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<v Speaker 1>Welcome. This is Marsha for Radio I, and today I

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<v Speaker 1>will be reading National Geographic magazine dated November twenty twenty five,

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<v Speaker 1>which is donated by the publisher as a reminder RADIOI

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<v Speaker 1>as a reading service intended for people who are blind

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<v Speaker 1>or have other disabilities that make it difficult to read

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<v Speaker 1>printed material. Please join me now for the first article

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<v Speaker 1>titled this Gibbon Can Do the Robot, Decoding the uncanny

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<v Speaker 1>moves of Asia's dancing apes. Most apes don't know how

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<v Speaker 1>to dance, but female crested gibbons of the genus Nomascus,

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<v Speaker 1>the long limbed primates, known for their acrobatics swinging from

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<v Speaker 1>tree to tree, regularly perform a series of boombents that

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<v Speaker 1>can only be described as the robot. Scientists recently analyzed

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<v Speaker 1>dozens of videos of mature, female crested gibbons living in

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<v Speaker 1>zoos and rescue centers around the world, and interviewed researchers

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<v Speaker 1>who had observed the dancing in the wilds of China

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<v Speaker 1>and Vietnam. Their study, released in the journal Primates, found

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<v Speaker 1>that the dances follow clear rhythmic patterns. In captivity, the

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<v Speaker 1>gibbons generally direct their routines at caretakers most likely to

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<v Speaker 1>socialize in solicit snacks in the wild, they seem to

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<v Speaker 1>dance as a mating invitation. This is especially puzzling, says

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<v Speaker 1>zoologists and study co author Kai Kasper of Germany's Heinrich

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<v Speaker 1>Heina University Duzeldorff. Most crested gibbons live in small family

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<v Speaker 1>groups that form around stable monogamous pairs, which means the

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<v Speaker 1>females don't have to compete for the attention of their partners,

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<v Speaker 1>says Kaspar, Dancing may just ease the tension. This by

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<v Speaker 1>Kelsey Noah Kowski. Next. How to photograph a firestorm. Scientists

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<v Speaker 1>say that the fires ravaging the Western United States are

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<v Speaker 1>burning differently these days. For one's landscape photographer, documenting the

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<v Speaker 1>aftermath requires a new approach as well. This by Brian Resnik.

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<v Speaker 1>Today's fires are different. Blazes have scarred and scorched the

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<v Speaker 1>Western United States for ages, but for scientists who study

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<v Speaker 1>extreme climate events, like UCLA's Daniel Swain, the wild flowers

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<v Speaker 1>are now defying historic precedent, moving and growing with devastating intensity.

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<v Speaker 1>As Swain puts it, these new fires are doing seemingly

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<v Speaker 1>impossible things. Take northern California's twenty twenty gigafire, the first

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<v Speaker 1>in the state's modern fire tracking history to burn more

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<v Speaker 1>than a million acres, a footprint larger than Rhode Island.

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<v Speaker 1>Its size wasn't unprecedented. The speed of the destruction was

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<v Speaker 1>two hundred years ago, you probably would have seen million

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<v Speaker 1>acre fires sometimes in California. Swain says, they wouldn't have

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<v Speaker 1>burned a million acres in a few days, It would

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<v Speaker 1>have taken months. More recently, Swain was monitoring the twenty

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<v Speaker 1>twenty four Bridge fire raging north of Los Angeles via

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<v Speaker 1>satellite thermal imagery. On his screen, he could see black

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<v Speaker 1>splotches on a map that indicated areas burning at temperatures

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<v Speaker 1>upwards of several hundred year greeze, temperatures so hot that

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<v Speaker 1>you're either looking at a volcanic eruption or a wildfire.

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<v Speaker 1>In just as second day, the fire expanded like an

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<v Speaker 1>ink stain through cotton, running across forty five thousand acres

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<v Speaker 1>about seventy square miles. That burn rate isn't unheard of.

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<v Speaker 1>It occurs with grass fires racing over flat plains, but

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<v Speaker 1>this was burning forest in some of the steepest mountains

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<v Speaker 1>of North America. The fire, Swain says, had to burn

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<v Speaker 1>up Mount Baldy and down Mount Baldy, and then up

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<v Speaker 1>the next mountain and down the next mountain, and up

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<v Speaker 1>and down. Researchers have been tracking fires with precision from

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<v Speaker 1>satellites for more than forty years, just a small slice

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<v Speaker 1>of time geographically speaking, but the trends they see are clear.

