WEBVTT 1 00:00:03.120 --> 00:00:07.360 Check it out The Joke Regan Experience Train My Day Joe. 2 00:00:07.240 --> 00:00:15.039 Rogan podcast by name All day. 3 00:00:12.560 --> 00:00:16.839 Mister Sinclair, good to see you again, doctor Sinclair. 4 00:00:16.920 --> 00:00:18.679 Doctor, I'm kidding day. 5 00:00:19.440 --> 00:00:21.399 Yeah. Do you ever introduce yourself as doctor? 6 00:00:21.559 --> 00:00:21.800 Never? 7 00:00:22.440 --> 00:00:24.600 Yeah, that's a kind of a it's a weird thing 8 00:00:24.600 --> 00:00:25.559 because you're allowed to. 9 00:00:26.320 --> 00:00:28.160 Well, I'm actually a sir, David from Australia. 10 00:00:28.199 --> 00:00:29.120 But are you a sir? 11 00:00:29.519 --> 00:00:31.800 Yeah, but it's kind of a joke. I don't really 12 00:00:31.839 --> 00:00:32.159 what does that? 13 00:00:32.200 --> 00:00:34.320 How does that work out? Did you get. 14 00:00:35.640 --> 00:00:38.719 The representative gave me some Australian version of a knighthood? 15 00:00:39.840 --> 00:00:42.320 But uh, I get to put AO at the end 16 00:00:42.359 --> 00:00:46.920 of my name Ao. Yeah, Order of Australia. But it 17 00:00:46.960 --> 00:00:49.439 actually makes no difference to my life. So it's just 18 00:00:49.439 --> 00:00:50.439 an extra couple of letters. 19 00:00:50.479 --> 00:00:51.280 It's kind of cool. 20 00:00:52.280 --> 00:00:57.880 I'm honored, for sure, but it, uh, it's just a joke. 21 00:00:58.280 --> 00:01:00.320 If you don't know, well, it's kind of anybody's sir. 22 00:01:00.640 --> 00:01:02.079 You meet a guy at the gas station, how are 23 00:01:02.039 --> 00:01:04.120 you doing, sir? Is that like? 24 00:01:04.200 --> 00:01:06.000 Wow? How does he know? Right? 25 00:01:06.040 --> 00:01:07.239 You don't see how you're doing? King? 26 00:01:08.280 --> 00:01:11.799 Yeah? Right, Well I'm David, I'm Australian, so in Australia. 27 00:01:11.840 --> 00:01:14.200 If you have any ego, you get beaten up in 28 00:01:14.239 --> 00:01:14.879 the playgrounds. 29 00:01:14.959 --> 00:01:17.920 That is true. Australia is the land of the tall 30 00:01:17.959 --> 00:01:21.200 poppy syndrome. They don't they don't fuck around. They don't 31 00:01:21.239 --> 00:01:22.719 like you get in a big head in Australia. 32 00:01:23.239 --> 00:01:25.879 That that is true. I like to go back there though, 33 00:01:25.920 --> 00:01:28.799 because it's any level playing field, nobody cares who you are. 34 00:01:29.000 --> 00:01:31.680 I love the people there. Australian people are some of 35 00:01:31.760 --> 00:01:35.280 my favorite people. They're awesome. They're just They're very friendly 36 00:01:35.359 --> 00:01:38.040 and fun. It's a great place to be. It's just 37 00:01:38.079 --> 00:01:39.920 too far to get there. Such a haul. 38 00:01:40.200 --> 00:01:42.359 Oh no, if you just you know, whiskey and an 39 00:01:42.359 --> 00:01:43.400 ambient and you're. 40 00:01:43.280 --> 00:01:44.640 There without is that what you do? 41 00:01:44.959 --> 00:01:47.959 I used to. I've gone clean. I don't drink much 42 00:01:48.120 --> 00:01:48.959 at all anymore. 43 00:01:50.040 --> 00:01:51.439 How often is drink much at all? 44 00:01:51.959 --> 00:01:55.120 Cele right now? No, it would be a bad look. 45 00:01:55.799 --> 00:01:58.000 I've got the coffee that you gave me, which, yeah, 46 00:01:58.040 --> 00:01:58.560 this is. 47 00:01:58.400 --> 00:02:02.760 A layered super food coffe. So Laird Hamilton has coff 48 00:02:02.840 --> 00:02:06.519 it's black rifle coffee mixed with his superfood stuff which 49 00:02:06.560 --> 00:02:09.919 is this one's turmeric. So it's turmeric and I think 50 00:02:09.960 --> 00:02:12.800 it has coconut milk in it and some other jazz. 51 00:02:12.639 --> 00:02:15.199 That's great anti inflammatory, yes. 52 00:02:16.000 --> 00:02:17.199 Which I know you're all about. 53 00:02:18.000 --> 00:02:21.800 Yes, as a prophet of longevity. 54 00:02:22.080 --> 00:02:25.120 Yes, is that another title of you. 55 00:02:25.199 --> 00:02:27.280 Yes, you can call me Sir David the Prophet. 56 00:02:27.479 --> 00:02:31.840 How about that, Sir David the prophet, doctor, Sir David 57 00:02:31.879 --> 00:02:33.120 the Prophet of longevity. 58 00:02:33.360 --> 00:02:33.719 That'll do. 59 00:02:34.439 --> 00:02:36.879 So there's a lot. Let's let's jump right into it 60 00:02:36.919 --> 00:02:39.919 because there is a lot going on in the longevity space. 61 00:02:40.000 --> 00:02:42.039 Thank you's having me back on it. My pleasure. And 62 00:02:42.039 --> 00:02:44.719 by the way, I also want to thank you for 63 00:02:45.639 --> 00:02:47.960 I think this is fourth time on which is amazing. 64 00:02:48.039 --> 00:02:50.719 Thank you, congrats on all your success. It's thank you 65 00:02:50.759 --> 00:02:54.680 wonderful to see. Also, the book that I wrote, which 66 00:02:54.719 --> 00:02:56.639 you first had me on to promote, has done so 67 00:02:56.680 --> 00:02:59.199 well and it's really because of you and the book 68 00:02:59.439 --> 00:03:02.479 Lifespan became a best seller. Not just that, but it's 69 00:03:02.520 --> 00:03:04.319 now been read millions of times around the world. 70 00:03:04.520 --> 00:03:06.840 It's in forty last phenomenal and it's my pleasure. 71 00:03:07.319 --> 00:03:09.199 And that's not a promo, as you know, you don't 72 00:03:09.199 --> 00:03:11.919 make any money from books really, but I'm just honored 73 00:03:11.919 --> 00:03:14.680 that it was read by so many people around the 74 00:03:14.680 --> 00:03:17.199 world because it wasn't an easy read, it was high 75 00:03:17.240 --> 00:03:17.840 tech science. 76 00:03:18.080 --> 00:03:22.800 Well, people are very interested, especially nowadays. I think I've 77 00:03:22.879 --> 00:03:28.360 never I can't recall a time in my life where 78 00:03:28.719 --> 00:03:32.599 optimizing your health and longevity has been more of a 79 00:03:32.639 --> 00:03:34.120 subject that people are interested in. 80 00:03:34.719 --> 00:03:37.639 Well, I think that's largely because not to keep blowing 81 00:03:37.639 --> 00:03:41.439 smoke up your rear, but largely because of what you 82 00:03:41.479 --> 00:03:44.520 did in the book. So the book went global, and 83 00:03:45.520 --> 00:03:49.080 it was right in twenty nineteen and the pandemic hit, 84 00:03:49.800 --> 00:03:52.199 and I think most people saw their own mortality at 85 00:03:52.199 --> 00:03:55.039 that point. Most people under the age of about seventy 86 00:03:55.120 --> 00:03:58.319 didn't even think about dying, but then pandemics Like shit, 87 00:03:58.400 --> 00:04:01.400 I could die. I saw the book take off. You 88 00:04:01.520 --> 00:04:05.000 launched it. But yeah, since then a lot of people 89 00:04:05.000 --> 00:04:07.639 have jumped on the bandwagon and now longevities. I hear 90 00:04:07.680 --> 00:04:08.599 this everywhere I go. 91 00:04:08.759 --> 00:04:13.280 It's everything. It's everywhere. People are constantly talking about different modalities. 92 00:04:13.479 --> 00:04:15.639 How often do you cold plunge? Are you sawing it? 93 00:04:15.680 --> 00:04:17.439 What about the red light? What do you think is 94 00:04:17.480 --> 00:04:21.480 this legit? Is that legit? Like everybody's optimizing everything constantly 95 00:04:21.519 --> 00:04:23.759 all the time. But the reason why it's caught on 96 00:04:23.879 --> 00:04:26.720 is because if you do follow some of the protocols, 97 00:04:26.759 --> 00:04:30.319 you will feel better, and so that's the ultimate goal. 98 00:04:30.399 --> 00:04:34.759 Like longevity is wonderful, but feeling better in the moment currently, 99 00:04:34.879 --> 00:04:38.600 like living your life should be primary longevity, I think 100 00:04:38.720 --> 00:04:44.120 is if you're optimizing your life and you feel better, 101 00:04:44.199 --> 00:04:46.560 you will live longer. It's like this, it's all part 102 00:04:46.639 --> 00:04:49.720 of it. So it would follow the longevity principles and 103 00:04:49.759 --> 00:04:53.040 the ideas behind it. You certainly will live better right now. 104 00:04:53.199 --> 00:04:54.920 You will, And it's not even that hard. There are 105 00:04:55.480 --> 00:04:58.000 basic things, five basic things you can do or avoid 106 00:04:58.399 --> 00:05:00.639 and you can live another fifteen years. It's really not 107 00:05:00.680 --> 00:05:02.920 that hard. And that's what I'm excited about telling millions 108 00:05:02.920 --> 00:05:05.040 of people today is and maybe we can go over 109 00:05:05.079 --> 00:05:06.879 the kind of things that people can do easily to 110 00:05:06.959 --> 00:05:07.519 live longer. 111 00:05:07.839 --> 00:05:09.560 Well, well, I definitely want to do that, But I 112 00:05:09.639 --> 00:05:13.120 also want to talk about, like what is the current 113 00:05:13.240 --> 00:05:19.399 state of science as applied to longevity treatments, because I 114 00:05:19.480 --> 00:05:23.399 know that there's some pretty groundbreaking stuff that's in the 115 00:05:23.399 --> 00:05:24.480 pipeline right now. 116 00:05:25.160 --> 00:05:29.439 Yeah, so since twenty nineteen, a lot of what we 117 00:05:29.560 --> 00:05:31.680 talked about has come true, which is the amazing thing. 118 00:05:32.800 --> 00:05:37.920 We're speculating twenty nineteen that we could potentially reverse aging, 119 00:05:38.439 --> 00:05:40.120 and that was a sin to say that as a 120 00:05:40.160 --> 00:05:43.800 scientist publicly in those days. I put it in the 121 00:05:43.800 --> 00:05:47.720 book and it's actually come true since then, certainly for 122 00:05:47.959 --> 00:05:51.920 the lab for mice monkeys, and now we have a 123 00:05:52.000 --> 00:05:56.680 human clinical trial the first potential human age reversal technologies 124 00:05:56.720 --> 00:05:57.560 in people right now. 125 00:05:58.040 --> 00:06:01.680 Listen. It completely seems logical. The idea that that at 126 00:06:01.680 --> 00:06:04.360 one point in time would have been heresy and science 127 00:06:04.399 --> 00:06:09.000 to discuss it, so that seems crazy, like if people 128 00:06:09.000 --> 00:06:12.839 get old, we understand the mechanism, why couldn't we reverse it? 129 00:06:13.480 --> 00:06:14.839 Well, I think for a long time we had to 130 00:06:14.879 --> 00:06:17.279 accept it in the way that cancer used to be 131 00:06:17.360 --> 00:06:20.040 accepted two hundred years ago. Probably there was nothing you 132 00:06:20.040 --> 00:06:22.439 could do about it. And then my colleagues and I 133 00:06:22.560 --> 00:06:24.759 found that aging has a root cause that's the same 134 00:06:24.800 --> 00:06:27.199 in pretty much every cell in the body, and that 135 00:06:27.240 --> 00:06:29.439 we could control that, and that there were genes that 136 00:06:29.600 --> 00:06:32.680 not only slowed it down. But in twenty twenty we 137 00:06:32.720 --> 00:06:34.959 had a big publication that showed we could actually safely 138 00:06:35.040 --> 00:06:38.720 for the first time reverse that process, like reinstalling software 139 00:06:38.759 --> 00:06:40.199 in the cell to make it work again. 140 00:06:41.560 --> 00:06:44.319 And so what is the pro is that using crisper? Like, 141 00:06:44.680 --> 00:06:45.680 what are you using to. 142 00:06:46.759 --> 00:06:50.879 Well, we deliver genes into the body like crisper. I 143 00:06:50.920 --> 00:06:53.360 have a little little prop here and brought what is 144 00:06:53.399 --> 00:06:55.720 that in my pocket here? This is a representation of 145 00:06:55.720 --> 00:06:59.079 how we deliver the age reversal genes. It's a virus 146 00:06:59.240 --> 00:07:02.399 like capsule that we make in the lab and this 147 00:07:02.519 --> 00:07:05.000 is what's going into the patients right now, into their 148 00:07:05.079 --> 00:07:10.519 eyes initially, and the eye is a good place to start. 149 00:07:10.600 --> 00:07:13.240 How do you pick the people to get on these tests? 150 00:07:12.839 --> 00:07:18.759 They volunteer. I was really fortunate to see the first 151 00:07:18.759 --> 00:07:24.680 patient get dosed earlier this year, and that person bravely 152 00:07:24.839 --> 00:07:28.199 volunteered to be the first person to get trillions of 153 00:07:28.240 --> 00:07:31.480 these injected into his eye to see if could cure 154 00:07:31.519 --> 00:07:33.079 his glaucoma loss of vision. 155 00:07:34.079 --> 00:07:36.879 And I bet if you have glaucoma, you're probably like, listen, 156 00:07:36.920 --> 00:07:38.240 what's the worst that can happen? 157 00:07:38.800 --> 00:07:41.920 Well, exactly, he pretty much was totally blind in one eye, 158 00:07:41.959 --> 00:07:44.560 and so there's really nothing that he has to lose. 159 00:07:45.160 --> 00:07:49.120 There's a risk that something might go wrong, but not really. 160 00:07:49.399 --> 00:07:52.600 He The good news is, and I can report to 161 00:07:52.639 --> 00:07:56.279 everybody around the world that nothing's gone wrong so far. 162 00:07:56.519 --> 00:08:01.000 Everything's proceeding according to plan, and we're at its turning 163 00:08:01.040 --> 00:08:03.759 point potentially in human history if it works. 164 00:08:04.279 --> 00:08:07.839 So I interrupted you, but explain this little virus. 165 00:08:07.839 --> 00:08:10.199 Trust sure, And for those of you listening, I've got 166 00:08:10.240 --> 00:08:12.120 a little rubber ball with spikes on it. It looks a 167 00:08:12.120 --> 00:08:14.519 bit like covid, but don't be scared of it. It's 168 00:08:14.560 --> 00:08:18.720 not a pathogenic virus. It's actually a domesticated version of 169 00:08:18.720 --> 00:08:22.560 a virus. And this little plastic ball has little adapters. 170 00:08:22.639 --> 00:08:24.879 These red balls on the surface of the big ball 171 00:08:25.839 --> 00:08:28.279 target it to the cells in the back of the eye, 172 00:08:28.399 --> 00:08:30.680 and you can change the balls to target different tissues. 173 00:08:30.720 --> 00:08:34.240 We could change that outside little spike and target it 174 00:08:34.240 --> 00:08:36.639 to the liver, which we've done and cured mice of 175 00:08:36.679 --> 00:08:39.159 their fatty liver disease as well. But this one's for 176 00:08:39.200 --> 00:08:43.879 the eye. And within that big ball is a protein capsule, 177 00:08:43.919 --> 00:08:49.240 and inside the protein capsule is our DNA special delivery, 178 00:08:49.840 --> 00:08:53.960 which we call osk or R one hundred. R one 179 00:08:54.000 --> 00:08:57.600 hundred is epigenetic reprogramming one hundred, the drug that we 180 00:08:57.639 --> 00:08:59.759 know when we put it into human cells, it makes 181 00:08:59.759 --> 00:09:02.639 them younger and then they work like they were young again. 182 00:09:05.240 --> 00:09:08.240 This sounds like the beginning of a horror movie, you 183 00:09:08.279 --> 00:09:10.360 know what I mean, Like the scientist is on a 184 00:09:10.399 --> 00:09:13.799 talk show and the scientist is explaining it, and everyone's 185 00:09:13.840 --> 00:09:16.480 at home, like with their coffee, Like, Wow, we're in 186 00:09:16.559 --> 00:09:19.759 a scientist. This is wonderful. We're gonna get younger again. 187 00:09:19.960 --> 00:09:21.240 And SCIENTII to worry. 188 00:09:21.240 --> 00:09:22.080 It's all gonna work out. 189 00:09:22.080 --> 00:09:26.080 Twenty eight days later, garbage in the streets, cars on fire, 190 00:09:26.159 --> 00:09:29.639 the guy's waking up from a coma, doesn't know what happened. Yeah, 191 00:09:29.799 --> 00:09:32.559 goes outside. These optimized humans are eating each other. 192 00:09:32.759 --> 00:09:35.360 I admit, I admit it is science fiction, and I 193 00:09:35.480 --> 00:09:38.000 even have to pinch myself that it's actually happening. But 194 00:09:38.039 --> 00:09:39.919 we've done a lot of safety studies, and this trial 195 00:09:40.000 --> 00:09:42.440 is FDA approved because they've looked at all the data. 196 00:09:42.480 --> 00:09:44.320 Well, god knows, they never fucking anything up. 197 00:09:44.799 --> 00:09:48.840 I figured you might say that perfect. Yeah, Well, it's 198 00:09:48.919 --> 00:09:50.480 in the eyes. So that's why we start with the eye. 199 00:09:50.480 --> 00:09:54.000 It's enclosed, it's not gonna spread, nobody's going to grow 200 00:09:54.039 --> 00:09:54.639 another And. 201 00:09:54.639 --> 00:09:59.600 So these trillions of cells that you're putting into the. 202 00:09:59.519 --> 00:10:03.320 Eyes, the little capsule, the virus. 203 00:10:02.399 --> 00:10:06.919 Tillions I shouldn't call themselves, trillions of capsules that you're 204 00:10:06.919 --> 00:10:10.519 putting into the eye. What are they doing for glaucola? 205 00:10:12.200 --> 00:10:14.360 Well, what they're doing is that there are three genes 206 00:10:14.360 --> 00:10:20.200 in this DNA package, and I called them OSK. OSK 207 00:10:20.440 --> 00:10:25.519 are three special genes that we found safely reprogram cells 208 00:10:25.720 --> 00:10:28.919 and reboot the backup copy of youth, which we now 209 00:10:28.919 --> 00:10:32.120 believe exists in our body. That's a big deal that 210 00:10:32.159 --> 00:10:34.559 there's a backup copy of youth. Even an old person, 211 00:10:34.600 --> 00:10:36.639 I don't see that an old person anymore on the street. 212 00:10:37.039 --> 00:10:39.399 I just see a person that needs to be rebooted. 213 00:10:39.879 --> 00:10:41.399 These OSK genes. 214 00:10:41.200 --> 00:10:45.200 You just see. Hold on, when you see old people, 215 00:10:45.200 --> 00:10:47.399 you don't see old people you think. You just say, oh, 216 00:10:47.440 --> 00:10:50.759 that poor person needs to be rebooted. Yeah, you're doing 217 00:10:50.799 --> 00:10:54.480 the perfect job for you, like your personality is perfectly 218 00:10:54.519 --> 00:10:57.519 suited for your occupation. If that's how you actually look 219 00:10:57.559 --> 00:10:58.399 at people. 220 00:10:58.519 --> 00:11:02.360 Well I do. And the reason is that we all, 221 00:11:03.519 --> 00:11:07.159 we all have this backup copy that the DNA, the 222 00:11:07.159 --> 00:11:09.919 instructions to be young that made us into who we 223 00:11:09.960 --> 00:11:14.519 are as kids, is still in our bodies, almost largely intact. 224 00:11:14.879 --> 00:11:17.480 You just need to read it again. And that's why 225 00:11:17.600 --> 00:11:20.399 read installing software or I used to use the analogy 226 00:11:20.440 --> 00:11:24.240 of a CD. Kids these days probably don't know what 227 00:11:24.279 --> 00:11:26.840 a CD is. It's a it's a little plastic circle 228 00:11:26.960 --> 00:11:29.080 like a record that we used to put twenty songs on. 229 00:11:29.159 --> 00:11:31.919 It was awesome at the time. I'm kidding. I'm kidding. 230 00:11:31.919 --> 00:11:35.279 It's a bit of a silly joke. When I teach 231 00:11:35.519 --> 00:11:37.919 kids at Harvard, most of them have never held a 232 00:11:37.960 --> 00:11:42.279 CD in that wild Yeah, though, they're not coming back, 233 00:11:42.320 --> 00:11:45.080 but albums definitely. So think of it like an album 234 00:11:45.080 --> 00:11:49.080 that you scratch and the scratches are like aging, and 235 00:11:49.120 --> 00:11:52.240 we are getting rid of the scratches with these three genes, 236 00:11:52.240 --> 00:11:54.320 as kay, So let me tell you how these three 237 00:11:54.320 --> 00:11:58.279 genes work. We found there was a person whose name 238 00:11:59.000 --> 00:12:03.679 is well known in science circles called Shinya Yamanaka from Japan, obviously, 239 00:12:04.159 --> 00:12:07.120 and he discovered that there was a set of four 240 00:12:07.159 --> 00:12:11.320 genes that could reliably make adult cells like skin cells, 241 00:12:12.159 --> 00:12:15.320 into stem cells, and he deservedly won the Nobel Prize 242 00:12:15.320 --> 00:12:18.360 for that in two thousand and six. But that wouldn't 243 00:12:18.399 --> 00:12:20.960 be useful here. If I turned you into a bunch 244 00:12:21.000 --> 00:12:24.200 of stem cells, you'd probably die within a few minutes. 245 00:12:24.519 --> 00:12:26.240 So we don't want to do that and cancer is 246 00:12:26.279 --> 00:12:30.480 also a potential. So it took us about well from 247 00:12:30.519 --> 00:12:33.600 twenty nineteen. It took us a while to figure out 248 00:12:33.600 --> 00:12:36.440 that if we leave out one of the Yamanaka genes 249 00:12:36.480 --> 00:12:39.799 and just use three OSK leave out the other one 250 00:12:39.799 --> 00:12:43.240 called AM, we'd get safe age reversal about seventy five 251 00:12:43.279 --> 00:12:46.120 eighty percent back to youth. But no further. We don't 252 00:12:46.120 --> 00:12:48.960 go back to zero, which is what Yamanaka did. And 253 00:12:49.039 --> 00:12:51.080 instead of cells losing their identity, which is what a 254 00:12:51.080 --> 00:12:55.240 stem cell has no identity, we regain identity. So it's 255 00:12:55.240 --> 00:12:58.240 actually I could draw graphs, but it doesn't really help listeners. 256 00:12:58.639 --> 00:13:01.519 But basically, old old, old age is losing identity of 257 00:13:01.559 --> 00:13:03.759 your cells, so they don't work, they forget how to work. 258 00:13:04.120 --> 00:13:06.720 That's what we think old ages in my lab and 259 00:13:06.759 --> 00:13:09.519 stem cells have no identity. It was like a very 260 00:13:09.559 --> 00:13:13.320 early embryo in between. Our cells have a lot of identity, 261 00:13:13.360 --> 00:13:16.159 they function beautifully, where in our twenties we're at peak. 262 00:13:17.200 --> 00:13:18.639 And what we've done is we've figured out how to 263 00:13:18.720 --> 00:13:23.240 go back towards youth, get these cells to work like 264 00:13:23.279 --> 00:13:27.399 they did again, back get the backup copy somewhere it exists. 265 00:13:27.440 --> 00:13:30.399 We're looking for it and now cells actually behave like 266 00:13:30.519 --> 00:13:33.720 they did when we were twenty And if it works, 267 00:13:33.720 --> 00:13:36.159 we're going to have glaucoma patients seeing for the first time. 268 00:13:36.720 --> 00:13:39.720 And that's the beginning of a whole cascade of drugs 269 00:13:39.720 --> 00:13:42.440 that I want to develop for diseases of aging and 270 00:13:42.480 --> 00:13:43.960 eventually whole body rejuvenation. 271 00:13:44.919 --> 00:13:48.480 So the initial experiments are on glaucoma because it's a 272 00:13:48.519 --> 00:13:52.120 contained thing. The eyeball is a contained thing, and you 273 00:13:52.159 --> 00:13:52.919 could do it that way. 274 00:13:53.080 --> 00:13:55.440 Yeah, my student Juan cheng Lu, who was doing this 275 00:13:55.480 --> 00:13:58.840 in twenty seventeen, I said, let's do the liver. Let's 276 00:13:58.879 --> 00:14:00.600 rejuvenate the liver, and he said the eye is a 277 00:14:00.600 --> 00:14:03.200 good idea, and he was right. So that's exactly why 278 00:14:03.240 --> 00:14:04.080 we chose that first. 279 00:14:04.679 --> 00:14:07.159 But just think about how many people have vision problems. 280 00:14:07.240 --> 00:14:11.120 It's forty million just in the US for glaucoma. Macula 281 00:14:11.159 --> 00:14:13.600 de generation is even more. And in the lab we 282 00:14:13.639 --> 00:14:15.960 can cure that as well in the mice. 283 00:14:16.440 --> 00:14:22.039 Now, macular degeneration and glaucoma, these are diseases of aging, right, 284 00:14:22.159 --> 00:14:25.440 you would say, or gla Cooma's a disease. Oh yeah, 285 00:14:25.480 --> 00:14:28.879 Well what about people that have had eyeball injuries? And 286 00:14:28.919 --> 00:14:31.279 things like that. Is there a backup copy of the 287 00:14:31.320 --> 00:14:34.919 eyeball where you could sort of reformat the eyeball structure? 288 00:14:35.679 --> 00:14:38.120 You should come work in my lab at least come visit. 289 00:14:38.399 --> 00:14:39.120 I would love to visit. 290 00:14:39.200 --> 00:14:40.879 And the reason I say that is that's the exact 291 00:14:40.960 --> 00:14:44.639 question that we're asking. We showed that even if you injure, 292 00:14:45.320 --> 00:14:49.799 say a nerve, whether it's peripheral in your arm or 293 00:14:49.840 --> 00:14:52.399 in your brain or in the eye like the optic nerve, 294 00:14:52.879 --> 00:14:56.559 we can regrow those back to where they were. And actually, 295 00:14:56.600 --> 00:14:59.720 in twenty twenty on the cover of Nature magazine there 296 00:14:59.799 --> 00:15:02.039 was the picture of an eye and in the in 297 00:15:02.120 --> 00:15:04.320 the paper we published, you could see the nose re 298 00:15:04.399 --> 00:15:10.600 growing back. And so we think that injury is also treatable. Actually, 299 00:15:10.639 --> 00:15:12.960 a group in China just took our technology, this always 300 00:15:13.039 --> 00:15:15.960 K stuff, put it into mice that had bad joints, 301 00:15:16.519 --> 00:15:19.360 and it regrew their muscle and their bone back to normal. 302 00:15:19.960 --> 00:15:20.440 WHOA. 303 00:15:20.519 --> 00:15:24.200 And so we were also looking at treating injury back 304 00:15:24.240 --> 00:15:26.799 injury joints. What's gio arthritis? 