47.590 --> 01:03:48.710 were on modafinil or something. 1320 01:03:48.929 --> 01:03:52.039 No. I've taken that before in the past. But the 1321 01:03:52.119 --> 01:03:54.760 problem with that stuff is I think I like it 1322 01:03:54.800 --> 01:03:56.920 too much and I want to take it all the time. 1323 01:03:57.219 --> 01:03:58.679 You know when I used to take that? If I 1324 01:03:58.719 --> 01:04:01.579 had a gig in San Diego and I drive home 1325 01:04:02.280 --> 01:04:04.960 after the gig and it was like 1 o'clock in 1326 01:04:05.000 --> 01:04:07.550 the morning when I'm done. And then I'm like, I'll 1327 01:04:07.570 --> 01:04:09.530 just go home. It's only two and a half hours. 1328 01:04:10.030 --> 01:04:11.880 And I start making the drive and you just get 1329 01:04:11.969 --> 01:04:16.460 so tired. But if I take NuVigil or ProVigil before 1330 01:04:16.500 --> 01:04:18.400 I do that, I would be able to drive. No problem. 1331 01:04:18.480 --> 01:04:20.559 Put a book on tape on. What's that? 1332 01:04:20.579 --> 01:04:21.519 Can you sleep after that? 1333 01:04:21.619 --> 01:04:21.900 Oh, yeah. 1334 01:04:22.260 --> 01:04:22.519 Yeah. 1335 01:04:22.699 --> 01:04:25.380 It doesn't seem to affect your ability to sleep, which 1336 01:04:25.440 --> 01:04:28.170 is really interesting. It's not like caffeine. Do you do it? 1337 01:04:28.219 --> 01:04:28.860 Do you take it at all? 1338 01:04:29.639 --> 01:04:32.400 I'm a definite for talks when I'm traveling. 1339 01:04:32.920 --> 01:04:33.500 Does it help you? 1340 01:04:34.139 --> 01:04:34.519 Definitely. 1341 01:04:34.820 --> 01:04:35.659 Like in what way? 1342 01:04:36.809 --> 01:04:39.530 It gets rid of my jet lag and I can focus. 1343 01:04:40.320 --> 01:04:43.860 My brain often is either scattered or filled with facts 1344 01:04:43.880 --> 01:04:46.500 that causes me like now to not be able to 1345 01:04:46.579 --> 01:04:48.920 talk properly. But if I'm on it, which I'm not, 1346 01:04:50.079 --> 01:04:51.260 I'm on point every time. 1347 01:04:52.179 --> 01:04:55.179 For me, the best thing for jet lag is exercise. 1348 01:04:55.340 --> 01:04:59.119 There's something about rigorous exercise. It doesn't even have to 1349 01:04:59.159 --> 01:05:02.300 be long. It just has to be where my heart 1350 01:05:02.340 --> 01:05:04.780 rate gets really elevated, like above 150 beats per minute 1351 01:05:04.800 --> 01:05:08.880 for a 15, 20 minutes. Like I have to really 1352 01:05:09.179 --> 01:05:13.579 go hard where I'm sweaty and breathing heavy, you know, 1353 01:05:13.639 --> 01:05:15.400 especially if I jack it up to like 180, 190, 1354 01:05:15.400 --> 01:05:18.519 like I'm doing like Tabata sprints on an airdyne bike, 1355 01:05:18.980 --> 01:05:21.239 that kind of stuff completely resets me. 1356 01:05:21.599 --> 01:05:21.800 Yeah. 1357 01:05:21.940 --> 01:05:24.769 Hard kettlebell workouts. Like I'll do like a hard series 1358 01:05:25.190 --> 01:05:27.889 where minimal amount of rest in between. So I'm really 1359 01:05:27.949 --> 01:05:32.480 pushing it. Once I relax, I'm back. It's like it, 1360 01:05:32.630 --> 01:05:34.849 whatever it is where your body just needs to like, 1361 01:05:35.320 --> 01:05:37.039 shake it up and like get all of it out 1362 01:05:37.059 --> 01:05:39.809 of your system it's like now i feel completely normal. 1363 01:05:39.590 --> 01:05:42.449 Yeah well you might remember last time we talked about 1364 01:05:42.489 --> 01:05:45.550 hormesis yes what doesn't kill you makes you stronger and 1365 01:05:45.590 --> 01:05:47.489 that's what you're doing you're putting your body into survival 1366 01:05:47.510 --> 01:05:50.900 mode so one of the reasons i mostly plants why 1367 01:05:51.139 --> 01:05:55.099 i take nmn and these other molecules is to mimic 1368 01:05:55.139 --> 01:05:57.940 that i don't work out like you do um i 1369 01:05:57.980 --> 01:06:01.989 should but i don't and why don't you uh i 1370 01:06:02.030 --> 01:06:06.909 think partly because i've Tell myself I'm too busy, which 1371 01:06:06.929 --> 01:06:12.039 is bullshit. I need a partner who will motivate me. 1372 01:06:12.219 --> 01:06:13.019 I think that would help. 1373 01:06:13.760 --> 01:06:14.739 Maybe just get a trainer. 1374 01:06:15.300 --> 01:06:16.519 That's a solution. 1375 01:06:16.539 --> 01:06:17.840 You got some cheddar. Get a trainer. 1376 01:06:19.280 --> 01:06:20.420 I got some cheddar. Oh, is that money? 1377 01:06:20.460 --> 01:06:21.059 Money, yeah. 1378 01:06:21.519 --> 01:06:25.079 No, I can definitely afford one. Yeah, you know, it's 1379 01:06:25.139 --> 01:06:27.079 on me. Actually, I will own that. 1380 01:06:27.300 --> 01:06:30.000 I just was explaining this to my friend last night. 1381 01:06:30.019 --> 01:06:31.360 He was like, I got to start working. I'm like, 1382 01:06:31.420 --> 01:06:34.369 just get a trainer. Get a trainer, someone who's good, 1383 01:06:34.809 --> 01:06:37.050 and that way they'll develop a program for you. All 1384 01:06:37.070 --> 01:06:39.190 you have to do is just show up and do 1385 01:06:39.210 --> 01:06:41.469 what they tell you to do. Just do it. And 1386 01:06:41.590 --> 01:06:44.449 it's mindless. You can just go through what they tell 1387 01:06:44.469 --> 01:06:48.159 you to do and you'll just– trust the process. You'll 1388 01:06:48.199 --> 01:06:49.179 improve radically. 1389 01:06:49.199 --> 01:06:51.039 All right. All right. Here's what we're going to do. 1390 01:06:51.500 --> 01:06:54.789 Okay. I'm going to take– Here's what we're going to do. 1391 01:06:54.820 --> 01:06:56.760 You're going to get me a jug of that fucking juice. 1392 01:06:57.179 --> 01:07:00.199 We'll swap, all right? And you'll be my trainer? 1393 01:07:00.800 --> 01:07:03.969 I'll be your trainer. I will. I've done that before 1394 01:07:03.989 --> 01:07:08.010 with my comedian friends. Really? Sure. Then I do it 1395 01:07:08.030 --> 01:07:10.969 the right way where I take him through it very easy. 1396 01:07:11.530 --> 01:07:14.059 I don't have him work out hard at all, especially 1397 01:07:14.079 --> 01:07:17.360 in the beginning. Everything is nice and easy. It's like 1398 01:07:17.400 --> 01:07:19.400 a little bit of strain. You're not going to be 1399 01:07:19.420 --> 01:07:24.300 exhausted afterwards, and we build you up. I'm a firm 1400 01:07:24.360 --> 01:07:28.340 believer in not overtaxing the system on people that are sedentary. 1401 01:07:28.889 --> 01:07:32.309 I really think it's a slow, gradual process. I think 1402 01:07:32.349 --> 01:07:33.849 you have to get better the same way you got 1403 01:07:33.929 --> 01:07:37.909 sick over time. You can make radical changes in a 1404 01:07:38.010 --> 01:07:40.809 short period of time. Don't get me wrong. And even 1405 01:07:40.889 --> 01:07:46.090 just a little bit of moderately rigorous exercise a few 1406 01:07:46.150 --> 01:07:48.469 days a week will– a few days a week. will 1407 01:07:48.510 --> 01:07:50.849 give you great improvements. But I'm not one of those 1408 01:07:50.889 --> 01:07:52.829 guys who's like, you know, we're going to do two 1409 01:07:52.889 --> 01:07:55.050 hours today and you're going to go to failure and 1410 01:07:55.070 --> 01:07:56.650 you're going to be throwing up in a garbage pan. 1411 01:07:56.949 --> 01:07:58.469 You're not going to do that again the next day. 1412 01:07:58.909 --> 01:08:00.239 I want you to do it again the next day. 1413 01:08:00.599 --> 01:08:03.599 I want you to have a nice workout where, you know, 1414 01:08:03.639 --> 01:08:06.679 you're doing like 10 push-ups and 10 sit-ups and 10 1415 01:08:06.679 --> 01:08:08.619 bodyweight squats and then we're going to do some of 1416 01:08:08.659 --> 01:08:13.389 these kettlebell cleans and kettlebell, nothing hard. Like everything's going 1417 01:08:13.409 --> 01:08:15.949 to be like, whew, okay, you put it down, you're fine. 1418 01:08:16.210 --> 01:08:19.010 And I want you to leave rejuvenated like you feel 1419 01:08:19.050 --> 01:08:22.430 like oh that was like exhilarating nothing crazy and then 1420 01:08:22.550 --> 01:08:25.409 we'll slowly start to add a little bit over time 1421 01:08:25.689 --> 01:08:27.430 that's what i think the right thing to do with 1422 01:08:27.449 --> 01:08:30.189 people who don't work out all the time you can't 1423 01:08:30.229 --> 01:08:32.510 just jump in and you know. 1424 01:08:32.529 --> 01:08:34.729 It's like fasting and skipping meals you just can't do 1425 01:08:34.989 --> 01:08:37.109 a day or three without practicing. 1426 01:08:37.020 --> 01:08:38.909 Well it's also you're going to get injured and this 1427 01:08:38.979 --> 01:08:41.020 is one of the main things that happens to people 1428 01:08:41.060 --> 01:08:42.699 that dive right into the deep end of the pool 1429 01:08:42.720 --> 01:08:44.359 when they start working out is they get hurt they 1430 01:08:44.380 --> 01:08:47.310 get muscle pulls they get They got all these different 1431 01:08:47.329 --> 01:08:49.529 things that happen because I think you just pushed your 1432 01:08:49.590 --> 01:08:53.569 body too quickly. It's like you're in boot camp. Like, well, 1433 01:08:54.180 --> 01:08:55.640 you don't have to be in boot camp. This is 1434 01:08:55.680 --> 01:08:56.939 not the way to do it. The way to do 1435 01:08:57.000 --> 01:09:01.630 it is slowly build up and trust the process. Slowly. 1436 01:09:02.050 --> 01:09:04.909 Start by, if you're overweight, like my friend Jelly Roll, 1437 01:09:04.930 --> 01:09:07.869 he lost 250 pounds. What did he do? Started walking. 1438 01:09:08.250 --> 01:09:11.350 Just started walking. Walking around the neighborhood. Walk around the block. 1439 01:09:11.670 --> 01:09:15.470 Walk upstairs. Just slowly. And then change the diet and 1440 01:09:15.489 --> 01:09:18.039 then add some stuff. Next thing you know, you're doing this. 1441 01:09:18.119 --> 01:09:20.319 And write it all down, too. That's the other thing. 1442 01:09:20.739 --> 01:09:23.170 Write down what you're going to do and write down 1443 01:09:23.229 --> 01:09:25.409 how you feel. And then keep doing that. And if 1444 01:09:25.430 --> 01:09:27.850 you can do that all the time, you'll start developing this, like, 1445 01:09:27.909 --> 01:09:30.930 momentum that we were talking about. Right. Like, okay, I'm 1446 01:09:31.270 --> 01:09:33.409 on the course. I'm on a process. But it doesn't 1447 01:09:33.449 --> 01:09:36.159 have to be like you're exhausted and then you go 1448 01:09:36.199 --> 01:09:38.859 to the lab and you're like, I can't even fucking concentrate. 1449 01:09:38.960 --> 01:09:42.220 You know, I was doing Tabata sprints on the Airdyne machine. Like, 1450 01:09:42.260 --> 01:09:42.840 this is crazy. 1451 01:09:43.300 --> 01:09:46.199 Well, that's– it's really good advice and I'm going to 1452 01:09:46.239 --> 01:09:48.180 take you up on it. So let's say I'm lucky 1453 01:09:48.199 --> 01:09:49.220 enough to come on the show again. 1454 01:09:49.659 --> 01:09:49.899 Yeah. 1455 01:09:49.960 --> 01:09:50.920 I'll wear a tight t-shirt. 1456 01:09:51.300 --> 01:09:51.819 Let's go. 1457 01:09:51.840 --> 01:09:54.520 Right. So 20 million people. 1458 01:09:54.539 --> 01:09:56.039 You're going to have to get off that fucking goofy 1459 01:09:56.159 --> 01:09:57.000 plant-based diet. 1460 01:09:57.479 --> 01:09:59.779 Well, let's speak about that because that's one of the 1461 01:09:59.800 --> 01:10:03.060 things we disagree on. I'm on a plant-based diet because 1462 01:10:03.119 --> 01:10:05.930 I've seen a lot of work on animals at least 1463 01:10:06.430 --> 01:10:09.909 that plants promote longevity. I eat a lot of protein. 1464 01:10:10.289 --> 01:10:12.659 It's interesting because you're not an animal. You know that, right? 1465 01:10:12.680 --> 01:10:13.199 I'm not a mouse. 1466 01:10:13.479 --> 01:10:14.140 You're not a mouse. 1467 01:10:14.180 --> 01:10:15.840 I'm definitely an animal, but I'm not a mouse. 1468 01:10:15.859 --> 01:10:20.840 I agree. Meat is the most nutrient-dense food that's available. 1469 01:10:20.880 --> 01:10:23.039 I love meat. I love meat. 1470 01:10:23.060 --> 01:10:26.579 She eats it all the time. I believe that there are. 1471 01:10:26.180 --> 01:10:31.279 Two states that we can be in. I should try meat, 1472 01:10:31.560 --> 01:10:32.560 and then we can see if it works. 1473 01:10:32.590 --> 01:10:33.159 You'll feel great. 1474 01:10:33.189 --> 01:10:36.210 Because I've been measuring myself with rings and blood tests. 1475 01:10:36.029 --> 01:10:38.710 For the last 20 years. You should try elk. I'll 1476 01:10:38.729 --> 01:10:39.590 get you an elk steak. 1477 01:10:40.350 --> 01:10:41.239 I'd love to try it. 1478 01:10:41.250 --> 01:10:41.710 It sounds good. Yeah. 1479 01:10:42.090 --> 01:10:42.869 I'm not against meat. 1480 01:10:42.930 --> 01:10:44.949 I will eat it. You'll eat it and you'll be like, whoa. Yeah. 1481 01:10:45.069 --> 01:10:46.210 Don't get me addicted to meat. 1482 01:10:46.229 --> 01:10:51.029 You feel it right away. Like, oh. Oh, your synapses 1483 01:10:51.050 --> 01:10:54.109 start firing. Your body starts like, yes, this is what we. 1484 01:10:54.010 --> 01:10:58.590 Wanted, David. Well, here's some science, which is what I do. 1485 01:10:59.289 --> 01:11:02.510 There are two states. This is my theory. There's the 1486 01:11:02.550 --> 01:11:05.029 abundance mode, which is very good for health. You'll build muscle. 1487 01:11:05.140 --> 01:11:09.920 You'll heal better. That's meat. Right. Killed a mammoth. There's 1488 01:11:10.239 --> 01:11:13.260 adversity mode, which is. We're out of meat. We've got 1489 01:11:13.279 --> 01:11:17.710 to eat roots and berries. That's adversity. We've got to run, running, exercise, 1490 01:11:18.189 --> 01:11:22.470 eating less. That's adversity. Both are good for you. This 1491 01:11:22.609 --> 01:11:26.810 one is pro-survival. This one is pro-growth. This one is longevity. 1492 01:11:27.050 --> 01:11:29.609 This one is you're going to be stronger, fitter. 1493 01:11:29.630 --> 01:11:31.829 How do you determine that though in terms of like 1494 01:11:31.930 --> 01:11:35.140 what is longevity versus what is just like health and 1495 01:11:35.189 --> 01:11:36.310 vitality currently? 1496 01:11:36.409 --> 01:11:38.819 Well, it's based on the last 30 years of research 1497 01:11:39.000 --> 01:11:40.199 in a variety of animals. 1498 01:11:40.380 --> 01:11:42.489 This doesn't have to do with the blue zones, does it? 1499 01:11:43.039 --> 01:11:43.340 No. 1500 01:11:43.359 --> 01:11:45.819 Because you know that's a horse shit, right? 1501 01:11:46.060 --> 01:11:47.420 I read that recently, yeah. 1502 01:11:47.600 --> 01:11:49.680 Isn't that nuts? It's unfortunate. 1503 01:11:49.720 --> 01:11:52.960 It's a lot of fraud. Well, records are hard. 1504 01:11:53.239 --> 01:11:55.119 Well, it's not just hard. A lot of it is 1505 01:11:55.310 --> 01:11:58.270 actual fraud where people are getting checks for their grandpa 1506 01:11:58.670 --> 01:12:01.210 and grandpa was dead. So they weren't writing it into 1507 01:12:01.229 --> 01:12:04.069 the government. They didn't expose– like this was the problem 1508 01:12:04.090 --> 01:12:07.939 with Okinawa in particular is that they would have to– 1509 01:12:08.000 --> 01:12:09.979 in order for these people to get taken off the list, 1510 01:12:10.420 --> 01:12:12.760 they would have to inform the government that this person 1511 01:12:12.800 --> 01:12:15.729 died and they just didn't do it. And so they 1512 01:12:15.770 --> 01:12:18.189 had this list of people that they were counting in 1513 01:12:18.229 --> 01:12:21.390 their census that were like so old. Like this is crazy. 1514 01:12:21.449 --> 01:12:23.930 What are you people doing? Everyone is 100 years old. 1515 01:12:23.970 --> 01:12:27.600 The oldest person in the world apparently, 122. There's a theory, 1516 01:12:27.680 --> 01:12:30.319 not proven, that the oldest person in the world was 1517 01:12:30.399 --> 01:12:35.300 actually the daughter who was faking it to get taxes 1518 01:12:35.340 --> 01:12:37.779 or avoid taxes I think it was in France. I 1519 01:12:37.819 --> 01:12:38.779 hope that that's not true. 1520 01:12:38.920 --> 01:12:40.739 I bet it's true. People are full of shit. 1521 01:12:41.649 --> 01:12:45.229 Well, either way, the maximum human lifespan is around 117, 118. 1522 01:12:45.229 --> 01:12:47.199 Which is still a lot more than we live. 1523 01:12:47.359 --> 01:12:49.439 And what's really crazy is none of those people are 1524 01:12:49.460 --> 01:12:50.340 doing everything right. 1525 01:12:50.800 --> 01:12:51.239 Exactly. 1526 01:12:51.479 --> 01:12:54.500 They're all smoking cigarettes and drinking wine and having a 1527 01:12:54.520 --> 01:12:57.560 good time. And that's a factor that we really need 1528 01:12:57.590 --> 01:13:03.369 to take into consideration. Loneliness and isolation and sadness are 1529 01:13:03.609 --> 01:13:07.229 one of the greatest contributors to poor health outcomes. It's 1530 01:13:07.250 --> 01:13:08.829 number one. Is it really? Yeah. 1531 01:13:08.880 --> 01:13:11.020 Robert Voldinger at Harvard had a study for I think 1532 01:13:11.039 --> 01:13:14.069 it was 40 years. World War II vets. They looked 1533 01:13:14.090 --> 01:13:17.050 at everything, blood pressure, cholesterol. The number one thing that 1534 01:13:17.090 --> 01:13:20.630 predicted longevity in those men was having a reliable partner. 1535 01:13:23.439 --> 01:13:27.140 Yeah. Not just a reliable partner. Someone that you love. 1536 01:13:28.079 --> 01:13:28.560 That's true. 1537 01:13:28.699 --> 01:13:31.340 Someone that you like want to be around all the time. 1538 01:13:31.380 --> 01:13:34.859 You enjoy them. You still enjoy their company, which is possible. 