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<v Speaker 1>Fires are hotter, burning faster, and destroying more property. Nearly

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<v Speaker 1>every year for the past decade, there's been at least

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<v Speaker 1>one town in California or a large part of town

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<v Speaker 1>completely decimated by wildfire that didn't use to happen. Swain says,

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<v Speaker 1>the changes we're seeing in deckscades are changes that would

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<v Speaker 1>take millennia to many millennia to unfold in a more

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<v Speaker 1>typical geological history context. When National Geographic Explorer and photographer

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<v Speaker 1>Matt Black saw these extraordinary changes happening so close to

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<v Speaker 1>his home in California's Sierra Nevada, a four hundred plus

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<v Speaker 1>mile mountain range that stretches along the interior of the state,

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<v Speaker 1>he took on the challenge of capturing the aftermath of

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<v Speaker 1>the fires. But as someone who shoots in black and white,

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<v Speaker 1>he was concerned about an obvious comparison. Over the past century,

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<v Speaker 1>no one has taken such iconic black and white images

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<v Speaker 1>of Sierra Nevada landscapes as ansel Atoms. His work was

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<v Speaker 1>integral to the modern conservation movement, inspiring generations of people

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<v Speaker 1>to work together to protect precious wilderness areas, but photographing

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<v Speaker 1>the landscape in a way reminiscent of the Atoms did

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<v Speaker 1>not feel like it was matching the moment. Black says,

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<v Speaker 1>Adams images convey a post guard perfect vision of imposing permanence,

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<v Speaker 1>that such places might stay untouched if we protected them,

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<v Speaker 1>but climate devastation has destroyed that ideal. So Black turned

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<v Speaker 1>to an unconventional tool. An industrial thermal camera more typically

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<v Speaker 1>used to inspect steel forging equipment. While a traditional camera

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<v Speaker 1>uses light to make images, a thermal camera uses heat.

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<v Speaker 1>The hottest objects in a thermal image are usually exposed

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<v Speaker 1>in bright white, the coolest in inky black. Beyond its

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<v Speaker 1>specialized lens and sensor, Black's hand held camera is fairly conventional,

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<v Speaker 1>yet when it's trained on the natural world, the thermal

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<v Speaker 1>images it produces are unexpectedly beautiful, but there's a sinister

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<v Speaker 1>quality to them too. An ever present reminder of what

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<v Speaker 1>made them. Our atmospheres holding more heat than it used to,

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<v Speaker 1>and some portion of the heat could radiate in each image.

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<v Speaker 1>They're built out of heat that came from elsewhere. That

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<v Speaker 1>came from the co two in the skies above, that

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<v Speaker 1>came from the exhaust pipes in the city below. Black

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<v Speaker 1>says taking the camera on trucks through burned down forest

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<v Speaker 1>felt like a revelation. What was amazing to me was

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<v Speaker 1>the way it reacted to dead trees, He says, The

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<v Speaker 1>charred black trunk's trap heat, so when you look through

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<v Speaker 1>the thermal camera, they become the brightest points on the landscape.

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<v Speaker 1>They appear alive again, but a ghostly kind of life,

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<v Speaker 1>shining spectrally among the ruin. Next what do the world's

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<v Speaker 1>oldest tattoos mean? A new breed of archaeologists wants to

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<v Speaker 1>unravel some ancient mysteries by studying long overlooked body art.

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<v Speaker 1>This by Sam Keane. Some years back, a man wandered

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<v Speaker 1>into Aaron deeeder Wolf's office in Nashville at the Tennessee

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<v Speaker 1>Division of Archaeology to hand over a two foot portion

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<v Speaker 1>of a Macedon dusk. The man had spotted the relic

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<v Speaker 1>poking out of a riverbank and saw it off the

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<v Speaker 1>exposed end. Removing the tusk sullied its scientific value, so

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<v Speaker 1>deeeder Wolf started trotting it out during talks at grade schools,

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<v Speaker 1>until a kid dropped it and its outer layers shattered.