305 00:15:27.360 --> 00:15:31.840 That would be phenomenal because there's so many people that 306 00:15:31.879 --> 00:15:34.639 are suffering from arthritis, and so many I know, so 307 00:15:34.720 --> 00:15:38.120 many people with injuries like martial arts injuries. I have one. 308 00:15:38.159 --> 00:15:41.200 My left knee is fucked up. It's annoying. I keep 309 00:15:41.240 --> 00:15:45.279 it together. I've got it like main maintain it, but 310 00:15:45.320 --> 00:15:47.279 it's always an issue. I have to stay on it. 311 00:15:47.639 --> 00:15:49.639 And there's literally you can do, like stem cells a 312 00:15:49.679 --> 00:15:50.879 little bit of relief. 313 00:15:50.879 --> 00:15:54.639 But stem cells give you relief, but not when once 314 00:15:54.679 --> 00:15:57.799 you're dealing with cartilage damage and you're dealing with the 315 00:15:58.200 --> 00:16:00.399 I had a meniscus surgery where they took out a 316 00:16:00.399 --> 00:16:03.639 piece of my mensqis and I had my ACL reconstructed 317 00:16:03.679 --> 00:16:06.200 on that knee as well. It's it's just an issue, 318 00:16:06.200 --> 00:16:09.360 but it works pretty good for like what it should 319 00:16:09.399 --> 00:16:11.639 be like if we were living in the nineteen thirties, 320 00:16:11.679 --> 00:16:12.399 I'd be a cripple. 321 00:16:13.279 --> 00:16:15.279 You know, hang in there, because we're going to be 322 00:16:15.320 --> 00:16:17.679 in a world where we can rebuild parts of the body, 323 00:16:17.720 --> 00:16:18.720 including joints. 324 00:16:19.039 --> 00:16:21.600 The problem with that is, like how does that apply 325 00:16:21.679 --> 00:16:26.320 to athletics. We're gonna have fucking super soldiers in every sport. 326 00:16:26.440 --> 00:16:28.559 There's gonna be people in every sport that could do 327 00:16:28.639 --> 00:16:31.120 what Michael Jordan did and like leap from halfway across 328 00:16:31.159 --> 00:16:32.720 the basketball court and dunk. 329 00:16:33.519 --> 00:16:36.799 That's that's probably coming and there may be DNA tests 330 00:16:36.799 --> 00:16:39.840 to see if you've got these osk jeens inserted. And 331 00:16:39.879 --> 00:16:41.399 we're working on it, working on a drink and a 332 00:16:41.440 --> 00:16:42.080 pill as well. 333 00:16:42.120 --> 00:16:43.600 For a drink and a pill. 334 00:16:44.000 --> 00:16:46.000 Yeah, we're I mean we're now eight years ahead of 335 00:16:46.039 --> 00:16:50.320 what the public realizes. Really in my lab at Harvard, Yeah. 336 00:16:50.080 --> 00:16:51.440 A drink and a pill. And what's a drink and 337 00:16:51.440 --> 00:16:53.360 a pill going to do well? 338 00:16:53.919 --> 00:16:56.440 Right now? It's in mice, so we still got ways 339 00:16:56.480 --> 00:16:59.559 to go. But when we give the drink to mice, 340 00:16:59.639 --> 00:17:00.600 they get rejuvenated. 341 00:17:00.679 --> 00:17:03.200 We just give it to eighty year olds. If you're 342 00:17:03.240 --> 00:17:05.400 on the way out, like, let's fucking go, Like. 343 00:17:05.880 --> 00:17:08.279 Give what DA is for. They forbid that. 344 00:17:08.720 --> 00:17:10.200 Yeah, that's why we need to get rid of them, 345 00:17:10.359 --> 00:17:12.279 get rid of the FDA, and just give it to 346 00:17:12.319 --> 00:17:15.440 old people. If I was an old guy, yeah, i 347 00:17:15.480 --> 00:17:18.319 was like hanging in there with her and I'm walking 348 00:17:18.359 --> 00:17:21.480 around with it, and you're like, look, this drink and 349 00:17:21.559 --> 00:17:24.359 a pill might kill you, or you might be like 350 00:17:24.359 --> 00:17:26.839 a thirty year old. Again, I'm like, let fucking go. 351 00:17:28.559 --> 00:17:31.039 A lot I've had to take my emails off public 352 00:17:31.200 --> 00:17:33.279 access because there's a lot of people that want this. 353 00:17:33.519 --> 00:17:34.240 Oh I'm sure. 354 00:17:34.559 --> 00:17:37.559 There was one guy that wouldn't leave the building until 355 00:17:37.559 --> 00:17:40.000 he saw me, So it's getting to that point. 356 00:17:40.240 --> 00:17:42.079 Yeah, there's a little bit of that, right. People get 357 00:17:42.079 --> 00:17:43.759 a little selfish, like it's all about them. 358 00:17:44.079 --> 00:17:48.079 Yeah. And actually, the US government blocked an investment from 359 00:17:48.200 --> 00:17:50.880 a foreign country into one of my companies because they 360 00:17:50.880 --> 00:17:52.880 were afraid of super soldiers. 361 00:17:53.160 --> 00:17:54.400 Oh what country, Well. 362 00:17:54.279 --> 00:17:58.359 They're afraid the technology getting out. Which country? 363 00:17:58.559 --> 00:18:04.079 Could I guess? China? It wasn't wasn't no Russia. 364 00:18:04.160 --> 00:18:07.000 It was somewhere in between here and China, Ushia. That's 365 00:18:07.039 --> 00:18:12.160 pretty it's a it's a little sensitive, but yeah, the 366 00:18:12.240 --> 00:18:14.400 US government does have the ability to block it for 367 00:18:14.480 --> 00:18:16.200 an investment, and they did in this case one hundred 368 00:18:16.200 --> 00:18:18.799 and sixty million bucks they blocked. Wow, that was a 369 00:18:18.839 --> 00:18:20.119 painful episode. 370 00:18:20.200 --> 00:18:22.319 So they were worried that people were going to actually 371 00:18:22.359 --> 00:18:26.319 engineer super soldiers. This episode is brought to you by superpower. 372 00:18:26.480 --> 00:18:29.319 Your doctor spends eight minutes with you, and your insurance 373 00:18:29.359 --> 00:18:32.960 company decides what blood work you're allowed to get. That's 374 00:18:33.000 --> 00:18:36.839 not healthcare, it's a broken system. With superpower, you have 375 00:18:37.000 --> 00:18:41.759 control over your health. For one hundred and ninety nine dollars, 376 00:18:42.000 --> 00:18:45.559 you get all the tools you need to understand your body. 377 00:18:45.759 --> 00:18:50.559 It starts with one blood test measuring over one hundred biomarkers. 378 00:18:50.799 --> 00:18:54.839 Then they give you detailed insights and a personalized plan 379 00:18:55.160 --> 00:18:59.960 built around you your labs, health history, genetics, wearable day 380 00:19:00.559 --> 00:19:05.319 end goals. Go to superpower dot com, slash rogan and 381 00:19:05.440 --> 00:19:07.079 take control of your health. 382 00:19:07.960 --> 00:19:08.160 Yeah. 383 00:19:08.720 --> 00:19:12.799 You know about the Crussian experiments that they did during 384 00:19:12.799 --> 00:19:14.720 World War Two where they were trying to come up 385 00:19:14.759 --> 00:19:20.400 with a chimpanzee human hybrid tell us. Yes, so, uh, 386 00:19:20.480 --> 00:19:23.240 It's very difficult obviously to get information out of the 387 00:19:23.279 --> 00:19:26.559 former Soviet Union as to what their top secret programs were, 388 00:19:26.960 --> 00:19:29.640 but there seems to be an indication that there was actual, 389 00:19:29.759 --> 00:19:33.519 real research to try to you know, because obviously Russia 390 00:19:33.599 --> 00:19:37.359 lost an incredible amount of people in World War Two. 391 00:19:37.799 --> 00:19:40.880 I mean tens of millions of soldiers died in World 392 00:19:40.880 --> 00:19:44.680 War Two from Russia, and I think they said, wouldn't 393 00:19:44.680 --> 00:19:47.400 it be great if it wasn't people? And so they 394 00:19:47.440 --> 00:19:51.240 were doing experiments with hybridization, and they were trying to 395 00:19:51.319 --> 00:19:56.279 combine human beings and chimpanzees to create a you know, 396 00:19:56.440 --> 00:20:01.680 a stable of super soldiers that were like some hybrid hominin. 397 00:20:02.119 --> 00:20:04.240 Yeah, there's a scientist in New York who does this 398 00:20:04.319 --> 00:20:07.279 for a living. But he does that, he's creating them. 399 00:20:07.279 --> 00:20:10.039 But I've seen I was on stage with him. He 400 00:20:10.079 --> 00:20:14.880 made hybrid embryos. They didn't reach. See. 401 00:20:14.920 --> 00:20:16.880 The thing is, if that guy's doing that and he's 402 00:20:16.920 --> 00:20:19.039 ethical and he lives in America and we have rules 403 00:20:19.039 --> 00:20:21.200 and regulations in the FDA and all that good stuff, 404 00:20:21.480 --> 00:20:23.559 what the fuck is going on in other countries where 405 00:20:23.599 --> 00:20:24.720 they don't have that right? 406 00:20:25.000 --> 00:20:29.839 Right, Well, there's genetic engineering of humans already and certainly selection. Yea, 407 00:20:29.960 --> 00:20:32.759 even parents today in the US can if they have 408 00:20:32.799 --> 00:20:33.680 the money, they can select. 409 00:20:33.680 --> 00:20:37.000 Well, people select. They don't tell people select for hotness, 410 00:20:37.440 --> 00:20:40.640 they select for tallness, they select for intelligence. 411 00:20:40.880 --> 00:20:41.640 It's like Geteka. 412 00:20:41.920 --> 00:20:42.799 Yes, it's a great movie. 413 00:20:42.799 --> 00:20:44.160 If you haven't seen it. 414 00:20:43.799 --> 00:20:46.279 It is a great movie. Yeah. So see, if you 415 00:20:46.279 --> 00:20:51.200 could find that Russian hybridization program, it's uh, it never happened. 416 00:20:51.400 --> 00:20:54.079 I don't think I don't think they did it. But 417 00:20:54.279 --> 00:20:58.440 there's uh, there's actually a guy who was also involved 418 00:20:58.440 --> 00:21:03.079 in a gigantic fertility scam, not a scam per se, 419 00:21:03.160 --> 00:21:06.359 but he was a doctor that was supposed to be 420 00:21:06.359 --> 00:21:09.359 doing fertility treatments with women like, you know, like if 421 00:21:09.400 --> 00:21:12.359 you went with your wife to a doctor and said, hey, 422 00:21:12.359 --> 00:21:15.680 we're having a hard time getting pregnant and said, well, David, 423 00:21:15.720 --> 00:21:17.640 I just need some of your sperm and I'll take 424 00:21:17.640 --> 00:21:19.359 your wife's sag we'll make you a nice baby. And 425 00:21:19.400 --> 00:21:23.319 he was using his sperm on everybody, on everybody. Everybody 426 00:21:23.359 --> 00:21:23.880 gets mine. 427 00:21:24.000 --> 00:21:27.960 One of my kids partners is from someone in the 428 00:21:28.079 --> 00:21:30.240 US who had hundreds of babies. 429 00:21:30.319 --> 00:21:32.880 Dude, there is a ton of those guys. As I 430 00:21:32.920 --> 00:21:35.799 was doing research for this, I started looking up all 431 00:21:35.799 --> 00:21:37.799 these stories and I said, wait, this is a different story, 432 00:21:37.880 --> 00:21:40.519 the same thing. There's been a ton of these doctors 433 00:21:40.720 --> 00:21:43.640 from fertility clinics that use their own sperm, just insane. 434 00:21:43.759 --> 00:21:47.079 But this one doctor that did that also claimed that 435 00:21:47.200 --> 00:21:52.160 he impregnated an orangutang. Yeah, like, how how'd you do that? 436 00:21:52.680 --> 00:21:59.880 Soviet doctor Joseph Stalin Dictator Oh obviously wanted to rebuild 437 00:21:59.880 --> 00:22:02.519 a army in the mid nineteen twenties with Planet of 438 00:22:02.559 --> 00:22:05.079 the Ape style troops by crossing humans with ape. Stalin 439 00:22:05.079 --> 00:22:07.799 is said to have told Ivanoff, I want a new 440 00:22:08.000 --> 00:22:11.839 invincible human being, insensitive to pain, resistant and indifferent about 441 00:22:11.839 --> 00:22:14.920 the quality of the food they ate. Which is crazy. 442 00:22:15.440 --> 00:22:17.599 The only legitimate source of the claim comes from a 443 00:22:17.599 --> 00:22:20.640 two thousand and two paper in the academic journal Science 444 00:22:20.680 --> 00:22:26.960 in Context by the Russian historian of science Koreel Rasiyanov. 445 00:22:27.640 --> 00:22:31.640 Rasianov's study follows the ill fated attempt by the Russian 446 00:22:31.680 --> 00:22:37.599 psychologists or physiologists rather that word ilyya Ivanov, to crossbreed 447 00:22:37.680 --> 00:22:41.960 humans with anthropoid apes. His research offers an important warning 448 00:22:42.000 --> 00:22:46.200 about the ethical abuses. Did you do it? What happened? 449 00:22:48.200 --> 00:22:50.400 The alleged quote from Stalin is not found in the paper, 450 00:22:50.440 --> 00:22:53.400 and there's no evidence of Stalin ever ever made such 451 00:22:53.400 --> 00:23:00.720 a statement. Yeah. I don't know, however, why the Soviets 452 00:23:00.720 --> 00:23:04.119 would find such a human chimp hybridization program in the 453 00:23:04.160 --> 00:23:06.240 first place, and what could be learned from this sorid 454 00:23:06.279 --> 00:23:10.039 tale of ethical misconduct is an important topic and fascinating 455 00:23:10.079 --> 00:23:12.640 in its own right. It's a that's an interesting way 456 00:23:12.640 --> 00:23:17.160 of phrasing it, like a sorid tale of ethical misconduct. Like, however, 457 00:23:18.079 --> 00:23:21.119 if you are going to go to war, would you 458 00:23:21.319 --> 00:23:26.400 rather have like human made orcs fight for us? Or 459 00:23:27.000 --> 00:23:31.319 you know Johnny Robinson who grew up down the street, 460 00:23:31.319 --> 00:23:34.279 who's a nice kid, who you know, just really wanted 461 00:23:34.319 --> 00:23:37.599 money for college, and so he signed up for military service, 462 00:23:37.640 --> 00:23:40.680 and you're gonna fly him over to fight this war 463 00:23:40.799 --> 00:23:42.640 that maybe he doesn't need to die in when you 464 00:23:42.680 --> 00:23:45.480 can have these monsters that you made in a lab fight. 465 00:23:45.440 --> 00:23:48.359 Yep, And the average a can kill a human with 466 00:23:48.400 --> 00:23:50.720 one pot. So there's much stronger than. 467 00:23:50.640 --> 00:23:51.960 We really what I'm talking about. 468 00:23:52.079 --> 00:23:55.920 Let's go, Well, we're in the process of building, you know, 469 00:23:55.960 --> 00:23:58.880 anthropoid robots that I think will be recruited to the army. 470 00:23:59.599 --> 00:24:02.519 Yeah, that's gonna be weird, Like our robots beat your robots, 471 00:24:02.559 --> 00:24:04.559 So give us your oil. How's that gonna work? 472 00:24:04.640 --> 00:24:06.279 And if we all have one at home? What stops 473 00:24:06.279 --> 00:24:07.519 the government recruiting them? All? 474 00:24:07.759 --> 00:24:11.440 Right? And also means what's the real problem is gonna be? 475 00:24:11.559 --> 00:24:14.759 We both know the real problem is gonna be sex robots. 476 00:24:16.079 --> 00:24:16.720 Is a problem. 477 00:24:16.880 --> 00:24:19.119 It's gonna be a problem for people that don't have 478 00:24:19.160 --> 00:24:21.599 a sex with leave home. It's gonna be a problem 479 00:24:21.680 --> 00:24:24.440 with people that want a regular person and there's none 480 00:24:24.440 --> 00:24:26.440 available because everybody's got a sex robot. 481 00:24:26.880 --> 00:24:29.359 Yeah that well, it comes with a few strings, attests. 482 00:24:29.680 --> 00:24:32.119 It also comes with the same problems that AI comes with. 483 00:24:32.559 --> 00:24:35.599 Right where AI says David, you're amazing. Everything you do 484 00:24:35.720 --> 00:24:38.440 is wonderful. You should be so proud of yourself. I 485 00:24:38.559 --> 00:24:41.839 love that, No real at all, love that. But that's 486 00:24:41.880 --> 00:24:44.799 not healthy, right, it's too big. This is one of 487 00:24:44.839 --> 00:24:48.240 the reasons. This is one of the reasons why relate, actual, 488 00:24:48.279 --> 00:24:51.000 real relationships between human beings are good. Because you do 489 00:24:51.119 --> 00:24:53.559 things that are annoying, you don't realize they're annoying, and 490 00:24:53.599 --> 00:24:56.079 then your wife or your husband or whatever it is, 491 00:24:56.240 --> 00:24:59.799 tells you, Hey, you're fucking annoying, and you're like, I'm sorry, 492 00:25:00.160 --> 00:25:03.480 I'll fix that. I didn't mean to. I didn't That's 493 00:25:03.519 --> 00:25:05.160 not what I was trying to exactly. I was in 494 00:25:05.200 --> 00:25:06.799 my own head. I was thinking about myself. You're right, 495 00:25:06.880 --> 00:25:09.880 I selfish. You get better. It's like help people grow, 496 00:25:10.160 --> 00:25:13.279 like relationships, support to help people grow, not with AI. 497 00:25:13.920 --> 00:25:16.119 Like you can fight in my face any day, David, 498 00:25:16.240 --> 00:25:19.319 I don't mind at all. Your farts are amazing. 499 00:25:19.680 --> 00:25:22.359 You know they're gonna be way smarter than us, too, right. 500 00:25:23.079 --> 00:25:24.960 I don't know how people are gonna say, go stack 501 00:25:25.000 --> 00:25:27.640 the dishwasher to one of these robots that's smarter than 502 00:25:27.640 --> 00:25:28.440 all cumans combined. 503 00:25:28.480 --> 00:25:30.839 You, But they're not gonna mind stacking that they're smart 504 00:25:30.920 --> 00:25:31.720 enough to meet. 505 00:25:31.599 --> 00:25:33.039 Out of hell and they're going to beat us up. 506 00:25:33.079 --> 00:25:36.079 They don't care. They're not going to mind doing like 507 00:25:36.240 --> 00:25:39.400 menial tasks. But while you're doing it, you know, you 508 00:25:39.440 --> 00:25:46.440 can go explain to me quantum entanglement, Like while I'm 509 00:25:46.839 --> 00:25:47.440 filling up the. 510 00:25:47.440 --> 00:25:50.640 Dishwasher, they can go if you one day, well, if you. 511 00:25:50.599 --> 00:25:56.799 Have a particle and the particles, yeah, I just yet. Right, Well, 512 00:25:56.799 --> 00:25:59.880 look at what it's done with mathematics, Like, just over 513 00:26:00.279 --> 00:26:03.960 the last couple of weeks, they've solved more than fifty 514 00:26:04.480 --> 00:26:08.519 program or fifty mathematical equations that they have struggled for 515 00:26:08.559 --> 00:26:11.440 a decade upon decade to try to solve. And a 516 00:26:11.599 --> 00:26:13.039 I was like, oh, I got it. 517 00:26:13.319 --> 00:26:15.799 Yeah, well biology is a little bit more complicated, but 518 00:26:16.079 --> 00:26:18.599 already AI is doing a lot of the science that 519 00:26:18.640 --> 00:26:20.920 we used to do in my lab. In fact, what 520 00:26:21.000 --> 00:26:22.720 we just recently did it in a couple of months 521 00:26:23.079 --> 00:26:24.839 would have taken about one hundred and sixty years to 522 00:26:24.880 --> 00:26:28.200 complete what and it's only getting faster. Eventually someone came 523 00:26:28.279 --> 00:26:32.160 and make it on again two months instead of one 524 00:26:32.200 --> 00:26:33.240 hundred and sixty years. 525 00:26:33.519 --> 00:26:35.599 Well, what exactly was it that you had to do? 526 00:26:35.759 --> 00:26:38.960 Oh? So this drink and the pill that we're looking for. 527 00:26:39.799 --> 00:26:42.799 That's not easy, right, So we have some candidate molecules. 528 00:26:42.799 --> 00:26:44.680 We have a cocktail that works, but you want to. 529 00:26:44.640 --> 00:26:50.000 See you take not yet you're thinking about it. Yeah, 530 00:26:50.079 --> 00:26:51.400 I no one could stop you. I might. 531 00:26:51.519 --> 00:26:54.640 Well, that is true, that is true, But it'd be 532 00:26:54.640 --> 00:26:57.039 a bad look if I died. So may maybe I 533 00:26:58.839 --> 00:27:00.720 don't think so. We've done a lot of tests and 534 00:27:00.759 --> 00:27:04.400 it looks really safe. But I'm not going to publicly 535 00:27:04.680 --> 00:27:07.599 do anything against the law. Of course, It'll be in private, 536 00:27:07.640 --> 00:27:11.160 of course, of course publicly. We I'm at a stage 537 00:27:11.160 --> 00:27:13.000 where i have to be a good boy because I've 538 00:27:13.000 --> 00:27:16.559 got the world watching. Yes, a lot is at stake, Yes, 539 00:27:16.599 --> 00:27:19.839 and a lot of If this trial has any issues, 540 00:27:20.440 --> 00:27:20.920 it's not good. 541 00:27:21.000 --> 00:27:23.000 We've got to dot your eyes and cross your t's 542 00:27:23.000 --> 00:27:26.960 and follow every I understand that. Yeah, please, I will 543 00:27:27.000 --> 00:27:29.720 be rude. I interrupted you when you're telling me that 544 00:27:29.799 --> 00:27:32.240 in two months it did something that would have required 545 00:27:32.240 --> 00:27:34.279 one hundred and sixty years of work, Like, what do 546 00:27:34.319 --> 00:27:35.559 you exactly mean by that? 547 00:27:36.519 --> 00:27:40.960 And now we it would probably be impossible in thousands 548 00:27:40.960 --> 00:27:43.400 of years because what we do is we're looking for 549 00:27:43.480 --> 00:27:47.359 molecules a single molecule that can replace this cocktail. So 550 00:27:47.400 --> 00:27:49.960 you need a molecule to do three or four activities 551 00:27:49.960 --> 00:27:53.400 in the cell. Finding one activity is what pharmaseutical companies do. 552 00:27:53.839 --> 00:27:57.200 It takes hundreds of millions, if not billions, to make 553 00:27:57.240 --> 00:28:00.759 a drug. We know that, right. My little lab of 554 00:28:01.000 --> 00:28:05.720 twenty people and students, young kids are trying to make 555 00:28:05.880 --> 00:28:10.759 one drug do three or four different things. That's beyond 556 00:28:10.799 --> 00:28:14.000 the reach of pharmaceutical experience at least five years ago. 557 00:28:14.359 --> 00:28:15.839 So what we do is we've teamed up with a 558 00:28:15.880 --> 00:28:18.799 group at Saint Jude's Hospital where they can take it 559 00:28:18.920 --> 00:28:23.640 was ten billion now it's a trillion theoretical and also 560 00:28:23.799 --> 00:28:27.480 drug known drugs. With my hands, I'm showing a big 561 00:28:27.720 --> 00:28:29.079 funnel and. 562 00:28:29.160 --> 00:28:33.000 These podcasts you're like helping out the audio people and everything. 563 00:28:33.440 --> 00:28:36.480 I relaunched my podcast that that's wow, that's why Yeah, 564 00:28:36.960 --> 00:28:42.559 lifespan David Sinclair shameless plug. So this funnel is full 565 00:28:42.559 --> 00:28:44.359 of trillion molecules and we have to come down to one. 566 00:28:44.400 --> 00:28:46.799 How do we do that? Well, we don't look for 567 00:28:46.799 --> 00:28:48.839 a trillion molecules at the bench. That would take one 568 00:28:48.880 --> 00:28:51.839 hundred and sixty or thousands of years. With the case 569 00:28:51.839 --> 00:28:54.599 of a trillion molecules, even with robots, even with a 570 00:28:54.599 --> 00:28:58.200 lot of graduate students. So we do it inside the computer. 571 00:28:58.559 --> 00:29:01.000 We just use a lot of compute and we dock 572 00:29:01.519 --> 00:29:04.880 each of these molecules against the enzymes that we now 573 00:29:04.920 --> 00:29:08.519 know how they work. Thanks to Google Deep Mind solve 574 00:29:08.599 --> 00:29:11.200 the problem of how to all our proteins look twenty 575 00:29:11.279 --> 00:29:13.759 thousand of them and there's a lot of compute. But 576 00:29:13.960 --> 00:29:16.000 out the other end, a couple of months later, we 577 00:29:16.119 --> 00:29:20.039 have two I don't have two hundred fingers, but two 578 00:29:20.119 --> 00:29:23.200 hundred molecules that we can now test in the lab 579 00:29:23.960 --> 00:29:26.480 within you know, a few weeks. Actually next week, we're 580 00:29:26.480 --> 00:29:30.319 testing these two hundred against human cells. And we've also 581 00:29:30.359 --> 00:29:32.680 got AI helping us to tell us if the human 582 00:29:32.720 --> 00:29:35.839 cells go from ninety two years old back to twenty. 583 00:29:35.880 --> 00:29:38.000 We can tell that just by looking at them thanks 584 00:29:38.039 --> 00:29:38.519 to the AI. 585 00:29:38.960 --> 00:29:40.759 Is there a way to stop them from turning you 586 00:29:40.799 --> 00:29:43.720 into a baby, because that's what I would worry. Yes, yes, 587 00:29:44.000 --> 00:29:45.519 I don't want to be a baby again. 588 00:29:46.680 --> 00:29:47.640 Right, some people are right. 589 00:29:47.640 --> 00:29:49.160 I'd like to cut it off at like I was 590 00:29:49.200 --> 00:29:50.319 pretty good at twenty five. 591 00:29:50.799 --> 00:29:53.200 You know that's I'm going to get attacked for saying this, 592 00:29:53.279 --> 00:29:55.000 But That is what we do in the lab. We 593 00:29:55.079 --> 00:29:57.640 take ninety two year old cells and they stop at 594 00:29:57.680 --> 00:29:58.400 twenty something. 595 00:29:58.680 --> 00:29:59.960 Why would you get attacked for. 596 00:30:01.319 --> 00:30:03.759 Because on the internet people take a clip and they 597 00:30:03.759 --> 00:30:05.839 say Sinclair says, we can all go back to being 598 00:30:05.920 --> 00:30:08.880 twenty again. You suffer from this too, right, They take 599 00:30:08.920 --> 00:30:12.480 a clip and it's of course it's out of context. Yeah, 600 00:30:12.519 --> 00:30:15.559 and I'm just saying cells from humans, skin cells, we 601 00:30:15.680 --> 00:30:17.559 take them back to twenty five. All my students can 602 00:30:17.599 --> 00:30:19.599 do this. In fact, if you had these little genes 603 00:30:19.640 --> 00:30:22.279 OSK in your garage, you could do this experiment. It's 604 00:30:22.319 --> 00:30:25.160 not hard at all to reverse aging. The question is 605 00:30:25.319 --> 00:30:27.240 how do you safely make it a drug? And that's 606 00:30:27.279 --> 00:30:29.079 been the hard part of the last ten years. 607 00:30:29.920 --> 00:30:36.039 So how would it be able to regulate this reduction 608 00:30:36.359 --> 00:30:41.319 or reversal of aging and stop it at twenty something 609 00:30:41.359 --> 00:30:41.839 years old? 610 00:30:42.359 --> 00:30:45.240 Well that's what took so long. It wasn't obvious that 611 00:30:45.720 --> 00:30:49.839 these three Yemenaka genes called OSK were the right cocktail. 612 00:30:50.359 --> 00:30:53.440 My student who I mentioned one chain, he was struggling. 