1539 01:13:35.399 --> 01:13:36.890 Most people don't believe that's possible. 1540 01:13:37.050 --> 01:13:38.529 Well, you're a role model in that. 1541 01:13:38.930 --> 01:13:42.319 I love my wife. I– Have fun with her. Like 1542 01:13:42.399 --> 01:13:43.800 we– I've been with her for a long– I've been 1543 01:13:43.819 --> 01:13:46.960 married for 17 years. I enjoy her. I enjoy hanging 1544 01:13:47.020 --> 01:13:50.260 out with her. She's cool. Like she's a– and I 1545 01:13:50.300 --> 01:13:53.600 have friends that aren't in situations like that. And it's 1546 01:13:55.319 --> 01:13:58.279 so bad when you're– like I have a friend who 1547 01:13:58.319 --> 01:14:01.199 just– we were actually talking last night. He just got 1548 01:14:01.279 --> 01:14:04.109 out of a crazy relationship where he was dating this 1549 01:14:04.130 --> 01:14:06.170 girl for seven years. It was chaos and this and that. 1550 01:14:06.689 --> 01:14:09.260 And I said to him– and he was like, I– 1551 01:14:09.729 --> 01:14:12.260 he's 40– And he goes, I don't think I'm ever 1552 01:14:12.300 --> 01:14:14.100 going to have a relationship again. He goes, it was 1553 01:14:14.220 --> 01:14:17.539 so bad. He goes, being single feels so good. And 1554 01:14:17.579 --> 01:14:20.340 I said, there's an old saying, it's so much better 1555 01:14:20.359 --> 01:14:23.250 to be alone than to wish you were alone. And 1556 01:14:23.270 --> 01:14:26.829 he's like, yes, that's it. Because he was like with 1557 01:14:26.850 --> 01:14:29.489 this crazy lady. And he was like, I just wish 1558 01:14:29.510 --> 01:14:32.170 I was free. And he finally got free. And now 1559 01:14:32.229 --> 01:14:34.449 he's like, I think I'm ruined. And I'm like, it 1560 01:14:34.489 --> 01:14:36.840 doesn't have to be like that. You can find someone 1561 01:14:36.859 --> 01:14:39.770 that you actually love. And you really enjoy their time. 1562 01:14:39.829 --> 01:14:42.069 You enjoy being with them. It's possible. 1563 01:14:42.109 --> 01:14:42.989 There's good people out there. 1564 01:14:43.090 --> 01:14:46.170 But you've got to also be someone that that kind 1565 01:14:46.189 --> 01:14:48.510 of person wants to be with. That's the other thing. 1566 01:14:48.989 --> 01:14:52.550 For sure. And stress of relationship. We've seen in studies 1567 01:14:52.770 --> 01:14:55.399 that clock with those chemicals on the DNA, it accelerates 1568 01:14:55.600 --> 01:14:57.920 when you're under stress or going through a breakup. 1569 01:14:58.500 --> 01:14:59.600 Oh, yeah. Oh, God. 1570 01:14:59.659 --> 01:15:00.199 You see it too. 1571 01:15:00.399 --> 01:15:02.319 Oh, I've seen people going through divorces and it just 1572 01:15:02.359 --> 01:15:04.739 like– it takes decades off of their life. They just 1573 01:15:04.779 --> 01:15:07.680 look wrecked. And it takes a year or two for 1574 01:15:07.699 --> 01:15:11.300 them to like achieve equilibrium again. It's hard. 1575 01:15:11.659 --> 01:15:14.680 It is. It is. I went through that actually just 1576 01:15:14.739 --> 01:15:19.779 during COVID when our family got shoved in a house together. Yeah, 1577 01:15:19.800 --> 01:15:21.779 it was brutal. It was unexpected too. 1578 01:15:22.600 --> 01:15:24.159 Wow. That's the stress test, right? 1579 01:15:24.619 --> 01:15:27.340 It was super stress. It was super stress. It's funny 1580 01:15:27.359 --> 01:15:29.180 that you said that. Without the pandemic, we might have 1581 01:15:29.199 --> 01:15:31.359 been able to make it. But forcing us all to 1582 01:15:31.399 --> 01:15:33.850 be in one little house with no internet working well, 1583 01:15:34.399 --> 01:15:37.850 it was tough. But in any case, I'm great now. 1584 01:15:37.989 --> 01:15:40.770 I'm very happy. But I do know how bad it 1585 01:15:40.810 --> 01:15:41.989 can get and it's brutal. 1586 01:15:42.289 --> 01:15:46.079 Yeah, bad relationships can fucking wreck people. I mean it 1587 01:15:46.119 --> 01:15:49.180 can wreck your health. But also it's not just relationships 1588 01:15:49.220 --> 01:15:52.539 in terms of your significant other, husband, wife, partner, whatever 1589 01:15:52.560 --> 01:15:55.739 you want to call it. But also bad relationships at work. 1590 01:15:56.380 --> 01:15:59.739 Like if you have a tyrant for a boss– And 1591 01:15:59.960 --> 01:16:03.060 every day you're getting– you're working overtime and you're getting 1592 01:16:03.100 --> 01:16:05.600 yelled at and you're on the phone and you're at 1593 01:16:05.649 --> 01:16:08.050 home trying to keep up with work and you never 1594 01:16:08.090 --> 01:16:11.369 get– like that kind of relationship where you have like 1595 01:16:11.390 --> 01:16:15.710 this like antagonistic, terrible relationship with people that you work with, 1596 01:16:15.789 --> 01:16:16.770 that's bad too. 1597 01:16:16.970 --> 01:16:17.449 Oh, for sure. 1598 01:16:17.489 --> 01:16:21.029 Your body doesn't differentiate between romantic relationships and those kind 1599 01:16:21.050 --> 01:16:23.170 of relationships are almost equally bad. 1600 01:16:23.229 --> 01:16:24.270 Cortisol will be high. 1601 01:16:24.310 --> 01:16:24.689 Yeah. 1602 01:16:24.750 --> 01:16:27.739 This will accelerate here. I used to keep fish. I 1603 01:16:27.760 --> 01:16:30.539 was one of those people at school. And the fish 1604 01:16:30.560 --> 01:16:33.180 that got picked on by the dominant fish was small, 1605 01:16:33.920 --> 01:16:37.869 lacked color, lived short. It's biology. If you're picked on 1606 01:16:37.970 --> 01:16:41.069 and you're stressed, you're going to age faster. Fortunately, I 1607 01:16:41.090 --> 01:16:44.210 think you're probably the same. At my age, I've managed 1608 01:16:44.229 --> 01:16:46.090 to weed out most of the jerks and I don't 1609 01:16:46.130 --> 01:16:48.199 work with them at all. I've got a great partner 1610 01:16:48.239 --> 01:16:51.920 who we have a hobby of longevity together. So I'm 1611 01:16:52.039 --> 01:16:52.939 lucky in that regard now. 1612 01:16:52.960 --> 01:16:53.590 You found a new one. 1613 01:16:54.449 --> 01:16:56.310 Yeah, longevity specialist. Imagine that. 1614 01:16:56.380 --> 01:16:59.119 Congratulations. Well, that's nice too, right? Find someone who just 1615 01:16:59.159 --> 01:17:02.220 like thinks the way you think and has similar likes 1616 01:17:02.819 --> 01:17:05.960 and interests. Yeah, that definitely can help. Yeah, I know 1617 01:17:06.239 --> 01:17:08.729 a lot of my friends that are in really good relationships, 1618 01:17:08.930 --> 01:17:12.829 their significant other has the same hobby as them, you know, 1619 01:17:13.050 --> 01:17:16.569 like whatever it is. They both like to climb mountains 1620 01:17:16.590 --> 01:17:18.760 or whatever the fuck it is. Find a thing. But 1621 01:17:18.899 --> 01:17:21.840 that helps too. So you actually enjoy spending time together 1622 01:17:21.899 --> 01:17:24.590 doing something that you're both really excited about. That helps too. 1623 01:17:24.850 --> 01:17:27.569 So relationships is one. And the other four major ones 1624 01:17:27.630 --> 01:17:31.739 from that study were don't smoke, don't drink, get enough rest, 1625 01:17:32.760 --> 01:17:35.260 and get exercise. And that was enough to extend by 1626 01:17:35.260 --> 01:17:35.539 15 years. 1627 01:17:36.750 --> 01:17:39.340 But what about those old people that live forever and 1628 01:17:39.399 --> 01:17:41.260 do smoke and drink? Because that's kind of weird. 1629 01:17:41.300 --> 01:17:44.579 Well, they're at 0.01%. They're not examples of what– Is. 1630 01:17:44.520 --> 01:17:45.239 That really what it is? 1631 01:17:45.279 --> 01:17:45.479 Yeah. 1632 01:17:45.659 --> 01:17:48.460 It's just– So the majority of people who get old 1633 01:17:48.699 --> 01:17:53.239 and live to like centenarians, like what are the common 1634 01:17:53.300 --> 01:17:54.100 things that they have? 1635 01:17:55.770 --> 01:17:57.569 The big one is that they don't stress a lot. 1636 01:17:57.909 --> 01:17:59.170 They usually have a good sense of humor. 1637 01:17:59.189 --> 01:18:01.189 Interesting. 1638 01:18:01.409 --> 01:18:05.470 Right. They haven't been overweight and they say that they 1639 01:18:05.529 --> 01:18:07.779 typically– couldn't remember when they last got sick. 1640 01:18:08.819 --> 01:18:11.279 I wonder how much time Twitter takes off your life. 1641 01:18:13.000 --> 01:18:17.310 Yeah, we should study that. It's already taken a lot 1642 01:18:17.529 --> 01:18:18.050 off mine. 1643 01:18:18.430 --> 01:18:19.430 It does. 1644 01:18:19.489 --> 01:18:20.930 And if you read the comments even more. 1645 01:18:21.010 --> 01:18:25.130 Yep, exactly. I'm so much happier since I swore off 1646 01:18:25.170 --> 01:18:27.289 of all that stuff. It's just not good for you. 1647 01:18:27.710 --> 01:18:30.970 It's really, really bad for you. It's also, you're constantly 1648 01:18:31.010 --> 01:18:33.439 dealing with the problems of the whole world, which I 1649 01:18:33.479 --> 01:18:37.100 think is a lot. for a human being that lives 1650 01:18:37.319 --> 01:18:41.079 in a community, in a neighborhood. That shit that's happening 1651 01:18:41.600 --> 01:18:46.010 over there really shouldn't be a primary focus of your life, 1652 01:18:46.210 --> 01:18:49.189 like where you're in the moment actually doing your life. 1653 01:18:49.810 --> 01:18:52.390 It's not the same. You're not in the same area 1654 01:18:52.750 --> 01:18:56.210 as this problem. But yet this problem is overwhelming your 1655 01:18:56.670 --> 01:18:57.789 all day long life. 1656 01:18:57.909 --> 01:18:59.350 And you're in fight or flight constantly. 1657 01:18:59.369 --> 01:19:02.220 All day. All day. And you're worried about the climate. Oh, 1658 01:19:02.260 --> 01:19:05.319 my God. Like there's so much. There's so much that 1659 01:19:05.359 --> 01:19:08.159 freaks people out that it really shouldn't be affecting you 1660 01:19:08.300 --> 01:19:09.689 at all. Exactly. 1661 01:19:09.949 --> 01:19:11.819 And actually the world doesn't change if you don't read it. 1662 01:19:12.529 --> 01:19:16.829 That's the key. But then you're like, well, you're passing 1663 01:19:16.869 --> 01:19:19.899 off the responsibility to other people. You should get involved. Like, 1664 01:19:20.920 --> 01:19:23.479 you should get involved. I'm going to be over here. 1665 01:19:23.500 --> 01:19:25.979 That's right. Well, if you focus on doing something good 1666 01:19:26.039 --> 01:19:26.770 and you're good at it. 1667 01:19:27.020 --> 01:19:27.279 Yes. 1668 01:19:27.659 --> 01:19:29.680 Like yourself. I think that you don't need to be 1669 01:19:29.699 --> 01:19:30.300 doing more than that. 1670 01:19:30.510 --> 01:19:33.050 You can't focus on everything. And anybody who tells you 1671 01:19:33.069 --> 01:19:35.869 you can is a fool. Or anybody who tells you 1672 01:19:35.970 --> 01:19:38.890 what you should or shouldn't be focusing on is a fool. Yeah. 1673 01:19:38.909 --> 01:19:40.930 A few years ago someone at a talk that I 1674 01:19:40.970 --> 01:19:43.189 gave said you should be working on climate change. 1675 01:19:43.520 --> 01:19:43.979 Fuck off. 1676 01:19:44.020 --> 01:19:46.859 I said after I cure aging, I'll get to climate change. 1677 01:19:47.039 --> 01:19:48.659 Yeah. Why don't you go to China and tell them 1678 01:19:48.680 --> 01:19:51.439 to stop making coal factories? Shut the fuck up. Just 1679 01:19:51.560 --> 01:19:55.569 shut up. No. You're not going to fix it. 1680 01:19:55.800 --> 01:19:55.979 Yeah. 1681 01:19:56.819 --> 01:19:59.279 Yeah. Somebody is. Somebody is working on it and that's 1682 01:19:59.300 --> 01:20:02.189 their goal and God bless them. Good luck. 1683 01:20:02.520 --> 01:20:04.840 Yeah. Well, what I try to spend my day is 1684 01:20:04.920 --> 01:20:07.649 efficiently helping the world so that people ask me why 1685 01:20:07.689 --> 01:20:09.789 do I study aging in the first place. And it 1686 01:20:09.810 --> 01:20:13.109 really is that I'm trying to please my grandmother like 1687 01:20:13.130 --> 01:20:15.229 some of us. She was the one that told me 1688 01:20:15.350 --> 01:20:17.670 that I need to make the world a better place 1689 01:20:17.729 --> 01:20:18.710 and she's gone now. 1690 01:20:18.750 --> 01:20:19.430 That's what she said to you? 1691 01:20:20.050 --> 01:20:23.069 When I was four. Wow. It's been that ever since. 1692 01:20:23.710 --> 01:20:26.460 She told me two things. Humans are evil. She lived 1693 01:20:26.479 --> 01:20:29.760 through World War II in Hungary and the Russians came 1694 01:20:29.840 --> 01:20:33.119 in and raped everybody, she said. Wow. And then– so 1695 01:20:33.149 --> 01:20:36.449 she escaped to Australia and then she said that the 1696 01:20:37.329 --> 01:20:41.010 other issue is that we don't do enough as humans 1697 01:20:41.270 --> 01:20:43.609 to better the world. And so I had that stuck 1698 01:20:43.630 --> 01:20:46.090 in my mind. She also, by the way, said, oh, 1699 01:20:46.130 --> 01:20:49.989 we all die. And I thought that's not really fair, 1700 01:20:50.050 --> 01:20:51.909 is it? And that set me on this path. 1701 01:20:53.210 --> 01:20:55.430 Make the world a better place and we all die. 1702 01:20:56.020 --> 01:20:57.260 And you're like, ah. 1703 01:20:58.699 --> 01:21:00.859 And what I've noticed with my kids is that even 1704 01:21:00.880 --> 01:21:03.550 if you tell them that, They forget about it because 1705 01:21:03.569 --> 01:21:06.569 it's brutal to think about death every day. Yeah. But 1706 01:21:06.670 --> 01:21:09.050 for some reason, it's just stuck in my head. And 1707 01:21:09.090 --> 01:21:11.369 every day, I'm like another 150,000 people are going to 1708 01:21:11.430 --> 01:21:16.930 die today due to aging-related diseases. So my lab is mission-oriented. 1709 01:21:16.949 --> 01:21:19.090 If we are a day late with something, there's a 1710 01:21:19.130 --> 01:21:23.130 lot of people that are suffering potentially avoidable diseases. 1711 01:21:23.689 --> 01:21:25.689 That's why it's sort of understandable that people show up 1712 01:21:25.729 --> 01:21:29.239 outside of your lab and like, I need to talk 1713 01:21:29.279 --> 01:21:30.920 to you. I need this. 1714 01:21:31.100 --> 01:21:32.920 Yeah, blind people want to get in the trial. 1715 01:21:33.939 --> 01:21:34.500 It's big. 1716 01:21:34.739 --> 01:21:36.479 And I think if the trial works, it's going to 1717 01:21:36.500 --> 01:21:38.829 be a very strange world, especially for my lab and 1718 01:21:38.869 --> 01:21:42.090 for me. But we'll see. And even if it doesn't 1719 01:21:42.310 --> 01:21:44.930 work this time, the science is strong enough that we'll 1720 01:21:44.949 --> 01:21:47.529 figure it out. We will do this. It's just a 1721 01:21:47.550 --> 01:21:48.050 question of when. 1722 01:21:48.310 --> 01:21:50.460 And so do you think that AI is going to 1723 01:21:50.479 --> 01:21:53.399 have a significant impact on the kind of improvements that 1724 01:21:53.420 --> 01:21:54.180 you're able to. 1725 01:21:54.720 --> 01:21:57.979 It already is. We're going super fast. And AI has 1726 01:21:58.020 --> 01:22:01.890 revolutionized biology. It's revolutionizing everything, of course. But particularly in 1727 01:22:01.930 --> 01:22:05.569 biology where we used to have to read 15 papers 1728 01:22:05.630 --> 01:22:07.949 a day. Now we can read a million if we want. 1729 01:22:08.229 --> 01:22:09.159 It's totally different. 1730 01:22:09.840 --> 01:22:10.159 Wow. 1731 01:22:11.260 --> 01:22:15.840 Yeah, it's super brain. A 19-year-old came to my lab 1732 01:22:15.880 --> 01:22:18.779 this summer and the lab grows from 20 to 40 people. 1733 01:22:19.579 --> 01:22:21.939 And we're trying to figure out how do these three 1734 01:22:22.020 --> 01:22:25.329 genes reset the cell? How does the cell remember what 1735 01:22:25.369 --> 01:22:28.970 it was 30, 40 years ago? Where's that information stored 1736 01:22:29.010 --> 01:22:32.989 in the cell? And I've got this theory that there's 1737 01:22:33.029 --> 01:22:35.909 some new biology. There's a record in the DNA somewhere. 1738 01:22:36.949 --> 01:22:39.119 And I gave him that task. I said, can you 1739 01:22:39.140 --> 01:22:42.500 just go to the databases of the whole world, look 1740 01:22:42.520 --> 01:22:45.560 at all the data that's there, exabytes of data, and 1741 01:22:45.640 --> 01:22:48.500 see if my prediction is true, or at least you 1742 01:22:48.520 --> 01:22:51.649 can get evidence for it. Two weeks later, he came back, 1743 01:22:52.170 --> 01:22:54.170 and the whole team, not the whole team, but five 1744 01:22:54.229 --> 01:22:57.050 other people were smiling. We have to show you something, David. 1745 01:22:57.520 --> 01:22:59.319 I come in my office. We sat down. He shows 1746 01:22:59.359 --> 01:23:03.119 up on the board on this LCD screen. I think 1747 01:23:03.180 --> 01:23:06.000 we found the smoking gun for what your theory suggests. 1748 01:23:06.659 --> 01:23:09.699 And he used AI to process all that data. And 1749 01:23:09.720 --> 01:23:12.220 the AI came back and said, yeah, you're probably right. 1750 01:23:12.979 --> 01:23:15.119 And it's a 19-year-old straight out of high school who 1751 01:23:15.140 --> 01:23:17.739 did this. That did something that the whole field and 1752 01:23:17.760 --> 01:23:21.020 all these professors and all these fancy sirs could not 1753 01:23:21.060 --> 01:23:22.649 figure out until now. 1754 01:23:24.050 --> 01:23:28.210 That is phenomenal. That's so promising. It's so exciting. 1755 01:23:28.850 --> 01:23:30.569 It is. I mean the future really does belong to 1756 01:23:30.609 --> 01:23:33.930 people who can wrangle AI even on their phone. I 1757 01:23:33.949 --> 01:23:35.449 think people on their phones are going to be making 1758 01:23:35.489 --> 01:23:37.159 medicines or at least designing them. 1759 01:23:37.520 --> 01:23:38.140 Or bombs. 