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<v Speaker 1>For many archaeologists, that might have marked the end of

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<v Speaker 1>the tusk's usefulness, but not for deeeder Wolf. He salvaged

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<v Speaker 1>a few shorts and later transformed them into tattooed needles,

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<v Speaker 1>carving each with flint and smoothing it on sandstone. But

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<v Speaker 1>when he tried tattooing a colleague with one, it went poorly.

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<v Speaker 1>Microfractures in the ivory snagged skin each time he withdrew

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<v Speaker 1>the tip it was, he recalls a bloody mess. By day,

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<v Speaker 1>deeterer Wolf surveys sights to assess the archaeological impacts of

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<v Speaker 1>new construction, but in his spare hours he's among the

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<v Speaker 1>foremost experts on ancient tattooing, a field formally discounted but

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<v Speaker 1>increasingly recognized as offering vital insight into cultures worldwide. Once

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<v Speaker 1>an outlier, he's now part of an emerging cohort of

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<v Speaker 1>researchers showing the practice was more widespread than archaeologists ever

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<v Speaker 1>knew and helping reveal new meaning in a historically suppressed art.

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<v Speaker 1>Hostility to tattoo research has colonialist roots, with missionaries and

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<v Speaker 1>officials having considered the practice of barbaric. As archaeologisgy emerged

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<v Speaker 1>as a discipline in the nineteenth century, its practitioners seemed

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<v Speaker 1>to inherit this disdain, mentioning tattoos in their work rarely

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<v Speaker 1>and pejoratively a practice of so called savages and deviants,

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<v Speaker 1>and as Deeeder Wolf learned early in his career, that

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<v Speaker 1>attitude lingered into the twenty first century now forty nine.

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<v Speaker 1>He started as a Mayanist before switching focus to the

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<v Speaker 1>pre colonial southeastern United States, but personal fondness for tattoos

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<v Speaker 1>he has a dozen drove his side research. After he

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<v Speaker 1>organized his first conference session on ancient tattooing in two

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<v Speaker 1>thousand and nine, an older attendee buttonholed him. The guy

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<v Speaker 1>told me there are more tattoos of ancient art on

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<v Speaker 1>graduate students than there ever were tattoos in the ancient world.

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<v Speaker 1>Deeter Wolf says he was one hundred percent wrong, and

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<v Speaker 1>it's not like the evidence was hidden. He just didn't

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<v Speaker 1>care to engage with it. In that lack of engagement,

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<v Speaker 1>Dieter Wolf says, has led archaeologists to overlook critical details

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<v Speaker 1>about those their striving to understand. As tattoos throughout history

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<v Speaker 1>have helped define group identity, marked rites of passage signaled

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<v Speaker 1>spiritual power, one way to combat colleagues dismissive stance. Peter

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<v Speaker 1>Wolf went looking for how best to identify tattoo tools

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<v Speaker 1>in the archaeological record. Doing so is tricky, since a

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<v Speaker 1>pointing instrument from a a dig site might have been

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<v Speaker 1>used to apply ink to skin, or it might have

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<v Speaker 1>been an all or a sewing needle. How to tell

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<v Speaker 1>the difference. Dieter Wulf started by assembling other archaeologists and

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<v Speaker 1>researchers who shared his interest, and together they launched a

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<v Speaker 1>series of experiments carried out over the better part of

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<v Speaker 1>a decade. Some formal and controlled, others were at hack

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<v Speaker 1>for each. He made tattoo needles out of materials that

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<v Speaker 1>ancient closeures may have used, feather shafts, deer bones, fish teeth,

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<v Speaker 1>cactus thorns, and yes, gastodon tusk shards. They applied either

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<v Speaker 1>modern tattoo ink or a mix of charcoal's soot and

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<v Speaker 1>water what most ancient cultures would likely have used. Then

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<v Speaker 1>he tried the tools out on volunteers and on pigskin,

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<v Speaker 1>as well as on his own skin. The feather proved

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<v Speaker 1>too soft, like tattooing with a sharpie. Deeeder Wolf says

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<v Speaker 1>he suspects a historical account that mentions tattooing with feathers

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<v Speaker 1>was mistaken. The tusk was a debacle, but thorn and