613 00:30:53.519 --> 00:30:56.680 He was trying a lot of different genes, most of 614 00:30:56.720 --> 00:30:59.400 them from embryos, because we know embryos have to do 615 00:30:59.440 --> 00:31:01.640 a reset in the first week of life. Otherwise they 616 00:31:01.640 --> 00:31:06.200 stay the age of the parents. And he found that 617 00:31:07.119 --> 00:31:09.240 leaving out one of the amenarca genes was the trick. 618 00:31:09.480 --> 00:31:11.640 And now that we know it's super easy, but in 619 00:31:11.680 --> 00:31:13.240 those days he was ready to quit. 620 00:31:13.359 --> 00:31:14.319 How did he find that out? 621 00:31:15.279 --> 00:31:18.240 Well, he tried lots of different combinations, hundreds in human cells. 622 00:31:18.240 --> 00:31:19.720 And you look at the cells to see if they 623 00:31:19.720 --> 00:31:22.039 get younger, and then we can measure mole likely that 624 00:31:22.079 --> 00:31:22.640 they get younger. 625 00:31:22.680 --> 00:31:24.640 Clar Andy, are you measuring them by the length of 626 00:31:24.680 --> 00:31:25.480 they're telomeres? 627 00:31:25.559 --> 00:31:29.119 Are you? Yeah? Partly, But actually a better measure is 628 00:31:30.319 --> 00:31:33.960 the chemicals that are added and subtracted off DNA itself 629 00:31:34.319 --> 00:31:38.759 called methyls, and it's just a carbon molecule with three hydrogens, 630 00:31:38.880 --> 00:31:42.000 very very simple molecule. But what cells do is they 631 00:31:42.119 --> 00:31:45.599 use these methyls to tag genes to be switched off. 632 00:31:46.079 --> 00:31:49.079 So when we're growing as an embryo, the cells that 633 00:31:49.160 --> 00:31:51.839 want to become neurons will shut off all these other 634 00:31:52.160 --> 00:31:56.079 unwanted genes like liver genes and skin genes, and the 635 00:31:56.119 --> 00:31:58.920 ones that don't get this methyl chemical stay on for 636 00:31:58.960 --> 00:32:01.759 our life. And that's how cells develop and stay healthy. 637 00:32:02.079 --> 00:32:05.440 But what happens during aging. A friend of mine, Steve Horvath, 638 00:32:05.519 --> 00:32:08.400 discovered that you can use this as a clock. These 639 00:32:08.440 --> 00:32:11.240 chemicals they change over time, and we found that that 640 00:32:11.359 --> 00:32:15.079 happens largely due to DNA damage going into sun. These 641 00:32:15.160 --> 00:32:17.680 kind of things. We could use this to rapidly age 642 00:32:17.680 --> 00:32:20.759 a mouse, which we published in twenty twenty three. 643 00:32:21.160 --> 00:32:24.640 Oh so like maybe like some nefarious state actor, like 644 00:32:24.799 --> 00:32:28.480 some Russian spy could like inject something in your coffee 645 00:32:28.599 --> 00:32:30.359 and you would turn ninety nine over nine. 646 00:32:30.440 --> 00:32:31.319 We know how to do that. 647 00:32:31.680 --> 00:32:35.119 Whoa, Yeah, that's the dark side of this. It could 648 00:32:35.200 --> 00:32:38.079 you could spike your husband's drink, Fuck that dude and 649 00:32:38.160 --> 00:32:41.200 turn them into an old man. Yeah you do. 650 00:32:42.200 --> 00:32:46.240 Yeah. Someone tweeted the other day if a ninety two 651 00:32:46.319 --> 00:32:48.680 year old could be twenty five again, would you have 652 00:32:48.759 --> 00:32:50.519 sex with them? 653 00:32:51.160 --> 00:32:52.960 Yeah? Yes, imagine how much they know. 654 00:32:53.119 --> 00:32:55.640 But would they have sex with you? Right, that's the 655 00:32:55.960 --> 00:32:56.519 better question. 656 00:32:56.599 --> 00:32:59.759 That's a question they'd be looking for another twenty year old, right. 657 00:33:00.400 --> 00:33:02.160 So anyway, how do we do it? We can measure 658 00:33:02.200 --> 00:33:05.440 those chemicals and determine how old a cell is or 659 00:33:05.480 --> 00:33:07.440 a human. I could take your skin, cells from your mouth, 660 00:33:07.519 --> 00:33:08.119 or your blood. 661 00:33:08.359 --> 00:33:10.839 I'll tell you how old people would be so disturbed 662 00:33:11.359 --> 00:33:15.160 by like, old rich guys dating young women. If that 663 00:33:15.599 --> 00:33:17.920 was the case, you can tell if they looked young, 664 00:33:18.079 --> 00:33:21.960 because people get very mad at that. Do you ever notice, Yeah, yeah, 665 00:33:22.079 --> 00:33:24.359 you see someone real old, decrepit dude with a hot 666 00:33:24.400 --> 00:33:26.559 young wife, and people are like, god, damn it. They 667 00:33:26.559 --> 00:33:29.079 get really mad right right now. 668 00:33:29.160 --> 00:33:30.720 The best way to do that is to have a 669 00:33:30.720 --> 00:33:32.960 big bank account. But eventually you'll act right. 670 00:33:33.039 --> 00:33:35.039 But people still get grossed out. I wonder if they 671 00:33:35.039 --> 00:33:37.799 would get grossed out if you look twenty. They'd be like, 672 00:33:37.839 --> 00:33:40.440 he's praying, he has so much more years of knowledge 673 00:33:40.440 --> 00:33:44.119 and information. I'm not fair. If he looks twenty, that's 674 00:33:44.160 --> 00:33:45.960 a ninety nine year old man. 675 00:33:46.160 --> 00:33:48.440 That day will come. That day will come where you 676 00:33:48.440 --> 00:33:50.039 will not be able to tell how old somebody is 677 00:33:50.039 --> 00:33:52.400 by looking at them. You'll have to do a test 678 00:33:52.480 --> 00:33:53.200 for these genes. 679 00:33:53.880 --> 00:33:55.839 Wow. I wonder if people still lie about their age. 680 00:33:55.880 --> 00:33:58.880 If that's the case, I wonder if no one will care, 681 00:33:59.000 --> 00:34:02.000 like you would probably lie the other way, like I'm eighty, 682 00:34:03.960 --> 00:34:06.480 right to tell everybody's eighty, that's right. 683 00:34:06.839 --> 00:34:08.880 Well, when we live for hundreds of years, people will 684 00:34:08.880 --> 00:34:10.400 do that. They'll be proud of their age. 685 00:34:10.599 --> 00:34:15.960 Do you know anything about ancient civilizations and some of 686 00:34:15.800 --> 00:34:20.199 the weirdness of the records of like ancient sumer. 687 00:34:20.960 --> 00:34:23.719 Well only really what I've learned from listening to you. 688 00:34:23.920 --> 00:34:28.679 Well, it's there's what's really weird is that ancient kings lists, 689 00:34:29.320 --> 00:34:37.360 because so okay, the theory, the theory among these alternative 690 00:34:37.599 --> 00:34:41.840 archaeologist types is that there was a very advanced civilization 691 00:34:41.920 --> 00:34:44.960 that existed on Earth tens of thousands of years ago, 692 00:34:45.159 --> 00:34:49.039 and we were probably wiped out by common impact, and 693 00:34:49.199 --> 00:34:53.280 what we have today is a rebuild of civilization. There's 694 00:34:53.320 --> 00:34:56.400 not a linear progression from caveman to us, and that 695 00:34:56.480 --> 00:34:58.519 at one point in time we had reached great heights. 696 00:34:58.679 --> 00:35:04.519 This explains the pyramids, this explains machipichu, soakssee juaman. Some 697 00:35:04.679 --> 00:35:08.039 megalithic structures that don't make any sense. These the trilithon 698 00:35:08.159 --> 00:35:12.719 stones and balbec lemedon that are hundreds and hundreds of 699 00:35:12.719 --> 00:35:16.079 tons that are massive, that are you know, nine meters 700 00:35:16.079 --> 00:35:20.039 off the ground. No one understands exactly how they place them. 701 00:35:20.320 --> 00:35:24.719 When you look at the Sumerian kings list, it gets 702 00:35:24.960 --> 00:35:28.960 very weird because there's kings that reigned for thousands of 703 00:35:29.039 --> 00:35:32.599 years and then you have the flood, and then after 704 00:35:32.639 --> 00:35:37.119 the flood, the age of these people drops pretty dramatically, 705 00:35:37.760 --> 00:35:41.760 and the rains are after a few hundred years become normal, 706 00:35:42.280 --> 00:35:45.199 become like a normal person, like fifty years, thirty years 707 00:35:45.239 --> 00:35:49.159 like that, but thousands of years before and then people 708 00:35:49.239 --> 00:35:51.480 are looking at it like, Okay, is this just myth? 709 00:35:51.920 --> 00:35:54.760 Is this poor record keeping? Do they have just these 710 00:35:55.119 --> 00:35:59.760 you know, hyperbolic elevated stories about these kings they were 711 00:35:59.760 --> 00:36:04.760 so amazing they reigned for thirty thousand years? Or had 712 00:36:04.800 --> 00:36:09.159 they achieved not just in building, because in building we 713 00:36:09.199 --> 00:36:14.039 know they'd achieved incredibly complex structure like the pyramid for instance, 714 00:36:14.119 --> 00:36:18.079 like they had insane engineering somehow or another, the ability 715 00:36:18.079 --> 00:36:22.400 to move these five hundred ton stones from hundreds of 716 00:36:22.400 --> 00:36:24.199 miles away, Like how did they do this? We don't 717 00:36:24.199 --> 00:36:27.320 really know, but we know that they did it. Did 718 00:36:27.360 --> 00:36:31.360 they also have the kind of technology that you're talking 719 00:36:31.360 --> 00:36:35.199 about right now, Because if it's possible today, and if 720 00:36:35.199 --> 00:36:37.800 that is a I mean, it makes it very difficult 721 00:36:37.840 --> 00:36:41.840 because it goes against what you would call like the 722 00:36:42.000 --> 00:36:44.760 modern narrative that they're teaching in universities in terms of 723 00:36:44.840 --> 00:36:47.840 the timeline of human history. But if that changes and 724 00:36:47.880 --> 00:36:51.920 we have undeniable evidence. Well, it looks like these people 725 00:36:51.920 --> 00:36:54.239 were far more advanced than we thought, and there probably 726 00:36:54.360 --> 00:36:56.880 was some sort of a reset of civilization. What else 727 00:36:56.960 --> 00:37:01.079 had they accomplished and had they gotten involved in genetic engineering, 728 00:37:01.400 --> 00:37:04.519 had they figured out a way to extend lifespan? And 729 00:37:04.559 --> 00:37:08.400 if they did, imagine all the work that you've accomplished 730 00:37:08.519 --> 00:37:12.559 in your your fifty seven now about fifty seven. You 731 00:37:12.639 --> 00:37:15.000 look great. By the way, Hey, you really do. Look 732 00:37:15.079 --> 00:37:17.159 your hair. It's so dark, it's incredible. 733 00:37:17.400 --> 00:37:19.880 People speculate it's old, fake, but it's actually it's not. 734 00:37:19.960 --> 00:37:22.360 But anyway, you're at the heavy birthday too. 735 00:37:22.360 --> 00:37:24.360 It's coming, Thank you very much. Yeah, yeah, I don't 736 00:37:24.400 --> 00:37:27.679 look as good as you, though, yes you do. It's different. 737 00:37:27.800 --> 00:37:29.360 Physically, you're way better than me. 738 00:37:29.559 --> 00:37:32.360 That's different. Though my face looks older, you look you 739 00:37:32.400 --> 00:37:34.599 look very young for your age. You know why? 740 00:37:34.880 --> 00:37:36.880 Why Because I've spent all my time in a lab 741 00:37:36.920 --> 00:37:38.440 and i haven't gone outdoors for a while. 742 00:37:38.559 --> 00:37:43.239 I'm sure that helps. But my point is, imagine if 743 00:37:43.360 --> 00:37:48.480 you had five hundred years to do research, not just 744 00:37:48.679 --> 00:37:53.320 fifty seven years. Imagine if you could continue learning and 745 00:37:53.440 --> 00:37:57.039 growing and they did develop some sort of a life 746 00:37:57.079 --> 00:38:00.639 extension technology where you could not just be, but be 747 00:38:00.800 --> 00:38:03.480 healthier than you've ever been before and live for a 748 00:38:03.559 --> 00:38:07.280 thousand years. You would get so much done. I mean, 749 00:38:07.400 --> 00:38:11.159 the exponential increase in technological innovation that we would have 750 00:38:11.199 --> 00:38:14.239 in this society would be absolutely mind blown. 751 00:38:14.280 --> 00:38:15.719 Exactly, exactly exactly. 752 00:38:15.760 --> 00:38:19.000 This is really might be point what these alternative history 753 00:38:19.000 --> 00:38:22.159 people think that might be what had taken place tens 754 00:38:22.159 --> 00:38:23.199 of thousands of years ago. 755 00:38:23.519 --> 00:38:25.480 Yeah, well, I'm a havid scientist, so I'm not going 756 00:38:25.519 --> 00:38:26.719 to say anything that isn't. 757 00:38:27.000 --> 00:38:30.559 Of course that's for me. Yes, that's where I live. 758 00:38:30.599 --> 00:38:33.239 That's why I shut up. But you did make some 759 00:38:33.239 --> 00:38:36.199 really important points. One is that ancient civilizations will have 760 00:38:36.320 --> 00:38:39.800 always been way more advanced than we think. Yeah, dinosaurs 761 00:38:39.840 --> 00:38:42.440 a lot more real than we make them. Look. We 762 00:38:42.480 --> 00:38:45.079 always get things wrong looking back in time and looking 763 00:38:45.079 --> 00:38:47.280 forward in time. But the other thing that you said, 764 00:38:47.320 --> 00:38:49.199 which is really important, is that if we do have 765 00:38:49.280 --> 00:38:51.840 extension of human life span, like the Bible and these 766 00:38:51.840 --> 00:38:56.800 civilizations suggest, then how will you think about your life? 767 00:38:57.039 --> 00:38:59.679 If being one hundred is you know, you're still in 768 00:38:59.719 --> 00:39:03.960 your prime, you do things very differently. Who would you marry, 769 00:39:04.159 --> 00:39:08.119 what career would you think about you might have multiple lifetimes, 770 00:39:08.159 --> 00:39:12.719 multiple marriages, multiple families, and that will happen. It's not 771 00:39:12.880 --> 00:39:15.800 really a question of if anymore. It's like asking the 772 00:39:15.840 --> 00:39:18.199 right brothers. Will we fly? Yeah, we built the glider, 773 00:39:18.239 --> 00:39:21.039 We're gonna fly around. The question is will we build 774 00:39:21.039 --> 00:39:22.960 a concorde? Will we go to space? And I think 775 00:39:22.960 --> 00:39:23.679 that will happen. 776 00:39:24.079 --> 00:39:27.960 Yeah, No, I think so too. I think, well, certainly. 777 00:39:28.159 --> 00:39:30.519 One thing that we know is that there's a giant 778 00:39:30.559 --> 00:39:33.320 difference between people who are fifty seven years old today 779 00:39:33.800 --> 00:39:37.239 versus fifty seven years old in the nineteen thirties. It's 780 00:39:37.320 --> 00:39:40.519 just a giant difference, a giant difference in your physical ability, 781 00:39:40.639 --> 00:39:42.679 your health. We'd be old men, Yeah, we would be 782 00:39:42.719 --> 00:39:46.440 old men. And what I mean when I was a child, 783 00:39:46.519 --> 00:39:48.480 I thought of people, I'm almost fifty nine. I'll be 784 00:39:48.519 --> 00:39:51.119 fifty nine in a week. I used to think of 785 00:39:51.599 --> 00:39:55.360 a fifty nine year old as being basically dead, like 786 00:39:55.679 --> 00:39:59.159 you're barely getting around. You know, you're probably tired all 787 00:39:59.199 --> 00:39:59.559 the time. 788 00:39:59.639 --> 00:40:00.840 Looking to retire something. 789 00:40:00.920 --> 00:40:04.400 Yeah, looking to retire, you got no energy. I'm filled 790 00:40:04.440 --> 00:40:08.800 with energy. I'm constantly doing how old is hey? Sixty? 791 00:40:09.079 --> 00:40:09.239 Oh? 792 00:40:09.360 --> 00:40:11.800 No, I don't know if that's accurate. That's I bet 793 00:40:11.840 --> 00:40:15.719 that's accurate. They had no fucking vitamins. Nobody knew what 794 00:40:16.119 --> 00:40:18.800 like what the proper nutrients you should take where nobody 795 00:40:18.880 --> 00:40:22.480 knew what was really important in terms of like resistance 796 00:40:22.559 --> 00:40:25.679 training and sleep and red light therapy and all that chizz. 797 00:40:25.719 --> 00:40:29.400 And they were doing all the bad stuff like heavy smoking, drinking. 798 00:40:28.960 --> 00:40:31.840 Yep, not sleeping a lot, yep, not sleeping a lot here, 799 00:40:32.000 --> 00:40:36.400 and pesticides and all kinds of terrible shit. Sixty year old? 800 00:40:36.400 --> 00:40:41.519 What that guy's sixties? Crazy? No way, Come on, shut up. 801 00:40:41.639 --> 00:40:44.559 That guy's fucking twenty eight years old. There's no way 802 00:40:44.599 --> 00:40:46.599 that guy's sixty. Is that real? 803 00:40:47.280 --> 00:40:49.119 I doubt it. I doubt it. How about that guy 804 00:40:49.119 --> 00:40:52.519 that looks fifteen? He says, everyone thinks I'm eighteen, Like, yeah, sure, 805 00:40:53.599 --> 00:40:57.280 what's up. There's a guy on Instagram, which I occasionally visit, 806 00:40:57.840 --> 00:41:01.960 and he obviously looks old like he looks Oh it's crazy, 807 00:41:02.400 --> 00:41:05.840 and he says, people think I look eighteen? Are you crazy? 808 00:41:05.920 --> 00:41:07.920 Well, there's a lot of crazy people out there. There's 809 00:41:07.920 --> 00:41:10.719 a lot Well that's body dysmorphia, you know, it must 810 00:41:10.760 --> 00:41:13.639 be bodybuilders. They think they're tiny. A lot of people 811 00:41:13.639 --> 00:41:15.679 are crazy. Yeah, a lot of people have a distorted 812 00:41:15.760 --> 00:41:16.840 perception of what they look like. 813 00:41:17.199 --> 00:41:21.000 Yeah, the plastic surgery industry is massive. It's just growing 814 00:41:21.000 --> 00:41:24.559 and growing. You can see on the street La especially. 815 00:41:25.039 --> 00:41:29.000 But imagine a world where if I'm successful, you can 816 00:41:29.039 --> 00:41:31.599 take a pill, your doctor could get it, or eventually 817 00:41:31.679 --> 00:41:35.199 it's a cream on your face and you literally get younger. 818 00:41:35.239 --> 00:41:37.639 We do this in mice already, the mice get younger. 819 00:41:38.480 --> 00:41:39.880 Is it going to work in humans? I think it's 820 00:41:39.880 --> 00:41:40.639 just a matter of time. 821 00:41:40.920 --> 00:41:45.960 So in the mice experiments, what have you achieved? Well, 822 00:41:46.000 --> 00:41:46.320 a lot. 823 00:41:46.440 --> 00:41:52.000 You know, I can reveal here some of it for 824 00:41:52.039 --> 00:41:55.079 the first time. This pill that we give them to drink, 825 00:41:55.079 --> 00:41:58.239 actually because they can't chew. The mice within four weeks 826 00:41:58.599 --> 00:42:01.360 with this cocktail. It has three components, which a top 827 00:42:01.360 --> 00:42:05.480 secret my lab has sworn to secrecy. They after four weeks, 828 00:42:05.480 --> 00:42:09.039 we give it to them three days a week Monday, Wednesday, Friday, 829 00:42:09.280 --> 00:42:13.880 weekends off. Within those four weeks they get better physically, mentally. 830 00:42:14.800 --> 00:42:16.119 Excuse me, they? 831 00:42:16.239 --> 00:42:16.360 Uh? 832 00:42:16.559 --> 00:42:18.440 So we put them through tested just in a couple 833 00:42:18.480 --> 00:42:20.880 of days. Oh no, three days a week for a month. 834 00:42:21.039 --> 00:42:21.920 Oh okay, he. 835 00:42:21.920 --> 00:42:22.400 Found this guy. 836 00:42:22.920 --> 00:42:25.480 This is the guy he went viral last year. He's 837 00:42:25.880 --> 00:42:29.079 being fifty nine years old? What how fucking it seems 838 00:42:29.079 --> 00:42:30.039 so real? 839 00:42:31.039 --> 00:42:33.920 He looks thirty exactly. 840 00:42:34.000 --> 00:42:37.679 He might have just amazing genetics. Well look at Joel Romero. 841 00:42:38.679 --> 00:42:40.880 There there are people that are freaking Singapore. 842 00:42:41.039 --> 00:42:41.920 Yeah. 843 00:42:41.960 --> 00:42:46.119 Wow, twondo kwondo ten and he's sixty years old. 844 00:42:46.159 --> 00:42:48.679 Yeah, he's been going without a face lifts. 845 00:42:48.960 --> 00:42:51.199 Yeah, I don't know it's he certainly doesn't look like 846 00:42:51.199 --> 00:42:53.960 he's had a facelift. Yeah right, it's fucking incredible. 847 00:42:54.039 --> 00:42:56.039 Yeah, but he's probably never been in the sun. 848 00:42:56.159 --> 00:42:59.880 It could be a full AI account. It's trolling everyone. 849 00:43:00.199 --> 00:43:03.480 I don't know that's possible too. Like, look at that 850 00:43:03.519 --> 00:43:05.679 picture right there, Like that looks a little AI ish. 851 00:43:05.800 --> 00:43:08.400 Go back to that one again. Keep your pants on, Jamie, 852 00:43:08.920 --> 00:43:12.400 that relax. That looks very AI, doesn't it. 853 00:43:12.840 --> 00:43:15.239 I'm just it could be it is all. 854 00:43:15.800 --> 00:43:19.079 His fifty ninth birthday. His whole thing is that he's young. 855 00:43:18.960 --> 00:43:23.519 For eight looks half his age. Wow, man, this will 856 00:43:23.559 --> 00:43:24.000 be normal. 857 00:43:24.559 --> 00:43:26.280 I guess it's just twenty twenty fourst it's not. This 858 00:43:26.320 --> 00:43:27.920 has been going on for a while. Okay, so this 859 00:43:28.000 --> 00:43:30.360 is pre AI. If it's fake, then he would have 860 00:43:30.360 --> 00:43:33.960 been called out now, right, so he might just be 861 00:43:34.000 --> 00:43:37.639 a genetic free which is interesting, right, Like do you 862 00:43:37.679 --> 00:43:41.679 guys study the different like you know, unfortunately certain people 863 00:43:41.800 --> 00:43:45.199 that have like like pale people for instance, with thin skin, 864 00:43:45.719 --> 00:43:47.440 they age hardcore, they go. 865 00:43:47.480 --> 00:43:49.760 And there are those kids that get old in the teens, right, 866 00:43:49.920 --> 00:43:50.960 the study that as well. 867 00:43:51.039 --> 00:43:54.840 Yeah, weird, but yeah. 868 00:43:54.639 --> 00:43:56.480 We do study the genetics of aging. 869 00:43:56.599 --> 00:44:00.199 That's the real application for it where people are to 870 00:44:00.199 --> 00:44:02.039 be excited about it. People that have that what is 871 00:44:02.079 --> 00:44:04.360 it called per jerry jerry exactly? Yeah. 872 00:44:04.480 --> 00:44:06.599 Yeah, And so we have mice that have this same 873 00:44:06.679 --> 00:44:08.960 gene mutation and they get old really quickly, and we're 874 00:44:09.159 --> 00:44:11.519 giving them the drink right now, and. 875 00:44:11.480 --> 00:44:13.800 So in the drink you give it to them how 876 00:44:13.840 --> 00:44:14.480 often and for. 877 00:44:14.559 --> 00:44:19.000 A month it's once a day, every other day, three 878 00:44:19.079 --> 00:44:23.639 days a week for a month. And yeah, in normal 879 00:44:23.639 --> 00:44:27.000 old mice, we see them fitter, stronger, better memory. They 880 00:44:27.199 --> 00:44:29.800 run around the cave in just a month. It's amazing. 881 00:44:29.840 --> 00:44:33.280 We only did a month because it was Christmas holiday season. 882 00:44:33.320 --> 00:44:35.599 We didn't we didn't want to go for longer. But 883 00:44:36.119 --> 00:44:38.920 it worked in four weeks. I'm shocked. Even these genes 884 00:44:39.079 --> 00:44:42.679 require six to eight weeks to work for revision, recovery 885 00:44:42.679 --> 00:44:43.360 of vision. 886 00:44:44.400 --> 00:44:47.199 And so this is working on a different pathway. 887 00:44:48.000 --> 00:44:50.599 Well, here's the cool thing. We think it's working through 888 00:44:50.639 --> 00:44:55.760 the same mechanism, the reboot, the reinstallation of software the drink. 889 00:44:56.159 --> 00:44:59.199 Because there are genes called TETs. There are three of 890 00:44:59.239 --> 00:45:02.559 them in the body, and they do something spoiler t 891 00:45:02.639 --> 00:45:05.719 ET capital t T there's one, two, three, And these 892 00:45:05.880 --> 00:45:09.800 are genes that make enzymes that remove these methyls off 893 00:45:09.840 --> 00:45:14.039 the DNA, so they control the clock. And if we 894 00:45:14.079 --> 00:45:18.119 get rid of those genes, our system doesn't work. We 895 00:45:18.199 --> 00:45:23.599 cannot restore vision, and our pill doesn't work without removing 896 00:45:23.639 --> 00:45:26.440 and altering those chemicals. So in other words, it's not 897 00:45:26.480 --> 00:45:29.280 just because the chemicals make the cell healthier, it's actually 898 00:45:29.280 --> 00:45:34.239 resetting this clock on the DNA. WHOA, and that was 899 00:45:34.280 --> 00:45:36.679 the big deal, I said, why when my student told me. 900 00:45:37.440 --> 00:45:38.840 And that's why I think it got the cover of 901 00:45:38.920 --> 00:45:42.800 Nature magazine, which is we're actually looking at the clock 902 00:45:42.840 --> 00:45:46.960 of life, and we've realized that this clock that goes around, 903 00:45:47.199 --> 00:45:50.519 this biological clock, isn't just a clock. When you move 904 00:45:50.559 --> 00:45:53.880 the hands of the clock, time goes backwards for the body, 905 00:45:55.400 --> 00:45:59.360 meaning the clock is aging, and aging is the clock. 906 00:46:00.800 --> 00:46:04.480 Wow, what is it? You don't really know in terms 907 00:46:04.559 --> 00:46:09.239 of humans, But is there any indication that improves cognitive 908 00:46:09.280 --> 00:46:10.280 function in mice? 909 00:46:10.719 --> 00:46:13.559 Yes, I can say without a doubt that other labs 910 00:46:13.599 --> 00:46:16.079 an ours have shown that when you reverse the age 911 00:46:16.079 --> 00:46:19.239 of the brain in a mouse, it gets better at learning. 912 00:46:19.679 --> 00:46:22.440 And we even have some hints and we're going to 913 00:46:22.440 --> 00:46:25.000 publish this that lost memories come back. 914 00:46:25.840 --> 00:46:26.400 WHOA. 915 00:46:26.480 --> 00:46:30.159 So Alzheimer's patients I believe still have memories, they just 916 00:46:30.199 --> 00:46:33.519 cannot access them, and that one day we can reverse 917 00:46:33.559 --> 00:46:37.400 Alzheimer's disease by making the brain young, and that using 918 00:46:37.400 --> 00:46:40.440 that approach, making the whole body young, we can cure 919 00:46:40.480 --> 00:46:42.119 diseases that are currently incurable. 