1760 01:23:38.899 --> 01:23:40.600 That's the problem. And bioweapons. 1761 01:23:41.359 --> 01:23:41.619 Right. 1762 01:23:42.100 --> 01:23:44.640 You recently had– was it Anna on the show? She'll 1763 01:23:44.659 --> 01:23:48.079 talk about bioweapons and this kind of stuff. That is 1764 01:23:48.180 --> 01:23:50.199 a big worry. I actually had to disclose to the 1765 01:23:50.270 --> 01:23:52.229 US government when I first got here that I did 1766 01:23:52.289 --> 01:23:54.050 have the capability of making a bioweapon. 1767 01:23:54.590 --> 01:23:58.229 The Annie Jacobson episode that we just did on bioweapons 1768 01:23:58.250 --> 01:24:02.840 was absolutely terrifying. Yeah. She's– I mean she scared the 1769 01:24:02.880 --> 01:24:04.560 shit out of the world with her nuclear war book 1770 01:24:04.619 --> 01:24:07.560 and now she's scaring everybody with her bioweapons book. 1771 01:24:07.920 --> 01:24:08.100 Yeah. 1772 01:24:08.520 --> 01:24:09.180 Yeah, that's scary. 1773 01:24:09.800 --> 01:24:12.270 It is. What I've got is a database of all 1774 01:24:12.310 --> 01:24:15.329 known pathogens and new ones that could come. So I'm 1775 01:24:15.350 --> 01:24:17.550 trying to do my bit there to help the world 1776 01:24:17.590 --> 01:24:20.829 if it happens again, pandemic or something unnatural. 1777 01:24:21.529 --> 01:24:24.689 Yeah. Well, that would be– I mean– When you think 1778 01:24:24.750 --> 01:24:28.590 about diseases that people get that just like wreck their 1779 01:24:28.630 --> 01:24:32.609 entire body, if you really do have an original copy 1780 01:24:32.729 --> 01:24:35.270 somewhere in their genome of what they look like as 1781 01:24:35.289 --> 01:24:38.850 a healthy person and you could switch that back on 1782 01:24:38.880 --> 01:24:43.899 with a factory reboot. I mean we could potentially get 1783 01:24:43.939 --> 01:24:46.840 rid of all diseases, which is just bananas. 1784 01:24:47.619 --> 01:24:52.100 And injuries, fixed injuries, grown new limbs potentially. There's a 1785 01:24:52.140 --> 01:24:53.859 new paper that just came out a few days ago. 1786 01:24:54.369 --> 01:24:56.829 that showed that the tips of the fingers of baby 1787 01:24:56.869 --> 01:24:59.989 mice can be coaxed once they've healed over as a 1788 01:25:00.010 --> 01:25:02.680 stub to regrow part of the finger. 1789 01:25:03.270 --> 01:25:04.819 Haven't people done that before? 1790 01:25:04.840 --> 01:25:08.779 Yeah, they found just two factors were enough. So it's 1791 01:25:08.800 --> 01:25:12.180 not that hard. The point is we've got the instructions 1792 01:25:12.239 --> 01:25:14.840 to be young and to regrow body parts in our body. 1793 01:25:15.180 --> 01:25:16.000 We just don't use them. 1794 01:25:17.020 --> 01:25:20.270 That's nuts. So like a salamander can grow an extra 1795 01:25:20.310 --> 01:25:22.329 leg or a leg that gets chopped off. Yeah. 1796 01:25:22.880 --> 01:25:25.000 I believe we still have that capability. We just don't 1797 01:25:25.159 --> 01:25:27.579 use it. It just didn't make sense to regrow a limb. 1798 01:25:27.619 --> 01:25:29.460 It was quicker and safer to just heal it over 1799 01:25:29.520 --> 01:25:32.239 as a stub and move on. But salamanders, which get 1800 01:25:32.279 --> 01:25:37.409 their limbs presumably eaten pretty often, maintain that ability. So 1801 01:25:37.449 --> 01:25:40.850 give us– I wouldn't say that we could evolve this, 1802 01:25:40.949 --> 01:25:44.550 but I think using a combination of our technology plus 1803 01:25:44.710 --> 01:25:46.899 this new technology that we're seeing come out where these 1804 01:25:46.939 --> 01:25:49.159 two factors can grow new limbs, I don't see a 1805 01:25:49.180 --> 01:25:52.210 reason why we can't. become like a deadpool where injury 1806 01:25:52.250 --> 01:25:55.289 doesn't hurt us aging can't hurt us and we can 1807 01:25:55.329 --> 01:25:56.289 regrow body parts. 1808 01:25:56.430 --> 01:25:58.550 How far do you think we are away from being 1809 01:25:58.590 --> 01:26:01.109 able to regrow body parts oh. 1810 01:26:01.529 --> 01:26:03.720 I mean realistically probably a couple of decades but i 1811 01:26:04.060 --> 01:26:06.260 i've seen enough that's not that far i've seen enough 1812 01:26:06.300 --> 01:26:07.340 to know that it's doable a. 1813 01:26:07.560 --> 01:26:12.079 Couple of decades ago was 2006. 1814 01:26:10.720 --> 01:26:12.640 Well things are going super fast i mean 10 years 1815 01:26:12.680 --> 01:26:14.659 ago we didn't even know aging was irreversible and now 1816 01:26:14.680 --> 01:26:15.579 it's in humans. 1817 01:26:17.840 --> 01:26:21.890 That's nuts think of that. Well, 2019 when you came here, 1818 01:26:21.949 --> 01:26:23.289 there was no AI. Right. 1819 01:26:23.289 --> 01:26:27.210 2019, it was an idea that we had just got 1820 01:26:27.229 --> 01:26:30.260 the result in mice, and I divulged that to the world. 1821 01:26:30.720 --> 01:26:33.800 Then it was published, and then we're in humans now. 1822 01:26:33.880 --> 01:26:36.560 So if it works, then it's going to be a 1823 01:26:36.560 --> 01:26:37.180 very different world. 1824 01:26:37.819 --> 01:26:42.039 And you feel very confidently that some of this stuff 1825 01:26:42.079 --> 01:26:42.619 is going to work? 1826 01:26:43.600 --> 01:26:46.069 Well, it's going to work. I don't know if this 1827 01:26:46.149 --> 01:26:48.720 trial is going to be successful, but there's going to 1828 01:26:48.739 --> 01:26:50.760 be a lot of people doing these trials. I have 1829 01:26:50.779 --> 01:26:54.350 some competition now. Do you know about that? No. Uh, 1830 01:26:54.409 --> 01:26:56.989 so since I started my company, Life Biosciences, which is 1831 01:26:57.050 --> 01:27:01.529 doing the trials with ER100, others have joined in, in 1832 01:27:01.550 --> 01:27:05.130 the party. Uh, so Jeff Bezos and others have started 1833 01:27:05.250 --> 01:27:09.689 Altos Pharma. Um, they are based in three cities around 1834 01:27:09.720 --> 01:27:13.380 the world. They have a few billion dollars to catch up. Um, 1835 01:27:13.859 --> 01:27:19.649 Sam Altman has RetroBio and, uh, Let's see. Brian Armstrong 1836 01:27:19.689 --> 01:27:23.079 from Coinbase, the CEO, started one called New Limit and 1837 01:27:23.100 --> 01:27:25.420 they've got a lot of money, all billions. 1838 01:27:27.239 --> 01:27:28.720 Do you think it's good that there's all these people 1839 01:27:28.760 --> 01:27:29.319 involved in this? 1840 01:27:29.460 --> 01:27:30.920 I welcome it. Yeah, definitely. 1841 01:27:31.199 --> 01:27:31.500 Yeah, yeah. 1842 01:27:31.579 --> 01:27:34.420 I'm not doing this for my own personal benefit. I 1843 01:27:34.460 --> 01:27:36.539 want humanity to be changed the way it could be. 1844 01:27:37.199 --> 01:27:39.510 And the more people like Jeff Bezos, the more people 1845 01:27:39.550 --> 01:27:41.789 with a large bank account that are invested in this, 1846 01:27:41.850 --> 01:27:42.189 the better. 1847 01:27:42.430 --> 01:27:42.970 Fantastic. 1848 01:27:43.029 --> 01:27:44.729 And of course, a guy like Bezos, he's balling out 1849 01:27:44.750 --> 01:27:46.130 of control. Why wouldn't he want to live forever? 1850 01:27:46.899 --> 01:27:48.460 Well, what's left if you've got everything else? 1851 01:27:49.180 --> 01:27:52.300 Well, also it's like if you've got the amount of 1852 01:27:52.359 --> 01:27:55.039 money that he has and you can tackle all these 1853 01:27:55.079 --> 01:27:57.939 different issues like his space program that he's working on, 1854 01:27:57.979 --> 01:28:00.119 all these different things. Like, of course, why wouldn't you 1855 01:28:00.140 --> 01:28:02.500 want to do cool things? Like what's cooler than being 1856 01:28:02.520 --> 01:28:03.420 able to grow limbs? 1857 01:28:03.939 --> 01:28:04.619 Yeah, yeah. 1858 01:28:04.659 --> 01:28:07.500 What's cooler than being able to cure all diseases and 1859 01:28:07.539 --> 01:28:08.380 reverse aging? 1860 01:28:08.680 --> 01:28:11.720 Well, I don't think there's much cooler. That's why I'm 1861 01:28:11.760 --> 01:28:13.590 doing it because that I think can be the biggest 1862 01:28:13.619 --> 01:28:16.659 gift to humanity is what you just said. So I 1863 01:28:16.680 --> 01:28:18.970 don't know if I'll achieve it. Probably not in my lifetime. 1864 01:28:19.470 --> 01:28:21.109 But at least I've moved the needle and pushed the 1865 01:28:21.149 --> 01:28:23.090 ball globally in that direction. 1866 01:28:24.449 --> 01:28:25.670 I wonder if we're going to get to a point 1867 01:28:25.689 --> 01:28:29.800 in time where we can engineer consciousness in terms of 1868 01:28:29.850 --> 01:28:33.399 like find out– like you find out someone is a sociopath. 1869 01:28:33.439 --> 01:28:36.340 You find out someone is a kleptomaniac or someone is 1870 01:28:36.880 --> 01:28:39.119 an arsonist. Like whatever it is. Like if you could 1871 01:28:40.260 --> 01:28:43.600 figure out like what these little flaws are in the 1872 01:28:43.640 --> 01:28:45.680 way the mind works. If we can completely map it 1873 01:28:45.840 --> 01:28:49.670 out and go, oh, this is the error. This is 1874 01:28:49.729 --> 01:28:51.850 where you're not making these two connections. Of course. 1875 01:28:52.189 --> 01:28:54.529 Of course. It's all just biology and engineering. There's nothing 1876 01:28:54.569 --> 01:28:57.189 that stops us. And this is the century that we 1877 01:28:57.229 --> 01:29:01.399 are able to control our own biology. Starting with cancer, 1878 01:29:01.420 --> 01:29:02.640 heart disease and aging. 1879 01:29:03.760 --> 01:29:07.039 A true utopian world of peaceful people living in harmony. 1880 01:29:07.399 --> 01:29:08.039 But healthy. 1881 01:29:08.359 --> 01:29:08.979 Not peaceful? 1882 01:29:09.340 --> 01:29:11.739 I don't think world peace– I think curing aging is 1883 01:29:11.800 --> 01:29:12.640 easier than world peace. 1884 01:29:13.260 --> 01:29:17.659 Well, if everybody achieved a state of consciousness that allowed 1885 01:29:17.729 --> 01:29:19.649 them to understand that we're all in this together. 1886 01:29:21.270 --> 01:29:22.050 Yeah, how do we do that? 1887 01:29:22.689 --> 01:29:23.090 Mushrooms. 1888 01:29:23.510 --> 01:29:23.810 Mushrooms. 1889 01:29:24.779 --> 01:29:25.119 Yeah. 1890 01:29:25.319 --> 01:29:27.520 Well, there are certain companies working on this. 1891 01:29:27.680 --> 01:29:30.630 I know. That's what's interesting, right? Like Eli Lilly is 1892 01:29:30.689 --> 01:29:34.630 involved in pharmaceuticals. Well, the pharmaceutical company rather is involved 1893 01:29:34.689 --> 01:29:35.449 in psychedelics. 1894 01:29:35.470 --> 01:29:36.590 They just bought a tie. 1895 01:29:36.970 --> 01:29:39.520 I think it was like $ 3. 8 billion. So they're all 1896 01:29:39.600 --> 01:29:42.229 in with real capital. Yeah. I love it. 1897 01:29:42.380 --> 01:29:42.979 Yeah, me too. 1898 01:29:43.039 --> 01:29:43.539 That's great. 1899 01:29:43.600 --> 01:29:45.359 I love that they're doing that. We need more of that. 1900 01:29:45.479 --> 01:29:47.880 There's too much depression. Anxiety in the world. 1901 01:29:47.920 --> 01:29:51.119 And drug addiction. I mean that's why I went to 1902 01:29:51.159 --> 01:29:54.060 the White House and got the president to get involved 1903 01:29:54.079 --> 01:29:55.939 in this executive order on Ibogaine. 1904 01:29:56.140 --> 01:29:56.460 Yes. 1905 01:29:56.760 --> 01:30:00.310 Because I've talked to so many people that have had 1906 01:30:00.350 --> 01:30:04.069 their life completely turned around with Ibogaine. So many people 1907 01:30:04.109 --> 01:30:08.630 that were opioid addiction and also brain injuries, oddly enough. 1908 01:30:09.170 --> 01:30:13.840 Brain injuries, all sorts of TBI and CTE issues. that 1909 01:30:13.880 --> 01:30:19.420 they've had like phenomenal results from this iboga tree, you know, 1910 01:30:19.520 --> 01:30:22.479 which is so crazy that this thing had been around 1911 01:30:22.520 --> 01:30:25.699 for so long and is a schedule one substance in 1912 01:30:25.720 --> 01:30:29.369 the United States for no reason whatsoever. There's no risk 1913 01:30:29.390 --> 01:30:32.109 of addiction. There is no recreational use of it. It's 1914 01:30:32.130 --> 01:30:35.430 a horrible experience. I've not done it, but apparently it's 1915 01:30:35.489 --> 01:30:38.449 fucking terrible. And it lasts for like 24 hours. Like 1916 01:30:38.510 --> 01:30:40.369 no one's going to be doing that for funsies. Right. 1917 01:30:40.869 --> 01:30:43.270 Well, the question I think That comes up with all 1918 01:30:43.310 --> 01:30:44.710 of these drugs is do you have to have the 1919 01:30:44.810 --> 01:30:47.050 trip and experience the craziness? 1920 01:30:47.850 --> 01:30:48.390 To get the benefits. 1921 01:30:48.409 --> 01:30:50.409 To get the benefit. And I don't think so. I 1922 01:30:50.430 --> 01:30:51.390 think you should be able to separate them. 1923 01:30:51.409 --> 01:30:55.329 Well, you know, they've actually figured this out with LSD. Yeah. Right? 1924 01:30:55.729 --> 01:30:58.670 Do you know about this? No. Okay. So they've engineered 1925 01:30:58.970 --> 01:31:03.130 a different version of LSD that doesn't give you the 1926 01:31:03.170 --> 01:31:07.750 hallucinogenic effects but does give you the benefits in terms 1927 01:31:07.829 --> 01:31:09.329 of like the cognitive effects. 1928 01:31:09.390 --> 01:31:10.649 The Atai guys or someone else? 1929 01:31:11.699 --> 01:31:14.560 I don't know what company has done this. See if 1930 01:31:14.590 --> 01:31:15.590 you can find that, Jamie. 1931 01:31:15.699 --> 01:31:16.710 I think it might be a time. 1932 01:31:16.770 --> 01:31:20.430 But what they've essentially done, and I think it's basically 1933 01:31:20.649 --> 01:31:23.029 in the lab work stage right now. I don't think 1934 01:31:23.050 --> 01:31:25.829 that's applied to humans yet. But what they've done is 1935 01:31:26.329 --> 01:31:30.229 engineered a version of LSD that has all the positive 1936 01:31:30.270 --> 01:31:35.079 effects that LSD has in terms of, like, introspection, being 1937 01:31:35.640 --> 01:31:38.880 able to, like, rethink and remap and reset the way 1938 01:31:38.920 --> 01:31:43.399 you view things, but without, like, Watching people's face melt 1939 01:31:43.479 --> 01:31:46.380 and thinking that demons are eating you and all the 1940 01:31:46.420 --> 01:31:47.600 weird stuff that comes with it. 1941 01:31:47.619 --> 01:31:51.350 Outstanding. It should happen with psychedelics the way it's happened 1942 01:31:51.390 --> 01:31:54.550 with all medicines, right? We start with something from the 1943 01:31:54.590 --> 01:31:56.529 bark of a willow tree and then we have aspirin. 1944 01:31:56.869 --> 01:31:57.310 Right. 1945 01:31:57.829 --> 01:31:59.369 We're not eating bark anymore. 1946 01:32:00.210 --> 01:32:05.630 Right. But sometimes the bark is the really way to go, right? Unfortunately, 1947 01:32:05.689 --> 01:32:08.449 sometimes that's the part of the problem is these pharmaceutical 1948 01:32:08.489 --> 01:32:13.819 drug companies, they patent– these natural compounds and use petroleum-based 1949 01:32:14.439 --> 01:32:18.829 synthetic methods of creating these medications now that they can 1950 01:32:18.869 --> 01:32:22.750 sell and profit wildly off of. Whereas really the best 1951 01:32:22.810 --> 01:32:24.369 way to do it is actually to get the plant. 1952 01:32:25.979 --> 01:32:26.350 It's true. 1953 01:32:26.489 --> 01:32:30.260 There's the whole issue though that if it's not approved, 1954 01:32:30.479 --> 01:32:32.460 then it's the Wild West. You don't know what you're getting. 1955 01:32:32.659 --> 01:32:34.060 Right. That's true too. 1956 01:32:34.399 --> 01:32:36.060 We need a middle ground. We need something you can 1957 01:32:36.079 --> 01:32:38.239 get fast on the market that's known to be safe. 1958 01:32:38.850 --> 01:32:42.010 So what we're going to need is mind reading because 1959 01:32:42.029 --> 01:32:43.189 we need to know if people are full of shit. 1960 01:32:43.210 --> 01:32:44.670 That's what we're going to need. 1961 01:32:44.689 --> 01:32:46.390 We're going to need– Got to work on that. 1962 01:32:46.569 --> 01:32:50.010 Yes. I think that's going to change humanity more than anything. 1963 01:32:50.109 --> 01:32:51.630 I think you've got a good bullshit detector. 1964 01:32:52.090 --> 01:32:55.840 It's OK. There's a few people that have snuck through, unfortunately. 1965 01:32:56.699 --> 01:32:58.800 Some people, they get through and they're like, it takes 1966 01:32:58.840 --> 01:33:01.079 a while. And you're like, ah, shit. 1967 01:33:01.159 --> 01:33:02.319 They're never coming back on the show. 1968 01:33:02.800 --> 01:33:07.260 Yeah. Well, there's that. The show, you learn a lot 1969 01:33:07.300 --> 01:33:10.340 from a person in about three hours. You can kind 1970 01:33:10.380 --> 01:33:13.199 of– after a while, you can kind of see little things. 1971 01:33:13.680 --> 01:33:16.359 And you have to be forgiving and you have to 1972 01:33:16.399 --> 01:33:18.979 be charitable. And some people are just nervous and they 1973 01:33:19.520 --> 01:33:23.689 misstate things or they exaggerate things or they forget something. 1974 01:33:23.699 --> 01:33:25.649 They get it wrong. But then there's people that are 1975 01:33:25.729 --> 01:33:30.630 just– essentially, they really don't care about anybody but themselves. 