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<v Speaker 1>bone tools worked nicely. The porous structure of bone held

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<v Speaker 1>ink particularly well, and when Deeter Wulf and his team

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<v Speaker 1>analyzed some of the tools microscopically, they noted distinct patterns

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<v Speaker 1>of wear. Tattooing blunted and smoothed the tips, and drove

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<v Speaker 1>in tiny charcoal fragments to day, The published bindings helped

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<v Speaker 1>archaeologists distinguish what is and isn't an ancient tattoo needle,

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<v Speaker 1>but some insight into millennia old methods can only be

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<v Speaker 1>gleaned from ancient bodies. Enter Butzi, the fifty three hundred

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<v Speaker 1>year old ice man discovered in the Alps in nineteen

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<v Speaker 1>ninety one. Researchers analyzing the sixty one lines and crosses

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<v Speaker 1>spread across his body. Initially suggested Botsi's tattoos were applied

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<v Speaker 1>by slicing his skin with sharp stones, then rubbing soot

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<v Speaker 1>into the wounds. Decades later, Deeter Wolf designed an experiment

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<v Speaker 1>that would allow him to test that theory, collaborating with

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<v Speaker 1>Maya Siluc Koch Madsten, a traditional Inuit tattoo artist from Greenland,

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<v Speaker 1>and Daniel Ride, a tattoo artist then based in New Zealand.

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<v Speaker 1>Using eight techniques, including poking with a needle and the

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<v Speaker 1>slice and rubbed method, Ride gave himself eight identical tattoos

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<v Speaker 1>of stacked triangles on his left thigh. He noted how

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<v Speaker 1>long each took to heel, along with how much pain

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<v Speaker 1>he felt. The work to grueling twelve hours, though time

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<v Speaker 1>and pain weren't equally distributed, some methods took minutes. One

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<v Speaker 1>Inuit technique executed with cock Medisene's guid guidance involved sowing

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<v Speaker 1>his skin with ink soaked thread and lasted three agonizing hours. Afterward,

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<v Speaker 1>Redae says his thighs looked like Swiss cheese. Dieter Wolf

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<v Speaker 1>later compared magnified images of Otzie's tattoos with Redays. On

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<v Speaker 1>the latter, he saw line segments for the slice and

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<v Speaker 1>rubb tattoos tapering into wisps on the needle poked ones

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<v Speaker 1>segments had blunt, rounded ends that matched Oatzie's. The Iceman's tattoos,

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<v Speaker 1>Deeterwolf concluded were not sliced in, but carefully strippled with needles.

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<v Speaker 1>The study shed light on Ossy's culture and provided the

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<v Speaker 1>first published reference set of what differing tattoo applications looked

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<v Speaker 1>like microscopically, now used by archaeologists to analyze tattoos in

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<v Speaker 1>other mummies. Anne Austin, a co author of Deeeder Wolf's

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<v Speaker 1>and an egyptologist at the University of Missouri Saint Louis,

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<v Speaker 1>says tattoos can convey details about societies that aren't found elsewhere.

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<v Speaker 1>The things you write down on skin, she says, are

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<v Speaker 1>different than things you write down on paper. Egyptian texts,

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<v Speaker 1>for example, have little to say about the role of

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<v Speaker 1>women in the clergy. But Austin, who has found some

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<v Speaker 1>of the most extensive evidence of tattooing on Egyptian mummies,

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<v Speaker 1>has studied a mummified Egyptian woman whose thirty plus tattoos

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<v Speaker 1>of hieroglyphs, musical instruments, snake deities, and more indicates she

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<v Speaker 1>was something like a priestess. Tattoos over the mummy's voice box,

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<v Speaker 1>Austin says, suggests she had an active speaking or singing role,

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<v Speaker 1>her voice imbued with sacred power to coach's new information

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<v Speaker 1>out of old mummies and tools. Tattoo archaeologists are increasingly

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<v Speaker 1>turning to imagining to imaging technology. Deeter Wolf and a

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<v Speaker 1>Canadian colleague, Benoi Robitale, recently used infrared sensitive cameras to

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<v Speaker 1>find hidden ink among one of the world's largest collections

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<v Speaker 1>of mummies from coastal Peru. Some specimens date back twenty