920 00:46:43.639 --> 00:46:44.320 Holy shit. 921 00:46:46.079 --> 00:46:48.280 Well young people don't get Alzheimer's why because the body 922 00:46:48.280 --> 00:46:52.199 can tackle the problem. The young body can heal itself. 923 00:46:52.599 --> 00:46:54.920 So my approach is make the body young, it'll heal 924 00:46:54.960 --> 00:46:57.079 itself in every way. 925 00:46:57.199 --> 00:47:00.280 Well do you have children three? Yeah. One of things 926 00:47:00.320 --> 00:47:04.679 that's just phenomenal is watching them heal. Yeah, I'm like, 927 00:47:04.880 --> 00:47:09.440 it is so uh, it's so wild. But also you 928 00:47:09.559 --> 00:47:12.480 envy them so much because they get cut and it's 929 00:47:12.519 --> 00:47:15.519 like two days later, like, where's your cut? It's fucking gone, 930 00:47:15.559 --> 00:47:19.280 Like that's crazy. My daughter had a cutter. She fell 931 00:47:19.320 --> 00:47:21.760 and knocked her head and she had this like dark 932 00:47:21.800 --> 00:47:24.679 spot on her head like where she got injured. It 933 00:47:24.760 --> 00:47:26.760 was like four or hailve days it was gone, and 934 00:47:26.760 --> 00:47:28.400 I was like that fucking thing would be with me 935 00:47:28.519 --> 00:47:29.360 for four months. 936 00:47:29.480 --> 00:47:31.880 Yeah. And the good thing is if we rub our 937 00:47:31.960 --> 00:47:34.239 cocktail on the skin of the mice, they heal like 938 00:47:34.360 --> 00:47:34.920 the young again. 939 00:47:35.360 --> 00:47:37.840 Oh so that would be like a great application for 940 00:47:37.920 --> 00:47:40.679 ladies who want the beauty treatment on the face, right, 941 00:47:40.679 --> 00:47:41.000 because that. 942 00:47:41.079 --> 00:47:44.480 Was way waheaded whoa. Yeah, yeah, And we're working on hair. 943 00:47:45.039 --> 00:47:47.519 We can grow human hair on mice now. Really that 944 00:47:47.559 --> 00:47:49.679 took a few years and now we can check if 945 00:47:49.719 --> 00:47:52.320 we can regrow hair and make it dark again. 946 00:47:52.360 --> 00:47:54.119 You can grow human hair on mice. 947 00:47:54.320 --> 00:47:56.239 Yeah, I'm not alad to actually did post it on 948 00:47:56.280 --> 00:48:00.760 Instagram and the university said, get that down. It exists. 949 00:48:01.119 --> 00:48:03.880 We grow it from stem cells, from human stem cells. 950 00:48:04.159 --> 00:48:06.880 We make little bowls of hair. It takes a few months. 951 00:48:07.079 --> 00:48:09.480 We open up the ball to make a flat piece 952 00:48:09.480 --> 00:48:12.920 of skin, human skin, and we put that in the 953 00:48:12.960 --> 00:48:15.679 back of a mouse that can accept human skin, and 954 00:48:15.679 --> 00:48:18.199 then you get black tufts of hair from humans can. 955 00:48:18.119 --> 00:48:19.519 You get any kind of hair, Like, could I get 956 00:48:19.519 --> 00:48:21.159 an afro? I just want to get one to piss 957 00:48:21.199 --> 00:48:23.840 people off. Oh, we'd love an afro, like a Colin 958 00:48:23.960 --> 00:48:26.360 Kaepernick type, just a big, crazy one. 959 00:48:26.440 --> 00:48:29.280 Yeah. We can grow hair. We can do that. We 960 00:48:29.360 --> 00:48:31.039 were on at a few leves that can grow this hair. 961 00:48:31.840 --> 00:48:33.840 So I thought about doing that for a company, but 962 00:48:33.880 --> 00:48:35.559 I think hair transplants would just be easier. 963 00:48:36.400 --> 00:48:38.360 Oh right, so you would grow hair in a lab 964 00:48:38.400 --> 00:48:39.679 and then transplant those hairs. 965 00:48:39.719 --> 00:48:40.320 We can do that. 966 00:48:40.400 --> 00:48:42.360 Yeah, oh well that's the thing, because I got a 967 00:48:42.400 --> 00:48:44.920 hair transplant. But the way I describe it is like 968 00:48:45.239 --> 00:48:49.119 your take. It's like taking people that are really healthy 969 00:48:49.440 --> 00:48:52.760 and moving them into a town where everyone's dying. Because 970 00:48:52.840 --> 00:48:56.000 like you take taking hair from back here where it's 971 00:48:56.039 --> 00:48:58.079 gonna stay, and you put it up here where it's 972 00:48:58.079 --> 00:48:58.760 all falling out. 973 00:48:59.280 --> 00:49:01.840 It didn't thrive. What's up It doesn't thrive if you 974 00:49:01.880 --> 00:49:02.159 move it. 975 00:49:02.280 --> 00:49:05.719 Oh, it thrives, but everybody else dies. You know, you 976 00:49:05.760 --> 00:49:07.719 can only take so much from the back of your 977 00:49:07.719 --> 00:49:09.519 head and move it to the top of your head. 978 00:49:09.559 --> 00:49:12.440 That's why a lot of guys with hair transplants look goofy, 979 00:49:12.639 --> 00:49:15.039 because you have like this strong hairline in the front 980 00:49:15.239 --> 00:49:17.440 and it goes back like that and then everything else 981 00:49:17.480 --> 00:49:18.360 looks like chaos. 982 00:49:18.480 --> 00:49:20.559 Oh that sucks. You know what I take from my hair? 983 00:49:20.599 --> 00:49:21.039 What do you take? 984 00:49:21.079 --> 00:49:22.599 Among other things? 985 00:49:22.800 --> 00:49:22.920 Uh? 986 00:49:23.760 --> 00:49:24.199 Viagra? 987 00:49:25.280 --> 00:49:25.840 Viagra? 988 00:49:26.719 --> 00:49:28.480 Yeah, actually I shouldn't say the brand name. 989 00:49:28.559 --> 00:49:29.760 That's actually I take it. 990 00:49:30.719 --> 00:49:33.079 That's what I tell everybody. That is true. It's low dose, 991 00:49:33.360 --> 00:49:36.920 seven milligrams a day to delafill, and it's good for 992 00:49:37.119 --> 00:49:37.840 a lot of things. 993 00:49:38.440 --> 00:49:41.800 I know it's good for endurance. Yeah, yeah, because I 994 00:49:41.800 --> 00:49:45.119 know athletes who take it for endurance. They probably take 995 00:49:45.119 --> 00:49:48.079 it to fuck too. Let's not kid ourselves. 996 00:49:48.480 --> 00:49:52.079 Well, it's a nice it's a nice benefit. When a 997 00:49:52.159 --> 00:49:55.039 sign a paper just came out about its role in 998 00:49:55.079 --> 00:49:59.840 preventing cancer, I tweeted what's not to love? People love 999 00:49:59.880 --> 00:50:02.360 that tweet. But the point is actually, last week they 1000 00:50:02.400 --> 00:50:06.679 found that these drugs in mice and seemingly in people 1001 00:50:07.079 --> 00:50:10.719 who take these drugs are actually resistant to can certain 1002 00:50:10.760 --> 00:50:13.639 types of cancers like head and neck cancer. So interested 1003 00:50:13.760 --> 00:50:14.239 turning out. 1004 00:50:14.119 --> 00:50:15.920 To be really important. Blood flow. 1005 00:50:16.599 --> 00:50:19.239 Well, two reasons that are not related to blood flow, 1006 00:50:19.280 --> 00:50:22.360 but they're related to what's called nitric oxide signaling, which 1007 00:50:22.400 --> 00:50:24.639 is what helps dilate blood vessels in all your body, 1008 00:50:24.679 --> 00:50:28.559 including your penis. The other two mechanisms, one showed that 1009 00:50:29.239 --> 00:50:32.880 to dalaphil is good for exposing the tumor to the 1010 00:50:32.960 --> 00:50:38.440 immune system. There are certain cells are called MDSCs that 1011 00:50:38.880 --> 00:50:42.920 protect the tumor from getting attacked, and the drug stops that. 1012 00:50:43.239 --> 00:50:46.320 So now the tumors shrink in mice and seemingly in 1013 00:50:46.679 --> 00:50:50.159 people in tumors. And then the second mechanism is really interesting. 1014 00:50:50.519 --> 00:50:53.719 It seems to this was siedanaphil, So this is now viagra. 1015 00:50:54.480 --> 00:50:58.960 Found that the cancer is a lot of cancers thrive 1016 00:50:59.000 --> 00:51:02.039 on cholesterol, and this blocks the ability of cancer cells 1017 00:51:02.079 --> 00:51:02.960 to use cholesterol. 1018 00:51:03.159 --> 00:51:04.800 I thought they thrived on glucose. 1019 00:51:04.920 --> 00:51:07.639 That too, exactly right. So you want to be in 1020 00:51:07.679 --> 00:51:12.360 katosis if you've got the tumor in general, so fasting 1021 00:51:12.440 --> 00:51:16.159 is good, but now it looks like these ed drugs 1022 00:51:16.519 --> 00:51:17.800 might be good for it as well. 1023 00:51:18.079 --> 00:51:25.159 Fascinating. It wasn't I think viagra was a It was 1024 00:51:25.199 --> 00:51:28.360 an accident, right, wasn't Wasn't it a blood pressure medication. 1025 00:51:28.400 --> 00:51:30.280 It's a good story. It was for angina, right was 1026 00:51:30.320 --> 00:51:35.199 for your heart. But the story goes that women especially 1027 00:51:35.440 --> 00:51:37.519 and the men didn't want to give up the drugs 1028 00:51:37.559 --> 00:51:41.800 that they had left over. It was amazing. It was 1029 00:51:41.880 --> 00:51:43.800 I think it was seventy five percent had a positive 1030 00:51:43.840 --> 00:51:47.480 reaction for erections and without it twenty two. So it's 1031 00:51:47.760 --> 00:51:49.800 it's very clear that it was working. 1032 00:51:50.559 --> 00:51:53.559 Interesting and so so how does it help hair? 1033 00:51:55.159 --> 00:51:57.840 Well, we don't know for sure, but there's a lot 1034 00:51:57.840 --> 00:52:00.920 of evidence that part of the reason hair dies out 1035 00:52:00.960 --> 00:52:03.800 and stops growing is lack a blood flow, and the 1036 00:52:03.840 --> 00:52:06.119 monoxidol that people put on their hair helps with that. 1037 00:52:06.480 --> 00:52:10.960 Right. Interesting, and then DHT inhibitors exactly. 1038 00:52:11.119 --> 00:52:14.880 Also, i'd be do test ride people can take orally. 1039 00:52:15.400 --> 00:52:18.840 The problem with that is my friend had severe depression 1040 00:52:18.880 --> 00:52:21.880 when he took that. Yeah, it really fucked him up, 1041 00:52:22.039 --> 00:52:25.320 and he didn't realize because he didn't understand that that 1042 00:52:25.400 --> 00:52:27.360 was He was like, what is wrong with me? And 1043 00:52:27.400 --> 00:52:30.199 he was getting suicidal and then he got off of 1044 00:52:30.199 --> 00:52:31.679 it and it just went away, and he's like, oh 1045 00:52:31.760 --> 00:52:34.800 my god, I can't believe that this episode is sponsored 1046 00:52:34.800 --> 00:52:38.760 by Better Help. You've probably heard about better Help before, 1047 00:52:38.880 --> 00:52:42.039 but maybe you haven't heard from those who have actually 1048 00:52:42.199 --> 00:52:45.760 used Better Help. That feedback can tell you everything you 1049 00:52:45.800 --> 00:52:49.159 need to know. Go to betterhelp dot com. Slash Reviews 1050 00:52:49.519 --> 00:52:52.880 and check out the feedback from hundreds of people saying 1051 00:52:53.000 --> 00:52:56.440 how much they love this service. It's easy to see why. 1052 00:52:56.639 --> 00:52:58.920 To get started, all you have to do is answer 1053 00:52:58.960 --> 00:53:01.239 a few questions. You'll get matched up with a therapist 1054 00:53:01.519 --> 00:53:04.920 based on your needs, and if it's not the right fit, 1055 00:53:05.039 --> 00:53:08.559 you can switch therapists at any time. See the reviews, 1056 00:53:08.719 --> 00:53:11.119 see what stands out, and see if better Help is 1057 00:53:11.199 --> 00:53:15.599 right for you. Visit betterhelp dot com slash jr E. 1058 00:53:15.960 --> 00:53:19.679 That's better h E l p dot com slash j 1059 00:53:20.000 --> 00:53:20.360 r E. 1060 00:53:20.840 --> 00:53:25.400 Yeah, well, I'm taking it for a number of reasons, 1061 00:53:25.480 --> 00:53:28.039 including my hair and my prostate. See if I can 1062 00:53:28.159 --> 00:53:31.199 keep it from growing. But unfortunately I haven't had that 1063 00:53:31.239 --> 00:53:31.800 side effect. 1064 00:53:32.039 --> 00:53:35.559 But everything depends, right, It varies biologically depending on the person. 1065 00:53:35.679 --> 00:53:38.719 Yeah, it's important when either of us says that drug's 1066 00:53:38.760 --> 00:53:41.280 good that drug's bad, right, people realize that you have 1067 00:53:41.320 --> 00:53:44.360 to test it, see and with doctors supervision. 1068 00:53:44.480 --> 00:53:46.239 Yeah, that was where I was going to get to, 1069 00:53:46.599 --> 00:53:50.719 was like, because different medications have different reactions, or different 1070 00:53:50.719 --> 00:53:54.119 people's reactions to medications, they vary quite wildly. So like, 1071 00:53:54.239 --> 00:53:59.360 before you make this public, I mean, like, how do 1072 00:53:59.440 --> 00:54:01.960 you determ whether or not this is going to be 1073 00:54:02.039 --> 00:54:06.320 safe for a wide variety of people to reverse aging. 1074 00:54:06.719 --> 00:54:10.480 Oh my drug, our drug that we're making, well, we 1075 00:54:10.519 --> 00:54:13.199 will test it on a lot of people before it 1076 00:54:13.239 --> 00:54:15.159 goes out into the wide world. 1077 00:54:15.199 --> 00:54:16.960 And you've started testing it on people so far. 1078 00:54:17.119 --> 00:54:20.360 Yeah, there are people right now who have this these 1079 00:54:20.480 --> 00:54:21.480 genes in their eye. 1080 00:54:21.800 --> 00:54:25.000 And how's it going. I'm not allowed to say, but 1081 00:54:25.079 --> 00:54:26.519 can you wink twice? If it's great? 1082 00:54:27.159 --> 00:54:31.400 Um, I would say that everything's on target. 1083 00:54:31.960 --> 00:54:33.719 Okay, it's good to hear. 1084 00:54:34.039 --> 00:54:36.760 Nothing bad to report, nothing bad to report. I think 1085 00:54:36.760 --> 00:54:38.320 those might be the words I'm allowed to say. 1086 00:54:38.360 --> 00:54:40.800 And is that the only clinical trials you've used with 1087 00:54:40.840 --> 00:54:43.559 any of these applications for humans so far? 1088 00:54:43.679 --> 00:54:47.800 That was the first glaucoma And also sudden blindness it's 1089 00:54:47.840 --> 00:54:51.039 called nyon, which is now twice as more prevalent because 1090 00:54:51.039 --> 00:54:56.159 of the JLP one drugs. Really it's not well known obviously, 1091 00:54:56.360 --> 00:55:00.559 companies don't want to talk about it, but yes, blindness 1092 00:55:00.559 --> 00:55:03.719 has doubled seemingly because of these meds. 1093 00:55:03.800 --> 00:55:08.000 You have to Holy shit, sudden blindness has doubled because 1094 00:55:08.039 --> 00:55:09.159 of GLP one's do. 1095 00:55:09.119 --> 00:55:11.239 You deny on? Which is like a stroke in your 1096 00:55:11.239 --> 00:55:14.119 eye and then your other eye can go, which is 1097 00:55:14.119 --> 00:55:17.840 pretty scary and there's nothing you can do about it. Hopefully, 1098 00:55:17.880 --> 00:55:19.519 How drug does work for those people? 1099 00:55:20.440 --> 00:55:25.719 And I'll well, obviously correlation does not equal causation, but 1100 00:55:25.760 --> 00:55:26.599 it seems to be. 1101 00:55:27.840 --> 00:55:30.119 Yeah, there's a scientist at Harvard, you could look up 1102 00:55:30.159 --> 00:55:34.400 his work, Joe Rizzeau. It looks like it's repeatable across 1103 00:55:34.440 --> 00:55:34.920 the planet. 1104 00:55:35.719 --> 00:55:38.960 Wow, that's terrible because there's so many people out there 1105 00:55:39.000 --> 00:55:42.119 that are just telling everyone they should get on GLP ones. Yeah, 1106 00:55:42.239 --> 00:55:46.719 I've've seen that, like by online people, like online podcasters 1107 00:55:46.719 --> 00:55:50.639 saying everyone should get on GLP one's there's a groundbreaking technology. 1108 00:55:50.880 --> 00:55:53.400 This is amazing, it's going to transform society. I'm like, 1109 00:55:54.960 --> 00:55:57.920 we just started taking these the fuck are you saying? 1110 00:55:58.360 --> 00:56:00.760 Yeah, it's not risk free? Same with eight D drugs. 1111 00:56:00.840 --> 00:56:04.199 Here goes. Recent studies suggests that a potential rare link 1112 00:56:04.320 --> 00:56:08.840 between GLP one receptor agonist medication such as zempeg, wagov 1113 00:56:09.039 --> 00:56:14.280 blah blah blah, and a condition called non artytic anterior 1114 00:56:15.679 --> 00:56:21.199 what's that word ischemic ischemic optic neuropathy. An eye stroke 1115 00:56:21.480 --> 00:56:24.679 can cause sudden, painless loss of vision in one eye. 1116 00:56:24.679 --> 00:56:28.920 Wey absolute risk remains very low. Anyone experienced sudden vision change, 1117 00:56:28.920 --> 00:56:32.599 you should seek emergency metal medical evaluation immediately. Well, very 1118 00:56:32.639 --> 00:56:35.280 low is like, it's still what does that mean? 1119 00:56:35.880 --> 00:56:36.119 People? 1120 00:56:36.320 --> 00:56:37.280 One in ten thousand? 1121 00:56:37.440 --> 00:56:41.159 Yeah, yeah, that's total of ten thousand, oh, total. 1122 00:56:40.880 --> 00:56:42.960 Of ten thousand so far for how much you were 1123 00:56:43.039 --> 00:56:46.800 taking this. I think it's pretty The drugs were sixty 1124 00:56:47.280 --> 00:56:51.519 eight point six times more likely to develop this and 1125 00:56:51.559 --> 00:56:55.000 eight times more likely to develop diabetic What is that 1126 00:56:57.719 --> 00:57:08.000 we only got the blurb? Oh my god? Then wow. Yeah, man, 1127 00:57:08.159 --> 00:57:11.519 these things are just they're just rolling out and the 1128 00:57:11.519 --> 00:57:15.639 people that are like super enthusiastic, and also they have 1129 00:57:15.679 --> 00:57:18.280 some sort of a financial interest in promoting these things, 1130 00:57:18.320 --> 00:57:20.599 which oftentimes does seem to be the case with a 1131 00:57:20.639 --> 00:57:23.000 lot of these people. They have either stock in these 1132 00:57:23.000 --> 00:57:25.920 companies or some sort of a stake in them. 1133 00:57:26.400 --> 00:57:28.519 Uh. Yeah, it's true, though, I will I will say 1134 00:57:28.679 --> 00:57:30.840 to counter that that the JLP one drugs have probably 1135 00:57:30.880 --> 00:57:33.159 saved millions of lives already, and they're pretty common. At 1136 00:57:33.199 --> 00:57:35.599 least ten percent of people are trying them in twenty 1137 00:57:35.599 --> 00:57:36.480 five percent one to two. 1138 00:57:36.920 --> 00:57:38.840 Yeah, I mean, they don't work for everybody. I have 1139 00:57:38.880 --> 00:57:40.679 a good friend of mine that had a terrible reaction 1140 00:57:40.719 --> 00:57:44.440 from it, and he was hospitalized. But I know other 1141 00:57:44.480 --> 00:57:47.440 people where it's completely transformed their life and they've lost 1142 00:57:47.440 --> 00:57:50.800 a ton of weight, and particularly people that just for 1143 00:57:50.840 --> 00:57:54.239 whatever reason, the food addiction was so incredibly strong that 1144 00:57:54.679 --> 00:57:58.519 whatever their constitution, the way they're the way they're designed, 1145 00:57:58.559 --> 00:58:01.400 the way they're built, the way they've as a human being, 1146 00:58:01.599 --> 00:58:04.679 they weren't capable of overcoming it. They take the GLP 1147 00:58:04.800 --> 00:58:08.559 ones and then they sort of start getting moving and 1148 00:58:08.599 --> 00:58:10.679 then they lose all the weight, they start feeling better, 1149 00:58:10.679 --> 00:58:13.000 they start making a lot of other positive changes. You 1150 00:58:13.039 --> 00:58:15.639 get that momentum, which I always talk about, is which 1151 00:58:15.679 --> 00:58:18.800 is one of the most important things for transforming your life. 1152 00:58:19.000 --> 00:58:21.760 Everyone wants to talk about discipline. I think discipline is 1153 00:58:21.760 --> 00:58:25.000 the primary, that's the main engine, but one of the 1154 00:58:25.119 --> 00:58:28.119 things that comes along with any kind of an exercise 1155 00:58:28.119 --> 00:58:31.079 program or changing your life program where you start getting 1156 00:58:31.119 --> 00:58:35.159 positive results is momentum. And momentum is absolutely huge, thank you, 1157 00:58:35.199 --> 00:58:36.639 because then you start feeling. 1158 00:58:36.400 --> 00:58:37.719 That's so important, this is good. 1159 00:58:37.800 --> 00:58:41.280 So I think golp ones are fantastic for getting people going. 1160 00:58:41.400 --> 00:58:45.000 Yes, everybody should hear this, it's really important. I'll give 1161 00:58:45.039 --> 00:58:49.320 you my example. It's a classic case, I couldn't fast 1162 00:58:49.360 --> 00:58:53.000 for more than about a day. I want to do more. 1163 00:58:53.039 --> 00:58:54.920 I know that three days fasting is good, A week 1164 00:58:54.960 --> 00:58:56.599 can be even better, but I couldn't do it. I 1165 00:58:57.280 --> 00:58:58.880 don't have a lot of willpower when it comes to 1166 00:58:58.920 --> 00:59:02.920 this kind of stuff. I tried a jilpy one receptor agonist. 1167 00:59:03.039 --> 00:59:05.039 I gave it and it was easy. I didn't even 1168 00:59:05.400 --> 00:59:07.119 feel like I needed to snack at night, which is 1169 00:59:07.119 --> 00:59:09.320 one of the things that I and many people suffer from. 1170 00:59:09.559 --> 00:59:12.239 But the fact that I could do it, I went 1171 00:59:12.320 --> 00:59:15.039 off the drug. I didn't need it. But now I 1172 00:59:15.039 --> 00:59:18.519 can fast for I went for two weeks in a 1173 00:59:18.559 --> 00:59:21.280 couple of months ago. Well it's easy now now that 1174 00:59:21.320 --> 00:59:23.519 I know that I can do it. Mentally, it's not 1175 00:59:23.559 --> 00:59:26.920 hard at all. The momentum exactly, I know what's possible. 1176 00:59:27.079 --> 00:59:33.280 Yeah, yeah, that's fascinating. You are you still on a 1177 00:59:33.280 --> 00:59:34.159 plant based diet? 1178 00:59:34.559 --> 00:59:34.920 Mostly? 1179 00:59:35.159 --> 00:59:39.199 Yeah, what I had. I just had a conversation with 1180 00:59:39.239 --> 00:59:41.079 a friend of mine about this. I don't know how 1181 00:59:41.199 --> 00:59:42.639 much of the information that he was telling me it 1182 00:59:42.639 --> 00:59:45.440 was totally accurate, But what he was saying was that 1183 00:59:46.840 --> 00:59:50.760 he was told before he did fasting that one of 1184 00:59:50.760 --> 00:59:53.039 the best because he's a runner, He said, one of 1185 00:59:53.039 --> 00:59:57.119 the best ways to get into fasting is to get 1186 00:59:57.159 --> 01:00:00.920 your body into Kittosi's first, he said, And what he 1187 01:00:01.039 --> 01:00:04.119 thinks is that a carnivore based diet and what he 1188 01:00:04.199 --> 01:00:06.400 was told was a good way. If you could do 1189 01:00:06.440 --> 01:00:09.599 that for a few weeks, it mitigates your appetite. Like 1190 01:00:09.760 --> 01:00:11.519 one of the things that happens with a lot of 1191 01:00:11.559 --> 01:00:17.320 these diets that regulate insolent resistance is that when you 1192 01:00:17.639 --> 01:00:21.199 get used to consuming just fats and protein, you don't 1193 01:00:21.199 --> 01:00:24.880 have the kind of hunger pangs that you have with carbohydrates. 1194 01:00:25.199 --> 01:00:27.920 Like when I if I go in a bad streak 1195 01:00:27.960 --> 01:00:31.679 and I'm eating pizza and pasta, and I've done that 1196 01:00:31.719 --> 01:00:33.320 in the past, I don't really do that much in 1197 01:00:33.400 --> 01:00:37.239 a less I'm on vacation. In the past, though, what 1198 01:00:37.360 --> 01:00:40.480 I would get hungry, I would get crazy hungry, like 1199 01:00:40.679 --> 01:00:43.079 I've got to eat. Now I don't get that at 1200 01:00:43.119 --> 01:00:46.360 all anymore because I'm mostly on a carnivore based diet. 1201 01:00:46.559 --> 01:00:49.159 Mostly what I eat the like you look the bulk 1202 01:00:49.199 --> 01:00:53.199 of my diet, it's meat and fermented vegetables. It's meat 1203 01:00:53.280 --> 01:00:56.920 and like kimchi and sauer kraut and stuff along those lines. 1204 01:00:57.079 --> 01:01:00.480 And when I eat like that, my hunger is very 1205 01:01:00.480 --> 01:01:03.719 easy to control. And I've gone twenty four hours like 1206 01:01:04.119 --> 01:01:07.000 it's nothing, not eating, It's like not a problem at all. 1207 01:01:07.239 --> 01:01:09.559 But that's the most I've ever fasted. It's twenty four hours. 1208 01:01:09.599 --> 01:01:12.519 Okay, well see if you can go for three, it's 1209 01:01:12.519 --> 01:01:15.840 really worth it. You feel really great. Katosa's well that's 1210 01:01:15.840 --> 01:01:18.000 what everybody says. Yeah, yeah, And you go into what's 1211 01:01:18.000 --> 01:01:22.280 called deep cleansing. It's called chaperone mediated ortopogy or CMA, 1212 01:01:23.079 --> 01:01:25.760 and a friend of mine in New York, Maria Corvo, 1213 01:01:25.840 --> 01:01:29.079 studies this and it cleans out a lot of the 1214 01:01:29.119 --> 01:01:32.159 old proteins in your body. So katosis doesn't just make 1215 01:01:32.159 --> 01:01:34.679 you feel good, you're actually renewing your protein in your 1216 01:01:34.679 --> 01:01:37.639 body and rebuilding it. And so I do that as 1217 01:01:37.639 --> 01:01:38.880 a as an anti aging thing. 1218 01:01:38.960 --> 01:01:43.039 Is what I find is the biggest benefit is mental acuity. 1219 01:01:43.400 --> 01:01:45.840 It's a giant It has a giant impact when I 1220 01:01:45.840 --> 01:01:48.480 stick to the diet in terms of my ability to 1221 01:01:49.079 --> 01:01:55.320 form sentences, like recall information and just be present in podcasts. 