1976 01:33:31.430 --> 01:33:33.590 And some of those people are really good at pretending 1977 01:33:33.609 --> 01:33:36.750 to be people. They're really good at pretending. You know, 1978 01:33:36.930 --> 01:33:40.420 they're really good at pretending to be like a normal person. Oh, 1979 01:33:40.449 --> 01:33:44.670 here's the LSD thing. Research has recently engineered an LSD 1980 01:33:44.789 --> 01:33:48.670 analog called, how do you say it, plus minus JRT, 1981 01:33:49.590 --> 01:33:52.600 that appears to keep many of the LSD's brain beneficial 1982 01:33:52.640 --> 01:33:56.810 and cognitive effects while dramatically reducing and possibly eliminating its 1983 01:33:56.850 --> 01:34:00.770 hallucinogenic trip in animal studies. So it's almost the same 1984 01:34:00.840 --> 01:34:04.319 molecule as LSD, but scientists swap the positions of just 1985 01:34:04.380 --> 01:34:07.659 two atoms in the structure. The subtle change makes JRT 1986 01:34:08.039 --> 01:34:11.279 bind more selectively to serotonin receptors in a way that 1987 01:34:11.300 --> 01:34:16.460 promotes neuroplasticity, growth and repair of synapses, but minimizes hallucinogenic signaling. 1988 01:34:17.199 --> 01:34:24.319 That's incredible. Antidepressant, look at this. Strong antidepressant effects at 1989 01:34:24.359 --> 01:34:27.859 doses reported to be around 100 times more potent than 1990 01:34:27.939 --> 01:34:33.760 ketamine in standard rodent tests. Cognitive benefits. Improved cognitive flexibility 1991 01:34:34.140 --> 01:34:38.130 and performance in tasks modeling the negative and cognitive symptoms 1992 01:34:38.170 --> 01:34:42.130 of schizophrenia. Holy shit. That's incredible. 1993 01:34:43.470 --> 01:34:44.380 When and where do we get it? 1994 01:34:45.050 --> 01:34:49.310 Well, I think it's fairly recent. It's a UC Davis study. 1995 01:34:49.369 --> 01:34:51.659 They just developed it. Oh, it's in my– Shout out 1996 01:34:51.699 --> 01:34:54.819 to our AI sponsor Perplexity for providing us with this information. 1997 01:34:55.159 --> 01:34:57.060 This is again– I mean like we could just get 1998 01:34:57.119 --> 01:35:00.640 this information now through AI. Like I mean this– the 1999 01:35:00.779 --> 01:35:03.189 AI for our show has been gigantic. I mean just 2000 01:35:03.229 --> 01:35:06.430 the ability to just ask it a question instead of 2001 01:35:06.489 --> 01:35:08.449 Google searching and having to go through all these different 2002 01:35:08.489 --> 01:35:11.010 fucking articles. What does it say? What is that? Who's right? 2003 01:35:11.270 --> 01:35:15.380 What's this one? What's the website? You just ask– AI 2004 01:35:15.489 --> 01:35:19.659 and perplexity just gives us all the information. So proceedings 2005 01:35:19.680 --> 01:35:22.819 from National Academy of Science researchers at California of San 2006 01:35:22.840 --> 01:35:28.399 Diego Davis, excuse me, University of California Davis reported the 2007 01:35:28.439 --> 01:35:31.939 creation of JRT, chemically modified version of LSD. So this 2008 01:35:32.020 --> 01:35:38.659 is like what year? So 2025, so last year. So 2009 01:35:38.680 --> 01:35:40.500 it's exciting. Five years away, but still. 2010 01:35:41.039 --> 01:35:41.420 You're right. 2011 01:35:41.460 --> 01:35:42.460 Is that the timeline? 2012 01:35:43.239 --> 01:35:46.140 At a minimum, usually it takes that long But that's exciting. 2013 01:35:46.239 --> 01:35:47.899 At least the principle is there that you don't need 2014 01:35:47.920 --> 01:35:48.260 to hallucinate. 2015 01:35:48.279 --> 01:35:50.380 Well, how about for schizophrenia? That's incredible. 2016 01:35:50.399 --> 01:35:50.899 You need something. 2017 01:35:51.100 --> 01:35:53.260 Yeah. I mean, that is incredible because that is one 2018 01:35:53.279 --> 01:35:55.840 of the saddest things, to watch somebody fall into the 2019 01:35:55.880 --> 01:35:58.939 grips of schizophrenia. Yeah. I've seen people fall in and 2020 01:35:58.979 --> 01:36:00.550 come out, which is interesting. 2021 01:36:01.770 --> 01:36:03.550 I thought for the bullshit detector, we could have an 2022 01:36:03.609 --> 01:36:06.550 AI that either dings or has a green or a 2023 01:36:06.609 --> 01:36:07.329 red on your forehead. 2024 01:36:07.409 --> 01:36:10.250 I'm pretty good at it, but I think no one's 2025 01:36:10.350 --> 01:36:13.210 perfect at it. And I think ultimately, if we get 2026 01:36:13.250 --> 01:36:18.600 to a place... whether it's a technological innovation or what 2027 01:36:18.640 --> 01:36:21.600 have you, where we can actually read the contents of 2028 01:36:21.640 --> 01:36:25.350 someone's thoughts. I don't think that's outside the realm of possibility. 2029 01:36:26.930 --> 01:36:28.130 You'd need an implant, I think. 2030 01:36:28.369 --> 01:36:30.270 Elon says the Neuralink is going to be able to 2031 01:36:30.289 --> 01:36:30.810 pull that off. 2032 01:36:31.470 --> 01:36:31.810 Yeah. 2033 01:36:32.149 --> 01:36:34.510 You're going to be able to talk without using words. 2034 01:36:35.289 --> 01:36:38.270 I'm like, what? I think he's right though. I think 2035 01:36:38.890 --> 01:36:42.609 if we all like lock into a hive mind and 2036 01:36:42.630 --> 01:36:47.409 then– If we develop– like through AI, if we develop 2037 01:36:47.449 --> 01:36:50.300 a universal language worldwide. 2038 01:36:51.319 --> 01:36:52.579 Well, we already have that. 2039 01:36:53.199 --> 01:36:53.619 What do we have? 2040 01:36:54.220 --> 01:36:56.199 Well, the new headphones from a big company that I 2041 01:36:56.220 --> 01:36:58.189 won't name. You can translate. 2042 01:36:58.649 --> 01:37:02.130 Translate. Yes. Translate. But it's translating to English. If we 2043 01:37:02.149 --> 01:37:05.409 just all– the problem with that is there's context. There's 2044 01:37:05.430 --> 01:37:08.680 all sorts of different things that Other cultures, different languages, 2045 01:37:08.699 --> 01:37:12.960 when it's deciphered and changed and translated into English, you 2046 01:37:12.979 --> 01:37:16.100 lose a lot of the meaning and the context is weird. 2047 01:37:16.659 --> 01:37:18.319 If we develop a universal language. 2048 01:37:19.220 --> 01:37:22.220 That would be ideal. English is a good substitute. I 2049 01:37:22.239 --> 01:37:25.520 was shocked. I'm always shocked traveling globally how many people 2050 01:37:25.619 --> 01:37:26.550 can just speak English now. 2051 01:37:26.810 --> 01:37:29.930 Yeah, it's pretty amazing. It's because America rules. You're welcome. 2052 01:37:31.210 --> 01:37:34.069 Well, we have to thank Britain for that. America should 2053 01:37:34.130 --> 01:37:34.840 say you're welcome. 2054 01:37:34.979 --> 01:37:38.460 Yeah, they're cute. They did a good job of starting 2055 01:37:38.479 --> 01:37:39.859 it out, but we took the ball. 2056 01:37:39.819 --> 01:37:42.659 And spread it all over the world. So who's next? China? 2057 01:37:43.020 --> 01:37:44.560 God, I hope not. I don't want to learn Chinese. 2058 01:37:44.579 --> 01:37:47.939 That's too hard. It's all fucking characters. That's ridiculous. Even 2059 01:37:47.960 --> 01:37:50.020 people that I know that can speak Mandarin, they can't 2060 01:37:50.060 --> 01:37:53.760 write it. To get to that level, I have a 2061 01:37:53.840 --> 01:37:56.770 couple friends that speak fluent Mandarin and they can't write it. 2062 01:37:57.850 --> 01:37:58.380 Writing it is. 2063 01:37:58.770 --> 01:38:01.229 Yeah, well, the students in my lab who come from China, 2064 01:38:02.010 --> 01:38:04.989 they're being picked on by by the immigration, but they 2065 01:38:05.029 --> 01:38:06.810 don't want to go home. They love it here. 2066 01:38:07.130 --> 01:38:08.930 I'm sure because they're stealing all your secrets and they 2067 01:38:08.970 --> 01:38:09.409 bring it back home. 2068 01:38:09.430 --> 01:38:11.029 Well, there's that. There's a lot of regulation on that 2069 01:38:11.069 --> 01:38:12.159 now as a scientist. 2070 01:38:12.560 --> 01:38:15.600 Oh, yeah. Oh, I can imagine. Yeah. I mean, it 2071 01:38:15.619 --> 01:38:17.720 has to be because that is an actual real threat. 2072 01:38:18.060 --> 01:38:20.600 Exactly. So the people that come through my lab have 2073 01:38:20.619 --> 01:38:21.520 to be vetted now. 2074 01:38:21.779 --> 01:38:23.430 Right. But the people that come over here and experience 2075 01:38:23.439 --> 01:38:26.010 the kind of freedom that you have in America. Oh, yeah. 2076 01:38:26.350 --> 01:38:28.470 I came here from Australia. Australia is pretty free, but 2077 01:38:28.689 --> 01:38:30.750 compared to Australia, America is so different. 2078 01:38:30.989 --> 01:38:31.229 Yeah. 2079 01:38:31.300 --> 01:38:31.979 I can't go back. 2080 01:38:33.229 --> 01:38:34.189 What's the big difference? 2081 01:38:35.500 --> 01:38:37.779 That I feel I can do anything I want if 2082 01:38:37.840 --> 01:38:40.760 I just put my mind to it. There's not social barriers. 2083 01:38:40.779 --> 01:38:44.020 There's not monetary barriers, at least for a white male 2084 01:38:44.039 --> 01:38:46.420 like me, who's got a degree. I know it's not 2085 01:38:46.439 --> 01:38:48.779 for everybody, but I feel like if I want to, 2086 01:38:49.460 --> 01:38:51.119 Start a company. I've got a great idea. I can 2087 01:38:51.159 --> 01:38:53.939 do that here. Fat chance you'll do that in Australia. 2088 01:38:54.020 --> 01:38:56.300 People aren't willing to invest in great ideas down there. 2089 01:38:57.119 --> 01:38:57.560 Not often. 2090 01:38:58.439 --> 01:39:00.850 That's a bummer. Do you think that changes anytime soon? 2091 01:39:01.390 --> 01:39:04.609 No. The US is so unique. There's a lot of 2092 01:39:04.630 --> 01:39:06.890 money flowing. People are willing to place a bet and 2093 01:39:06.909 --> 01:39:10.649 even lose the money. That's rare. Australians, most of the world, 2094 01:39:11.170 --> 01:39:13.260 if not all, people are scared to lose their money 2095 01:39:13.300 --> 01:39:15.930 if they have it. Here, it's like, okay, I risked it. 2096 01:39:16.359 --> 01:39:18.890 I helped the world. I feel good. It's a very 2097 01:39:18.949 --> 01:39:22.560 generous country, very. And I love it here. When I 2098 01:39:22.569 --> 01:39:24.069 arrived here, I just felt, ah, I'm home. 2099 01:39:24.689 --> 01:39:26.270 I love hearing that from people that have come from 2100 01:39:26.310 --> 01:39:30.380 somewhere else because it kind of reaffirms why people in 2101 01:39:30.420 --> 01:39:33.340 America are so proud of what this country is. 2102 01:39:33.359 --> 01:39:34.500 It should be, yeah. 2103 01:39:34.600 --> 01:39:36.039 And that's why it bums me out when people are 2104 01:39:36.060 --> 01:39:39.640 so mad at America in terms of– I get looking 2105 01:39:39.659 --> 01:39:41.420 in terms of foreign policy and some of the things 2106 01:39:41.439 --> 01:39:44.420 that are wrong with America. But just in overall, this 2107 01:39:44.500 --> 01:39:46.819 experiment in self-government is pretty remarkable. Yeah. 2108 01:39:47.550 --> 01:39:50.810 Yeah, I watched the TV show. Was it The American Experiment? 2109 01:39:51.390 --> 01:39:54.090 It came out for the anniversary, the 250th. 2110 01:39:54.350 --> 01:39:54.890 I haven't seen it. 2111 01:39:55.189 --> 01:39:55.760 You've got to see it. 2112 01:39:56.310 --> 01:39:56.810 What's it on? 2113 01:39:57.310 --> 01:40:00.250 It's the founding fathers and their lives and how they 2114 01:40:00.270 --> 01:40:02.840 were fighting and what was going on behind the scenes. 2115 01:40:03.680 --> 01:40:05.569 They were just young kids. They were in their 20s, 30s. 2116 01:40:05.600 --> 01:40:06.960 I know. Isn't that nuts? Yeah. 2117 01:40:07.300 --> 01:40:09.760 Just Benjamin Franklin was the old dude. But they were 2118 01:40:09.880 --> 01:40:12.529 so young. But they were in the middle of it. 2119 01:40:13.039 --> 01:40:16.359 They kind of realized they were making history. But so 2120 01:40:16.380 --> 01:40:18.920 many things could have gone wrong We would not have 2121 01:40:18.960 --> 01:40:21.180 had the United States if just a few votes went 2122 01:40:21.300 --> 01:40:21.960 one way or the other. 2123 01:40:22.340 --> 01:40:23.079 A few wars. 2124 01:40:23.619 --> 01:40:23.880 Yeah. 2125 01:40:23.899 --> 01:40:26.840 A few different battles that they had. Exactly. 2126 01:40:27.000 --> 01:40:29.680 The US was losing the war against Britain badly. 2127 01:40:30.180 --> 01:40:32.979 Yeah. They burned the White House down. Yeah. Yeah. 2128 01:40:33.000 --> 01:40:34.380 We don't thank the French enough actually. 2129 01:40:34.579 --> 01:40:38.399 I know. Right? Somehow they became our enemy. Yeah. Remember 2130 01:40:38.460 --> 01:40:41.960 during the Gulf War, they turned French fries into freedom 2131 01:40:41.979 --> 01:40:44.000 fries because people hated the French? Yeah. 2132 01:40:44.020 --> 01:40:47.560 But everyone hates the French because they're so arrogant. Sorry, French. 2133 01:40:48.050 --> 01:40:49.909 I have some friends who are good friends. 2134 01:40:49.970 --> 01:40:52.050 I think generally when people are arrogant, it's because they 2135 01:40:52.069 --> 01:40:53.170 did something fucking awesome. 2136 01:40:54.390 --> 01:40:58.890 Well, in the 1800s, they did. They conquered Europe. Not 2137 01:40:59.090 --> 01:40:59.949 sure if that's awesome. 2138 01:41:00.210 --> 01:41:02.060 Here's a fun perplexing search I just did. I said, 2139 01:41:02.069 --> 01:41:05.680 do Americans have a risk gene? A risk gene? Yeah. 2140 01:41:05.880 --> 01:41:08.439 One of the best studied variants in the dopamine receptor 2141 01:41:08.479 --> 01:41:15.000 gene DRD4, specifically the 7-repeat-7R version- It's associated in some 2142 01:41:15.020 --> 01:41:20.350 studies with novelty-seeking impulsivity and higher financial or social risk-taking. 2143 01:41:20.890 --> 01:41:24.609 I wonder if I have that gene. For sure. Probably not. 2144 01:41:24.890 --> 01:41:29.510 Who knows? The 7R variant is unevenly distributed around the world. 2145 01:41:30.130 --> 01:41:33.060 In populations across the Americas, it shows up in roughly 2146 01:41:33.060 --> 01:41:36.359 48% of chromosomes studied, while in East Asia, it's found 2147 01:41:36.399 --> 01:41:41.489 in only about 2%. Whoa, that's crazy. 2148 01:41:41.529 --> 01:41:42.789 It all comes down to genetics. 2149 01:41:43.189 --> 01:41:45.630 Evolutionary work suggests it became more common in groups that 2150 01:41:45.750 --> 01:41:50.350 migrated further after leaving Africa. And those lineages are strongly 2151 01:41:50.409 --> 01:41:55.159 represented in the Americas today. That actually makes... I was 2152 01:41:55.180 --> 01:41:57.520 thinking of the people that had the balls to fucking 2153 01:41:57.560 --> 01:42:01.119 come here. You don't have to do that much, but 2154 01:42:01.600 --> 01:42:04.569 you can still have balls to gamble and... Yeah. 2155 01:42:05.010 --> 01:42:06.970 That must be it. But then Australians should have it. 2156 01:42:07.170 --> 01:42:09.930 That completely– well, sort of. You guys got forced there. 2157 01:42:10.510 --> 01:42:13.130 They moved everybody over there because they were criminals. Right. 2158 01:42:13.890 --> 01:42:18.100 This DDR gene that you just saw, was it DDR4? 2159 01:42:19.220 --> 01:42:20.479 I know a bit about it because I'm writing it 2160 01:42:20.899 --> 01:42:24.560 in my next book. DRD4? Thanks, Jamie. I call this 2161 01:42:24.600 --> 01:42:27.500 the FU gene because I'm trying to figure out what 2162 01:42:27.539 --> 01:42:31.020 makes humans special over other animals. And this is one 2163 01:42:31.039 --> 01:42:35.960 of them that we are. seekers of explorers and uh 2164 01:42:36.079 --> 01:42:38.180 it's it turns out turns out that this gene is 2165 01:42:38.220 --> 01:42:42.500 turned on in teenagers it gets eventually switched off not 2166 01:42:42.539 --> 01:42:46.310 totally but that might be why teenagers say fu to 2167 01:42:46.319 --> 01:42:49.050 their parents but it's a way genetically to get them 2168 01:42:49.090 --> 01:42:51.250 out of the nest like oh i can't stand these 2169 01:42:51.289 --> 01:42:54.310 parents they suck they're idiots i'm out of here that's 2170 01:42:54.390 --> 01:42:56.010 in this in this gene. 2171 01:42:57.760 --> 01:43:02.479 Well it's also um I, as a parent, have been 2172 01:43:02.579 --> 01:43:06.000 very aware of not doing that to my kids, like 2173 01:43:06.060 --> 01:43:08.239 not forcing them into something that they don't want to 2174 01:43:08.300 --> 01:43:11.770 do or pushing them in any general direction, but rather 2175 01:43:11.909 --> 01:43:15.909 encouraging them to seek out their interests and encouraging them 2176 01:43:16.050 --> 01:43:19.069 to just like take chances. And if I ever correct them, 2177 01:43:19.289 --> 01:43:21.550 if I ever get upset about something, one of the 2178 01:43:21.609 --> 01:43:24.159 first things that I tell them is I've done everything 2179 01:43:24.180 --> 01:43:27.180 that you've done. I've made every mistake. I've fucked up. 2180 01:43:27.970 --> 01:43:31.470 You're smarter than me. I've fucked up everything. I've lied 2181 01:43:31.489 --> 01:43:35.270 to my parents. I lied to teachers. I've done everything 2182 01:43:35.489 --> 01:43:37.989 that you're doing. So this is not a unique thing. 2183 01:43:38.050 --> 01:43:40.949 I'm just telling you from my own personal experience and 2184 01:43:40.989 --> 01:43:44.039 my perspective, this is why I think because I love 2185 01:43:44.079 --> 01:43:45.640 you and I want you to do well in life. 2186 01:43:45.800 --> 01:43:48.619 I just want you to recognize this. And that's how 2187 01:43:48.880 --> 01:43:50.020 I correct my kids. 2188 01:43:50.060 --> 01:43:50.819 I love that. 2189 01:43:51.020 --> 01:43:53.220 It's never like you listen to me because I'm your father. 