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<v Speaker 1>four hundred years, their tattoos obscured by the darkening and

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<v Speaker 1>weathering of skin over time, the pair are finding. Robitai

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<v Speaker 1>says that religious iconography and tattoos stayed consistent over almost

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<v Speaker 1>two millennia, suggesting the local beliefs persevered even during periods

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<v Speaker 1>of invasion and conflict. The frontiers of the discipline likely

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<v Speaker 1>involve applying such modern techniques to more museum collections, and

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<v Speaker 1>as new generation of tattoo savvy scholars are reassessing what

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<v Speaker 1>lies in tombs and sarcophagi, they're also belatedly recognizing and

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<v Speaker 1>collaborating with indigenous stewards of ancestral tattooing techniques. As indigenous people,

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<v Speaker 1>we've kind of been taught that there were people before

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<v Speaker 1>and then there's us. Cock Medicine says. This science is

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<v Speaker 1>building a bridge between the two so we can feel

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<v Speaker 1>connected to our ancestors again. Opportunities for more discovery seem

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<v Speaker 1>almost limitless, Geter Wolff says, noting that researchers have found

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<v Speaker 1>more evidence of tattoos on mummies in the past five

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<v Speaker 1>years than was documented over the previous one hundred and fifty.

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<v Speaker 1>We've got this outrageous data set, he says, Now, what

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<v Speaker 1>are we going to do with it next? Searching for

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<v Speaker 1>Sleep Mode by Adam Piore. Putting humans into hibernation is

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<v Speaker 1>a sci fi concept that could revolutionize medicine and transform

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<v Speaker 1>space travel. It's also a lot closer to becoming real

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<v Speaker 1>than you might think. The test subject had slipped into

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<v Speaker 1>what physician Clinton Callaway describes as a twilight kind of

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<v Speaker 1>sleep eighteen hours after Callaway's team at the University of

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<v Speaker 1>Pittsburgh's Applied Physiology Lab started the man on a sedative

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<v Speaker 1>that suppressed his body's natural shivering response. His internal temperature

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<v Speaker 1>had sunk from ninety eight point six degrees fahrenheit to

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<v Speaker 1>ninety five degrees fahrenheit. His heart rate and blood pressure

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<v Speaker 1>had dropped. His metabolism and along with it, his need

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<v Speaker 1>for food, oxygen, and carbon dioxide removal had plunged twenty percent.

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<v Speaker 1>Yet the subject could still rise from his bed, shuffle

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<v Speaker 1>to the bathroom to empty his bladder, and when hungry,

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<v Speaker 1>ring a bell to ask for food or a drink,

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<v Speaker 1>alleviating the need for a catheter or intravenous lines and

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<v Speaker 1>ensuring he could still respond and react. The man was

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<v Speaker 1>one of five exceedingly fit volunteers raging in age from

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<v Speaker 1>twenty one to fifty four, who quietly doozed in the

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<v Speaker 1>semi darkness. Pretend astronauts on a nine month journey to

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<v Speaker 1>Mars Nassau had tasked Callaway, an expert in cardiac care

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<v Speaker 1>and induced typothermia, with figuring out a simple way to

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<v Speaker 1>put human beings into a state that mimics some of

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<v Speaker 1>the key features of hibernation with out the use of

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<v Speaker 1>a ventilator or immobilizing drugs and careful dosing of dex metodonomine.

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<v Speaker 1>Did the trick. His subject. Callaway says now was woozy, dreamy,

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<v Speaker 1>but still able to function in an emergency if required,

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<v Speaker 1>just like a bear. Humans in hibernation mode are a

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<v Speaker 1>classic staple of space travel and science fiction movies, whether

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<v Speaker 1>it's Hal nine thousand fatally unplugging a few of his

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<v Speaker 1>passengers in two thousand and one A Space Odyssey, or

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<v Speaker 1>Chris Pratt waking up Jennifer Lawrence too soon because he's

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<v Speaker 1>lonely in passengers. But NASA has grand ambitions of sending

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<v Speaker 1>astronauts to Mars for reel as soon as the twenty thirties,

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<v Speaker 1>and putting humans in hibernation mode for real could be

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<v Speaker 1>the key to achieving it, which is why both NASA

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<v Speaker 1>and the European Space Agency are supporting studies like Callaways.