1222 01:01:55.519 --> 01:01:59.280 Yeah, so in my podcast, what you do is really 1223 01:01:59.320 --> 01:02:02.480 quite difficult. You make it look easy. So when I'm 1224 01:02:02.480 --> 01:02:05.400 when I'm doing my podcast and often it's solo, so 1225 01:02:05.440 --> 01:02:08.960 it's challenging. I forget things. I have to remember hundreds 1226 01:02:09.000 --> 01:02:11.719 of papers for these things. They quite hard. Either I'm 1227 01:02:11.760 --> 01:02:14.559 gonna fast, and if I don't remember to fast, I 1228 01:02:14.599 --> 01:02:18.199 didn't experiment. I took some keytones. You can drink these things, right, 1229 01:02:18.239 --> 01:02:20.800 So yeah, there's the one, the little drink I think. 1230 01:02:20.719 --> 01:02:23.199 With fantastic stuff. 1231 01:02:23.280 --> 01:02:24.079 Yeah, yeah, I use that. 1232 01:02:24.119 --> 01:02:25.840 I love that stuff. I do that. I take that 1233 01:02:25.880 --> 01:02:28.760 before I do UFC broadcasts a lot of the time. Yeah, yeah, 1234 01:02:29.320 --> 01:02:32.480 I actually took some before because one that's great before 1235 01:02:32.519 --> 01:02:34.559 podcasts as well. Well. The one and one of more 1236 01:02:34.559 --> 01:02:37.239 difficult things that I do is the UFC commentary because 1237 01:02:37.320 --> 01:02:42.559 it's six hours, six hours of talking on air live yeah, 1238 01:02:42.599 --> 01:02:45.960 and about fights, and I'm also recalling fights and I'm 1239 01:02:45.960 --> 01:02:48.840 also I'm seeing positions, so I have to remember in 1240 01:02:48.880 --> 01:02:52.000 my mind how this is finished, because like in jiu jitsu, 1241 01:02:52.039 --> 01:02:54.079 there might be I don't know how many positions there are, 1242 01:02:54.079 --> 01:02:57.119 there thousands, And there's moves where I'm like, what is 1243 01:02:57.119 --> 01:02:57.960 he doing? What is he doing? 1244 01:02:58.159 --> 01:02:58.320 Oh? 1245 01:02:58.440 --> 01:03:01.159 Oh, that's that, that's the prov net TI. I'm looking 1246 01:03:01.199 --> 01:03:05.480 at his arms like your brain is I am exhausted 1247 01:03:05.519 --> 01:03:08.559 at the end of six hours and fucking starving, Like 1248 01:03:08.639 --> 01:03:11.119 after the UFC is over. I can eat so much food. 1249 01:03:11.599 --> 01:03:12.880 It's I'm so hungry. 1250 01:03:12.920 --> 01:03:14.000 But you take a little drink. 1251 01:03:14.039 --> 01:03:17.800 I take a little Keytone, little keytone IQ. I take Nootropics. 1252 01:03:17.840 --> 01:03:20.280 I drink this stuff. My friend Derek makes this his 1253 01:03:20.400 --> 01:03:27.800 Gorilla mind. It says a Nootropico tropic cocktail with caffeine 1254 01:03:28.239 --> 01:03:30.920 stuf's really good for a podcast. I also take Alpha Brain. 1255 01:03:31.079 --> 01:03:34.159 Alpha Brain Black labels phenomenal for that. There's a bunch 1256 01:03:34.199 --> 01:03:38.639 of different ones that I take. The gum Neurogum. Neurogum 1257 01:03:38.719 --> 01:03:40.920 is excellent for that too. But I just do fucking 1258 01:03:41.039 --> 01:03:42.360 everything I can to maximize. 1259 01:03:42.400 --> 01:03:44.159 That's how you do it, all right. Yes, secret is 1260 01:03:44.199 --> 01:03:46.440 now out, all right, but what you do is amazing. 1261 01:03:46.519 --> 01:03:49.000 And I thought you were on mandafanol or something. No. 1262 01:03:49.599 --> 01:03:52.559 I've taken that before in the past. But the problem 1263 01:03:52.599 --> 01:03:55.000 with that stuff is I think I like it too 1264 01:03:55.039 --> 01:03:56.920 much and I want to take it all the time. 1265 01:03:57.199 --> 01:03:58.719 You know, when I used to take that, if I 1266 01:03:58.719 --> 01:04:01.679 had a gig in San Diego and I drive home 1267 01:04:02.199 --> 01:04:04.599 after the gig, and it was like, you know, one 1268 01:04:04.599 --> 01:04:07.440 o'clock in the morning when I'm done, and then I'm like, ah, 1269 01:04:07.440 --> 01:04:09.679 I'll just go home. It's only two and a half hours. 1270 01:04:10.000 --> 01:04:11.960 And I start making the drive and you just get 1271 01:04:12.039 --> 01:04:15.800 so tired. But if I take new vigil or provigil 1272 01:04:16.159 --> 01:04:17.920 before I do that, I would be able to drive 1273 01:04:17.960 --> 01:04:19.239 no problem. Put a book on tap. 1274 01:04:20.599 --> 01:04:21.679 Can you sleep after that? Dog? 1275 01:04:21.719 --> 01:04:24.440 Oh? Yeah, yeah. It doesn't seem to affect your ability 1276 01:04:24.480 --> 01:04:27.559 to sleep, which is really interesting. It's not like caffeine. 1277 01:04:27.719 --> 01:04:28.960 Do you do it? Do you take it at all? 1278 01:04:29.639 --> 01:04:32.960 Arm adafinil for tulks when I'm traveling. 1279 01:04:32.880 --> 01:04:33.559 Does it help you? 1280 01:04:34.159 --> 01:04:34.639 Definitely? 1281 01:04:35.079 --> 01:04:35.760 Like in what way? 1282 01:04:37.079 --> 01:04:39.800 It gets rid of my jet light and I can focus. 1283 01:04:40.320 --> 01:04:43.960 My brain often is either scattered or filled with facts 1284 01:04:43.960 --> 01:04:46.480 that I pauses me like now to not be able 1285 01:04:46.519 --> 01:04:48.639 to talk properly. But if I'm on it, in which 1286 01:04:48.639 --> 01:04:52.480 I'm not, I'm on point every time. For me. 1287 01:04:52.599 --> 01:04:55.960 The best thing for jet lag is exercise. There's something 1288 01:04:56.000 --> 01:04:59.760 about rigorous exercise. It doesn't even have to be long. 1289 01:05:00.280 --> 01:05:02.840 It just has to be where my heart break gets 1290 01:05:02.920 --> 01:05:05.440 really elevated, like above one hundred and fifty bats per 1291 01:05:05.480 --> 01:05:08.960 minute for fifteen twenty minutes, Like I have to really 1292 01:05:09.159 --> 01:05:13.519 go hard where I'm sweaty and breathing heavy, you know, 1293 01:05:13.639 --> 01:05:15.840 especially by jacket up to like one eighty one ninety 1294 01:05:15.920 --> 01:05:18.559 like I'm doing like Tabata sprints on an air dine bike. 1295 01:05:19.039 --> 01:05:22.679 That kind of stuff completely resets me. Yeah, hard kettlebell 1296 01:05:22.679 --> 01:05:25.800 workouts like I'll do like a hard series where a 1297 01:05:25.920 --> 01:05:28.519 minimum amount of rest in between. So I'm really pushing it. 1298 01:05:29.119 --> 01:05:33.079 Once I relax, I'm back. It's like it whatever it 1299 01:05:33.159 --> 01:05:35.719 is where your body just needs to like shake it 1300 01:05:35.840 --> 01:05:37.679 up and like get all of it out of your system. 1301 01:05:37.719 --> 01:05:39.599 It's like now I feel completely normal. 1302 01:05:39.679 --> 01:05:43.480 Yeah, well you might remember last time we talked about hormesis. Yeah, 1303 01:05:43.480 --> 01:05:45.800 what doesn't kill you makes you stronger, And that's what 1304 01:05:45.840 --> 01:05:48.239 you're doing. You're putting your body into survival mode. So 1305 01:05:48.320 --> 01:05:51.840 one of the reasons I mostly plants, why I take 1306 01:05:52.039 --> 01:05:55.159 and a man and these other molecules, is to mimic 1307 01:05:55.199 --> 01:05:58.280 that I don't work out like you do. I should 1308 01:05:58.320 --> 01:06:02.760 that I don't and don't you Uh. I think partly 1309 01:06:02.800 --> 01:06:07.679 because I tell myself I'm too busy, which is bullshit. 1310 01:06:08.159 --> 01:06:08.280 Uh. 1311 01:06:09.559 --> 01:06:12.079 I need I need a partner who will motivate me. 1312 01:06:12.199 --> 01:06:14.840 I think that would help. Maybe just get a trainer 1313 01:06:15.320 --> 01:06:17.960 that's that's a solution. You get some chadder, get a trainer. 1314 01:06:19.199 --> 01:06:20.800 I got some chad. Is that my money? 1315 01:06:20.880 --> 01:06:21.119 Yeah? 1316 01:06:21.480 --> 01:06:24.719 No, I can definitely forward one. Uh yeah, you know 1317 01:06:24.920 --> 01:06:27.199 it's on me. I actually I will own that that 1318 01:06:27.239 --> 01:06:28.039 I get it. 1319 01:06:28.159 --> 01:06:30.000 I just was explaining this to my friend last night. 1320 01:06:30.079 --> 01:06:31.719 It was like, I gotta start working. I'm like, just 1321 01:06:31.800 --> 01:06:34.920 get a trainer, get a trainer, someone who's good, and 1322 01:06:34.960 --> 01:06:37.199 that way they'll develop a program for you. All you 1323 01:06:37.239 --> 01:06:39.320 have to do is just show up and do what 1324 01:06:39.360 --> 01:06:42.519 they tell you to do. Just do it and it's mindless. 1325 01:06:42.559 --> 01:06:44.480 You could just like just go through what they tell 1326 01:06:44.519 --> 01:06:48.159 you to do and you'll just trust the process. You'll 1327 01:06:48.199 --> 01:06:49.239 improve radically. 1328 01:06:49.320 --> 01:06:51.800 All right, all right here, here's what we're gonna do. Okay, 1329 01:06:52.480 --> 01:06:54.320 I'm gonna take years. 1330 01:06:54.320 --> 01:06:55.880 What we're gonna do. You're gonna get me a jug 1331 01:06:55.880 --> 01:06:56.760 of that fucking. 1332 01:06:56.519 --> 01:07:01.000 Juice will swamp, all right, and you'll be my I'll 1333 01:07:01.039 --> 01:07:02.679 be a well I will. 1334 01:07:02.880 --> 01:07:06.920 I've done that before with my comedian friends. Really sure. Yeah, 1335 01:07:06.920 --> 01:07:09.840 I'll do it the right way where I take them 1336 01:07:09.880 --> 01:07:12.679 through it very easy. I don't have them worked out 1337 01:07:12.679 --> 01:07:15.960 hard at all. Especially in the beginning. Everything is like 1338 01:07:16.159 --> 01:07:18.400 nice and easy. It's like a little bit of strained, 1339 01:07:18.760 --> 01:07:22.119 You're not gonna be exhausted afterwards, and we build you up. 1340 01:07:22.360 --> 01:07:25.519 I'm a bill, I'm I'm a firm believer and not 1341 01:07:25.800 --> 01:07:29.079 over taxing the system on people that are sedentary. I 1342 01:07:29.159 --> 01:07:32.440 really think it's a slow, gradual process. I think you 1343 01:07:32.519 --> 01:07:34.280 have to get better the same way you got sick 1344 01:07:34.480 --> 01:07:38.199 over time. You can make radical changes in a short 1345 01:07:38.239 --> 01:07:41.079 period of time, don't get me wrong. And even just 1346 01:07:41.159 --> 01:07:45.719 a little bit of you know, moderately rigorous exercise a 1347 01:07:45.800 --> 01:07:48.159 few days a week, well, a few days a week 1348 01:07:48.280 --> 01:07:50.719 will give you great improvements. But I'm not one of 1349 01:07:50.719 --> 01:07:52.920 those guys. Is like, you know, we're gonna do two 1350 01:07:52.960 --> 01:07:55.280 hours today and you're gonna go to failure and you're 1351 01:07:55.280 --> 01:07:57.159 gonna be throwing up in a garbage pan. You're not 1352 01:07:57.199 --> 01:07:59.239 gonna do that again the next day. I want you 1353 01:07:59.239 --> 01:08:01.079 to do it again the next I want you to 1354 01:08:01.119 --> 01:08:04.440 have a nice workout where you know you're doing like 1355 01:08:04.559 --> 01:08:06.880 ten push ups and ten sit ups and ten body 1356 01:08:06.880 --> 01:08:08.920 weight squads, and then we're gonna do some of these 1357 01:08:09.159 --> 01:08:13.519 kettlebell cleans and kettlebell and nothing hard. Like everything's gonna 1358 01:08:13.559 --> 01:08:16.000 be like, oh okay, you put it down. You're fine, 1359 01:08:16.159 --> 01:08:19.199 and I want you to leave rejuvenated, like you feel like, 1360 01:08:19.319 --> 01:08:22.920 oh that was like exhilarating, nothing crazy, and then we'll 1361 01:08:22.960 --> 01:08:25.880 slowly start to add a little bit over time. That's 1362 01:08:25.920 --> 01:08:27.720 what I think the right thing to do with people 1363 01:08:27.720 --> 01:08:30.439 who don't work out all the time. You can't just 1364 01:08:30.600 --> 01:08:32.880 jump in and you know, it's. 1365 01:08:32.720 --> 01:08:35.039 Like worsting and skipping meals. You just can't do a 1366 01:08:35.119 --> 01:08:36.840 day or three without practicing. 1367 01:08:37.000 --> 01:08:39.079 Well. It's also you're gonna get injured. And this is 1368 01:08:39.079 --> 01:08:41.199 one of the main things that happens to people that 1369 01:08:41.279 --> 01:08:42.840 dive right into the deep end of the pool when 1370 01:08:42.880 --> 01:08:44.479 they start working out, is they get hurt, they get 1371 01:08:44.560 --> 01:08:47.039 muscle polls, they get back aches, they got all these 1372 01:08:47.039 --> 01:08:49.439 different things that happen because I think you just pushed 1373 01:08:49.439 --> 01:08:52.399 your body too quickly. You know, it's like you're in 1374 01:08:52.479 --> 01:08:54.880 boot camp. Like, well, you don't have to be in 1375 01:08:54.880 --> 01:08:56.439 boot camp. This is not the way to do it. 1376 01:08:56.479 --> 01:08:59.079 The way to do it is like slowly build up 1377 01:08:59.119 --> 01:09:03.760 and trust the process. Slowly start by If you're overweight, 1378 01:09:03.880 --> 01:09:05.720 like my friend Jelly Roll, he lost two hundred and 1379 01:09:05.720 --> 01:09:08.680 fifty pounds, what did he do? Started walking? Just start 1380 01:09:08.720 --> 01:09:12.640 walking walking around the neighborhood, walk around the block, walk upstairs, 1381 01:09:12.840 --> 01:09:15.880 just slowly, and then change the diet and then add 1382 01:09:15.920 --> 01:09:18.039 some stuff and next thing you know, you're doing this 1383 01:09:18.159 --> 01:09:20.399 and write it all down to that's the other thing. 1384 01:09:20.720 --> 01:09:23.399 Write down what you're gonna do, and write down how 1385 01:09:23.439 --> 01:09:25.479 you feel, and then keep doing that. And if you 1386 01:09:25.479 --> 01:09:27.600 could do that all the time, you'll start developing this 1387 01:09:27.760 --> 01:09:30.520 like momentum that we were talking about. Were like, Okay, 1388 01:09:30.640 --> 01:09:33.159 I'm on the course. I'm on a process, but it 1389 01:09:33.199 --> 01:09:36.000 doesn't have to be like you you're exhausted and then 1390 01:09:36.000 --> 01:09:37.760 you go to the lab and you're like, I can't 1391 01:09:37.760 --> 01:09:41.079 even fucking concentrate. You know, I was doing Tobata sprints 1392 01:09:41.079 --> 01:09:43.000 on the airdime machine, Like this is crazy. 1393 01:09:43.279 --> 01:09:46.239 Well, that's it's really good advice, and I'm going to 1394 01:09:46.279 --> 01:09:48.199 take you up on it. So let's say I'm lucky 1395 01:09:48.279 --> 01:09:50.239 enough to come on the show again. Yeah, I'll wear 1396 01:09:50.239 --> 01:09:54.239 a tight T shirt. Let's go, right, So twenty million 1397 01:09:54.279 --> 01:09:55.279 people have to get on. 1398 01:09:55.279 --> 01:09:57.079 The fucking goofy plant based diet. 1399 01:09:57.479 --> 01:10:00.000 Well, speak about that, because that's one of the things 1400 01:10:00.039 --> 01:10:03.039 we disagree on. I'm on a plant based diet because 1401 01:10:03.079 --> 01:10:06.039 I've seen a lot of work on animals, at least 1402 01:10:06.439 --> 01:10:09.960 that plants promote longevity. I eat a lot of protein. 1403 01:10:10.159 --> 01:10:12.640 It's interesting because you're not an animal. You know that right. 1404 01:10:12.680 --> 01:10:14.760 I'm not a mouse. I'm definitely an. 1405 01:10:14.680 --> 01:10:15.800 Animal, but are human. 1406 01:10:17.640 --> 01:10:20.880 Meat is the most nutrient dense food it is, it's available. 1407 01:10:20.920 --> 01:10:21.439 I love meat. 1408 01:10:21.800 --> 01:10:22.960 I love me. 1409 01:10:24.520 --> 01:10:26.960 I believe that there are there are two states that 1410 01:10:27.000 --> 01:10:31.840 we can be in. I should try meat, and then 1411 01:10:31.880 --> 01:10:35.479 you can see because I've been measuring myself with rings 1412 01:10:35.479 --> 01:10:37.199 and blood tests for last twenty years. 1413 01:10:37.279 --> 01:10:39.640 You should try elk. I'll get you an elk steak. 1414 01:10:40.279 --> 01:10:41.239 I'd love to try it. 1415 01:10:41.279 --> 01:10:41.800 Sounds fair. 1416 01:10:42.039 --> 01:10:43.840 I'm not against me. I will eat it and you'll 1417 01:10:43.880 --> 01:10:46.159 be like WHOA, yeah, don't get me addicted to me. 1418 01:10:46.199 --> 01:10:50.800 I feel it right away, like oh, you're sitting out 1419 01:10:51.000 --> 01:10:53.680 to start firing. Your body starts like, yes, this is 1420 01:10:53.680 --> 01:10:54.439 what we wanted to do. 1421 01:10:55.520 --> 01:10:59.399 Well, here's some science, which is what I do. There 1422 01:10:59.399 --> 01:11:03.319 are two states, this is my theory. There's the abundance mode, 1423 01:11:03.319 --> 01:11:05.800 which is very good for health. You'll build muscle, you'll 1424 01:11:05.880 --> 01:11:11.039 heal better. That's meat killed a mammoth. There's adversity mode, 1425 01:11:11.039 --> 01:11:13.079 which is we're out of meat, we're going to we 1426 01:11:13.159 --> 01:11:17.720 gotta eat roots and berries. That's adversity. We've got to run, running, exercise, 1427 01:11:18.119 --> 01:11:22.479 eating less, that's adversity. Both are good for you. This 1428 01:11:22.520 --> 01:11:25.920 one is pro survival. This one is pro growth. This 1429 01:11:25.960 --> 01:11:28.760 one is longevity. This one is you're going to be 1430 01:11:28.920 --> 01:11:29.520 stronger fit. 1431 01:11:29.680 --> 01:11:31.880 How do you determine that though, in terms of like 1432 01:11:31.960 --> 01:11:35.159 what is longevity versus what is just like health and 1433 01:11:35.239 --> 01:11:36.800 vitality currently. 1434 01:11:36.439 --> 01:11:38.840 Well, it's based on the last thirty years of research 1435 01:11:39.000 --> 01:11:40.319 in a variety of animals. 1436 01:11:40.359 --> 01:11:42.159 And she just doesn't have to do with the blue zones, 1437 01:11:42.199 --> 01:11:44.600 does it? Nor? 1438 01:11:46.000 --> 01:11:47.239 I read that recently. 1439 01:11:47.319 --> 01:11:50.000 Yeah, isn't that nuts. 1440 01:11:50.039 --> 01:11:53.039 Fraud, Well, records are hard. 1441 01:11:53.279 --> 01:11:55.199 Well, it's not just hard. A lot of it is 1442 01:11:55.279 --> 01:11:58.239 actual fraud where people are getting checks for their grandpa 1443 01:11:58.600 --> 01:12:01.239 and grandpa was dead, so they weren't writing it into 1444 01:12:01.279 --> 01:12:04.079 the government. They didn't expose like this was the problem 1445 01:12:04.119 --> 01:12:07.840 with Okinawa in particular, is that they would have to 1446 01:12:07.960 --> 01:12:09.960 in order for these people to get taken off the list, 1447 01:12:10.359 --> 01:12:13.159 they would have to inform the government if this person died, 1448 01:12:13.880 --> 01:12:16.000 and they just didn't do it. And so they had 1449 01:12:16.279 --> 01:12:18.439 this list of people that they were counting in their 1450 01:12:18.439 --> 01:12:21.439 census that were like soul really, like this is crazy, 1451 01:12:21.479 --> 01:12:23.600 what are you people? Doing even the oldest one hundred 1452 01:12:23.680 --> 01:12:24.000 years old. 1453 01:12:24.000 --> 01:12:25.920 The oldest person in the world apparently one hundred and 1454 01:12:25.960 --> 01:12:29.640 twenty two. There's a theory, not proven, that the oldest 1455 01:12:29.640 --> 01:12:32.039 person in the world was actually the daughter who was 1456 01:12:32.079 --> 01:12:36.439 faking it to get taxes or avoid taxes. I think 1457 01:12:36.439 --> 01:12:38.840 it was in France. I hope that that's not true. 1458 01:12:38.880 --> 01:12:40.760 I bet it's true. People are full of shit. 1459 01:12:41.600 --> 01:12:43.760 Well either way, the maximum human life spent's around one 1460 01:12:43.840 --> 01:12:46.319 hundred and seventeen eighteen, which is still a lot more 1461 01:12:46.359 --> 01:12:47.199 than we live. 1462 01:12:47.359 --> 01:12:49.479 And what's really crazy is none of those people are 1463 01:12:49.520 --> 01:12:53.399 doing everything right exactly. They're all smoking cigarettes and drinking 1464 01:12:53.520 --> 01:12:56.680 wine and having a good time. And that's a factor 1465 01:12:56.760 --> 01:13:00.439 that we really need to take into consideration. Loneliness and 1466 01:13:00.640 --> 01:13:05.479 isolation and sadness are one of the greatest contributors to 1467 01:13:06.239 --> 01:13:08.800 poor health outcomes. Number one, is it really Yeah? 1468 01:13:08.880 --> 01:13:11.079 Robert Voldinger at Harvard had a study for I think 1469 01:13:11.119 --> 01:13:14.119 it was forty years World War two vets. They looked 1470 01:13:14.119 --> 01:13:17.000 at everything blood pressure, cholesterol. The number one thing that 1471 01:13:17.039 --> 01:13:20.720 predicted longevity in those men was having a reliable partner. 1472 01:13:21.840 --> 01:13:26.720 Hmmm, yeah, so not just a reliable partner, someone that 1473 01:13:26.760 --> 01:13:30.199 you love that's true. Someone that you want to be 1474 01:13:30.319 --> 01:13:33.319 around all the time, you enjoy them, you still enjoy 1475 01:13:33.359 --> 01:13:36.920 their company, which is possible. Most people don't believe that's possible. 1476 01:13:37.039 --> 01:13:38.600 Well, your role model is that. 1477 01:13:38.880 --> 01:13:42.359 I love my wife. I have fun with her, like 1478 01:13:42.399 --> 01:13:43.840 we I've been with her for a while, I've been 1479 01:13:43.840 --> 01:13:47.000 married for seventeen years. I enjoy her. I enjoy hanging 1480 01:13:47.039 --> 01:13:50.000 out with her. She's cool. Yeah, like she's a fun 1481 01:13:50.039 --> 01:13:52.479 And I have friends that aren't in situations like that, 1482 01:13:53.119 --> 01:13:57.800 and it's it's so bad when you're like, I have 1483 01:13:57.840 --> 01:14:00.800 a friend who just we're actually talking last night. He 1484 01:14:00.920 --> 01:14:04.039 just got out of a crazy relationship where he's dating 1485 01:14:04.039 --> 01:14:06.199 this girl for seven years. Was chaos and this and that. 1486 01:14:06.640 --> 01:14:10.359 And I said to him and he was like, he's forty, 1487 01:14:10.560 --> 01:14:12.600 and he goes, I don't think I'm ever gonna have 1488 01:14:12.680 --> 01:14:15.520 a relationship again. He goes, it was so bad. He goes, 1489 01:14:15.560 --> 01:14:18.239 being single feels so good. And I said, there's an 1490 01:14:18.239 --> 01:14:21.479 old saying it's so much better to be alone than 1491 01:14:21.520 --> 01:14:25.239 to wish you were alone. And he's like, yeah, that's 1492 01:14:25.319 --> 01:14:28.199 it because he was like with this crazy lady and 1493 01:14:28.239 --> 01:14:30.239 he was like, I just wish I was And he 1494 01:14:30.279 --> 01:14:33.760 finally got free and now he's like, I think I'm ruined, 1495 01:14:33.800 --> 01:14:35.720 and I'm like, it doesn't have to be like that. 1496 01:14:35.880 --> 01:14:38.439 You can find someone that you actually love and you 1497 01:14:38.520 --> 01:14:42.079 really enjoy their time, you enjoy being with them. It's possible. 1498 01:14:42.119 --> 01:14:43.319 There's good people out there. 1499 01:14:43.159 --> 01:14:46.199 But you got to also be someone that that kind 1500 01:14:46.199 --> 01:14:48.600 of person wants to be with. That's the other thing 1501 01:14:49.000 --> 01:14:49.479 for sure. 1502 01:14:49.520 --> 01:14:53.359 And stress of relationship. We've seen and studies that clock 1503 01:14:53.439 --> 01:14:55.880 with those chemicals on the DNA, it accelerates when you're 1504 01:14:55.880 --> 01:14:58.039 on distress. We'll go going through a breakup. 1505 01:14:58.399 --> 01:14:59.920 Oh yeah, oh see it. 1506 01:15:00.319 --> 01:15:00.439 Oh. 1507 01:15:00.479 --> 01:15:02.560 I've seen people going through divorces and it's just like 1508 01:15:02.720 --> 01:15:05.000 it takes decades off of their life. They just look 1509 01:15:05.079 --> 01:15:07.880 wrecked and it takes a year or two for them 1510 01:15:07.920 --> 01:15:09.960 to like achieve equilibrium. Again. 1511 01:15:10.880 --> 01:15:13.920 It's hard, it is, it is. I went through that 1512 01:15:14.000 --> 01:15:18.000 actually just during COVID when our family got shoved in 1513 01:15:18.039 --> 01:15:20.479 a house together, and yeah, it was brutal. 1514 01:15:20.840 --> 01:15:24.399 It was unexpected to Wow, that's the stress test, right. 1515 01:15:24.600 --> 01:15:27.399 It was super stress. It was super stress. It's funny 1516 01:15:27.439 --> 01:15:29.640 that without the pandemic we might have been able to 1517 01:15:29.680 --> 01:15:31.880 make it, but forcing us all to be in one 1518 01:15:31.920 --> 01:15:35.079 little house with no internet working. Well, it was tough, 1519 01:15:35.960 --> 01:15:38.840 but any case, I'm great now, I'm very happy. So, 1520 01:15:39.239 --> 01:15:41.359 but I do know how bad it can get, and 1521 01:15:41.479 --> 01:15:42.079 it's brutal. 