2190 01:43:53.239 --> 01:43:54.399 There's none of that shit. 2191 01:43:54.420 --> 01:43:54.640 Yeah, yeah. 2192 01:43:54.659 --> 01:43:55.399 The old way we were raised. 2193 01:43:55.420 --> 01:43:55.899 I hate that shit. 2194 01:43:56.270 --> 01:43:56.850 It doesn't work. 2195 01:43:57.090 --> 01:44:00.729 No. And it makes you resentment. But also probably makes 2196 01:44:00.789 --> 01:44:03.189 you want to do better than your parents. So it 2197 01:44:03.229 --> 01:44:05.729 motivates you in a certain way. My parents were not 2198 01:44:05.829 --> 01:44:09.010 risk takers at all. And my whole life I've been 2199 01:44:09.029 --> 01:44:10.189 like a wild risk taker. 2200 01:44:10.369 --> 01:44:13.189 Really same. Yeah, I was resentful that my father didn't 2201 01:44:13.609 --> 01:44:16.449 have enough ambition. Now he's a great guy. We're best 2202 01:44:16.470 --> 01:44:19.510 friends actually. It's been the greatest thing for me. But 2203 01:44:19.529 --> 01:44:20.949 one of the things I did with my kids, you're 2204 01:44:20.970 --> 01:44:24.600 reminding me, is he's 19. He's a well-built guy because 2205 01:44:24.640 --> 01:44:26.520 we were going to the gym for a number of years. 2206 01:44:26.560 --> 01:44:30.149 I tried to train him in health. But he spent 2207 01:44:30.159 --> 01:44:32.569 the summer with me. He's literally still working for me 2208 01:44:32.609 --> 01:44:35.670 this summer to help with the podcast and the magazine 2209 01:44:35.829 --> 01:44:38.710 we're about to launch. And Benjamin's his name. He's the 2210 01:44:38.750 --> 01:44:42.329 best kid. But he slacked off. He was like, Ben, 2211 01:44:42.350 --> 01:44:43.949 I put you in charge of social media. You haven't 2212 01:44:43.970 --> 01:44:46.550 posted in a week. What's going on? Well, you know, 2213 01:44:46.569 --> 01:44:48.520 I slept in. So I had to think, am I 2214 01:44:48.560 --> 01:44:50.079 going to get mad at him like I would a 2215 01:44:50.100 --> 01:44:53.489 normal employee or do I treat him differently? And I 2216 01:44:53.550 --> 01:44:56.909 decided to treat him differently probably because he's my son. 2217 01:44:56.949 --> 01:44:59.670 But I didn't want to ruin the relationship. But what 2218 01:44:59.689 --> 01:45:04.250 I did was I said, you know, I really think 2219 01:45:04.289 --> 01:45:07.510 you can do better. I think everything you've done, the weightlifting, 2220 01:45:07.609 --> 01:45:13.100 the calculus, you're amazing. But in this, you're not. So 2221 01:45:13.109 --> 01:45:16.800 what's going on? And it worked. We've become closer. He's 2222 01:45:17.000 --> 01:45:19.130 really into it. He's doing a good job now. 2223 01:45:19.140 --> 01:45:19.579 That's great. 2224 01:45:19.960 --> 01:45:21.239 So that's the way to do it, I think. You 2225 01:45:21.279 --> 01:45:23.989 can't be too hard on them. Can't say you fucked up. 2226 01:45:24.100 --> 01:45:26.819 Yeah. I mean that kind of can work but it's 2227 01:45:26.859 --> 01:45:30.300 a blunt instrument and it doesn't work on everybody and 2228 01:45:30.340 --> 01:45:34.670 it also develops resentment. And they also– they miss out 2229 01:45:35.010 --> 01:45:40.270 on experiencing your perspective as a– like for them to 2230 01:45:40.329 --> 01:45:42.720 understand that you are just a person who has lived 2231 01:45:42.779 --> 01:45:46.810 longer than them. And that you can help them navigate 2232 01:45:46.850 --> 01:45:47.350 this road. 2233 01:45:47.390 --> 01:45:50.909 Yeah, so you don't have to make the same mistakes. 2234 01:45:50.189 --> 01:45:54.140 That we did. That's why you're helping them. You're talking 2235 01:45:54.180 --> 01:45:57.659 to them about this not because you're just a mean 2236 01:45:57.760 --> 01:46:00.020 dad who likes to fucking tell the kids what to do. 2237 01:46:00.039 --> 01:46:02.579 Because we've all experienced that. I mean I had friends 2238 01:46:02.619 --> 01:46:04.680 growing up whose fathers would fucking scream at them and 2239 01:46:04.720 --> 01:46:09.479 throw things and beat them. And it's like, God. And 2240 01:46:09.500 --> 01:46:13.460 then you just grow up fucking traumatized and always resentful 2241 01:46:13.520 --> 01:46:18.640 and angry. Instead of just recognizing that like, oh, I'm 2242 01:46:18.739 --> 01:46:23.039 so fortunate that my parents have this perspective where they 2243 01:46:23.060 --> 01:46:26.199 can explain to me why I'm going through what I'm 2244 01:46:26.239 --> 01:46:28.210 going through and how they got through it. 2245 01:46:28.720 --> 01:46:31.270 Like a mentor. You're not their best friend. You're their mentor. 2246 01:46:31.359 --> 01:46:31.739 Yes. 2247 01:46:32.100 --> 01:46:33.130 Best friend doesn't work either. 2248 01:46:33.710 --> 01:46:36.329 No, that doesn't work either because that just allows too 2249 01:46:36.350 --> 01:46:39.409 much shenanigans. You have to have some rules. You have 2250 01:46:39.449 --> 01:46:41.289 to have some sort of regulations. 2251 01:46:41.590 --> 01:46:41.789 Yeah. 2252 01:46:42.010 --> 01:46:44.369 And your kids turned out well. What's that? 2253 01:46:44.449 --> 01:46:45.069 How'd your kids do? 2254 01:46:45.149 --> 01:46:48.829 Oh, they're great. Great. I'm so, so lucky. So fucking lucky. 2255 01:46:49.069 --> 01:46:52.289 I mean, I feel so fortunate. They're so smart and 2256 01:46:52.350 --> 01:46:55.640 ambitious and driven. And so it's wild. It's wild to watch, 2257 01:46:55.680 --> 01:47:00.140 you know, and talented. And it's, um, and also like 2258 01:47:00.220 --> 01:47:03.640 we never went through that period where, um, they hit 2259 01:47:03.680 --> 01:47:07.840 teenage years and they hate you like that. Well, God, 2260 01:47:07.899 --> 01:47:11.020 that's so nice. I mean, my youngest, she'd get upset 2261 01:47:11.039 --> 01:47:13.539 at me sometimes about certain things, but she bounces back quickly. 2262 01:47:13.979 --> 01:47:16.800 It's never like some kids where they just grow to 2263 01:47:16.840 --> 01:47:17.619 hate their parents. 2264 01:47:18.100 --> 01:47:21.659 The RD4 gene. Maybe they don't have a strong one. 2265 01:47:21.880 --> 01:47:24.739 I don't know about that. I think it's how you 2266 01:47:24.819 --> 01:47:27.539 communicate with them. I really do. I think that's a 2267 01:47:27.640 --> 01:47:30.510 big factor. You have to communicate with them like you 2268 01:47:31.010 --> 01:47:35.109 truly care about their development. And the most important thing 2269 01:47:35.609 --> 01:47:39.649 I think is that I always tell them, whatever you've done, 2270 01:47:40.029 --> 01:47:42.729 whatever mistake you've made, I made way worse mistakes. I 2271 01:47:42.729 --> 01:47:44.560 was like I am not coming at you from a 2272 01:47:44.560 --> 01:47:48.479 flawless person. I'm not coming at you from the perspective 2273 01:47:48.520 --> 01:47:52.079 of someone who like you're an idiot. I figured that out. 2274 01:47:52.359 --> 01:47:56.100 You should figure it out. Like no. Whenever– from the 2275 01:47:56.140 --> 01:47:58.659 time they were really little, anytime I had to correct them, 2276 01:47:58.739 --> 01:48:02.260 I said I did everything that you're doing. Everything. 2277 01:48:03.489 --> 01:48:05.250 I threw my food on the floor too. 2278 01:48:05.470 --> 01:48:09.779 Yes. All the above. Whatever fucking stupid thing you've done 2279 01:48:09.840 --> 01:48:11.039 as a kid, I guarantee you. 2280 01:48:11.100 --> 01:48:14.699 That is great advice. Really great advice. So I hope 2281 01:48:14.770 --> 01:48:17.670 everyone listening hears that because I actually had to learn 2282 01:48:17.689 --> 01:48:19.670 the hard way. My first kid, I did what my 2283 01:48:19.689 --> 01:48:22.680 parents did. did which was you can't say that yeah 2284 01:48:22.840 --> 01:48:25.340 and my first is a lot more rebellious and distant 2285 01:48:25.399 --> 01:48:28.850 than my third for that reason interesting yeah it actually 2286 01:48:28.869 --> 01:48:29.909 is really true i've seen it. 2287 01:48:30.170 --> 01:48:31.689 Yeah and it's i thought it was going to kill 2288 01:48:31.710 --> 01:48:34.590 their motivation but it doesn't at all i thought like 2289 01:48:35.289 --> 01:48:38.050 making things easy for them and not being strict. Like 2290 01:48:38.109 --> 01:48:39.970 maybe it's good to be strict because then you just 2291 01:48:40.010 --> 01:48:43.479 have this determination to show everybody. I don't think that 2292 01:48:43.520 --> 01:48:46.779 was my thing as a child. Like I'll fucking show you. 2293 01:48:47.239 --> 01:48:50.119 But I don't think everybody needs that. I think you're 2294 01:48:50.180 --> 01:48:55.079 much better off having a healthy relationship with ambition where 2295 01:48:55.100 --> 01:48:58.079 you're excited about things because you're passionate about them and 2296 01:48:58.100 --> 01:49:04.569 you find great reward in being creative or being enthusiastic 2297 01:49:04.609 --> 01:49:05.210 about something. 2298 01:49:05.310 --> 01:49:08.369 Exactly. And open their eyes to the world that exists. 2299 01:49:08.430 --> 01:49:09.050 Yes. 2300 01:49:09.590 --> 01:49:11.390 We used to do work experience. You go and do 2301 01:49:11.430 --> 01:49:13.710 a job and that's your work experience. The reason I 2302 01:49:13.729 --> 01:49:15.430 wanted my son Ben to work with me is he 2303 01:49:15.470 --> 01:49:18.010 can see what it's like to be an entrepreneur and 2304 01:49:18.090 --> 01:49:20.930 build something and be excited. And work is super fun 2305 01:49:20.949 --> 01:49:23.390 when you get into it. I think a lot of 2306 01:49:23.409 --> 01:49:26.029 kids just don't get that experience. They don't know what's possible. 2307 01:49:26.329 --> 01:49:26.510 Right. 2308 01:49:26.529 --> 01:49:29.010 And just showing them the world is what we can 2309 01:49:29.050 --> 01:49:29.590 do as parents. 2310 01:49:29.869 --> 01:49:34.560 That's awesome. Yeah. And You know, I mean, some people 2311 01:49:34.640 --> 01:49:37.279 don't have that at home, unfortunately, but that's one of 2312 01:49:37.300 --> 01:49:39.600 the cool things about the world that we live in 2313 01:49:40.060 --> 01:49:43.659 is that kids today have access to so many different 2314 01:49:43.699 --> 01:49:47.970 perspectives now because of the internet. There's so many different 2315 01:49:48.130 --> 01:49:52.130 podcasts and YouTube conversations and different things where they can 2316 01:49:52.409 --> 01:49:55.470 just take a little tool from that, just take a 2317 01:49:55.489 --> 01:49:57.649 little piece from that and apply it to the way 2318 01:49:57.720 --> 01:50:00.100 they interact with the world. Yeah. 2319 01:50:00.739 --> 01:50:04.750 Um, For sure. And I would encourage parents to give 2320 01:50:04.770 --> 01:50:08.300 their kids stuff to read. We talked about social media, 2321 01:50:08.340 --> 01:50:11.600 how that's just addictive. I saw how my kids wanted 2322 01:50:11.619 --> 01:50:14.800 to just scroll through their phones and read. And if 2323 01:50:14.840 --> 01:50:17.119 they can't read a book, give them a magazine. I 2324 01:50:17.380 --> 01:50:22.029 subscribe to Nat Geo, National Geographic, for my kids. And 2325 01:50:22.050 --> 01:50:25.210 I think get them used to reading. It's going to 2326 01:50:25.310 --> 01:50:26.529 be a lost art if we don't. 2327 01:50:27.289 --> 01:50:31.039 I know. Isn't that nuts? I maybe read 10% of 2328 01:50:31.079 --> 01:50:33.880 the things that I consume. I consume so much in 2329 01:50:34.020 --> 01:50:39.739 audio just for time reasons because there's so much time 2330 01:50:39.779 --> 01:50:42.720 where I'm driving my car or I'm working out or 2331 01:50:42.739 --> 01:50:45.840 I'm in the sauna or I'm in the hyperbaric chamber 2332 01:50:46.060 --> 01:50:47.319 or I'm in the red light therapy. 2333 01:50:47.500 --> 01:50:48.510 That's reading three years. 2334 01:50:48.619 --> 01:50:53.090 It is similar, but I think it's only like 70% 2335 01:50:53.090 --> 01:50:55.510 of reading. I don't think it's 100%. I don't think 2336 01:50:55.529 --> 01:50:57.489 you get the full effect, but it's still way better 2337 01:50:57.529 --> 01:51:01.449 than not doing it. But I'm aware that like sitting 2338 01:51:01.510 --> 01:51:05.390 there concentrating, actually reading a book without hearing another person's 2339 01:51:05.489 --> 01:51:09.069 voice talking, there's another mechanism. There's another thing that's going on. 2340 01:51:10.300 --> 01:51:12.880 It's a different way you interact with the material, whether 2341 01:51:12.899 --> 01:51:14.140 it's nonfiction or fiction. 2342 01:51:14.699 --> 01:51:16.619 Yeah, I like the fact that I can listen to 2343 01:51:16.640 --> 01:51:18.460 you and I'm doing something else. I don't have to 2344 01:51:18.479 --> 01:51:20.500 sit down. I can move, go for a walk. 2345 01:51:21.420 --> 01:51:25.439 For me, it's just I have too many interests. I 2346 01:51:25.460 --> 01:51:27.979 have way too many things that I do. So it's 2347 01:51:28.039 --> 01:51:30.720 very hard for me to just allocate a certain amount 2348 01:51:30.739 --> 01:51:32.560 of time to sit there in silence and read. 2349 01:51:32.760 --> 01:51:34.920 Yeah. I use reading to fall asleep. That's a good way. 2350 01:51:35.479 --> 01:51:37.390 It does do that, right? It's kind of nuts how 2351 01:51:37.470 --> 01:51:38.710 well it does that. Yeah. 2352 01:51:38.989 --> 01:51:41.050 Although I am finding it's harder to read now that 2353 01:51:41.409 --> 01:51:42.449 my eyes aren't young. 2354 01:51:42.470 --> 01:51:45.060 I need some of my gene therapy myself. 2355 01:51:46.079 --> 01:51:47.880 I've tried that. Does it work for you? 2356 01:51:47.979 --> 01:51:51.989 Oh, yeah. Oh, I mean– People are skeptical about this 2357 01:51:52.109 --> 01:51:54.510 and they think I'm full of shit. No, I don't 2358 01:51:54.609 --> 01:51:58.250 need reading glasses anymore. Really? Yes. I had reading– I 2359 01:51:58.329 --> 01:52:00.750 always have these fucking things laying around. I don't even 2360 01:52:00.829 --> 01:52:01.810 use them anymore. That's awesome. 2361 01:52:01.850 --> 01:52:03.750 Yeah, there's a lot of science now for red light. 2362 01:52:04.050 --> 01:52:07.649 It's real. I can tell you as a regular user 2363 01:52:07.710 --> 01:52:11.920 for multiple years, it took a while. It took like– 2364 01:52:11.949 --> 01:52:13.770 I was waiting for it in the beginning like, what 2365 01:52:14.109 --> 01:52:16.699 the fuck? And not only that, in the beginning because 2366 01:52:16.739 --> 01:52:18.880 I don't close my eyes in the red light bed, 2367 01:52:19.350 --> 01:52:21.649 I thought it was making things blurrier. I was like, 2368 01:52:21.699 --> 01:52:23.810 oh my god, am I fucking up my eyesight like 2369 01:52:23.869 --> 01:52:27.829 listening to these assholes? But no, it just took a while. 2370 01:52:28.250 --> 01:52:31.329 And then over the course of like many months, I 2371 01:52:31.369 --> 01:52:34.970 started seeing some small improvements. And then I started seeing 2372 01:52:35.010 --> 01:52:37.850 some pretty big improvements over the course of about a year. 2373 01:52:38.430 --> 01:52:42.829 Whereas now, it's not– my eyes aren't perfect. They aren't 2374 01:52:42.890 --> 01:52:44.890 like they were when I was 20. But they are 2375 01:52:45.050 --> 01:52:47.090 way better than they were when I was 50. 2376 01:52:47.069 --> 01:52:48.850 How often did you have to do that? 2377 01:52:49.350 --> 01:52:51.680 I do it three times a week minimum. That's what 2378 01:52:51.699 --> 01:52:53.460 I try to do. But sometimes I'll do it five 2379 01:52:53.500 --> 01:52:55.539 days a week. I just get in there and it's 2380 01:52:55.539 --> 01:52:57.779 20 minutes. I lay in a light bed, close my eyes, 2381 01:52:58.159 --> 01:53:01.239 open my eyes, whatever. It seems to work on your 2382 01:53:01.319 --> 01:53:03.220 vision even if you wear a blindfold. 2383 01:53:03.699 --> 01:53:05.439 What about people that can't afford a bed? Can you 2384 01:53:05.479 --> 01:53:06.159 get little devices? Yes. 2385 01:53:06.569 --> 01:53:11.689 You can get– well, there's a company called– it's called Juve, right? J-U-U-V. 2386 01:53:12.329 --> 01:53:14.170 Is that the name of the company? They were our 2387 01:53:14.250 --> 01:53:16.189 sponsor at one point in time. That's how I started it. 2388 01:53:16.739 --> 01:53:20.380 They had– it's just a light panel that you stand 2389 01:53:20.420 --> 01:53:21.100 in front of. Oh, yeah. 2390 01:53:21.119 --> 01:53:21.899 I've got one of those. 2391 01:53:21.920 --> 01:53:26.239 Yeah. And that works too. But this one, the one 2392 01:53:26.260 --> 01:53:33.449 that I got, a red and near infrared light therapy devices, JOOV, J-O-O-V-V, 2393 01:53:34.029 --> 01:53:37.670 medical grade light therapy devices. I had one of those 2394 01:53:37.810 --> 01:53:42.210 and that's when I started seeing benefits. But the big 2395 01:53:42.270 --> 01:53:44.390 one that I got, I got from Gary Brekka from 2396 01:53:44.470 --> 01:53:47.090 his company and it's a like a fucking tanning bed 2397 01:53:47.130 --> 01:53:49.369 and you lie in it and that one's amazing but 2398 01:53:49.390 --> 01:53:51.670 that's expensive but i don't think you have to have 2399 01:53:51.710 --> 01:53:54.659 that for that those kind of improvements also improves collagen 2400 01:53:54.699 --> 01:53:58.579 your skin makes you look better and um the but 2401 01:53:58.779 --> 01:54:02.399 for me the most obvious and profound was the improvement 2402 01:54:02.420 --> 01:54:03.239 in my vision. 