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<v Speaker 1>A bear like state of hibernation could, in theory, help

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<v Speaker 1>astronauts snooze through the tum of extended space travel and

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<v Speaker 1>limit crew made conflict there. Slowed metabolism could help reduce

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<v Speaker 1>cargo missions would require less food in oxygen and consequently

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<v Speaker 1>less fuel. Space Agency funded research is even exploring whether

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<v Speaker 1>slowing a person's metabolism weakens the health impact of harmful radiation.

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<v Speaker 1>This would be an encouraging boost for the viability of

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<v Speaker 1>extended travel through space, where radiation is as much as

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<v Speaker 1>two hundred times greater than on Earth. In fact, when

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<v Speaker 1>it comes to achieving the dream of crew missions to Mars,

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<v Speaker 1>says ESA's chief exploration scientists, Angelique than Omburgen, space radiation

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<v Speaker 1>is a big showstopper. Scientists aren't studying hibernation just so

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<v Speaker 1>we can ship astronauts ever deeper into space, though its

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<v Speaker 1>physiological superpowers could save countless lives here on Earth. If

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<v Speaker 1>we can unlock the secrets to the mysterious molecular level

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<v Speaker 1>changes that shift animals in and out of a state

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<v Speaker 1>of hibernation or torpor, a miraculously reversible state of dormancy

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<v Speaker 1>characterized by extreme lethargy, a lowered body temperature and metabolic rate,

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<v Speaker 1>and host of other remarkable changes. It's a well established principle.

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<v Speaker 1>Calaua explains that at low temperatures, like in hibernating animals,

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<v Speaker 1>you tolerate lack of oxygen lack of blood flow better

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<v Speaker 1>and longer. But why why don't bears muscles atrophy when

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<v Speaker 1>they sleep? How come their blood doesn't clot and what

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<v Speaker 1>triggers the process to begin with. In their hunt for answers,

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<v Speaker 1>scientists are now inching closer to their most ambitious discovery yet,

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<v Speaker 1>A central switch in the brains of hibernating animals that

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<v Speaker 1>activates the various beneficial phenomena of hibernation all at once.

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<v Speaker 1>Mimicking the colder body temperature of bears during hibernation, for instance,

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<v Speaker 1>could lessen the severity of reperfusion injuries, the often devastating

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<v Speaker 1>damage that occurs after cardiac arrest when blood flow is

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<v Speaker 1>restored to the oxygen deprived tissues of the body, setting

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<v Speaker 1>off massive inflammation, oxid exeitative stress, and cell death. It

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<v Speaker 1>could also help extend the narrow window of time that

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<v Speaker 1>doctors have to provide critical care during strokes and heart attacks.

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<v Speaker 1>A clearer understanding of how hibernating bears preserve muscle mass

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<v Speaker 1>and turned insulin resistance on and off could have other benefits.

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<v Speaker 1>It might help us treat chronic obesity and diabetes in humans.

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<v Speaker 1>Ice you patients can lose more than ten percent of

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<v Speaker 1>their muscle mass in seven days. Could an induced state

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<v Speaker 1>of hibernation staller even stop the decline. Scientists are searching

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<v Speaker 1>beyond bears for the answers, because, of course, bears aren't

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<v Speaker 1>the only animals that hibernate. A team at Colorado State

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<v Speaker 1>University is investigating how the thirteen lined ground squirrel can

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<v Speaker 1>rapidly fatten and then switch off its appetite before hibernation

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<v Speaker 1>for clues to combating obesity. UCLA research examining the genes

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<v Speaker 1>of yellow bellied marmots have recently found that epigenic epigenetic

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<v Speaker 1>aging is essentially stalled during the seven to eight months

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<v Speaker 1>they hibernate each year. Experts in Germany are exploring how

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<v Speaker 1>bats maintain blood circulation at low temperatures with an eye

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<v Speaker 1>to human hibernation applications, and biologists at the University of

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<v Speaker 1>Alaska Fairbanks are studying a squirrel that could drop its

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<v Speaker 1>body temperature by seventy degrees and heart rate down to

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<v Speaker 1>five beats permitted, and survive eight months in subzero temperatures.