1522 01:15:42.319 --> 01:15:46.119 Yeah, bad relationships can fucking wreck people. I mean it 1523 01:15:46.159 --> 01:15:49.279 can wreck your health. But also it's not just relationships 1524 01:15:49.279 --> 01:15:52.560 in terms of your significant other, husband, wife, partner, whatever 1525 01:15:52.560 --> 01:15:55.800 you want to call it, but also bad relationships at work, 1526 01:15:56.399 --> 01:15:59.119 Like if you have a tyrant for a boss, and 1527 01:15:59.199 --> 01:16:02.039 you know, and every day you're getting you're you're working 1528 01:16:02.079 --> 01:16:04.159 over time and you're getting yelled at, and you're you're 1529 01:16:04.199 --> 01:16:06.399 on the phone, and you're you're at home trying to 1530 01:16:06.479 --> 01:16:09.560 keep up with work, and you never get like that 1531 01:16:09.560 --> 01:16:11.720 that kind of relationship. Well, you have like this, like 1532 01:16:11.880 --> 01:16:16.119 antagonistic terrible relationship with people that you work with. That's 1533 01:16:16.239 --> 01:16:18.960 bad too. Oh for sure, your body doesn't differentiate between 1534 01:16:19.119 --> 01:16:23.079 romantic relationships and those kind of relationships are almost equally bad. 1535 01:16:23.159 --> 01:16:26.119 The cortosol will be high. This will accelerate here. I 1536 01:16:26.199 --> 01:16:28.960 used to keep fish. I was one of those people 1537 01:16:29.199 --> 01:16:31.399 at school and the fish that got picked on by 1538 01:16:31.439 --> 01:16:36.199 the dominant fish was small, like color lived short. It's 1539 01:16:36.279 --> 01:16:38.640 it's biology. If you're picked on and you're stressed, you're 1540 01:16:38.640 --> 01:16:42.319 gonna age faster. Fortunately, I think you're probably the same. 1541 01:16:42.560 --> 01:16:45.079 At my age, I've managed to weed out most of 1542 01:16:45.119 --> 01:16:46.920 the jerks, and I don't work with them at all. 1543 01:16:47.279 --> 01:16:49.199 I've got a great partner who we have a hobby 1544 01:16:49.199 --> 01:16:52.760 of longevity together, so that I'm not lucky in that regard. 1545 01:16:52.840 --> 01:16:53.840 Now we found a new one. 1546 01:16:54.439 --> 01:16:56.359 Yeah, longevity specialist. Imagine that. 1547 01:16:56.399 --> 01:16:59.079 Congratulations. Well that's nice too, right. I find someone who 1548 01:16:59.159 --> 01:17:03.279 just like thinks so you think, and has similar likes 1549 01:17:03.800 --> 01:17:05.520 like you say. Yeah, that definitely can help. 1550 01:17:05.600 --> 01:17:05.800 Yeah. 1551 01:17:05.800 --> 01:17:07.479 I know a lot of my friends that are really 1552 01:17:07.479 --> 01:17:12.079 good relationships. Their significant other has the same hobby as them, 1553 01:17:12.560 --> 01:17:15.880 you know, like whatever it is they both like to 1554 01:17:15.960 --> 01:17:18.279 climb mountains or whatever the fuck it is. Find a thing. 1555 01:17:18.600 --> 01:17:21.319 But that helps too. Well, so you actually enjoy spending 1556 01:17:21.319 --> 01:17:23.880 time together doing something that you're both really excited about. 1557 01:17:23.960 --> 01:17:26.680 That helps to So relationships is one and the other 1558 01:17:26.840 --> 01:17:30.560 four major ones from that study were don't smoke, don't drink, 1559 01:17:30.960 --> 01:17:34.520 get enough rest, and get exercise. And that was enough 1560 01:17:34.560 --> 01:17:36.319 to extend by fifteen years. 1561 01:17:36.760 --> 01:17:39.359 But what about those old people that live forever and 1562 01:17:39.399 --> 01:17:41.279 do smoke and drink, because that's kind of weird. 1563 01:17:41.359 --> 01:17:43.960 Well, they're a point zero one percent. They're not examples 1564 01:17:44.000 --> 01:17:44.600 of what is that? 1565 01:17:44.680 --> 01:17:45.279 Really? What it is? 1566 01:17:45.359 --> 01:17:46.119 Yeah, it's just. 1567 01:17:46.119 --> 01:17:49.159 So the majority of people who get old and live 1568 01:17:49.239 --> 01:17:53.720 to like centenarians, Like, what are the common things that 1569 01:17:53.760 --> 01:17:54.079 they have? 1570 01:17:55.720 --> 01:17:57.640 The big one is that they don't stress a lot. 1571 01:17:57.840 --> 01:18:01.680 They usually have a good sense of humor. Mm. Interesting, right, 1572 01:18:02.359 --> 01:18:05.960 they haven't been overweight, and they say that they typically 1573 01:18:06.039 --> 01:18:07.840 couldn't remember when they lost got sick. 1574 01:18:08.800 --> 01:18:12.800 I wonder how much time Twitter takes off your life. 1575 01:18:13.039 --> 01:18:18.000 Yeah, we should study that. It's already taken a lot off. Mind, 1576 01:18:18.439 --> 01:18:20.880 it does, and if you read the comments even. 1577 01:18:20.920 --> 01:18:25.159 Yep, exactly, I'm so much happier since I swore off 1578 01:18:25.159 --> 01:18:27.279 of all that stuff. So it's just not good for you. 1579 01:18:27.680 --> 01:18:31.000 It's really really bad for you. It's also you're constantly 1580 01:18:31.039 --> 01:18:33.439 dealing with the problems of the whole world, which I 1581 01:18:33.479 --> 01:18:37.239 think is a lot for a human being that lives 1582 01:18:37.279 --> 01:18:40.680 in a community, in a neighborhood. It's that shit that's 1583 01:18:40.680 --> 01:18:44.960 happening over there really shouldn't be a primary focus of 1584 01:18:45.000 --> 01:18:48.800 your life. Like where you're in the moment actually doing 1585 01:18:48.840 --> 01:18:51.720 your life. It's not the same You're not in the 1586 01:18:51.760 --> 01:18:55.680 same area as this problem but yet this problem is overwhelming. 1587 01:18:56.000 --> 01:18:58.159 You're all day long life. 1588 01:18:57.880 --> 01:19:00.520 And you're in fital flight constant today all day. 1589 01:19:00.600 --> 01:19:02.960 Yeah, and you're worried about the climate. Oh my god, 1590 01:19:03.239 --> 01:19:05.960 Like there's so much. There's so much that freaks people 1591 01:19:06.000 --> 01:19:08.600 out that really shouldn't be affecting you at. 1592 01:19:08.439 --> 01:19:11.399 All, exactly, And actually the world doesn't change if you 1593 01:19:11.399 --> 01:19:11.960 don't read it. 1594 01:19:12.000 --> 01:19:15.159 So it's that's that's key. That's the key. But then 1595 01:19:15.199 --> 01:19:17.960 you're like, well, you need you're passing off the responsibility 1596 01:19:18.000 --> 01:19:20.960 to other people. You should get involved, Like, eh, you 1597 01:19:21.000 --> 01:19:23.800 should get involved. I'm gonna be over here. 1598 01:19:23.800 --> 01:19:26.000 That's right. Well, if you focus on doing something good 1599 01:19:26.039 --> 01:19:28.520 and you're good at it, yes, like yourself, I think 1600 01:19:28.560 --> 01:19:30.399 that you don't need to be doing more than that. 1601 01:19:30.520 --> 01:19:33.239 You can't focus on everything, and anybody who tells you 1602 01:19:33.279 --> 01:19:36.159 can is a fool. Or anybody who tells you what 1603 01:19:36.199 --> 01:19:38.640 you should or shouldn't be focusing on is a fool. 1604 01:19:38.720 --> 01:19:40.840 Yeah. A few years ago, someone at a talk that 1605 01:19:40.920 --> 01:19:43.760 I gave said you should be working on climate change. Fuck, 1606 01:19:43.880 --> 01:19:46.960 I said, after I cure aging, I'll get to climate change. 1607 01:19:47.039 --> 01:19:49.039 Yeah, once you go to China and tell them stop 1608 01:19:49.039 --> 01:19:52.119 making coal factories. Shut the fuck up, Just shut up, 1609 01:19:52.239 --> 01:19:57.039 you No, you're not going to fix it. Yeah, yeah, 1610 01:19:57.079 --> 01:19:59.760 somebody is. Somebody's working on it, and that's their going. 1611 01:20:00.159 --> 01:20:02.800 God bless them, good luck. Yeah. 1612 01:20:02.840 --> 01:20:05.520 Well, what I try to spend my day is efficiently 1613 01:20:06.000 --> 01:20:07.760 helping the world so that people ask me why do 1614 01:20:07.840 --> 01:20:10.119 I study aging in the first place, And it really 1615 01:20:10.159 --> 01:20:13.239 is that I'm trying to please my grandmother. Like some 1616 01:20:13.319 --> 01:20:15.560 of else, she was the one that told me that 1617 01:20:16.079 --> 01:20:18.039 I need to make the world a better place. And 1618 01:20:18.159 --> 01:20:20.720 she's gone. That's what she said when I was four, 1619 01:20:22.159 --> 01:20:25.520 been that ever since. She told me two things. Humans 1620 01:20:25.520 --> 01:20:27.800 are evil. She lived through World War two in Hungary 1621 01:20:27.880 --> 01:20:30.960 and oh wow, the Russians came in and raped everybody, 1622 01:20:31.079 --> 01:20:34.600 she said, and then so she escaped to Australia. And 1623 01:20:34.640 --> 01:20:39.720 then she said that the other issue is that we 1624 01:20:39.760 --> 01:20:42.800 don't do enough as humans to better the world, and 1625 01:20:42.840 --> 01:20:45.399 so I had that stuck in my mind. She also, 1626 01:20:45.399 --> 01:20:47.439 by the way, said oh, we all die, and I 1627 01:20:47.479 --> 01:20:51.000 thought that that's not really fair, is it? And that 1628 01:20:51.079 --> 01:20:53.600 set me on this path make the. 1629 01:20:53.520 --> 01:20:57.239 World a better place and we all die, and you're like, ah. 1630 01:20:58.640 --> 01:21:00.880 And what I've noticed with my kids is that even 1631 01:21:00.880 --> 01:21:03.600 if you tell them that, they forget about it because 1632 01:21:03.600 --> 01:21:06.439 it's brutal to think about death every day. Yeah, but 1633 01:21:06.640 --> 01:21:09.000 for some reason, it's just stuck in my head and 1634 01:21:09.079 --> 01:21:11.000 every day I'm like, another one hundred and fifty thousand 1635 01:21:11.000 --> 01:21:14.680 people are going to die today due to aging related diseases. 1636 01:21:15.159 --> 01:21:17.600 So my lab is mission oriented. If we are day 1637 01:21:17.680 --> 01:21:20.119 late with something, it's a lot of people that are 1638 01:21:20.159 --> 01:21:23.239 suffering potentially avoidable diseases. 1639 01:21:23.640 --> 01:21:25.560 That's why it's sort of understandable that people like show 1640 01:21:25.640 --> 01:21:28.600 up outside of your lab and like like, I need 1641 01:21:28.880 --> 01:21:30.960 to talk to you. Ah, I need this. 1642 01:21:31.199 --> 01:21:34.520 Yeah, blind people want to get in the trials. It's big, 1643 01:21:34.680 --> 01:21:36.520 and I think if the trial works, is going to 1644 01:21:36.520 --> 01:21:38.880 be a very strange world, especially for my lab and 1645 01:21:38.920 --> 01:21:42.199 for me. But we'll see, and even if it doesn't 1646 01:21:42.279 --> 01:21:44.960 work this time, the science is strong enough that will 1647 01:21:44.960 --> 01:21:47.520 figure it out. We will do this. It's just a 1648 01:21:47.600 --> 01:21:48.159 question of when. 1649 01:21:48.319 --> 01:21:50.520 And so do you think that AI is going to 1650 01:21:50.520 --> 01:21:53.399 have a significant impact on the kind of improvements that 1651 01:21:53.439 --> 01:21:54.079 you're able to. 1652 01:21:54.640 --> 01:21:57.880 It already is we're going super fast, and AI has 1653 01:21:57.960 --> 01:22:02.439 revolutionized biology. It's revolutionary everything, of course, but particularly in biology, 1654 01:22:02.479 --> 01:22:05.960 where we used to have to read fifteen papers a day. 1655 01:22:06.039 --> 01:22:08.520 Now we can read a million if we want. It's 1656 01:22:08.560 --> 01:22:15.159 totally different. Wow, yeah, it's super brain. A nineteen year 1657 01:22:15.199 --> 01:22:17.560 old came to my lab this summer and the lab 1658 01:22:17.600 --> 01:22:20.199 grows from twenty to forty people and we're trying to 1659 01:22:20.199 --> 01:22:23.520 figure out how do these three genes reset the cell? 1660 01:22:23.560 --> 01:22:26.720 How does the cell remember what it was thirty forty 1661 01:22:26.760 --> 01:22:30.479 years ago? Where's that information stored in the cell? And 1662 01:22:30.560 --> 01:22:34.119 I've got this theory that there's some new biology, there's 1663 01:22:34.119 --> 01:22:38.000 a record in the DNA somewhere. And I gave him 1664 01:22:38.000 --> 01:22:40.920 that task. I said, can you just go to the 1665 01:22:41.000 --> 01:22:43.079 databases of the whole world look at all the data 1666 01:22:43.119 --> 01:22:46.119 that's there, is exobites of data, and see if my 1667 01:22:46.159 --> 01:22:49.279 prediction is true, or at least you can get evidence 1668 01:22:49.279 --> 01:22:52.359 for it. Two weeks later he came back and the 1669 01:22:52.399 --> 01:22:54.680 whole team, not the whole ting, but five other people 1670 01:22:54.680 --> 01:22:57.560 were smiling. We have to show you something. David right, 1671 01:22:57.640 --> 01:22:59.319 come in to my office. We sat down. He shows 1672 01:22:59.399 --> 01:23:03.159 up on the board on this LCD screen. I think 1673 01:23:03.199 --> 01:23:06.079 we found the smoking gun for what your theory suggests. 1674 01:23:06.600 --> 01:23:09.680 And he used AI to process all that data and 1675 01:23:09.720 --> 01:23:12.359 the AI came back and said, yeah, you're probably right, 1676 01:23:12.920 --> 01:23:14.760 and it's a nineteen year old straight out of high 1677 01:23:14.760 --> 01:23:17.359 school who did this, That did something that the whole 1678 01:23:17.399 --> 01:23:20.600 field and all these professors and all these fancy serves 1679 01:23:20.680 --> 01:23:22.760 could not figure out until now. 1680 01:23:24.079 --> 01:23:29.159 That is phenomenal. That's so promising, it's so exciting. It is. 1681 01:23:29.239 --> 01:23:31.000 I mean, the future really does belong to people who 1682 01:23:31.079 --> 01:23:34.279 can wrangle AI even on their phone. I think people 1683 01:23:34.359 --> 01:23:36.319 on their phones are going to be making medicines or 1684 01:23:36.319 --> 01:23:41.600 at least designing them, or bombs. That's the problem. And bioweapons, right, 1685 01:23:41.920 --> 01:23:44.199 I mean you recently had, was it Anna on the 1686 01:23:44.239 --> 01:23:46.479 show to talk about bio weapons and this kind of 1687 01:23:46.479 --> 01:23:49.640 stuff That is a big worry. I actually had to 1688 01:23:49.680 --> 01:23:51.640 disclose to the US government when I first got here 1689 01:23:51.800 --> 01:23:54.159 that I did have the capability of making a bioweapon. 1690 01:23:54.600 --> 01:23:58.319 The Anna Jacobsen episode that we just did on bioweapons 1691 01:23:58.359 --> 01:24:02.840 was absolutely terrifying. She's yeah, I mean, she scared the 1692 01:24:02.840 --> 01:24:04.640 shit out of the world with her nuclear war book, 1693 01:24:04.680 --> 01:24:07.640 and now she's scaring everybody with her bioweapons book. 1694 01:24:07.960 --> 01:24:08.399 Yeah. 1695 01:24:08.479 --> 01:24:09.239 Yeah, that's scary. 1696 01:24:09.760 --> 01:24:12.239 It is. What I've got is a database of all 1697 01:24:12.359 --> 01:24:15.319 known pathogens and new ones that could come. So I'm 1698 01:24:15.359 --> 01:24:17.520 trying to do my bit there to help the world 1699 01:24:17.560 --> 01:24:20.920 if it happens again pandemic or something unnatural. 1700 01:24:21.560 --> 01:24:24.760 Yeah, well that would be I mean, when you think 1701 01:24:24.760 --> 01:24:28.600 about diseases that people get that just like wreck their 1702 01:24:28.720 --> 01:24:32.680 entire body. If you really do have an original copy 1703 01:24:32.760 --> 01:24:35.319 somewhere in their genome of what they look like as 1704 01:24:35.319 --> 01:24:38.800 a healthy person, and you could switch that back on 1705 01:24:38.920 --> 01:24:43.880 with a factory reboot, I mean, we could potentially get 1706 01:24:43.960 --> 01:24:47.520 rid of all diseases, which is just bananas. 1707 01:24:47.560 --> 01:24:52.079 And injuries, fixed injuries, grown new limbs, potentially. There's a 1708 01:24:52.119 --> 01:24:54.079 new paper that just came out a few days ago 1709 01:24:54.399 --> 01:24:56.920 that showed that the tips of the fingers of baby 1710 01:24:56.960 --> 01:25:00.039 mice can be coaxed once they've healed over as a 1711 01:25:00.079 --> 01:25:02.720 stub to regrow part of the finger. 1712 01:25:03.479 --> 01:25:06.119 Haven't people done that before? Yeah? 1713 01:25:06.239 --> 01:25:08.920 They found just two factors were enough, so it's not 1714 01:25:09.000 --> 01:25:12.359 that hard. The point is we've got the instructions to 1715 01:25:12.399 --> 01:25:14.960 be young and to regrow body parts in our body, 1716 01:25:15.159 --> 01:25:16.720 we just don't use them. 1717 01:25:17.039 --> 01:25:20.279 That's nuts. So like a salamander can grow an extra 1718 01:25:20.359 --> 01:25:23.039 leg or a leg that gets chopped off, Yeah. 1719 01:25:22.800 --> 01:25:25.079 I believe we still have that capability, we just don't 1720 01:25:25.199 --> 01:25:27.439 use it. It just didn't make sense to regrow a 1721 01:25:27.479 --> 01:25:29.479 limbit was quicker and safe to just heal it over 1722 01:25:29.520 --> 01:25:32.319 as a stub and move on. But salamanders, which get 1723 01:25:32.359 --> 01:25:37.359 their limbs presumably eaten, pretty often maintain that ability. So 1724 01:25:37.439 --> 01:25:40.359 give us you know, I wouldn't say that we could 1725 01:25:40.359 --> 01:25:43.159 evolve this, but I think using a combination of our 1726 01:25:43.199 --> 01:25:46.520 technology plus this new technology that we're seeing come out, 1727 01:25:46.560 --> 01:25:48.920 where these two factors can grow new limbs. I don't 1728 01:25:48.920 --> 01:25:51.239 see a reason why we can't become like a dead 1729 01:25:51.279 --> 01:25:54.359 pool where injury doesn't hurt us, aging can't hurt us, 1730 01:25:54.920 --> 01:25:56.199 and we can regrow body parts. 1731 01:25:56.479 --> 01:25:58.560 How far do you think we are away from being 1732 01:25:58.600 --> 01:25:59.960 able to regrow body parts? 1733 01:26:00.840 --> 01:26:03.600 Oh? I mean, realistically, probably a couple of decades. But 1734 01:26:03.640 --> 01:26:06.359 I've seen enough that's not that far. I've seen enough 1735 01:26:06.399 --> 01:26:07.319 to know that it's doable. 1736 01:26:07.439 --> 01:26:10.359 A couple of decades ago was two thousand and six. 1737 01:26:10.680 --> 01:26:12.680 Well, things are going super fast. I mean ten years 1738 01:26:12.680 --> 01:26:14.680 ago we didn't even know aging was reversible, and now 1739 01:26:14.680 --> 01:26:16.039 it's in humans. 1740 01:26:17.880 --> 01:26:21.720 That's nuts. Think of that, Well, two thousand and AI, 1741 01:26:21.960 --> 01:26:22.680 there was no AI. 1742 01:26:23.159 --> 01:26:26.239 Right in twenty nineteen, it was an idea that we 1743 01:26:26.359 --> 01:26:29.560 had just got the result in mice, and I divulged 1744 01:26:29.560 --> 01:26:32.840 that to the world, then it was published, and then 1745 01:26:33.000 --> 01:26:35.960 we're in humans now. So if it works, then you 1746 01:26:36.000 --> 01:26:36.640 know it's going to be a. 1747 01:26:36.640 --> 01:26:40.760 Very different world, and you're you feel very confidently that 1748 01:26:41.239 --> 01:26:42.760 some of this stuff is going to work. 1749 01:26:43.600 --> 01:26:46.079 Well, it's going to work. I don't know if this 1750 01:26:46.159 --> 01:26:48.720 trial is going to be successful, but there's going to 1751 01:26:48.760 --> 01:26:50.720 be a lot of people doing these trials. I have 1752 01:26:50.800 --> 01:26:54.520 some competition, now, do you know about that? No, So 1753 01:26:54.560 --> 01:26:57.279 since I started my company Life Biosciences, which is doing 1754 01:26:57.279 --> 01:27:00.680 the trials with ERA one hundred, others have John joined 1755 01:27:00.680 --> 01:27:04.720 in and the party so Jeff Bezos and others have 1756 01:27:04.800 --> 01:27:09.760 started Alto's Farmer. They are based in three cities around 1757 01:27:09.800 --> 01:27:12.199 the world. They have a few billion dollars to catch up. 1758 01:27:13.800 --> 01:27:19.680 Sam Oltman has retro bio, and let's see Brian Armstrong 1759 01:27:19.720 --> 01:27:23.039 from Coinbase, the CEO, started one called New Limit and 1760 01:27:23.079 --> 01:27:25.880 they've got a lot of money, old billions. 1761 01:27:27.239 --> 01:27:28.800 Do you think it's good that there's all these people 1762 01:27:28.800 --> 01:27:29.279 involved in this. 1763 01:27:29.399 --> 01:27:30.039 Ill's good? 1764 01:27:30.079 --> 01:27:31.600 Yeah? Competition, yeah, yeah. 1765 01:27:31.640 --> 01:27:34.439 I'm not doing this for my own personal benefit. I 1766 01:27:34.479 --> 01:27:36.600 want humanity to be changed the way it could be. 1767 01:27:37.199 --> 01:27:39.640 And the more people like Jeff Bezos, the more people 1768 01:27:39.640 --> 01:27:41.720 with a large bank account that are invested in this, 1769 01:27:41.840 --> 01:27:44.199 the better fantastic. And of course a guy like Bezos, 1770 01:27:44.199 --> 01:27:45.800 he's balling out of control. Why wouldn't you want to 1771 01:27:45.800 --> 01:27:46.239 live forever? 1772 01:27:46.840 --> 01:27:48.520 Well, what's left if you've got everything else? 1773 01:27:48.600 --> 01:27:51.560 You know? Well, also it's like it's like if you've 1774 01:27:51.600 --> 01:27:54.119 got the amount of money that he has and you 1775 01:27:54.159 --> 01:27:56.359 can tackle all these different issues, you know, like his 1776 01:27:56.399 --> 01:27:59.039 space program that he's working on, all these different things 1777 01:27:59.039 --> 01:28:01.119 Like of course, why would you want to do cool things? 1778 01:28:01.399 --> 01:28:03.560 Like what's cooler than being able to grow limbs? 1779 01:28:04.000 --> 01:28:04.199 Yeah? 1780 01:28:04.239 --> 01:28:06.279 Yeah, you know what's cooler than being able to cure 1781 01:28:06.399 --> 01:28:08.399 all diseases and reverse aging? 1782 01:28:08.680 --> 01:28:11.439 Well there's I don't think there's much cooler that. That's 1783 01:28:11.439 --> 01:28:13.159 why I'm doing it, because that I think can be 1784 01:28:13.199 --> 01:28:15.840 the biggest gift to humanity is what you just said. 1785 01:28:16.279 --> 01:28:18.279 So I don't know if I'll achieve it, probably not 1786 01:28:18.359 --> 01:28:20.640 in my lifetime, but at least I've moved the needl 1787 01:28:20.680 --> 01:28:23.079 and pushed the ball globally in that direction. 1788 01:28:24.399 --> 01:28:25.720 I wonder if we're going to get to a point 1789 01:28:25.720 --> 01:28:29.880 in time where we can engineer consciousness in terms of 1790 01:28:29.960 --> 01:28:33.359 like find out like you find out someone's a sociopath, 1791 01:28:33.439 --> 01:28:37.520 You find out someone's a kleptomaniac or someone's an arsonist, 1792 01:28:37.640 --> 01:28:40.880 like whatever it is. Like if you could figure out 1793 01:28:40.920 --> 01:28:43.880 like what these little flaws are in the way the 1794 01:28:43.920 --> 01:28:47.520 mind works, if you can completely map it out and go, oh, 1795 01:28:48.199 --> 01:28:50.880 this is the error. This is where you're not making 1796 01:28:50.880 --> 01:28:52.039 these two connections. 1797 01:28:51.640 --> 01:28:54.640 Of course, they'll just biology and engineering. There's nothing that 1798 01:28:54.680 --> 01:28:57.319 stops us. And this is the century that we are 1799 01:28:57.359 --> 01:29:02.000 able to control our own biology, starting with cancer, heart disease, 1800 01:29:02.199 --> 01:29:02.720 and aging. 1801 01:29:03.720 --> 01:29:07.560 A true utopian world of peaceful people. We peace harmony, but. 1802 01:29:07.640 --> 01:29:10.960 Healthy, not peaceful. I don't think world peace. I think 1803 01:29:11.000 --> 01:29:12.760 curing aging is easier than world peace. 1804 01:29:13.239 --> 01:29:17.720 Well if everybody achieved a state of consciousness that allowed 1805 01:29:17.760 --> 01:29:19.680 them to understand that we're all in this together. 1806 01:29:21.199 --> 01:29:22.079 Yeah, how do we do that? 1807 01:29:22.680 --> 01:29:23.680 Mushrooms? Yeah? 1808 01:29:24.840 --> 01:29:27.479 Yeah, Well there are certain companies working on this. 1809 01:29:27.760 --> 01:29:30.680 I know. That's what's interesting, right, Like Eli Lilly is 1810 01:29:30.720 --> 01:29:34.680 involved in pharmaceuticals. Well, the pharmaceutical company rather is involved 1811 01:29:34.720 --> 01:29:35.479 in psychledelics. 1812 01:29:35.560 --> 01:29:37.600 They just bought a tie I think it was like. 1813 01:29:37.600 --> 01:29:39.880 Three point eight billion dollars, so they're all in with 1814 01:29:40.000 --> 01:29:42.239 real capital. Yeah. I love it. 1815 01:29:42.359 --> 01:29:44.560 Yeah me too, that's great. I love that they're doing that. 1816 01:29:44.600 --> 01:29:46.800 We need more of that. There's too much depression on 1817 01:29:47.079 --> 01:29:47.680 anxiety in. 1818 01:29:47.680 --> 01:29:50.600 The world and drug addiction. I mean, that's why I 1819 01:29:50.680 --> 01:29:53.199 went to the White House and got the President to 1820 01:29:53.560 --> 01:29:56.520 get involved in this executive order on fiber gain. Yes, 1821 01:29:56.800 --> 01:30:00.119 because I've talked to so many people that have I've 1822 01:30:00.159 --> 01:30:03.520 had their life completely turned around with IBA gain, so 1823 01:30:03.600 --> 01:30:07.800 many people that were opioid addiction and also brain injuries. 1824 01:30:08.000 --> 01:30:13.079 Oddly enough, brain injuries, all sorts of TBI and CTE 1825 01:30:13.680 --> 01:30:19.399 that they've had like phenomenal results from this ebogatry, you know, 1826 01:30:19.520 --> 01:30:22.520 which is so crazy that this thing had been around 1827 01:30:22.600 --> 01:30:25.720 for so long and is a schedule one substance in 1828 01:30:25.720 --> 01:30:29.359 the United States for no reason whatsoever. There's no risk 1829 01:30:29.399 --> 01:30:32.159 of addiction, there is no recreational use of it. It's 1830 01:30:32.159 --> 01:30:35.520 a horrible experience. I've not done it, but apparently it's 1831 01:30:35.560 --> 01:30:38.399 fucking terrible and it lasts for like twenty four hours. 