2403 01:54:03.680 --> 01:54:05.850 Well it makes sense the the science behind red light 2404 01:54:05.939 --> 01:54:08.229 wasn't there 10 years ago and people were questioning it 2405 01:54:08.689 --> 01:54:11.449 but now we know if you shine certain wavelengths like 2406 01:54:11.949 --> 01:54:15.909 near infrared on cells The mitochondria, which are important for 2407 01:54:16.149 --> 01:54:19.729 reversing aging or slowing it, get revved up. It's actually 2408 01:54:19.770 --> 01:54:24.189 related to Viagra. Long story, but Viagra and red light 2409 01:54:24.220 --> 01:54:27.579 have something in common, and it does help mitochondria. And 2410 01:54:27.600 --> 01:54:29.760 that's very important for the eye. The mitochondria are actually 2411 01:54:29.779 --> 01:54:32.920 the most important in any part of your body. The 2412 01:54:33.060 --> 01:54:35.680 eye is the most important part. And part of the 2413 01:54:35.699 --> 01:54:38.100 reason we lose our vision is the mitochondria don't make 2414 01:54:38.119 --> 01:54:38.869 enough energy for the eye. 2415 01:54:38.920 --> 01:54:41.489 How come you haven't done red light therapy before then? 2416 01:54:42.050 --> 01:54:46.189 Well, I do, but not. routinely so I have one 2417 01:54:46.199 --> 01:54:48.109 of those bricks that I turn on while I'm in 2418 01:54:48.130 --> 01:54:50.310 the shower and I have a red light cap for 2419 01:54:50.329 --> 01:54:52.090 my hair which there's some evidence. 2420 01:54:52.270 --> 01:54:54.050 My wife has one of those it works a little 2421 01:54:54.069 --> 01:54:55.569 bit she looks like a fucking alien. 2422 01:54:55.729 --> 01:54:57.770 What I do is I yeah it does it looks 2423 01:54:57.789 --> 01:54:59.310 a little bit silly it's weird I don't wear it 2424 01:54:59.329 --> 01:55:02.109 in public but I do lower it and I look 2425 01:55:02.170 --> 01:55:03.770 at it and it shines in my eyes and on 2426 01:55:03.789 --> 01:55:06.090 my face in the hopes that it might help. 2427 01:55:06.210 --> 01:55:08.029 Yeah they have one that you wear like Dr. Doom 2428 01:55:08.069 --> 01:55:10.510 like fits over your face and like blast red light 2429 01:55:10.590 --> 01:55:11.550 in your whole face. 2430 01:55:11.430 --> 01:55:14.890 I definitely feel a bit weird afterwards and I can 2431 01:55:14.930 --> 01:55:17.670 see speckles, but I think the science says that it 2432 01:55:17.689 --> 01:55:18.010 can help. 2433 01:55:18.609 --> 01:55:22.810 Well, all I know is my own anecdotal experience. And 2434 01:55:22.970 --> 01:55:25.750 for me, it has radically improved my vision. 2435 01:55:26.310 --> 01:55:26.989 That's a good tip. 2436 01:55:27.109 --> 01:55:31.829 Yeah. It stopped. It was, my vision was degrading. Like 2437 01:55:32.090 --> 01:55:34.930 it was, it was pretty odd. Like I first started 2438 01:55:35.090 --> 01:55:38.229 using like reading glasses, like a one X, like it 2439 01:55:38.250 --> 01:55:39.510 made it a little better. I'm like, Oh, there's a 2440 01:55:39.510 --> 01:55:41.229 little better. It makes it clear. And then I went 2441 01:55:41.270 --> 01:55:43.800 to two and And then I was using 2.5. Right. 2442 01:55:44.500 --> 01:55:46.220 And it made it better. But it was like, God, 2443 01:55:46.260 --> 01:55:49.039 this is annoying. And then if I would try to 2444 01:55:49.119 --> 01:55:52.819 like read an email and I didn't have my reading glasses, 2445 01:55:52.859 --> 01:55:55.529 I couldn't read shit. Now, crystal clear. 2446 01:55:55.649 --> 01:55:55.869 Yeah. 2447 01:55:56.310 --> 01:55:56.970 No problem at all. 2448 01:55:57.149 --> 01:55:59.729 Well, so my latest show is about the eye and 2449 01:55:59.750 --> 01:56:03.210 how to protect the eye's health. And so there's a 2450 01:56:03.289 --> 01:56:07.109 lot you can do actually, supplements, red light, other things. 2451 01:56:07.850 --> 01:56:09.510 I take supplements for it too. I should mention that. 2452 01:56:09.630 --> 01:56:13.050 I take– I have no affiliation with these people, but 2453 01:56:13.090 --> 01:56:17.920 Pure Encapsulations makes a supplement called Macular Support, and I 2454 01:56:17.960 --> 01:56:20.680 take that. And it's a combination of lutein and a 2455 01:56:20.720 --> 01:56:21.340 few other things. 2456 01:56:21.920 --> 01:56:25.479 Yeah, there was a trial a while ago that showed 2457 01:56:25.539 --> 01:56:32.300 that taking xanthine and others, astaxanthine, lutein, they're good for 2458 01:56:32.319 --> 01:56:34.079 the eye. So you can get products like that. 2459 01:56:34.100 --> 01:56:34.560 Do you take it? 2460 01:56:35.279 --> 01:56:37.500 Not that brand, but yes, I take something similar. 2461 01:56:37.520 --> 01:56:40.420 And has it helped you at all? I don't know. 2462 01:56:40.439 --> 01:56:41.579 I haven't done an experiment. 2463 01:56:41.979 --> 01:56:43.939 Right. Well, if you weren't taking it, maybe you would 2464 01:56:43.979 --> 01:56:45.279 have more degeneration. 2465 01:56:45.539 --> 01:56:48.520 Yeah. Well, you know, I've got near perfect vision. I 2466 01:56:48.560 --> 01:56:49.300 don't need glasses. 2467 01:56:49.319 --> 01:56:49.699 Do you really? 2468 01:56:49.720 --> 01:56:50.810 Yeah. 2469 01:56:51.239 --> 01:56:51.779 Near perfect? 2470 01:56:51.970 --> 01:56:54.069 Near perfect. I mean, I think low light. 2471 01:56:54.350 --> 01:56:56.649 Low light is with me. Where I'll go to a 2472 01:56:56.710 --> 01:56:58.850 restaurant with my kids and they can read the menu. 2473 01:56:58.949 --> 01:57:02.029 And I'm like, that is so embarrassing. You can read that? 2474 01:57:02.409 --> 01:57:04.329 How do you even read that? I can't read shit. 2475 01:57:04.409 --> 01:57:06.189 Do you know why? Why? 2476 01:57:06.390 --> 01:57:09.399 Well, this is what I think. So we know from 2477 01:57:09.479 --> 01:57:12.770 my lab's work that the retina, because it has tens 2478 01:57:12.810 --> 01:57:16.449 of thousands of endings that pick up the light, as 2479 01:57:16.470 --> 01:57:19.909 you get older, those nerves lose their identity and they're 2480 01:57:19.930 --> 01:57:22.770 not working as well. And what we do is with 2481 01:57:22.850 --> 01:57:26.729 our therapy, we can restore those nerves back to being 2482 01:57:27.609 --> 01:57:32.770 functional nerves. And that's why mice and monkeys that lose 2483 01:57:32.810 --> 01:57:38.609 their retinal function get their perfect vision back again. We're reminding... 2484 01:57:38.539 --> 01:57:40.340 those cells that have forgotten how to work so in 2485 01:57:40.359 --> 01:57:43.300 your eye and my eye we're 22 months apart that 2486 01:57:43.340 --> 01:57:46.100 those nerves about half of them have forgotten how to 2487 01:57:46.159 --> 01:57:48.619 work properly so we want to fix that and go 2488 01:57:48.659 --> 01:57:50.140 back to being young it's not that our nerves are 2489 01:57:50.239 --> 01:57:52.510 gone they're not dead they're right there and we can 2490 01:57:52.569 --> 01:57:54.729 restore them and that's going to be true for a 2491 01:57:54.729 --> 01:57:56.729 lot of organs is that the cells are still there 2492 01:57:57.329 --> 01:58:00.170 they just need to be reminded how to work again what. 2493 01:58:00.050 --> 01:58:03.729 Are the potential negative consequences of this kind of work 2494 01:58:03.789 --> 01:58:05.520 like when you when you sit up at night and 2495 01:58:05.529 --> 01:58:09.609 you worry i hope it doesn't do this Is it cancer? 2496 01:58:09.640 --> 01:58:11.140 Is that the big one? Yeah. 2497 01:58:11.539 --> 01:58:14.539 It's– though we've done a lot of work to allay 2498 01:58:14.939 --> 01:58:18.220 real fears. It is possible that if we go too young, 2499 01:58:19.079 --> 01:58:21.989 we can cause dysplasia which is cells doing what they 2500 01:58:22.010 --> 01:58:25.050 shouldn't or if they multiply and spread, that would be cancer. 2501 01:58:25.069 --> 01:58:26.770 If you make the cells too young. Like what I 2502 01:58:26.770 --> 01:58:28.909 was saying before about don't turn me into a baby. Right. 2503 01:58:29.130 --> 01:58:31.140 We don't want to go there. That's what Yamanaka did 2504 01:58:31.720 --> 01:58:34.229 and got the Nobel for it. But that's not good here. 2505 01:58:35.109 --> 01:58:38.090 But we never see our cells turn into stem cells again. 2506 01:58:38.170 --> 01:58:41.210 We can't. We had mice that we left the gene 2507 01:58:41.229 --> 01:58:45.390 therapy on for 21 months in the eye and 19 2508 01:58:45.390 --> 01:58:47.729 months in the whole body of the animal. And if anything, 2509 01:58:47.770 --> 01:58:51.079 they had less tumors than the ones that didn't get treated. 2510 01:58:51.699 --> 01:58:55.539 And we actually know from a wonderful student in my lab, Nalat, 2511 01:58:56.260 --> 01:58:58.140 she's a PhD student. She found that when you turn 2512 01:58:58.180 --> 01:59:00.859 on these three same genes, not in the eye, but 2513 01:59:00.880 --> 01:59:04.470 in cancer cells and tumors growing in mice, human cancers 2514 01:59:04.510 --> 01:59:07.289 growing in mice, they shrink. So we think it might 2515 01:59:07.310 --> 01:59:09.890 actually help for cancer as well, which was a nice surprise. 2516 01:59:10.289 --> 01:59:12.430 Wow. That's incredible. 2517 01:59:12.449 --> 01:59:14.130 It makes sense, right? If you wake up a cancer 2518 01:59:14.149 --> 01:59:18.420 cell and it says, crap, I shouldn't be growing. I 2519 01:59:18.439 --> 01:59:24.319 should be a liver cell or something similar. Now it 2520 01:59:24.479 --> 01:59:26.840 kills itself. So we see that. Cells wake up. They 2521 01:59:26.880 --> 01:59:29.590 realize what they were 30 years ago. And then they 2522 01:59:29.609 --> 01:59:30.210 kill themselves. 2523 01:59:32.149 --> 01:59:34.829 What is on the horizon in terms of like what 2524 01:59:34.850 --> 01:59:37.130 would you like to accomplish or would you like to 2525 01:59:37.189 --> 01:59:39.029 work on that you can't do currently? 2526 01:59:40.710 --> 01:59:44.649 Well, lots, lots. Funding in my lab got completely cut 2527 01:59:44.909 --> 01:59:48.750 last year and we've managed to survive through donations. 2528 01:59:49.689 --> 01:59:52.130 Why did the funding get cut? Was it a USAID thing? 2529 01:59:52.390 --> 01:59:55.060 You remember there was a spat between Harvard and the 2530 01:59:55.100 --> 01:59:58.069 federal government? All of the funding to Harvard Medical School 2531 01:59:58.090 --> 01:59:58.409 got covered. 2532 01:59:58.430 --> 02:00:02.680 Was that during the time where the president was defending 2533 02:00:02.760 --> 02:00:05.720 those anti-Semitic comments on campuses? 2534 02:00:07.000 --> 02:00:07.220 Yeah. 2535 02:00:07.720 --> 02:00:08.500 Well, allegedly. 2536 02:00:09.079 --> 02:00:10.939 I'm not getting into the politics. No need to. 2537 02:00:10.899 --> 02:00:13.520 Get into politics. But during that whole thing, yeah. 2538 02:00:13.920 --> 02:00:17.619 Yeah. So what we– I almost had to fire most 2539 02:00:17.640 --> 02:00:19.359 of the people in my lab during that episode. It 2540 02:00:19.390 --> 02:00:23.899 was quite scary. But I raised– So now my lab 2541 02:00:23.939 --> 02:00:28.699 survives on donations, not on federal government money. Thank you, friends. 2542 02:00:29.060 --> 02:00:29.720 Thank you, thank you. 2543 02:00:30.439 --> 02:00:33.699 Well, the thing is you've accomplished enough where people are like, 2544 02:00:33.859 --> 02:00:35.729 I think he's on to something and I want to 2545 02:00:35.750 --> 02:00:36.449 live forever. 2546 02:00:36.489 --> 02:00:39.029 Well, I'm lucky. Most scientists can't raise money like that. 2547 02:00:39.050 --> 02:00:41.750 So really, really it's a blessing. And now I'm raising 2548 02:00:41.789 --> 02:00:46.470 money through a foundation to help other scientists survive. But yeah, 2549 02:00:46.729 --> 02:00:50.119 it's been a blessing. But your question was what do 2550 02:00:50.140 --> 02:00:50.960 I wish I could do? 2551 02:00:51.220 --> 02:00:51.380 Yeah. 2552 02:00:51.600 --> 02:00:53.250 I wish I could go faster. I wish I could 2553 02:00:53.270 --> 02:00:56.750 try multiple approaches so we don't just have one shot 2554 02:00:56.789 --> 02:01:00.789 on goal. It's going slower than I would want with 2555 02:01:00.829 --> 02:01:02.649 a big injection of cash. We could do a lot 2556 02:01:02.689 --> 02:01:04.439 of trials, a lot of different tissues. We could do 2557 02:01:04.479 --> 02:01:07.920 a whole body rejuvenation as well. 2558 02:01:07.939 --> 02:01:09.899 Do you have a website where people can donate? 2559 02:01:12.000 --> 02:01:14.159 I do. It's Lifespan.com. 2560 02:01:14.779 --> 02:01:17.890 So if you go to Lifespan.com, there's a link there. 2561 02:01:18.199 --> 02:01:21.119 We have a foundation and we're raising money for this 2562 02:01:21.199 --> 02:01:21.979 type of research. 2563 02:01:22.079 --> 02:01:24.560 Is it tax deductible? 2564 02:01:24.840 --> 02:01:28.260 Depends on how big the donation is. For $ 10, you 2565 02:01:28.279 --> 02:01:31.119 get the new magazine that we're putting out and you 2566 02:01:31.140 --> 02:01:34.399 learn all about how to live longer. I'm hoping to 2567 02:01:34.439 --> 02:01:36.859 build the world's largest longevity community of millions of people 2568 02:01:37.239 --> 02:01:40.119 who can learn how to really live longer and build 2569 02:01:40.159 --> 02:01:42.119 healthcare from the ground up because top down from the 2570 02:01:42.159 --> 02:01:45.590 government hasn't worked. Actually, I have a gift for you. 2571 02:01:46.430 --> 02:01:46.819 What do you got? 2572 02:01:47.279 --> 02:01:53.600 I made something for you that's unique. This is for you, Joe, 2573 02:01:53.819 --> 02:01:56.979 as a thanks to all the support you've given me 2574 02:01:57.149 --> 02:01:58.369 and the scientists over the years. 2575 02:01:58.390 --> 02:02:03.350 First edition. Lifespan magazine, ladies and gentlemen. Look at that. 2576 02:02:03.850 --> 02:02:04.890 It's written by scientists. 2577 02:02:04.930 --> 02:02:07.289 What a great cover. It's like a velvet cover. What 2578 02:02:07.350 --> 02:02:08.390 is this material? 2579 02:02:08.409 --> 02:02:10.529 I figured you might like that. Inside is the magazine. 2580 02:02:10.550 --> 02:02:13.989 What is this material? It's beautiful. Velour. Velour. 2581 02:02:14.109 --> 02:02:16.920 Oh, velour, of course. At great expense. No, the magazine 2582 02:02:16.979 --> 02:02:19.760 doesn't come with velour. That's just special for Joe as 2583 02:02:19.779 --> 02:02:20.720 a thank you present. 2584 02:02:21.180 --> 02:02:22.340 Thank you very much. 2585 02:02:22.539 --> 02:02:25.800 Most science out there is written by reporters who don't 2586 02:02:25.859 --> 02:02:29.789 know what they're talking about. And so we wrote this 2587 02:02:29.949 --> 02:02:32.069 for the public, and you can believe whatever you read 2588 02:02:32.109 --> 02:02:32.369 in there. 2589 02:02:32.909 --> 02:02:35.930 All right. Beautiful. And it's velour, so you have to 2590 02:02:35.970 --> 02:02:36.350 trust it. 2591 02:02:36.470 --> 02:02:39.810 So that's at Lifespan.com. You can subscribe. Get that every 2592 02:02:39.869 --> 02:02:40.949 month just for $ 10. 2593 02:02:40.850 --> 02:02:43.949 I like the take at the bottom. Life's too short. 2594 02:02:44.069 --> 02:02:44.829 Let's fix that. 2595 02:02:45.350 --> 02:02:46.090 That's our slogan. 2596 02:02:46.109 --> 02:02:47.649 That's a great slogan. 2597 02:02:48.069 --> 02:02:48.489 Yeah. 2598 02:02:48.510 --> 02:02:49.590 That's an awesome slogan. 2599 02:02:50.029 --> 02:02:53.489 So it's a community. It's the show. My show is 2600 02:02:53.550 --> 02:02:56.250 also called Lifespan on YouTube. But the magazine is a 2601 02:02:56.289 --> 02:02:59.710 passion project. I want to put out something that people love. 2602 02:02:59.770 --> 02:03:05.310 It's beautiful. It's like National Geographic. By the way, just today, 2603 02:03:05.890 --> 02:03:10.090 this is no joke. It seems crazy. But my lab's 2604 02:03:10.130 --> 02:03:11.869 research is on the cover of National Geographic. 2605 02:03:12.350 --> 02:03:12.930 Oh, that's awesome. 2606 02:03:12.949 --> 02:03:15.890 That just came out today. They heard, by the way, 2607 02:03:15.949 --> 02:03:19.020 at NatGeo, they said, you going on Joe Rogan? I went, yeah. 2608 02:03:19.039 --> 02:03:20.859 They goes, all right, we'll put it out early. So 2609 02:03:20.880 --> 02:03:24.079 you can now read about my lab's research on NatGeo 2610 02:03:24.119 --> 02:03:24.659 as well today. 2611 02:03:24.819 --> 02:03:27.840 That's very cool. That's very cool. So you would just 2612 02:03:27.899 --> 02:03:32.319 like to do more, have more funding, do more. That's 2613 02:03:32.380 --> 02:03:34.430 the thing that you wish you could be working on now, 2614 02:03:34.489 --> 02:03:39.680 just having more different, more different. studies and tests running concurrently. 2615 02:03:39.720 --> 02:03:42.020 We could go so fast with AI because it's spitting 2616 02:03:42.060 --> 02:03:44.460 out new drug candidates all the time that we can't test. 2617 02:03:44.520 --> 02:03:47.260 It takes years to get through. So with money, we 2618 02:03:47.300 --> 02:03:49.819 could do a lot more trials and put these through 2619 02:03:50.140 --> 02:03:51.760 different diseases much faster. 2620 02:03:52.000 --> 02:03:54.220 If you had no regulations, like an island of Dr. 2621 02:03:54.260 --> 02:03:55.239 Moreau type deal? 2622 02:03:57.460 --> 02:04:02.899 Well, at the risk of getting kicked out of my university, theoretically, 2623 02:04:03.100 --> 02:04:07.529 we could very safely do more animal studies And with 2624 02:04:07.590 --> 02:04:11.539 those best candidates, put them into humans quicker. Right now, 2625 02:04:11.680 --> 02:04:14.340 it takes years. It's taken us close to 10 years 2626 02:04:14.380 --> 02:04:18.020 to go from the first discovery in my lab in 2627 02:04:18.060 --> 02:04:20.989 Nature magazine to now. But that's too slow. There are 2628 02:04:21.010 --> 02:04:24.470 people dying, 150,000 a day on this planet. It's terrible. 