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<v Speaker 1>Their goal is to develop a hibernation mimetic drug that

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<v Speaker 1>might safely allow clinicians to place humans into an immediate

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<v Speaker 1>state of hibernation without a long prep time in a

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<v Speaker 1>rural hospital lacking advanced equipment, or even in an ambulance

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<v Speaker 1>racing through the streets. It would instantly dial down cellular metabolism,

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<v Speaker 1>slow cell death, and catalyze a whole host of other

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<v Speaker 1>biol logical processes associated with hibernation. Callaway's twilight sleep experiment

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<v Speaker 1>provides a glimpse into what might be possible for humans,

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<v Speaker 1>but what happens in the lab and in the wild

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<v Speaker 1>are clearly two different things. Bears don't need drugs to

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<v Speaker 1>settle in for the winner. They have a natural torpor switch,

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<v Speaker 1>he says, which is flipped through some process that we

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<v Speaker 1>don't fully understand. And though their unruly bears still offer

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<v Speaker 1>a good comparison for our own potential, they're at least

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<v Speaker 1>closer to us in size than a rodent, and perhaps

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<v Speaker 1>most critically, their temperature drop during sleep deep sleep is

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<v Speaker 1>well within the range of human survivability. One bright afternoon

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<v Speaker 1>in late March, biologist Haiko Jansen stood outside of fence

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<v Speaker 1>dan Pasture at the Washington State University Bear Research, Education

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<v Speaker 1>and Conservation Center in Pullman and watched as a shaggy,

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<v Speaker 1>three hundred pound female grizzly bear named Kiyo struggled to

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<v Speaker 1>eat a marshmallow. Other than a serious case of BedHead

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<v Speaker 1>than the glacier pace of quees chewing. There were few

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<v Speaker 1>visible clothes that the dangerous, disheveled giant with the four

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<v Speaker 1>inch claws was undergoing a profound metamorphosis. Looking from the outside,

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<v Speaker 1>little about Hugh's metabolic process seems applicable to humans. Ten

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<v Speaker 1>days earlier, she rose from her bed of straw and

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<v Speaker 1>began to slowly work through a feast of bare kibble,

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<v Speaker 1>apples and elk bones and leg meat. It was her

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<v Speaker 1>first meal in five months. Her salverary glands were still sluggish.

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<v Speaker 1>Then she pooped out a fecal plug composed of plants,

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<v Speaker 1>dried feces, dead cells, and hair lodged in her glower intestine.

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<v Speaker 1>Those three key activities rise, eat, poop out the plug

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<v Speaker 1>seemed to have helped to flip a series of microscopic

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<v Speaker 1>genetic switches inside her cells, catalyzing the slow motion reversal

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<v Speaker 1>of a host of bizarre biological cycles her body had

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<v Speaker 1>entered into over the winter. Q's metabolism, which had been

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<v Speaker 1>operated at one quarter its normal speed, kicked into gear

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<v Speaker 1>more than doubling by the time she was struggling with

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<v Speaker 1>the marshmallow. Her core body temperature hovering about twelve degrees

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<v Speaker 1>below normal, began to rise. Two of her heart's four chambers,

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<v Speaker 1>which had all but shut down for the winter, reopened

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<v Speaker 1>for business. Her fat cells, for months miraculously resistant to insulin,

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<v Speaker 1>the hormone that tells the body when to absorb sugars,

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<v Speaker 1>started to respond to it again. Her appetite, absent for months,

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<v Speaker 1>rumbled to life five months earlier, back in November, when

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<v Speaker 1>Ki lay down and packed it in for the winter,

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<v Speaker 1>she stopped eating. Her gut entered stasis, her saliva glands

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<v Speaker 1>shut down, and she began living on her own body fat.

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<v Speaker 1>Over the following months, she burned roughly twenty percent, or

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<v Speaker 1>seventy pounds of her body weight. To facilitate this, her

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<v Speaker 1>body became resistant to insulin, a good thing for hibinator's.