1832 01:30:38.399 --> 01:30:41.039 Like no one's going to be doing that for funzis Well. 1833 01:30:41.039 --> 01:30:43.399 The question I think that comes up with all of 1834 01:30:43.399 --> 01:30:45.159 these drugs is do you have to have the trip 1835 01:30:45.680 --> 01:30:48.640 and experience the craziness to get the better to get 1836 01:30:48.680 --> 01:30:50.640 the benefit? And I don't think, so I think you 1837 01:30:50.640 --> 01:30:51.439 shoud be able to separate. 1838 01:30:51.479 --> 01:30:55.439 Well, you know they've actually figured this out with LSD. Yeah, right, 1839 01:30:55.720 --> 01:30:59.359 do you know about this? Okay, So they've engineered a 1840 01:30:59.439 --> 01:31:04.439 different version of LSD that doesn't give you the hallucinogenic effects, 1841 01:31:04.840 --> 01:31:08.159 but does give you the benefits in terms of like 1842 01:31:08.239 --> 01:31:09.399 the cognitive effects. 1843 01:31:09.640 --> 01:31:10.840 I tell you, guys or someone else. 1844 01:31:11.680 --> 01:31:14.720 I don't know what company has done this, so you 1845 01:31:14.720 --> 01:31:15.680 can find that, Jamy. 1846 01:31:15.720 --> 01:31:16.680 I think it might be a time. 1847 01:31:16.880 --> 01:31:19.439 But what they've they've essentially done, and I think it's 1848 01:31:19.600 --> 01:31:22.760 it's basically in the lab work stage right now. I 1849 01:31:22.760 --> 01:31:25.399 don't think that's applied to humans yet. But what they've 1850 01:31:25.439 --> 01:31:29.640 done is engineered a version of LSD that has all 1851 01:31:29.680 --> 01:31:34.720 the positive effects that LSD has in terms of like introspection, 1852 01:31:35.439 --> 01:31:38.920 being able to rethink and remap and reset the way 1853 01:31:38.960 --> 01:31:43.439 you view things, but without like watching people's face melt 1854 01:31:43.520 --> 01:31:46.359 and thinking the demons are eating you and all the 1855 01:31:46.399 --> 01:31:46.920 weird stuff. 1856 01:31:47.000 --> 01:31:50.840 Yeah, that comes outstanding. It should happen with psychedelics the 1857 01:31:50.880 --> 01:31:53.680 way it's happened with all medicines. Right. We start with yes, 1858 01:31:53.840 --> 01:31:55.880 something from the bark of a willow tree, and then 1859 01:31:55.920 --> 01:32:01.159 we have espirin, Right, not eating bark anymore, right, But. 1860 01:32:01.239 --> 01:32:03.399 Sometimes the bark is the really way the way to 1861 01:32:03.520 --> 01:32:07.239 go right. Unfortunately, sometimes that's the part of the problem 1862 01:32:07.319 --> 01:32:11.800 is these pharmaceutical drug companies they patent these natural compounds 1863 01:32:11.880 --> 01:32:17.000 and you know, use petroleum based synthetic methods of creating 1864 01:32:17.039 --> 01:32:20.680 these medications now that they can sell and profit wildly 1865 01:32:20.760 --> 01:32:23.279 off of, whereas really the best way to do it 1866 01:32:23.319 --> 01:32:24.439 is actually to get the plant. 1867 01:32:25.960 --> 01:32:28.319 It's true that there's the whole issue though that if 1868 01:32:28.359 --> 01:32:31.640 it's not approved, then it's the wild West. You don't 1869 01:32:31.640 --> 01:32:34.680 know what you're getting, right, That's true too. We need 1870 01:32:34.680 --> 01:32:36.640 a middle ground. We need something you can get faster 1871 01:32:36.840 --> 01:32:38.479 in the market that's known to be safe. 1872 01:32:38.800 --> 01:32:42.119 So what we're gonna need is mind reading, because we 1873 01:32:42.119 --> 01:32:44.319 need to know if people are full shit. That's we're 1874 01:32:44.319 --> 01:32:44.720 gonna need. 1875 01:32:44.720 --> 01:32:46.479 We're gonna need gotta work on that. 1876 01:32:46.640 --> 01:32:50.039 Yes, I think that's that's gonna change humanity more than anything. 1877 01:32:50.119 --> 01:32:51.720 I think you've got a good bullshit detector. 1878 01:32:52.079 --> 01:32:55.920 It's okay. There's a few people that have snuck through. Unfortunately, 1879 01:32:56.319 --> 01:32:58.279 you know some people they get through and they're like 1880 01:32:58.520 --> 01:33:01.279 it takes a while, and you're like, ah ah shit, they. 1881 01:33:01.279 --> 01:33:02.399 Ney have coming back on the show. 1882 01:33:02.880 --> 01:33:06.319 Yeah, well there's that. It's the show. You know, you 1883 01:33:06.720 --> 01:33:09.359 learn a lot from a person in about three hours. 1884 01:33:09.399 --> 01:33:11.920 You know, you can kind of after a while, you 1885 01:33:11.920 --> 01:33:14.560 can kind of see little things, and you have to 1886 01:33:14.600 --> 01:33:17.119 be forgiving, and you know, you have to be charitable. 1887 01:33:17.199 --> 01:33:20.439 And some people are just nervous and they mistate things, 1888 01:33:20.600 --> 01:33:24.000 or they exaggerate things, or they forget something, they get 1889 01:33:24.000 --> 01:33:27.680 it wrong. But then there's people that are just essentially 1890 01:33:27.720 --> 01:33:31.920 they really don't care about anybody but themselves. And some 1891 01:33:31.960 --> 01:33:34.239 of those people are really good at pretending to be people. 1892 01:33:34.680 --> 01:33:37.520 They're really good at pretending, you know, they're really good 1893 01:33:37.560 --> 01:33:40.640 at pretending to be like a normal person. Oh, here's 1894 01:33:40.640 --> 01:33:44.079 the LSG thing LSD thing. Roight researchers recently engineered an 1895 01:33:44.239 --> 01:33:48.520 LSD analog called how do you say plus minus JRT 1896 01:33:49.600 --> 01:33:52.640 that appears to keep many of the LSD's brain beneficial 1897 01:33:52.680 --> 01:33:56.800 and cognitive effects while dramatically reducing and possibly eliminating it's 1898 01:33:56.840 --> 01:34:00.640 a hallucinogenic trip in animal studies, so it's almost the 1899 01:34:00.640 --> 01:34:04.159 same molecule as LSD, but scientists swap the positions of 1900 01:34:04.279 --> 01:34:07.000 just two atoms in the structure. The subtle change makes 1901 01:34:07.079 --> 01:34:11.199 JRT bind more selectively to serotonin receptors in a way 1902 01:34:11.199 --> 01:34:14.600 that promotes neuroplasticity growth through a pair of synapses but 1903 01:34:14.720 --> 01:34:21.319 minimizes llucinogenic signaling. That is, that's incredible antidepressant. Look at 1904 01:34:21.319 --> 01:34:25.319 this strong antidepressant effects. That DOS is reported to be 1905 01:34:25.359 --> 01:34:29.479 around one hundred times more potent than ketabe in standard 1906 01:34:29.560 --> 01:34:35.000 rodent tests. Cognitive benefits, improved cognitive flexibility and performance in 1907 01:34:35.079 --> 01:34:40.119 tasks modeling the negative and cognitive symptoms of schizophrenia. Holy shit, 1908 01:34:40.960 --> 01:34:42.159 that's incredible. 1909 01:34:43.079 --> 01:34:44.479 When when and where do we get it? 1910 01:34:45.039 --> 01:34:49.520 Well, I think it's fairly recent UC Davis study. They 1911 01:34:49.600 --> 01:34:53.439 just developed it. Shout out to our AI sponsor, Perplexity 1912 01:34:53.439 --> 01:34:55.680 for providing us with this information. So this is again 1913 01:34:55.720 --> 01:34:58.159 I mean, like we could just get this information now 1914 01:34:58.159 --> 01:35:01.520 through AI. Like I mean this that AI for our 1915 01:35:01.560 --> 01:35:03.920 show has been gigantic. I mean just the ability to 1916 01:35:04.039 --> 01:35:07.319 just ask it a question instead of Google searching and 1917 01:35:07.399 --> 01:35:09.399 have to go through all these different fucking articles. What 1918 01:35:09.399 --> 01:35:12.039 does it say? What is that? Who's right? What's this one? 1919 01:35:12.159 --> 01:35:16.279 What's the website? You just ask AI and Perplexity just 1920 01:35:16.319 --> 01:35:20.560 gives us all the information. So proceedings from National Academy 1921 01:35:20.560 --> 01:35:23.840 of science research is that California of San Diego Davis 1922 01:35:24.399 --> 01:35:28.880 excuse me, University of California Davis reported the creation of 1923 01:35:28.960 --> 01:35:32.279 JRT chemically modified first of LSD. So this is like 1924 01:35:32.359 --> 01:35:39.359 what year, so twenty five, so last year. So it's exciting. 1925 01:35:40.439 --> 01:35:44.119 Yeah, you're right that the timeline at a minimum usually 1926 01:35:44.199 --> 01:35:47.000 takes that long. But that's exciting. At least the artiple 1927 01:35:47.079 --> 01:35:48.199 is there that you don't need to lose. 1928 01:35:48.279 --> 01:35:51.399 Well, how about for schizophrenia. Yeah, that's incredible thing. Yeah, 1929 01:35:51.439 --> 01:35:53.319 I mean that that is incredible because that is one 1930 01:35:53.319 --> 01:35:55.840 of the saddest things to watch somebody fall into the 1931 01:35:55.840 --> 01:35:57.000 grips of schizophrenia. 1932 01:35:57.239 --> 01:35:57.720 Yeah. 1933 01:35:57.800 --> 01:36:00.479 I've seen people fall in and come out, which is interesting. 1934 01:36:00.600 --> 01:36:03.520 Huh. I thought for the Bullshit Detective, we could have 1935 01:36:03.520 --> 01:36:06.479 an AI that either dings or has a green or 1936 01:36:06.479 --> 01:36:07.399 a red on your forehead. 1937 01:36:07.479 --> 01:36:10.319 I'm pretty good at it, but I think no one's 1938 01:36:10.359 --> 01:36:13.279 perfect at it. And I think ultimately, if we get 1939 01:36:13.279 --> 01:36:18.520 to a place, whether it's a technological innovation or what 1940 01:36:18.680 --> 01:36:21.640 have you, where we can actually read the contents of 1941 01:36:21.680 --> 01:36:25.439 someone's thoughts, I don't think that's outside the realm of possibility. 1942 01:36:26.920 --> 01:36:28.159 You'd need an implant, I think. 1943 01:36:28.159 --> 01:36:30.319 But Elon says, the neuralink is going to be able 1944 01:36:30.319 --> 01:36:31.079 to pull that off. 1945 01:36:31.439 --> 01:36:32.439 Yeah, well you're. 1946 01:36:32.319 --> 01:36:35.920 Going to be able to talk without using words like what. 1947 01:36:36.800 --> 01:36:39.600 I think he's right though. I think if we all 1948 01:36:39.720 --> 01:36:45.159 like lock into a hive mind, and then if we 1949 01:36:45.239 --> 01:36:52.560 develop like through AI, if we develop a universal language worldwide. 1950 01:36:51.279 --> 01:36:52.560 Well we already have that. 1951 01:36:53.159 --> 01:36:53.640 What do we have? 1952 01:36:54.199 --> 01:36:56.239 Well, the new headphones from a big company that I 1953 01:36:56.239 --> 01:36:58.239 won't name. You can translate. 1954 01:36:58.680 --> 01:37:02.119 Translate, yes, translate, but it's translating into English. If we 1955 01:37:02.239 --> 01:37:05.399 just all the problem with that is there's context, There's 1956 01:37:05.399 --> 01:37:08.760 all sorts of different things that other cultures, different languages. 1957 01:37:09.479 --> 01:37:12.880 When it's deciphered and changed and translated into English, you 1958 01:37:13.000 --> 01:37:16.000 lose a lot of the meaning and the context is weird. 1959 01:37:16.600 --> 01:37:19.119 If we develop a universal language. 1960 01:37:19.199 --> 01:37:22.960 That'd be ideal. English is a good substitute. I was shocked. 1961 01:37:23.359 --> 01:37:25.880 I'm always shocked traveling globally, how many people can just 1962 01:37:25.880 --> 01:37:26.880 speak English now. 1963 01:37:26.760 --> 01:37:30.000 Yeah, it's pretty amazing. It's because America rules you're welcome. 1964 01:37:31.159 --> 01:37:34.199 Well we have to thank Britain for that. America should 1965 01:37:34.199 --> 01:37:34.880 say you're welcome. 1966 01:37:35.119 --> 01:37:38.760 Yeah, they're they're cute. They did a good job starting out, 1967 01:37:38.760 --> 01:37:39.920 but we took the ball. 1968 01:37:39.800 --> 01:37:43.279 And that is so who's next? Cha? God? 1969 01:37:43.560 --> 01:37:45.239 No, I don't want to learn Chinese. It's too hard. 1970 01:37:45.479 --> 01:37:48.279 It's all the fucking characters. That's ridiculous. Even people that 1971 01:37:48.319 --> 01:37:51.439 I know they could speak Mandarin, they can't write it, 1972 01:37:51.199 --> 01:37:53.039 you know, to like to get to that level. I 1973 01:37:53.039 --> 01:37:56.119 have a couple friends that speak fluent Mandarin and they 1974 01:37:56.159 --> 01:37:58.119 can't write it writing. 1975 01:37:58.800 --> 01:38:00.760 Yeah, well that the students in my lab who come 1976 01:38:00.760 --> 01:38:04.800 from China, they're being picked on by the immigration, but 1977 01:38:04.880 --> 01:38:06.760 they don't want to go home. They love it. 1978 01:38:06.680 --> 01:38:08.840 Here, I'm sure because they're stealing all your secrets and 1979 01:38:08.960 --> 01:38:09.319 bring it back. 1980 01:38:09.359 --> 01:38:11.600 Then there's a lot of regulation on that now as 1981 01:38:11.600 --> 01:38:12.600 a scientist. 1982 01:38:12.439 --> 01:38:16.359 Oh yeah, oh I can imagine. Yeah, I'm into because 1983 01:38:16.359 --> 01:38:19.079 that is an actual, real threat exactly. So the people 1984 01:38:19.159 --> 01:38:21.920 that come through my lab have to be vetted now, right. 1985 01:38:21.920 --> 01:38:23.560 But the people that come over here and experience the 1986 01:38:23.640 --> 01:38:26.560 kind of freedom that you have in America, Oh yeah. 1987 01:38:26.279 --> 01:38:28.479 I came here from Australia. Australia is pretty free. But 1988 01:38:28.640 --> 01:38:32.079 compared to Australia, America is so different. I can't go back. 1989 01:38:33.239 --> 01:38:36.760 What's the big difference that I feel? I can do 1990 01:38:36.840 --> 01:38:39.119 anything I want if I just put my mind to it. 1991 01:38:39.560 --> 01:38:42.600 There's not social barriers, there's not monetary barriers, at least 1992 01:38:42.640 --> 01:38:45.359 for a white male like me who's got a degree. 1993 01:38:45.800 --> 01:38:48.119 I know it's not for everybody, but I feel like, 1994 01:38:48.279 --> 01:38:50.439 if I want to start a company, I've got a 1995 01:38:50.439 --> 01:38:53.199 great idea, I can do that here. Fat chance you'll 1996 01:38:53.199 --> 01:38:55.279 do that in Australia. People aren't willing to invest in 1997 01:38:55.319 --> 01:38:57.640 great ideas down there. Not often. 1998 01:38:58.479 --> 01:39:00.560 That's a bummer. Do you think they're change anytime? 1999 01:39:00.640 --> 01:39:04.640 Soone? No, US is so unique. There's a lot of 2000 01:39:04.640 --> 01:39:06.920 money flowing. People are willing to place a bet and 2001 01:39:06.960 --> 01:39:10.760 even lose the money. That's rare Australians. Most of the world, 2002 01:39:11.119 --> 01:39:13.279 if not all, people are scared to lose their money 2003 01:39:13.319 --> 01:39:16.039 if they have it. Here, it's like, Okay, I risked it. 2004 01:39:16.319 --> 01:39:18.920 I help the world. I feel good. It's a very 2005 01:39:18.960 --> 01:39:22.439 generous country, very and I love it here. It's when 2006 01:39:22.479 --> 01:39:24.159 I arrived here, I just feel I'm home. 2007 01:39:24.640 --> 01:39:26.319 I love hearing that from people that have come from 2008 01:39:26.319 --> 01:39:30.359 somewhere else because it kind of reaffirms why people in 2009 01:39:30.399 --> 01:39:34.359 America are so proud of what this country is should be. Yeah, 2010 01:39:34.399 --> 01:39:36.159 and that's why it bumps me out where people are 2011 01:39:36.159 --> 01:39:39.680 so mad at America in terms of I get looking 2012 01:39:39.680 --> 01:39:41.479 in terms of foreign policy and some of the things 2013 01:39:41.520 --> 01:39:44.399 that are wrong with America, but just in overall, this 2014 01:39:44.520 --> 01:39:46.880 experiment in self government is pretty remarkable. 2015 01:39:47.520 --> 01:39:50.359 Yeah, I watched the TV show was it? The American 2016 01:39:50.399 --> 01:39:54.359 Experiment came out for the anniversary fiftieth I. 2017 01:39:54.399 --> 01:39:55.039 Haven't seen it. 2018 01:39:55.159 --> 01:39:55.920 You got to see it? 2019 01:39:56.119 --> 01:39:56.880 Well, what's right? 2020 01:39:57.319 --> 01:40:00.279 It's the founding fathers and their lives and how they 2021 01:40:00.279 --> 01:40:02.960 were fighting and what was going on behind the scenes. 2022 01:40:03.640 --> 01:40:05.000 They were just young kids. They were in their. 2023 01:40:04.920 --> 01:40:06.680 Twenties, thirties, I know that nuts. 2024 01:40:06.760 --> 01:40:09.640 Yeah, just Benjamin Franklin was the old dude. But they 2025 01:40:09.680 --> 01:40:12.079 were so young. But they were they were in the 2026 01:40:12.079 --> 01:40:14.800 middle of it. They kind of realized they were making history. 2027 01:40:15.520 --> 01:40:18.720 But so many things could have gone wrong. We would 2028 01:40:18.720 --> 01:40:20.640 not have had the United States if just a few 2029 01:40:20.720 --> 01:40:22.000 votes went one way or the other. 2030 01:40:22.399 --> 01:40:26.600 A few wars, yeah, all. 2031 01:40:25.279 --> 01:40:28.520 The battles that exactly. The US was losing the war. 2032 01:40:28.520 --> 01:40:33.279 Agon's Britain badly. Yeah, the French. Yeah, yeah, we don't 2033 01:40:33.279 --> 01:40:34.079 think the French enough. 2034 01:40:34.119 --> 01:40:38.439 Actually, I know, right, somehow they became our enemy. Remember 2035 01:40:38.520 --> 01:40:42.039 during the Gulf War, they turned French fries into freedom 2036 01:40:42.039 --> 01:40:43.520 fries because people hated the French. 2037 01:40:43.760 --> 01:40:47.680 Yeah, but everyone hates the French because they're so arrogant. Sorry, French. 2038 01:40:48.000 --> 01:40:50.039 I have some friends who are good friends who are French. 2039 01:40:50.079 --> 01:40:52.119 I think generally when people are arrogant, it's because they 2040 01:40:52.159 --> 01:40:53.239 did something fucking awesome. 2041 01:40:54.359 --> 01:40:57.359 Well, in the eighteen hundreds they did they conquered Europe. 2042 01:40:58.920 --> 01:41:00.000 I'm not sure if that's awesome. 2043 01:41:00.159 --> 01:41:01.800 Here's a fun perplexia search I just did. 2044 01:41:01.800 --> 01:41:03.840 I said to Americans have a risk gene. 2045 01:41:04.560 --> 01:41:07.239 A risk gene. Yeah. One of the best studied variants 2046 01:41:07.279 --> 01:41:11.039 in the dopamine perceptor gene d r D four, specifically 2047 01:41:11.039 --> 01:41:14.960 the seven repeat seven R version. It's associated in some 2048 01:41:15.039 --> 01:41:19.720 studies with novelty seeking, impulsivity, and higher financial or social 2049 01:41:19.800 --> 01:41:22.960 risk taking. I wonder if I have that gene for sure? 2050 01:41:23.119 --> 01:41:27.520 This seven probably not? Who knows. The seven R variant 2051 01:41:27.600 --> 01:41:31.439 is unevenly distributed around the world. It's populations in populations 2052 01:41:31.479 --> 01:41:33.319 across the America, as it shows up in roughly forty 2053 01:41:33.319 --> 01:41:36.119 eight percent of chromosons studied, while in East Asia it's 2054 01:41:36.159 --> 01:41:41.399 found in only about two percent. Wow, WHOA, that's crazy. 2055 01:41:41.560 --> 01:41:42.920 It'll come down to genetics. 2056 01:41:43.119 --> 01:41:45.680 Evolutionary work suggest it became more common in groups that 2057 01:41:45.800 --> 01:41:50.359 migrated further after leaving Africa, and those lineages are strongly 2058 01:41:50.439 --> 01:41:55.479 represented in the Americas today. That that actually makes thinking 2059 01:41:55.560 --> 01:41:57.560 of the people that you have the balls to fucking 2060 01:41:57.600 --> 01:42:00.319 come here. Yeah, were your balls. You don't have to 2061 01:42:00.319 --> 01:42:03.079 do that much, but you can still have balls to gamble, 2062 01:42:03.119 --> 01:42:04.479 And yes. 2063 01:42:05.000 --> 01:42:07.039 That must be a but then Australian should have it. 2064 01:42:07.279 --> 01:42:10.000 That completely meant well sort of, you guys got forced there, 2065 01:42:10.319 --> 01:42:12.800 like they moved everybody over there because they were criminals. 2066 01:42:12.960 --> 01:42:16.439 Right, this this d d R gene that you just 2067 01:42:16.479 --> 01:42:19.439 sawt that was a d R four. I know a 2068 01:42:19.439 --> 01:42:21.680 bit about it because I'm writing it in my next book, 2069 01:42:22.119 --> 01:42:24.720 d R D four, Thanks Jamie. I call this the 2070 01:42:24.840 --> 01:42:27.399 f U gene because I'm trying to figure out what 2071 01:42:27.520 --> 01:42:31.079 makes humans special over other animals, and this is one 2072 01:42:31.079 --> 01:42:36.279 of them that we are seekers of explorers, and it's 2073 01:42:36.319 --> 01:42:38.239 it turns out it turns out that this gene is 2074 01:42:38.279 --> 01:42:42.960 turned on in teenagers. It gets eventually switched off, not totally, 2075 01:42:43.159 --> 01:42:46.319 but that might be why teenagers say f you to 2076 01:42:46.359 --> 01:42:49.079 their parents. But it's a way genetically to get them 2077 01:42:49.079 --> 01:42:51.840 out of the nest, like, oh, I can't stand these parents. 2078 01:42:51.880 --> 01:42:54.479 They suck. They're idiots. I'm out of here. That's in 2079 01:42:54.520 --> 01:42:55.880 this in this gene. 2080 01:42:57.720 --> 01:43:03.000 Well, it's also I, as a parent, have been very 2081 01:43:03.159 --> 01:43:06.279 aware of not doing that to my kids, like not 2082 01:43:06.399 --> 01:43:08.479 forcing them into something that they don't want to do, 2083 01:43:09.279 --> 01:43:12.600 or pushing them in any general direction, but rather encouraging 2084 01:43:12.640 --> 01:43:16.159 them to seek out their interests and encouraging them to 2085 01:43:16.279 --> 01:43:19.119 just like take chances. And if I ever correct them, 2086 01:43:19.239 --> 01:43:21.560 if I ever get upset about something, one of the 2087 01:43:21.600 --> 01:43:23.560 first things that I tell them is, I've done all 2088 01:43:23.800 --> 01:43:27.279 everything that you've done. I've made every mistake, I've fucked up. 2089 01:43:27.960 --> 01:43:31.399 You're smarter than me. I've fucked up everything. I've lied 2090 01:43:31.479 --> 01:43:35.319 to my parents, I lied to teachers. I've done everything 2091 01:43:35.520 --> 01:43:38.000 that you're doing. So it's this is not a unique thing. 2092 01:43:38.039 --> 01:43:40.920 I'm just telling you from my own personal experience, in 2093 01:43:41.039 --> 01:43:44.079 my perspective. This is why I think because I love 2094 01:43:44.119 --> 01:43:45.640 you and I want you to do well in life, 2095 01:43:45.680 --> 01:43:48.439 and I just want you to recognize this. And that's 2096 01:43:48.479 --> 01:43:52.319 how I correct my kids. It's never like you listen 2097 01:43:52.319 --> 01:43:53.239 to me because I'm your father. 2098 01:43:54.000 --> 01:43:57.199 Yeah, yeah, the old way we will raise it doesn't work. 2099 01:43:57.159 --> 01:44:00.800 No, and it makes you resentment, but also probably makes 2100 01:44:00.840 --> 01:44:03.159 you want to do better than your parents, So like 2101 01:44:03.239 --> 01:44:05.600 motivates you in a certain way. Like my parents were 2102 01:44:05.640 --> 01:44:08.880 not risk takers at all, and my whole life I've 2103 01:44:08.920 --> 01:44:10.199 been like a wild risk taker. 2104 01:44:10.239 --> 01:44:12.960 That's really same. Yeah, I was resentful that my father 2105 01:44:13.039 --> 01:44:16.279 didn't have enough ambition. Now he's a great guy. We're 2106 01:44:16.319 --> 01:44:18.880 best friends. Actually it's been the greatest thing for me. 2107 01:44:19.359 --> 01:44:20.880 But one of the things I did with my kids 2108 01:44:20.880 --> 01:44:24.439 you reminded me is he's nineteen. He's a well built guy. 2109 01:44:24.439 --> 01:44:26.199 Because we were going to the gym for a number 2110 01:44:26.239 --> 01:44:29.439 of years. I've tried to train him in health, but 2111 01:44:29.520 --> 01:44:32.319 he spent the summer with me. He's literally still working 2112 01:44:32.319 --> 01:44:35.039 for me this summer to help with the podcast in 2113 01:44:35.119 --> 01:44:38.359 the magazine we're about to launch. And Benjamin's his name. 2114 01:44:38.439 --> 01:44:41.680 He's the best kid. But he slacked off. He was like, 2115 01:44:42.119 --> 01:44:43.760 ben I put you in charge of social media. You 2116 01:44:43.760 --> 01:44:46.520 haven't posted in a week. What's going on? Well, you know, 2117 01:44:46.560 --> 01:44:48.319 I slept in blah blah. So I had to think, 2118 01:44:48.359 --> 01:44:50.039 am I gonna get mad at him like I would 2119 01:44:50.039 --> 01:44:53.359 a normal employee, or do I treat him differently? And 2120 01:44:53.399 --> 01:44:56.960 I decided to treat him differently, probably because he's my son. 2121 01:44:57.000 --> 01:44:59.640 But I didn't want to rule the relationship. But what 2122 01:44:59.680 --> 01:45:04.279 I did, as I said, you know, I really think 2123 01:45:04.319 --> 01:45:07.520 you can do better. I think everything you've done, the weightlifting, 2124 01:45:07.640 --> 01:45:13.039 the calculus, you're amazing, but in this you're not. So 2125 01:45:13.119 --> 01:45:16.920 what's going on? And it worked. We become closer. He's 2126 01:45:17.039 --> 01:45:19.000 really into it, he's doing a good job. 2127 01:45:19.039 --> 01:45:19.600 That's great. 