2629 02:04:25.170 --> 02:04:27.510 So I would love to have the resources, you know, 2630 02:04:27.590 --> 02:04:31.399 like Jeff Bezos and others. My company, by the way, 2631 02:04:31.439 --> 02:04:33.239 even though we lead the pack of all these guys, 2632 02:04:34.300 --> 02:04:39.149 we're really small. We're a pretty small little outfit in Boston. 2633 02:04:40.130 --> 02:04:42.630 We've raised a lot less money. But because I think 2634 02:04:42.649 --> 02:04:45.770 we're focused, we have. And we started earlier. We're doing 2635 02:04:45.810 --> 02:04:46.149 pretty well. 2636 02:04:46.170 --> 02:04:48.640 That's the big one. You started earlier. You have a 2637 02:04:48.659 --> 02:04:49.819 lot of momentum on your side. 2638 02:04:49.840 --> 02:04:54.279 Yeah. I think we could have a big impact on 2639 02:04:54.359 --> 02:04:58.680 aging in our lifetime with more money directed in general 2640 02:04:58.760 --> 02:05:01.489 at the field, not just me, but spread it. And 2641 02:05:01.609 --> 02:05:04.010 so the money that we raise from the magazine is 2642 02:05:04.050 --> 02:05:08.380 going to support Other labs as well and students who 2643 02:05:08.420 --> 02:05:10.180 can find these medicines quicker. 2644 02:05:10.720 --> 02:05:13.600 So if you– in a perfect world and you had 2645 02:05:13.779 --> 02:05:18.050 unlimited resources, you would just run a bunch of different 2646 02:05:18.100 --> 02:05:20.770 clinical trials and studies concurrently? 2647 02:05:20.789 --> 02:05:23.770 Yeah. AI is feeding us molecules. We put them into mice. 2648 02:05:23.789 --> 02:05:25.329 We go to monkeys. We go to humans and it 2649 02:05:25.350 --> 02:05:29.529 would just be fast. One of my friends, Alex Zakharonkov, 2650 02:05:29.949 --> 02:05:33.710 he has a similar company but not on exactly what 2651 02:05:33.729 --> 02:05:36.890 we do, not on reprogramming. But he's able– I think 2652 02:05:36.930 --> 02:05:41.850 he's on his 35th drug. But he's driven by AI 2653 02:05:42.470 --> 02:05:45.760 and robots. His whole lab is robots. At least he 2654 02:05:45.800 --> 02:05:48.949 says they are. And then he goes into humans. And 2655 02:05:48.989 --> 02:05:53.140 his company is worth billions. That approach applied to what 2656 02:05:53.180 --> 02:05:54.319 we do would be incredible. 2657 02:05:56.300 --> 02:06:00.840 That's best-case scenario. That would be incredible. Well, I'm hoping 2658 02:06:00.920 --> 02:06:03.340 through this conversation that people are going to reach out. 2659 02:06:03.869 --> 02:06:07.350 And I'm hoping through this conversation that people are realizing like, oh, well, 2660 02:06:07.909 --> 02:06:11.189 so much work has been done and so many breakthroughs 2661 02:06:11.260 --> 02:06:14.279 have been made. If they had more access to resources, 2662 02:06:14.500 --> 02:06:18.819 more access to different– whatever you need and that you 2663 02:06:18.840 --> 02:06:20.199 could run all these different studies. 2664 02:06:21.619 --> 02:06:25.060 We could. Our budget in my lab is only– it's 2665 02:06:25.640 --> 02:06:28.819 almost three and a bit million. It's not much compared 2666 02:06:28.840 --> 02:06:30.500 to what impact it could have on the planet, which 2667 02:06:30.560 --> 02:06:33.579 is trillions of dollars saved. Just in the U.S. 2668 02:06:33.619 --> 02:06:33.960 Alone. 2669 02:06:34.439 --> 02:06:39.300 So it's a little bit of donation or getting a magazine. 2670 02:06:39.960 --> 02:06:43.500 The impact would be life-changing for all of us. Who 2671 02:06:43.539 --> 02:06:44.920 doesn't age? Who doesn't get diseases? 2672 02:06:45.260 --> 02:06:46.819 Right. And who doesn't want to feel better? 2673 02:06:47.609 --> 02:06:47.869 Yeah. 2674 02:06:48.409 --> 02:06:51.010 It's also like so much– you can get so much 2675 02:06:51.090 --> 02:06:52.729 more done if you feel better. 2676 02:06:53.869 --> 02:06:56.130 Well, we take it for granted until we feel sick 2677 02:06:56.170 --> 02:06:57.829 and then it's like, oh, I forgot what it's like 2678 02:06:57.850 --> 02:06:58.470 to feel well. 2679 02:06:58.789 --> 02:07:02.060 Exactly. Exactly. I had a day a week and a 2680 02:07:02.079 --> 02:07:06.399 half ago. Where I came back from Italy. I was 2681 02:07:06.420 --> 02:07:09.350 a little jet lagged. I didn't sleep right. And I 2682 02:07:09.390 --> 02:07:11.229 worked out really hard a bunch of days in a row. 2683 02:07:11.270 --> 02:07:13.489 And I was working constantly. And then I had one 2684 02:07:13.529 --> 02:07:15.970 day I was like, I kind of feel like shit. 2685 02:07:16.069 --> 02:07:20.529 Like I better not do anything today. And, you know, 2686 02:07:21.050 --> 02:07:24.359 after I was done work, I just watched TV and relaxed. 2687 02:07:25.680 --> 02:07:28.020 And I was like, I can't wait to feel better again. 2688 02:07:28.199 --> 02:07:29.880 Well, imagine what it's like being old. 2689 02:07:30.279 --> 02:07:30.619 Yes. 2690 02:07:30.739 --> 02:07:32.500 And frail. Yes. That's every day. 2691 02:07:32.539 --> 02:07:33.140 Yes, or sick. 2692 02:07:33.239 --> 02:07:34.890 And right now you can't do anything about it. 2693 02:07:35.039 --> 02:07:40.380 Yes. Yeah. And while you're healthy, you take it for granted, 2694 02:07:40.500 --> 02:07:43.979 and that's the real sin. You're like, ah, I'm fine. 2695 02:07:44.100 --> 02:07:46.090 I'm great. I mean, this is what people do when 2696 02:07:46.109 --> 02:07:48.930 they go out drinking, right? They take advantage of the 2697 02:07:48.970 --> 02:07:51.250 fact that it's worth it for a good time to 2698 02:07:51.250 --> 02:07:53.010 just poison myself for a night. 2699 02:07:53.010 --> 02:07:56.130 Well, it's not worth it because that also accelerates uh 2700 02:07:56.210 --> 02:07:58.270 aging but big time right that's what i tell my 2701 02:07:58.329 --> 02:08:02.149 kids who like alcohol like most kids you know you 2702 02:08:02.189 --> 02:08:04.750 might feel better in a few days but the memory 2703 02:08:04.770 --> 02:08:07.090 of that is going to be in your body yeah 2704 02:08:07.529 --> 02:08:09.270 you can drink it's you know it's fine to get 2705 02:08:09.300 --> 02:08:11.350 drunk once in a while uh but not a lot 2706 02:08:11.520 --> 02:08:14.119 not constantly i used to drink once a day and 2707 02:08:14.140 --> 02:08:16.640 i do not do that anymore because the The data 2708 02:08:16.680 --> 02:08:19.399 is incontrovertible that it affects the brain, even the size 2709 02:08:19.430 --> 02:08:21.109 of the brain, if you drink constantly. 2710 02:08:21.850 --> 02:08:24.069 I took eight months off of no alcohol at all 2711 02:08:24.170 --> 02:08:27.109 and I felt a lot better. I started drinking again 2712 02:08:27.430 --> 02:08:29.130 one night. I went to dinner with my wife and 2713 02:08:29.149 --> 02:08:33.399 had a margarita. I was like, ooh, I think I'm back. Ah, really? 2714 02:08:34.500 --> 02:08:37.239 So I drink now, but I do not get drunk. 2715 02:08:37.300 --> 02:08:39.039 I haven't gotten drunk. This was over a year ago. 2716 02:08:39.079 --> 02:08:41.640 It was when I had a drink again, I think. 2717 02:08:41.659 --> 02:08:43.579 I think it was a year. I'm not sure. But 2718 02:08:43.600 --> 02:08:46.579 the point is I have not been drunk. Since then. 2719 02:08:46.880 --> 02:08:47.060 Yeah. 2720 02:08:47.199 --> 02:08:49.359 I will have a glass of wine with dinner or 2721 02:08:49.460 --> 02:08:53.079 I will have like a shot of whiskey before I 2722 02:08:53.100 --> 02:08:56.199 go on stage, like a little bit. But I do 2723 02:08:56.239 --> 02:08:58.899 not get drunk anymore. It's just not worth it to me. 2724 02:08:59.079 --> 02:09:03.489 The feeling afterwards is so terrible. The morning– and especially 2725 02:09:03.529 --> 02:09:05.470 for me because I work out so much. When I 2726 02:09:05.510 --> 02:09:08.350 wake up, it's like that workout is going to get done, OK? 2727 02:09:08.369 --> 02:09:10.390 Whether I feel like shit or not, that workout is 2728 02:09:10.409 --> 02:09:12.350 going to get done and this is going to be rough. 2729 02:09:12.449 --> 02:09:13.369 And then you got the sweats. 2730 02:09:13.449 --> 02:09:13.789 It's horrible. 2731 02:09:13.810 --> 02:09:13.989 Right. 2732 02:09:14.010 --> 02:09:18.020 Versus– When I feel great, I love the workout. I'm excited. 2733 02:09:18.430 --> 02:09:20.949 Like I look forward to it. Even when it's hard, 2734 02:09:21.210 --> 02:09:23.590 when it's over, I'm like, whew, all right, let's eat. 2735 02:09:23.869 --> 02:09:26.970 And I don't feel bad. I feel good. And it's like, 2736 02:09:27.090 --> 02:09:31.920 why am I giving up that for a few hours of, 2737 02:09:32.319 --> 02:09:35.159 you know, it's just not worth it. It's not worth it. Yeah. 2738 02:09:35.180 --> 02:09:37.800 Well, you're funny even without alcohol, but I'm not. So 2739 02:09:37.840 --> 02:09:41.659 I've lost a lot of my humor. But there's nothing 2740 02:09:41.699 --> 02:09:42.850 better than feeling great, right? 2741 02:09:42.859 --> 02:09:43.060 Yes. 2742 02:09:43.270 --> 02:09:47.130 Nothing better than feeling great. of working on your health 2743 02:09:47.189 --> 02:09:50.949 and your longevity, you'll enjoy it. It shouldn't be a chore. 2744 02:09:51.310 --> 02:09:55.319 It'll also directly affect the other things that you love 2745 02:09:55.380 --> 02:09:58.739 because you will have more energy. Your life energy, your 2746 02:09:58.840 --> 02:10:02.680 vitality is so important for anything you're doing, whether it's 2747 02:10:02.720 --> 02:10:06.489 a creative thing or an intellectual thing, like anything that 2748 02:10:06.510 --> 02:10:08.770 you're doing, if you have more energy, You'll be able 2749 02:10:08.779 --> 02:10:11.369 to apply more energy to that thing. It's that simple. 2750 02:10:11.649 --> 02:10:15.409 You're building a bigger gas tank for yourself. You're building 2751 02:10:15.510 --> 02:10:17.649 a larger engine. And that's what you're doing. 2752 02:10:17.729 --> 02:10:20.829 Exactly. Mentally, physically, you can do so much when you 2753 02:10:20.869 --> 02:10:22.590 feel good. You jump out of bed. If you wake 2754 02:10:22.649 --> 02:10:27.060 up and you're tired, woozy, your eyes are puffy, that's 2755 02:10:27.100 --> 02:10:29.579 not how it should be when you wake up. And 2756 02:10:29.739 --> 02:10:31.939 sleep is important for longevity, of course. If you're getting 2757 02:10:31.979 --> 02:10:34.479 good deep sleep, then you should wake up and you 2758 02:10:34.500 --> 02:10:34.840 feel great. 2759 02:10:35.210 --> 02:10:35.510 Yes. 2760 02:10:36.270 --> 02:10:38.590 Yes. You don't even necessarily need a cup of coffee, 2761 02:10:38.630 --> 02:10:40.449 but it's not bad if you have one. 2762 02:10:40.750 --> 02:10:42.810 I like coffee. I'm not going to stop drinking it. 2763 02:10:42.810 --> 02:10:45.069 I don't give a fuck what anybody says. Right. 2764 02:10:45.130 --> 02:10:45.489 It's good. 2765 02:10:45.649 --> 02:10:48.560 And there's also like conflicting information. Some people say it's 2766 02:10:48.800 --> 02:10:50.079 good for you. There's benefits. 2767 02:10:50.380 --> 02:10:52.899 It's good for you. Come on. That's what I say. No, 2768 02:10:52.920 --> 02:10:55.180 it really is. Anyone that says it's not doesn't read 2769 02:10:55.199 --> 02:10:55.680 the literature. 2770 02:10:55.699 --> 02:11:00.619 Well, I would imagine an overabundance of caffeine is not good. 2771 02:11:01.100 --> 02:11:03.720 Too much is not good. But that's– It's true for everything. 2772 02:11:03.729 --> 02:11:05.479 Too much salt will kill you. Yeah, exactly. If you 2773 02:11:05.500 --> 02:11:07.579 eat a pound of salt, you'll be dead in an hour. Right. 2774 02:11:07.840 --> 02:11:09.659 And you can get away with very little sleep actually 2775 02:11:09.699 --> 02:11:12.300 as long as it's deep sleep because what it's doing 2776 02:11:12.340 --> 02:11:15.260 is clearing out the misfolded proteins in your brain and 2777 02:11:15.279 --> 02:11:18.739 the toxins. We know this, the glymphatic system. And if 2778 02:11:18.779 --> 02:11:22.600 you get deep sleep for an hour, you're actually going 2779 02:11:22.619 --> 02:11:27.539 to wake up much cleaner, healthier. And what I've been 2780 02:11:27.560 --> 02:11:30.920 able to do with some work is figure out how 2781 02:11:30.960 --> 02:11:34.420 to get deep sleep every night. Efficiency on these rings 2782 02:11:34.460 --> 02:11:35.779 that say above 90 sometimes. 2783 02:11:36.119 --> 02:11:38.880 I like you say rings because you're wearing two Aura rings. 2784 02:11:40.199 --> 02:11:42.020 Different companies. 2785 02:11:42.159 --> 02:11:42.439 Okay. 2786 02:11:42.500 --> 02:11:46.060 Why do you wear two different rings? 2787 02:11:47.979 --> 02:11:50.649 Because when I've got two, neither of them is correct. 2788 02:11:51.609 --> 02:11:51.729 No. 2789 02:11:53.090 --> 02:11:56.449 The truth is some of them are really good for sleep. 2790 02:11:56.470 --> 02:11:59.489 The others are good for heart. And so this one 2791 02:11:59.510 --> 02:12:00.770 is my heart and this is my sleep. 2792 02:12:01.300 --> 02:12:03.819 What is the difference in the companies? Which one's which? 2793 02:12:06.010 --> 02:12:07.050 You don't mind me saying who they are? 2794 02:12:07.069 --> 02:12:07.949 No, I don't care. 2795 02:12:07.970 --> 02:12:09.369 This is an Aura, the fat one. 2796 02:12:09.409 --> 02:12:09.550 Right. 2797 02:12:09.569 --> 02:12:11.250 And then the thinner one is called Ultra Human. 2798 02:12:11.649 --> 02:12:12.409 Ultra Human. 2799 02:12:12.810 --> 02:12:13.069 Yeah. 2800 02:12:13.210 --> 02:12:14.529 And which one is good for what? 2801 02:12:14.829 --> 02:12:17.409 Well, I find Aura really good for sleep. That's their specialty. 2802 02:12:18.210 --> 02:12:21.399 And then the heart for Ultra Human, my cardiac age. 2803 02:12:22.479 --> 02:12:24.920 Oh, okay. So it's just like giving you data all 2804 02:12:24.960 --> 02:12:25.359 the time? 2805 02:12:26.060 --> 02:12:28.619 Yeah, and they're getting even better because they– I don't 2806 02:12:28.640 --> 02:12:30.979 get paid by these companies, but– I do like that 2807 02:12:31.000 --> 02:12:34.680 they pop up with AI information now. Have you noticed 2808 02:12:34.739 --> 02:12:37.720 that da-da-da or I noticed that you ate a meal 2809 02:12:37.760 --> 02:12:41.470 last night that spiked your glucose? And this one I 2810 02:12:41.590 --> 02:12:43.569 have a monitor on right now so I can see 2811 02:12:43.590 --> 02:12:45.630 what's going on anyway. But yeah, they're. 2812 02:12:45.510 --> 02:12:47.829 Becoming like a– You are fucking monitored, bro. 2813 02:12:48.069 --> 02:12:48.350 I am. 2814 02:12:48.430 --> 02:12:49.829 Two rings and a patch? 2815 02:12:50.130 --> 02:12:53.350 It's a hobby. It's a hobby. But you learn a 2816 02:12:53.369 --> 02:12:54.970 lot and I put one of these on my son 2817 02:12:55.710 --> 02:12:58.189 and he stopped eating bad food for a long while. 2818 02:12:58.659 --> 02:13:00.840 Really? Because he was just recognizing the impact that it. 2819 02:13:00.840 --> 02:13:02.500 Had on his body. It's good for kids. Now, I 2820 02:13:02.500 --> 02:13:07.319 wouldn't say slap it on a kid without pediatrician recommendation, 2821 02:13:07.420 --> 02:13:10.689 but it was amazing what happened when he could see 2822 02:13:11.069 --> 02:13:13.090 the crap that was going in his mouth was doing 2823 02:13:13.109 --> 02:13:13.770 to his blood sugar. 2824 02:13:14.109 --> 02:13:14.489 Really? 2825 02:13:14.510 --> 02:13:16.829 It was amazing. I think it's a great learning tool, 2826 02:13:16.890 --> 02:13:17.430 if nothing else. 2827 02:13:17.989 --> 02:13:20.930 Right. Just to have actual data. I know a lot 2828 02:13:20.970 --> 02:13:24.060 of people, it's changed their opinion on alcohol, particularly the 2829 02:13:24.159 --> 02:13:25.640 Oura ring when they look at their sleep. 2830 02:13:25.659 --> 02:13:25.819 Yeah. 2831 02:13:26.170 --> 02:13:28.970 Because even just a couple of drinks before you go 2832 02:13:29.010 --> 02:13:31.430 to bed, like a couple of drinks at dinner, and 2833 02:13:31.489 --> 02:13:34.449 then you realize like, oh, God, my sleep was all 2834 02:13:34.510 --> 02:13:36.369 fucked up because of those drinks. 2835 02:13:37.010 --> 02:13:40.140 Yeah. Lay off the modafinil too, for me anyway. 2836 02:13:40.880 --> 02:13:43.279 Yeah. Some modafinil fucks with your sleep as well? Yeah. 2837 02:13:43.300 --> 02:13:47.239 I have to work really hard to sleep well. There's 2838 02:13:47.680 --> 02:13:51.899 quiet time. There's relaxation. The lights are dimmed. I think 2839 02:13:51.960 --> 02:13:55.069 about a happy place rather than work. I had to 2840 02:13:55.090 --> 02:13:56.710 do that because for 50 years I was burning the 2841 02:13:56.729 --> 02:14:00.029 candle at all ends. I was really burnt out and 2842 02:14:00.090 --> 02:14:01.720 so I've fixed that now. I don't worry. 2843 02:14:01.979 --> 02:14:04.020 So are you one of those guys that like dims 2844 02:14:04.079 --> 02:14:06.340 the lights in your house a couple hours before you 2845 02:14:06.359 --> 02:14:09.779 go to bed and prepare– stay off your phone, all 2846 02:14:09.800 --> 02:14:10.220 that stuff? 2847 02:14:10.279 --> 02:14:12.439 Well, I don't stay off my phone as much as 2848 02:14:12.520 --> 02:14:13.640 I want to, but yes. 2849 02:14:13.680 --> 02:14:16.640 Do you wear red light glasses or anything like blockers? 2850 02:14:16.659 --> 02:14:19.659 I used to. I haven't found a big difference for myself. 