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<v Speaker 1>Humans who become insulin resistance often developed diabetes, clearly a

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<v Speaker 1>bad thing. Bears can switch that resistance and on and

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<v Speaker 1>off depending on the season, without health consequences. If we

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<v Speaker 1>could understand how, maybe we could figure out a way

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<v Speaker 1>for humans to do it too. The notion got a

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<v Speaker 1>boost of confidence in twenty eighteen when a Canadian group

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<v Speaker 1>published the first complete grizzly bear DNA sequence. A year later,

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<v Speaker 1>Jansen headed up a team that used a technique known

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<v Speaker 1>as RNA sequencing to identify which genes are activated in beer, muscle, fat,

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<v Speaker 1>and liver tissue samples before, during, and after hibernation. They

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<v Speaker 1>found seasonal changes in more than ten thousand of a

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<v Speaker 1>grizzly's thirty thousand, seven hundred and twenty three genes. Now,

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<v Speaker 1>in order to decode how bears switch insulin resistance on

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<v Speaker 1>and off, Jansen has been extracting stem cells from blood

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<v Speaker 1>samples collected from Pullman's bears at different times of year,

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<v Speaker 1>methodically eliminating individual genes, and then growing colonies of fat

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<v Speaker 1>cells in peatrie dishes to see what happens. We're not

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<v Speaker 1>saying that we'll find something that can reverse diabetes, Jansen offers,

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<v Speaker 1>but at least by looking at a model system the

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<v Speaker 1>cells that change their sensitivity, we can begin to develop

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<v Speaker 1>some clues as to what's going on. Q's cardiac function

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<v Speaker 1>may also yield insights that help treat human blood clotting disorders.

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<v Speaker 1>While Q was hibernating, her heart rate slowed from eighty

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<v Speaker 1>to one hundred beats per minute to about ten Normally.

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<v Speaker 1>This would cause her blood to clot into dangerous blockages

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<v Speaker 1>and induce a stroke. If that happened to us, as Jansen,

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<v Speaker 1>we'd be dead. But hibernating bears also experience a remarkable

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<v Speaker 1>drop in their blood clotting platelets. It was Q's ability

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<v Speaker 1>to maintain muscle tone, however, that particularly transfixed some of

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<v Speaker 1>her researchers. Unlike humans, who began to lose muscle mass

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<v Speaker 1>within a week of inactivity, Q rose from her hibernation

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<v Speaker 1>bed as fit as if she'd spent the winter chasing chipmunks.

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<v Speaker 1>Up in Alaska, researchers vaudem Fidu Goorov and Anna Goropashnaya

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<v Speaker 1>are trying to unlock the mystery of how beers do

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<v Speaker 1>this and test the hypothesis that humans might be able

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<v Speaker 1>as well. The Russian born husband and wife teams specialized

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<v Speaker 1>in evolutionary genetics at the University of Alaska's Institute of

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<v Speaker 1>Arctic Biology IAB in Fairbanks. When they began analyzing gene

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<v Speaker 1>expression patterns in tissue samples collected from captive black bears

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<v Speaker 1>nearly twenty years ago. The results shocked them, seeing as

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<v Speaker 1>how beers stop eating and slow their metabolism during hibernation.

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<v Speaker 1>Federov and Gorophashnaya assumed that the gene activity involved in

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<v Speaker 1>building new muscles would be dialed down to preserve energy. Instead,

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<v Speaker 1>the genes were just as active and even appeared to

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<v Speaker 1>ramp up. We checked it several times, says Goropashnaya. We

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<v Speaker 1>couldn't believe it. The findings were illogical, but somehow correct.

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<v Speaker 1>Scores of genes known to be part of muscle protein

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<v Speaker 1>biosynthesis were turned up in what appear to be a

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<v Speaker 1>coordinated and metabolically costly frenzy of activity. The two presented

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<v Speaker 1>their first paper on the phenomenon in twenty eleven. Now,

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<v Speaker 1>with the aid of newer DNA sequencing technologies, they're able

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<v Speaker 1>to study twice as many genes and with far more specificity,

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<v Speaker 1>which is what led them to the m tour pathway,

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<v Speaker 1>a well known circular dial that also plays a key

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<v Speaker 1>role in controlling the rate of cell division. This concludes

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<v Speaker 1>readings from National Geographic Magazine for to day. Your reader

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<v Speaker 1>has been Marsha. Thank you for listening, Keep on listening

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<v Speaker 1>and have a great day.