2851 02:14:19.840 --> 02:14:24.390 But interesting fact that isn't well-known. If you block blue 2852 02:14:24.430 --> 02:14:27.520 light during the day or just stay indoors, there's a 2853 02:14:27.560 --> 02:14:31.699 guy in Japan who says that what happens is you 2854 02:14:31.720 --> 02:14:32.640 get short-sightedness. 2855 02:14:34.380 --> 02:14:34.619 Really? 2856 02:14:34.720 --> 02:14:38.380 Because the mice that lack the ability to sense violet 2857 02:14:38.420 --> 02:14:42.579 light get myopia, short-sighted. And he's got a device that 2858 02:14:42.699 --> 02:14:46.090 indoors you can shine this. But our modern world, the LEDs, 2859 02:14:46.890 --> 02:14:49.449 and being indoors means we barely get violet light. And 2860 02:14:49.529 --> 02:14:52.689 that would be so interesting if that's what's causing... Our 2861 02:14:52.710 --> 02:14:53.890 staff have to wear glasses. 2862 02:14:54.609 --> 02:14:55.029 Wow. 2863 02:14:55.829 --> 02:14:57.310 And he claims that people that live out in the 2864 02:14:57.329 --> 02:14:59.210 countryside that see blue light all the time because they 2865 02:14:59.250 --> 02:15:02.489 go out don't have as much need for glasses. 2866 02:15:02.750 --> 02:15:06.750 That actually makes sense. Well, particularly artificial light and then 2867 02:15:06.949 --> 02:15:10.890 also light that's from a close source. Like one of 2868 02:15:10.909 --> 02:15:14.220 the things that if I do– if I'm tired and 2869 02:15:14.300 --> 02:15:16.260 I lay in bed and I try to read something 2870 02:15:16.319 --> 02:15:19.770 online on my phone, it hurts my eyes. The room 2871 02:15:19.850 --> 02:15:23.390 is dark. It irritates my eyes where it never irritates 2872 02:15:23.430 --> 02:15:25.529 my eyes normally. But it's like at the end of 2873 02:15:25.550 --> 02:15:29.510 the day, I guess I'm more fatigued. And you're trying 2874 02:15:29.529 --> 02:15:31.979 to focus on the screen. So like now think about 2875 02:15:32.020 --> 02:15:34.159 that when people are doing it all day long. Maybe 2876 02:15:34.180 --> 02:15:35.720 you're doing it at work where you have to stare 2877 02:15:36.000 --> 02:15:39.119 at a computer monitor from three feet away or closer. 2878 02:15:39.300 --> 02:15:41.100 And then you're looking at your phone all the time 2879 02:15:41.199 --> 02:15:44.239 or you're working from a tablet or you're watching television. 2880 02:15:44.340 --> 02:15:46.600 It's like you're constantly staring at these light sources that 2881 02:15:46.640 --> 02:15:47.220 are artificial. 2882 02:15:48.069 --> 02:15:51.010 Yeah, and also keep in mind that the muscles have 2883 02:15:51.029 --> 02:15:55.489 to focus. You don't naturally look this far. You naturally relax. 2884 02:15:55.529 --> 02:15:57.789 You see out there. But to look here, your muscles 2885 02:15:57.869 --> 02:16:01.029 here have to be straining for hours, and they get 2886 02:16:01.069 --> 02:16:03.960 very tired. And I guess eventually they age to a 2887 02:16:04.000 --> 02:16:07.140 point where you cannot keep it up. And sometimes I 2888 02:16:07.159 --> 02:16:09.619 do this to see better, though. 2889 02:16:10.720 --> 02:16:13.350 Well, it all makes sense if you think about it, 2890 02:16:13.399 --> 02:16:16.479 particularly like if your eyes are accustomed to only focusing 2891 02:16:16.520 --> 02:16:18.359 on things that are close. I mean that was what 2892 02:16:18.420 --> 02:16:20.930 they would say about reading when people would have glasses. Oh, 2893 02:16:20.970 --> 02:16:23.850 you fucked up your vision reading, which I used to 2894 02:16:23.869 --> 02:16:26.470 think was nonsense. But I was like, well, it kind 2895 02:16:26.489 --> 02:16:29.050 of makes sense if you spend all day long focusing– 2896 02:16:29.130 --> 02:16:30.989 even though it's on a screen, you're spending all day 2897 02:16:31.060 --> 02:16:33.120 long focusing on a book that's only a foot from 2898 02:16:33.159 --> 02:16:34.780 your face. Yeah. It does make sense. 2899 02:16:34.819 --> 02:16:37.299 And the lens gets really inflexible. 2900 02:16:37.479 --> 02:16:37.760 Right. 2901 02:16:37.979 --> 02:16:39.819 And I'm seeing this with my father. He's otherwise in 2902 02:16:39.840 --> 02:16:42.620 perfect health at 87, which is amazing. But it's his 2903 02:16:42.860 --> 02:16:44.309 eyes that are failing him. 2904 02:16:44.829 --> 02:16:46.010 Maybe you should get him a red light bed. 2905 02:16:46.809 --> 02:16:47.590 That's a great idea. 2906 02:16:47.610 --> 02:16:48.010 Yeah. 2907 02:16:48.069 --> 02:16:51.709 I'm going to do that. He's arriving tonight actually from Sydney. 2908 02:16:52.190 --> 02:16:52.959 He's an amazing guy. 2909 02:16:52.969 --> 02:16:54.829 Yeah, get him a red light bet, man, because I'm 2910 02:16:54.870 --> 02:16:57.069 telling you there's not a thing that I've done that's 2911 02:16:57.309 --> 02:17:01.209 impacted me in a more obvious way than that in 2912 02:17:01.229 --> 02:17:02.969 terms of like something that's hugely important. 2913 02:17:02.989 --> 02:17:05.569 Yeah, I'm going to do it. I mean he's into science. 2914 02:17:05.670 --> 02:17:10.979 He's been taking NMN, resveratrol, metformin, exercising. He goes to 2915 02:17:11.000 --> 02:17:12.399 the gym two or three times a week. 2916 02:17:12.540 --> 02:17:13.260 Oh, that's great. Yeah. 2917 02:17:14.829 --> 02:17:17.350 He's a role model at 87 with no diseases, no 2918 02:17:17.829 --> 02:17:18.569 aches or pains. 2919 02:17:18.590 --> 02:17:19.229 That's awesome. 2920 02:17:19.250 --> 02:17:20.670 And he's traveling the world. He was in Japan two 2921 02:17:20.690 --> 02:17:21.110 weeks ago. 2922 02:17:21.409 --> 02:17:22.229 Wow. 2923 02:17:22.450 --> 02:17:23.329 Coming to Boston. 2924 02:17:23.569 --> 02:17:26.989 That's so cool. I love hearing about people that are 2925 02:17:27.090 --> 02:17:29.149 older that just keep on top of it and stay 2926 02:17:29.250 --> 02:17:31.610 active and stay alive and enjoy life. 2927 02:17:31.670 --> 02:17:34.590 Yeah, exactly. He's a great role model. And what it 2928 02:17:34.629 --> 02:17:36.350 shows is he was an average guy until he was 2929 02:17:36.389 --> 02:17:39.399 in his 60s. And he figured he was going to 2930 02:17:39.430 --> 02:17:41.659 die in his 70s probably because everyone in my family 2931 02:17:41.690 --> 02:17:44.239 dies young because we've got pretty bad genes. But he's 2932 02:17:44.280 --> 02:17:47.030 just taken life by the horns and just is running 2933 02:17:47.049 --> 02:17:50.979 with it and has not physically aged. except for his 2934 02:17:51.139 --> 02:17:53.040 eyes in the last 20 years. 2935 02:17:53.500 --> 02:17:54.000 That's incredible. 2936 02:17:54.020 --> 02:17:57.239 And that's not an exaggeration. Anyone who's seen him knows 2937 02:17:57.280 --> 02:18:00.090 he walks, he moves, he travels, he does everything like 2938 02:18:00.329 --> 02:18:02.829 he was when he was 40. 2939 02:18:02.829 --> 02:18:06.329 Things like resistance exercises are so important because it maintains 2940 02:18:06.389 --> 02:18:09.729 bone density, maintains muscle mass. Maintains your ability to just 2941 02:18:09.770 --> 02:18:10.989 get around and do things. 2942 02:18:11.889 --> 02:18:14.610 That's the other reason to do that. I mean, you're 2943 02:18:14.629 --> 02:18:16.479 going to be really strong when you're older and you 2944 02:18:16.500 --> 02:18:18.340 won't fall. And if you do fall, you'll bounce. You 2945 02:18:18.360 --> 02:18:21.219 won't break a bone. And he's like that. He's been 2946 02:18:21.260 --> 02:18:24.260 working out at the gym, mostly strength training, but balance 2947 02:18:24.299 --> 02:18:27.260 as well. It's very important to maintain balance. He's better 2948 02:18:27.280 --> 02:18:29.069 at the gym than me at 87. 2949 02:18:29.069 --> 02:18:29.930 That's incredible. 2950 02:18:29.950 --> 02:18:33.850 That just shows how weak I am. Yeah, I got 2951 02:18:33.870 --> 02:18:36.309 to go to the gym. How about next time if 2952 02:18:36.350 --> 02:18:37.010 you have me on? 2953 02:18:37.709 --> 02:18:40.020 You're going to be buff. We'll get you a trainer. 2954 02:18:40.479 --> 02:18:42.719 You're in Massachusetts. There's a ton of trainers out there. 2955 02:18:42.819 --> 02:18:43.040 Great. 2956 02:18:43.620 --> 02:18:47.000 It's a deal. We'll find you someone. We'll find you someone. 2957 02:18:47.079 --> 02:18:49.620 Three days a week. That's all you need. The other days, 2958 02:18:49.680 --> 02:18:53.239 you could do stuff elective. Do stuff that you want. 2959 02:18:54.020 --> 02:18:56.829 But three days a week, get a personal trainer and 2960 02:18:56.860 --> 02:18:57.829 work out with them. 2961 02:18:57.909 --> 02:18:58.309 You're on. 2962 02:18:58.329 --> 02:18:59.530 All right. 2963 02:18:59.649 --> 02:19:01.329 I will let you know when it's going or you 2964 02:19:01.350 --> 02:19:03.770 help me. I can hear though that there's probably a 2965 02:19:04.409 --> 02:19:06.670 few million people right now screaming, David, just go to 2966 02:19:06.690 --> 02:19:07.770 the lab. Forget about the gym. 2967 02:19:08.190 --> 02:19:10.250 You need to Well, it will help your lab work. 2968 02:19:10.409 --> 02:19:12.389 It will help everything. It will help the amount of 2969 02:19:12.430 --> 02:19:14.750 research you're able to do. You'll have more energy. You'll 2970 02:19:14.790 --> 02:19:17.559 be more excited about things. I'm sure you've seen those 2971 02:19:17.750 --> 02:19:21.719 MRI cross-sections of people's tissue where they take like a 2972 02:19:21.739 --> 02:19:25.280 70-year-old man who's sedentary versus a 70-year-old man who's a 2973 02:19:25.299 --> 02:19:28.639 marathon runner. It's fucking extraordinary. 2974 02:19:28.659 --> 02:19:31.700 I've seen my own. There's too much fat in the muscle. 2975 02:19:31.739 --> 02:19:32.350 Got to get rid of it. 2976 02:19:32.620 --> 02:19:36.120 Yeah, yeah. It's really extraordinary when you see those images. 2977 02:19:36.159 --> 02:19:37.319 Like those really bring it home. 2978 02:19:37.399 --> 02:19:41.020 And the bone changes. Bone turns to fat too, parts 2979 02:19:41.040 --> 02:19:44.010 of the bone. So you've got to have the strength 2980 02:19:44.049 --> 02:19:44.750 training for sure. 2981 02:19:44.750 --> 02:19:48.780 100%. Keep your bones strong. Yeah, 100%. Strength training is– 2982 02:19:49.270 --> 02:19:50.590 that's mandatory. 2983 02:19:51.090 --> 02:19:53.450 Yeah. And then do you do a lot of aerobic exercises? 2984 02:19:53.510 --> 02:19:54.639 Yes. Good. Yeah. 2985 02:19:54.739 --> 02:19:56.379 I saw the training bike. 2986 02:19:56.739 --> 02:19:59.540 Oh, yeah. Well, you saw my hypoxia machine that I 2987 02:19:59.579 --> 02:20:05.069 just got installed today. Yeah. Yeah. The– The hypoxia thing, 2988 02:20:05.450 --> 02:20:10.030 what it does is it replicates 14,000 feet above sea level. 2989 02:20:10.579 --> 02:20:12.940 And you train in it. And it also has a 2990 02:20:13.000 --> 02:20:15.079 heat element so you could ramp the heat up to 2991 02:20:15.079 --> 02:20:19.340 115 degrees. So 115 degrees and 14,000 feet above sea level. 2992 02:20:19.379 --> 02:20:22.780 What's that? Machu Picchu kind of stuff? Yeah. You're going 2993 02:20:22.799 --> 02:20:25.389 to hell. That's what it is. You're going straight to hell. 2994 02:20:25.450 --> 02:20:28.280 It'll feel like it. But it should work, right? Hypoxia 2995 02:20:28.319 --> 02:20:29.100 is great for muscle. 2996 02:20:29.340 --> 02:20:32.780 Yes, and for adaptation. That's the big thing. And my 2997 02:20:32.829 --> 02:20:35.870 friend Roman who installed it, who's one of the guys 2998 02:20:35.889 --> 02:20:41.309 from the company, they're very specific with this protocol in 2999 02:20:41.350 --> 02:20:43.459 terms of monitoring your heart rate, when to do it, 3000 02:20:43.489 --> 02:20:46.559 when to push, how much time to spend and how 3001 02:20:46.590 --> 02:20:49.059 you do it. And it's very scientific in terms of 3002 02:20:49.100 --> 02:20:53.379 the application on athletes. And my friend Adam Greentree turned 3003 02:20:53.399 --> 02:21:00.280 me on to it, fellow Australian. And he's a big 3004 02:21:00.360 --> 02:21:02.420 hunter and does a lot of mountain hunting. And he 3005 02:21:02.459 --> 02:21:04.819 said there's nothing he's ever done that's had more of 3006 02:21:04.860 --> 02:21:07.219 an impact on his cardio. So it's been phenomenal. 3007 02:21:07.979 --> 02:21:11.139 Sounds wonderful, actually. There's a lot of science behind that. 3008 02:21:11.959 --> 02:21:16.430 You probably know it. The best results are when people 3009 02:21:16.690 --> 02:21:21.010 are either having too much oxygen or not enough. And 3010 02:21:21.030 --> 02:21:23.450 you might say, well, that's weird. Why does it matter? Well, 3011 02:21:23.489 --> 02:21:25.950 you got to get out of your comfort zone, hormesis 3012 02:21:25.969 --> 02:21:30.700 we keep talking about. And there's a big study in 3013 02:21:30.760 --> 02:21:33.020 Israel where they put people in these hyperbaric chambers. 3014 02:21:33.059 --> 02:21:37.040 I've done that protocol. Yeah. Yeah. 60 sessions of 90 3015 02:21:37.040 --> 02:21:38.659 minutes over 90 days. 3016 02:21:38.840 --> 02:21:39.500 Yeah. 3017 02:21:40.139 --> 02:21:41.180 Yeah. I have one in my house. 3018 02:21:41.360 --> 02:21:41.670 You do? 3019 02:21:41.889 --> 02:21:42.079 Yeah. 3020 02:21:42.100 --> 02:21:46.090 Because the data is intercontrovertible, better wound healing, better memory. 3021 02:21:46.270 --> 02:21:47.950 Increase in telomere length. Yeah. 3022 02:21:47.989 --> 02:21:50.090 I saw that one. That's the Israel study. 3023 02:21:50.510 --> 02:21:50.770 Yes. 3024 02:21:51.030 --> 02:21:53.250 What I thought was interesting was when I went over 3025 02:21:53.270 --> 02:21:56.909 there myself and sat in that thing, they made a 3026 02:21:56.930 --> 02:21:58.690 joke over there in Israel, by the way. They said, 3027 02:21:59.250 --> 02:22:02.440 this gas chamber here that you're going into, made by Germans. 3028 02:22:02.639 --> 02:22:06.059 I thought, that's not a funny joke. Don't say that again. Anyway, 3029 02:22:06.479 --> 02:22:09.559 I probably shouldn't have shared that. I did go into 3030 02:22:09.579 --> 02:22:13.819 the chamber. And what I found out was that they 3031 02:22:13.840 --> 02:22:16.059 believe what I believe, which is it's not so much 3032 02:22:16.120 --> 02:22:19.229 the high pressure that's good for you. It's the coming down. 3033 02:22:19.659 --> 02:22:22.860 that mimics hypoxia, which your room will mimic. So the 3034 02:22:22.959 --> 02:22:25.420 lack of oxygen or the perceived lack of oxygen from 3035 02:22:25.459 --> 02:22:27.239 a high state is the benefit. 3036 02:22:27.620 --> 02:22:28.079 Interesting. 3037 02:22:28.100 --> 02:22:29.180 And that makes a lot of sense. You're going to 3038 02:22:29.200 --> 02:22:32.739 grow new blood vessels, just like Viagra is going to 3039 02:22:32.819 --> 02:22:37.020 open things up. We actually had a paper, 2012, that 3040 02:22:37.620 --> 02:22:39.819 found that one of the supplements that I take, which 3041 02:22:40.280 --> 02:22:44.649 everyone knows about NMN, could allow animals to grow new 3042 02:22:44.670 --> 02:22:49.450 blood vessels by getting rid of a protein that accumulates 3043 02:22:49.479 --> 02:22:53.940 with aging. The bottom line is we could mimic this 3044 02:22:54.040 --> 02:22:57.280 lack of blood vessels with this pill, but by exercising, 3045 02:22:57.479 --> 02:23:03.100 it's the same. What I really believe, which is barely 3046 02:23:03.139 --> 02:23:05.860 talked about in the medical establishment, is that a major 3047 02:23:05.899 --> 02:23:08.260 reason we get sick when we get older is lack 3048 02:23:08.280 --> 02:23:12.079 of blood flow. It's rarely talked about, right? Vascular dementia, 3049 02:23:12.680 --> 02:23:17.000 second largest cause of dementia in the world, blood flow. 3050 02:23:17.760 --> 02:23:20.340 And it's the easiest to reverse. You just do exercise 3051 02:23:20.620 --> 02:23:25.639 or take one of these PDE5 inhibitors, Viagra. Or you 3052 02:23:25.680 --> 02:23:28.219 take my stuff, which is NMN, which we think also works. 3053 02:23:28.360 --> 02:23:30.760 Or all the above, which is probably the best approach. 3054 02:23:31.819 --> 02:23:36.219 I'm two out of three. Hopefully soon three out of three. 3055 02:23:36.680 --> 02:23:39.340 But yeah, to protect your brain, which is the most 3056 02:23:39.379 --> 02:23:41.100 important because you don't want to be old and demented. 3057 02:23:41.139 --> 02:23:44.709 That's worse than anything. Keep the blood flowing in your body. 3058 02:23:44.950 --> 02:23:47.469 Remember that. Blood flowing is important. Yes. 3059 02:23:47.989 --> 02:23:52.350 Couldn't agree more. David, you're a treasure. I really appreciate you. 3060 02:23:52.930 --> 02:23:53.670 Thank you for being here. 3061 02:23:53.719 --> 02:23:55.479 You've been so kind. And thank you for getting the 3062 02:23:55.520 --> 02:23:57.600 word out here about the great science that's going on. 3063 02:23:57.700 --> 02:24:00.200 Oh, my pleasure, dude. I'm so happy there's someone like 3064 02:24:00.420 --> 02:24:03.459 you out there doing this. I mean, it's such an 3065 02:24:03.639 --> 02:24:06.500 enormous benefit to people that are listening to the world. 3066 02:24:07.180 --> 02:24:09.469 And you're doing– you're literally doing God's work. 3067 02:24:09.750 --> 02:24:10.750 We'll try to do more. 3068 02:24:10.969 --> 02:24:16.270 Thank you very much. Thank you, sir. Lifespan.com is the website. Please, folks, 3069 02:24:16.309 --> 02:24:19.840 if you're so inclined, go donate. It'll really help. It'll 3070 02:24:19.860 --> 02:24:23.680 change the world. David, love you too. Thank you. Bye, everybody.