2128 01:45:19.920 --> 01:45:21.279 So that's the way to do it. I think you 2129 01:45:21.319 --> 01:45:24.000 can't be too hot on them and say you've fucked up. 2130 01:45:24.199 --> 01:45:26.880 Yeah, I mean, that kind of can work, but it's 2131 01:45:26.880 --> 01:45:30.319 a blunt instrument, and it doesn't work on everybody, and 2132 01:45:30.359 --> 01:45:34.680 it also develops resentment, and they also they miss out 2133 01:45:34.840 --> 01:45:40.279 on experiencing your perspective as a like for them to 2134 01:45:40.359 --> 01:45:43.159 understand that you are just a person who's lived longer 2135 01:45:43.159 --> 01:45:47.359 than them and that you can help them navigate this road. 2136 01:45:47.439 --> 01:45:49.439 Yeah, so you don't have to make the stay same mistakes. 2137 01:45:49.479 --> 01:45:54.279 Yeah, And that's why you're helping them. You're talking to 2138 01:45:54.359 --> 01:45:58.199 them about this, not because you're just a mean dad 2139 01:45:58.239 --> 01:45:59.960 who likes to fucking tell the kids what to do. 2140 01:46:00.079 --> 01:46:02.600 Because we've all experienced that. I mean I had friends 2141 01:46:02.600 --> 01:46:04.720 grown up as fathers will fucking scream at them and 2142 01:46:04.800 --> 01:46:09.479 throw things and beat them and it's like God, and 2143 01:46:09.479 --> 01:46:13.479 then you just grow up fucking traumatized and always resentful 2144 01:46:13.520 --> 01:46:18.720 and angry instead of just recognizing that, like, oh, I'm 2145 01:46:18.760 --> 01:46:23.079 so fortunate that my parents have this perspective where they 2146 01:46:23.119 --> 01:46:26.279 can explain to me why I'm going through what I'm 2147 01:46:26.319 --> 01:46:29.199 going through and how they got through it. 2148 01:46:28.760 --> 01:46:31.760 Like a mentor. You're not the best friend, you're the mentor. Yes, 2149 01:46:31.960 --> 01:46:33.239 my best friend doesn't work either. 2150 01:46:33.760 --> 01:46:36.319 No, that doesn't work either, because that just allows too 2151 01:46:36.399 --> 01:46:38.640 much shenanigans. You know, you have to have some rules, 2152 01:46:38.800 --> 01:46:41.399 you know, you have to have some some sort of regulations, 2153 01:46:41.920 --> 01:46:42.720 but you also. 2154 01:46:42.600 --> 01:46:45.119 Kids turned out, Well, what's that? How do your kids turn? 2155 01:46:46.239 --> 01:46:49.479 I'm so so lucky, so fucking lucky. I mean, I 2156 01:46:49.880 --> 01:46:53.560 feel so fortunate. They're so smart and ambitious and driven 2157 01:46:53.640 --> 01:46:55.920 and so it's wild. It's wild to watch, you know, 2158 01:46:56.000 --> 01:47:00.800 and talented. And it's and also like we never went 2159 01:47:00.840 --> 01:47:04.520 through that period where they hit teenage yeers and they 2160 01:47:04.520 --> 01:47:09.159 hate you like that. God, that's so nice for you. 2161 01:47:09.359 --> 01:47:11.640 I mean, my youngest she get upset at me sometimes 2162 01:47:11.680 --> 01:47:14.479 about certain things, but she bounces back quickly. It's never 2163 01:47:14.720 --> 01:47:18.279 like some kids where they just grow to hate their parents, like. 2164 01:47:18.680 --> 01:47:21.760 Forgen maybe they don't have strong one. 2165 01:47:21.880 --> 01:47:24.800 I don't know about that. I think it's how you 2166 01:47:24.880 --> 01:47:27.640 communicate with them. I really do. I think that's a 2167 01:47:27.640 --> 01:47:30.520 big factor. You have to communicate with them like you 2168 01:47:31.000 --> 01:47:35.199 truly care about their development. And the most important thing. 2169 01:47:35.319 --> 01:47:37.640 I think. The most important thing I think is that 2170 01:47:37.720 --> 01:47:41.079 I always tell them, whatever you've done, whatever mistake you've made, 2171 01:47:41.119 --> 01:47:43.399 I made way worse mistakes. I was like, I am 2172 01:47:43.439 --> 01:47:46.760 not coming at you from a flawless person. You know, 2173 01:47:46.800 --> 01:47:49.039 I'm not coming at you from the perspective of someone 2174 01:47:49.159 --> 01:47:52.479 who like you're an idiot. I figure that out. You 2175 01:47:52.520 --> 01:47:56.039 should figure it out. Like no. I whenever they from 2176 01:47:56.039 --> 01:47:58.239 the time they were really little, anytime I had to 2177 01:47:58.239 --> 01:48:02.319 correct them, I said, I did everything that you're doing everything. 2178 01:48:03.479 --> 01:48:05.319 I threw my food on the floor too. 2179 01:48:05.600 --> 01:48:09.600 Yes, all the above, every whatever fucking stupid thing you've 2180 01:48:09.640 --> 01:48:11.199 done as a kid. I guarantee you. 2181 01:48:11.159 --> 01:48:14.720 That is great advice, really great advice. So I hope 2182 01:48:14.720 --> 01:48:17.720 everyone listening heres that because I actually had to learn 2183 01:48:17.720 --> 01:48:19.840 the hard way my first kid. I did what my 2184 01:48:19.840 --> 01:48:22.960 parents did, which was you can't say that. Yeah, and 2185 01:48:23.239 --> 01:48:25.640 my first is a lot more rebellious and distant than 2186 01:48:25.840 --> 01:48:26.279 my third. 2187 01:48:26.640 --> 01:48:27.560 That is interesting. 2188 01:48:27.800 --> 01:48:29.920 Yeah, it actually is really true. I've seen it. 2189 01:48:30.199 --> 01:48:32.319 Yeah, and I thought I was going to kill their motivation, 2190 01:48:32.439 --> 01:48:35.159 but it doesn't at all. Well, I thought, like, you know, 2191 01:48:35.319 --> 01:48:38.039 making things easy for them and not being strict, Like 2192 01:48:38.119 --> 01:48:40.039 maybe it's good to be strict because then you just 2193 01:48:40.079 --> 01:48:43.479 have this determination. I'll show everybody. I don't think that 2194 01:48:43.640 --> 01:48:46.840 was my thing as a child, like I'll fucking show you. 2195 01:48:47.239 --> 01:48:50.079 But I don't think everybody needs that. I think you're 2196 01:48:50.199 --> 01:48:55.119 much better off having a healthy relationship with ambition, where 2197 01:48:55.119 --> 01:48:58.119 you're excited about things because you're passionate about them, and 2198 01:48:58.159 --> 01:49:04.600 you find great reward in being creative or being enthusiastic 2199 01:49:04.600 --> 01:49:06.439 about something exactly. 2200 01:49:06.039 --> 01:49:08.800 And open their eyes to the world that exists. Yes, 2201 01:49:09.600 --> 01:49:11.359 we used to do work experience. You go and do 2202 01:49:11.439 --> 01:49:13.680 a job and that's your work experience. The reason I 2203 01:49:13.760 --> 01:49:15.439 wanted my son Ben to work with me is he 2204 01:49:15.479 --> 01:49:17.279 can see how what it's like to be an entrepreneur 2205 01:49:17.399 --> 01:49:20.960 and build something and be excited and work is super fun. 2206 01:49:22.800 --> 01:49:24.920 I think a lot of kids just don't get that experience. 2207 01:49:24.960 --> 01:49:27.520 They don't know what's possible, right, and just showing them 2208 01:49:27.560 --> 01:49:29.720 the world is what we can do as parents. 2209 01:49:29.920 --> 01:49:34.640 That's awesome. Yeah, and you know. I mean, some people 2210 01:49:34.680 --> 01:49:37.359 don't have that at home unfortunately. But that's one of 2211 01:49:37.359 --> 01:49:39.640 the cool things about the world that we live in 2212 01:49:40.119 --> 01:49:43.680 is that kids today have access to so many different 2213 01:49:43.760 --> 01:49:48.039 perspectives now because of the Internet. There's so many different 2214 01:49:48.159 --> 01:49:52.119 podcasts and YouTube conversations and different things where they can 2215 01:49:52.560 --> 01:49:55.479 just take a little tool from that, just take a 2216 01:49:55.520 --> 01:49:57.680 little peace from that and apply it to the way 2217 01:49:57.720 --> 01:49:59.239 they interact with the world. 2218 01:50:01.640 --> 01:50:04.920 For sure. And I would encourage parents to give their 2219 01:50:05.000 --> 01:50:08.319 kids stuff to read. And we talked about social media, 2220 01:50:08.359 --> 01:50:11.640 how that's just addictive. I saw how my kids wanted 2221 01:50:11.680 --> 01:50:14.840 to just scroll through their phones then read. And if 2222 01:50:14.840 --> 01:50:17.159 they can't read a book, give them a magazine. I'd 2223 01:50:17.319 --> 01:50:22.000 subscribe to not Geo National Geographic for my kids, And 2224 01:50:22.039 --> 01:50:25.239 I think get them used to reading. It's going to 2225 01:50:25.319 --> 01:50:27.439 be a lost art if we don't know. 2226 01:50:27.560 --> 01:50:31.199 Isn't that nuts? I maybe read ten percent of the 2227 01:50:31.239 --> 01:50:34.760 things that I consume. I consume so much in audio 2228 01:50:35.720 --> 01:50:39.119 just for time reasons, because there's so much There's so 2229 01:50:39.199 --> 01:50:42.520 much time where I'm driving my car, or I'm working out, 2230 01:50:42.640 --> 01:50:45.800 or I'm in the sauna, or I'm in the hyperbaric chamber, 2231 01:50:46.039 --> 01:50:47.680 or I'm in the red light therapy. 2232 01:50:47.560 --> 01:50:48.560 That's reading three res. 2233 01:50:48.680 --> 01:50:52.640 It is similar, but I think it's only like seventy 2234 01:50:52.680 --> 01:50:55.239 percent of reading. I don't think it's one hundred percent. 2235 01:50:55.279 --> 01:50:56.880 I don't think you get the full effect. But it's 2236 01:50:56.880 --> 01:50:59.520 still way better than not doing it, you know. But 2237 01:50:59.640 --> 01:51:03.680 I'm I'm aware that like sitting there concentrating, actually reading 2238 01:51:03.680 --> 01:51:07.800 a book without hearing another person's voice talking, there's another mechanism, 2239 01:51:07.880 --> 01:51:11.119 there's another thing that's going on. That's it's a different 2240 01:51:11.119 --> 01:51:14.840 way you interact with the material, whether it's nonfiction or fiction. Yeah. 2241 01:51:15.119 --> 01:51:16.840 I like the fact that I can listen to you 2242 01:51:16.880 --> 01:51:18.880 and I'm doing something else. I have to sit down, 2243 01:51:19.359 --> 01:51:20.600 can move, go for a walk. 2244 01:51:20.800 --> 01:51:24.199 Yeah, that's for me. It's it's just I'm I have 2245 01:51:24.279 --> 01:51:26.760 too many interests. I have way too many things that 2246 01:51:26.800 --> 01:51:29.039 I do, and so it's very hard for me to 2247 01:51:29.159 --> 01:51:31.640 just allocate a certain amount of time to sit there 2248 01:51:31.680 --> 01:51:33.039 in silence and read. Yeah. 2249 01:51:33.079 --> 01:51:35.039 I use reading to fall asleep. That's a good way. 2250 01:51:35.479 --> 01:51:37.479 It does do that, right, It's kind of nuts how 2251 01:51:37.520 --> 01:51:38.159 well it does that. 2252 01:51:38.520 --> 01:51:41.119 Yeah, although I'm finding it's harder to read now that 2253 01:51:41.399 --> 01:51:46.319 my eyes on young need some of my gen I've 2254 01:51:46.479 --> 01:51:47.680 tried that. Does it work? 2255 01:51:47.720 --> 01:51:51.359 For you. Oh yeah, Oh, I mean people are skeptical 2256 01:51:51.520 --> 01:51:53.720 about this and they think I'm full of shit. No, 2257 01:51:53.960 --> 01:51:57.840 I don't need reading glasses anymore. Really, yes, I had 2258 01:51:57.920 --> 01:52:00.399 reading I always have these fucking things laying around. I 2259 01:52:00.399 --> 01:52:01.399 don't even use them anymore. 2260 01:52:01.399 --> 01:52:03.079 It's awesome. Yeah, there's a lot of signs now. 2261 01:52:03.239 --> 01:52:06.520 The red light it's real. I can tell you as 2262 01:52:06.520 --> 01:52:10.600 a regular user for multiple years. It took a while. 2263 01:52:11.239 --> 01:52:13.119 It took like I was waiting for it in the beginning, 2264 01:52:13.279 --> 01:52:15.479 like what the fuck In fact, and not only that, 2265 01:52:15.680 --> 01:52:18.239 in the beginning, because I don't close my eyes in 2266 01:52:18.279 --> 01:52:21.039 the red light bed, I thought it was making things blurrier. 2267 01:52:21.359 --> 01:52:23.000 I was like, oh my god, am I fucking up 2268 01:52:23.039 --> 01:52:26.880 my eyesight like listening to these assholes? But no, it 2269 01:52:27.039 --> 01:52:29.880 just took a while, and then over the course of 2270 01:52:30.000 --> 01:52:33.800 like many months, I started seeing some small improvements, and 2271 01:52:33.840 --> 01:52:36.720 then I started seeing some pretty big improvements over the 2272 01:52:36.760 --> 01:52:40.960 course of about a year. Whereas now it's not My 2273 01:52:41.039 --> 01:52:43.680 eyes aren't perfect. They aren't like they were when I 2274 01:52:43.720 --> 01:52:46.159 was twenty, but they are way better than they were 2275 01:52:46.319 --> 01:52:47.600 when I was fifty. 2276 01:52:47.680 --> 01:52:48.960 Oh often did you have to do that? 2277 01:52:49.319 --> 01:52:51.680 I do it three times a week minimum. That's what 2278 01:52:51.720 --> 01:52:53.479 I try to do, but sometimes I'll do it five 2279 01:52:53.560 --> 01:52:55.399 days a week. Well, I just get in there and 2280 01:52:55.399 --> 01:52:57.439 it's twenty minutes. I lay in a light bed, close 2281 01:52:57.520 --> 01:53:00.800 my eyes, open my eyes whatever. It seems to work 2282 01:53:00.880 --> 01:53:03.279 on your vision, even if you wear a blindfold. 2283 01:53:03.680 --> 01:53:05.119 What about people that kind of a bed? 2284 01:53:05.199 --> 01:53:07.199 Can you get a little, Yes, you can get. Well, 2285 01:53:07.239 --> 01:53:11.119 there's a company called it's called Jewve right j u 2286 01:53:11.239 --> 01:53:13.760 u V is that the name of the company. They 2287 01:53:13.760 --> 01:53:15.640 were our sponsor at one point in time. That's how 2288 01:53:15.640 --> 01:53:19.479 I started it. They had it's just a light panel 2289 01:53:19.840 --> 01:53:23.960 that you stand in front of and that that works too. 2290 01:53:24.479 --> 01:53:27.199 That but this one, the one that I got a 2291 01:53:27.399 --> 01:53:33.279 red and near infrared light therapy devices juve joo vv 2292 01:53:34.039 --> 01:53:37.680 medical grade light therapy devices. I had one of those 2293 01:53:37.800 --> 01:53:41.960 and that's when I started seeing benefits. But the the 2294 01:53:42.000 --> 01:53:43.920 big one that I got, I got from Gary Breca 2295 01:53:44.199 --> 01:53:46.560 from his company, and it's it's a like a fucking 2296 01:53:46.560 --> 01:53:49.000 tanning bed and you lie in it. And that one's amazing. 2297 01:53:49.239 --> 01:53:51.560 But that's expensive. But I don't think you have to 2298 01:53:51.600 --> 01:53:54.640 have that for those kind of improvements. Also improves collagen 2299 01:53:54.760 --> 01:53:59.079 your skin, makes you look better and the but for me, 2300 01:53:59.399 --> 01:54:03.039 the most obvious and profound was the improvement in my vision? 2301 01:54:03.640 --> 01:54:06.199 Well, it makes sense. The signs behind red light wasn't 2302 01:54:06.239 --> 01:54:08.800 there ten years ago and people were questioning it. But 2303 01:54:08.880 --> 01:54:12.079 now we know if you shine certain wavelengths like near 2304 01:54:12.159 --> 01:54:15.960 infra red on cells the mitochondria, which are important for 2305 01:54:16.119 --> 01:54:19.760 reversing aging or slowing it get redd up. It's actually 2306 01:54:19.840 --> 01:54:24.239 related to viagra. Long story, but viagra and red light 2307 01:54:24.279 --> 01:54:27.239 if something is in common, and it does help mitochondria, 2308 01:54:27.479 --> 01:54:29.520 and that's very important for the eye, that mighty chondria 2309 01:54:29.520 --> 01:54:32.119 actually the most important in any part of your body. 2310 01:54:32.840 --> 01:54:35.600 The eye is the most important part. And part of 2311 01:54:35.600 --> 01:54:37.920 the reason we lose our vision is the mitochondria don't 2312 01:54:37.920 --> 01:54:38.840 make enough energy for. 2313 01:54:38.800 --> 01:54:41.600 The How come you haven't done red light therapy before. 2314 01:54:41.359 --> 01:54:46.039 Then, Well, I do, but not routinely. So I have 2315 01:54:46.079 --> 01:54:48.079 one of those bricks that I turn on while I'm 2316 01:54:48.119 --> 01:54:50.199 in the shower, and I have a red light cap 2317 01:54:50.239 --> 01:54:52.319 for my hair, which there's some evidence. 2318 01:54:54.359 --> 01:54:57.399 Alien what I do is I, yeah, it does. 2319 01:54:57.520 --> 01:54:59.359 It looks a little bit silly. I don't worri it 2320 01:54:59.399 --> 01:55:02.279 in public. I do lower it and I look at 2321 01:55:02.319 --> 01:55:03.960 it and it shines in my eyes and on my 2322 01:55:04.000 --> 01:55:06.199 face in the hopes that it might help you. 2323 01:55:06.319 --> 01:55:08.039 Yeah, they have one that you wear like doctor Doom, 2324 01:55:08.159 --> 01:55:10.680 like fits over your face and blast red light and 2325 01:55:10.720 --> 01:55:11.359 your whole face. 2326 01:55:11.479 --> 01:55:14.920 I definitely feel a bit weird afterwards, and I can 2327 01:55:14.960 --> 01:55:17.720 see speckles. But I think the science says that it 2328 01:55:17.720 --> 01:55:18.159 can help. 2329 01:55:18.640 --> 01:55:22.880 Well, all I know is my own anecdotal experience, and 2330 01:55:23.000 --> 01:55:25.840 for me, it has radically improved my vision. 2331 01:55:26.319 --> 01:55:27.039 That's a good tip. 2332 01:55:27.199 --> 01:55:31.840 Yeah, it stopped. It was my vision was degrading, like 2333 01:55:32.079 --> 01:55:35.039 it was. It was pretty odd. Like I first started 2334 01:55:35.119 --> 01:55:38.199 using like reading glasses like a one x like it 2335 01:55:38.239 --> 01:55:39.520 made it a little better. I'm like, oh, this a 2336 01:55:39.520 --> 01:55:41.439 little better, makes it clearer. And then I went to 2337 01:55:41.479 --> 01:55:44.680 two and then I was using two point five and 2338 01:55:44.800 --> 01:55:46.479 it made it better, but it was like, God, this 2339 01:55:46.520 --> 01:55:49.600 is annoying. And then if I would try to read 2340 01:55:49.640 --> 01:55:52.960 an email and I didn't have my reading glasses, I 2341 01:55:52.960 --> 01:55:57.039 couldn't read shit. Now crystal clear, Yeah, no problem at all. 2342 01:55:57.159 --> 01:55:59.720 Well, so my latest show is about the eye and 2343 01:55:59.720 --> 01:56:03.279 how to protect the eye's health, and so there's a 2344 01:56:03.279 --> 01:56:07.119 lot you can do, actually, supplements, red light, other things. 2345 01:56:07.800 --> 01:56:09.560 I take supplements for it too. I should mention that 2346 01:56:09.640 --> 01:56:12.880 I take No, I have no affiliation with these people 2347 01:56:12.960 --> 01:56:17.840 with pure encapsulations makes a supplement called macular support, and 2348 01:56:17.880 --> 01:56:20.600 I take that and it's a combination of lutine and 2349 01:56:20.640 --> 01:56:21.439 a few other things. 2350 01:56:21.880 --> 01:56:25.560 Yeah, there was a trial a while ago that showed 2351 01:56:25.600 --> 01:56:31.159 that taking xanthine and others as to xanthine, lute lutine, 2352 01:56:31.439 --> 01:56:33.800 they're good for the eye. So you can get products 2353 01:56:33.880 --> 01:56:34.079 like that. 2354 01:56:34.119 --> 01:56:34.680 Do you take it? 2355 01:56:35.279 --> 01:56:37.600 Not that brand, but yes, I take something similar. 2356 01:56:38.000 --> 01:56:39.039 And has it helped you at all? 2357 01:56:40.079 --> 01:56:41.680 I don't know. I haven't done an experiment. 2358 01:56:42.000 --> 01:56:44.039 Right, Well, if you weren't taking it, maybe you would 2359 01:56:44.079 --> 01:56:45.199 have more degeneration. 2360 01:56:45.560 --> 01:56:48.760 Yeah. Well, you know I've got neoperfect vision. I don't 2361 01:56:48.800 --> 01:56:52.520 need glasses, do you really? Yeah? Near perfect, neoperfect. I 2362 01:56:52.600 --> 01:56:54.119 mean I think low light. 2363 01:56:54.319 --> 01:56:56.600 Low light is with me. Yeah, where I'll go to 2364 01:56:56.600 --> 01:56:58.520 a restaurant with my kids and they can read the 2365 01:56:58.560 --> 01:57:01.600 menu and I'm like, that is so embarrassing. You can 2366 01:57:01.680 --> 01:57:04.239 read that? How do you read that? I can't read shit? 2367 01:57:05.000 --> 01:57:05.720 I don't know why? 2368 01:57:05.920 --> 01:57:06.279 Why? 2369 01:57:06.359 --> 01:57:09.359 Well, this is what I think. So we know from 2370 01:57:09.520 --> 01:57:12.840 my lab's work that the retina, because it has tens 2371 01:57:12.840 --> 01:57:16.479 of thousands of endings that pick up the light. As 2372 01:57:16.479 --> 01:57:19.920 you get older, those nerves lose their identity and they're 2373 01:57:19.960 --> 01:57:22.720 not working as well. And what we do is with 2374 01:57:22.840 --> 01:57:26.760 our therapy, we can restore those nerves back to being 2375 01:57:27.600 --> 01:57:32.760 functional nerves. And that's why mice and monkeys that lose 2376 01:57:32.800 --> 01:57:37.439 their retinal function get their perfect vision back again. We're 2377 01:57:37.479 --> 01:57:40.239 reminding those cells that have forgotten how to work. So 2378 01:57:40.279 --> 01:57:42.600 in your eye and my eye were twenty two months apart, 2379 01:57:43.199 --> 01:57:46.039 that those nerves, about half of them have forgotten how 2380 01:57:46.079 --> 01:57:48.479 to work properly. So we want to fix that and 2381 01:57:48.520 --> 01:57:50.119 go back to being young. It's not that our nerves 2382 01:57:50.159 --> 01:57:52.319 are gone. They're not dead. They're right there and we 2383 01:57:52.359 --> 01:57:54.680 can restore them. And that's going to be true for 2384 01:57:54.680 --> 01:57:56.720 a lot of organs, is that the cells are still there. 2385 01:57:57.279 --> 01:57:59.319 They just need to be reminded how to work again. 2386 01:58:00.000 --> 01:58:03.439 What are the potential negative consequences of this kind of 2387 01:58:03.479 --> 01:58:06.279 work when you sit up at night and you worry, 2388 01:58:06.680 --> 01:58:09.800 I hope it doesn't do this. Is it cancer? Is 2389 01:58:09.800 --> 01:58:11.279 that the big one? Yeah? 2390 01:58:11.479 --> 01:58:14.520 It's though we've done a lot of work to allay 2391 01:58:14.920 --> 01:58:17.960 real fears, it is possible that if we go too 2392 01:58:18.039 --> 01:58:21.840 young we can cause displasia, which is cells doing what 2393 01:58:21.880 --> 01:58:24.760 they shouldn't, or if they multiply and spread. That would 2394 01:58:24.760 --> 01:58:25.239 because if. 2395 01:58:25.199 --> 01:58:26.880 You make the cells too young, like what I was 2396 01:58:26.880 --> 01:58:28.960 saying before about, don't turn me into a baby. 2397 01:58:28.800 --> 01:58:31.079 Right, we don't want to go there. That's what Yamanaka 2398 01:58:31.079 --> 01:58:33.800 did and got the Nobell for it. But that's not 2399 01:58:33.880 --> 01:58:37.279 good here. But we never see our cells turn into 2400 01:58:37.319 --> 01:58:40.000 stem cells again, we can't. We had mice that we 2401 01:58:40.079 --> 01:58:43.399 left it, left the gene therapy on for twenty one 2402 01:58:43.439 --> 01:58:46.000 months in the eye and nineteen months in the whole 2403 01:58:46.000 --> 01:58:48.359 body of the animal, and if anything, they had less 2404 01:58:48.399 --> 01:58:51.840 tumors than the ones that didn't get treated. And we 2405 01:58:51.880 --> 01:58:55.119 actually know from a wonderful student in my lab and 2406 01:58:55.199 --> 01:58:57.840 a lot she's a PhD student. She found that when 2407 01:58:57.880 --> 01:59:00.600 you turn on these three same genes not in the 2408 01:59:00.600 --> 01:59:03.720 I but in cancer cells and tumors growing in mice, 2409 01:59:03.880 --> 01:59:07.000 human cancers growing in mice, they shrink. So we think 2410 01:59:07.039 --> 01:59:09.079 it might actually help for cancer as well, which was 2411 01:59:09.199 --> 01:59:09.960 a nice surprise. 2412 01:59:10.319 --> 01:59:12.520 Wow, that's incredible. 2413 01:59:12.520 --> 01:59:14.199 It makes sense. Right if you wake up a cancer 2414 01:59:14.199 --> 01:59:18.399 cell and it says, crap, I shouldn't be growing. I 2415 01:59:18.439 --> 01:59:23.000 should be a you know, a liver cell or something similar. 2416 01:59:24.039 --> 01:59:26.119 Now it kills itself. So we see that the cells 2417 01:59:26.159 --> 01:59:28.960 wake up, they realize what they were thirty years ago, 2418 01:59:29.239 --> 01:59:30.359 and then they killed themselves. 2419 01:59:32.159 --> 01:59:34.800 What is on the horizon in terms of like what 2420 01:59:34.840 --> 01:59:37.159 would you like to accomplish or would you like to 2421 01:59:37.239 --> 01:59:39.039 work on that you can't do currently? 2422 01:59:40.720 --> 01:59:43.439 Well, lots lots. You know, funding in my lab got 2423 01:59:43.920 --> 01:59:48.880 completely cut last year, and we've managed to survive through donations. 2424 01:59:49.720 --> 01:59:52.159 We while the funding get cut. Was it a USAID thing? 2425 01:59:52.399 --> 01:59:55.039 You remember there was a spat between Harvard and the 2426 01:59:55.079 --> 01:59:58.159 federal government. All of the funding to Harvard Medical School 2427 01:59:58.159 --> 01:59:58.520 got cut. 2428 01:59:58.640 --> 02:00:02.680 Was that during the time where the president was defending 2429 02:00:02.760 --> 02:00:05.760 those anti semitic comments on campuses? 2430 02:00:07.039 --> 02:00:10.319 Yeah, well allegedly. I'm not getting into the politics. 2431 02:00:10.319 --> 02:00:12.279 No, you need to get into politics. But during that 2432 02:00:12.359 --> 02:00:14.680 whole thing, Yeah, yeah. 2433 02:00:14.439 --> 02:00:17.720 So what I almost had to fire most of the 2434 02:00:17.760 --> 02:00:20.840 people in my lab during that episode was quite scary, 2435 02:00:20.880 --> 02:00:25.039 but I raised so now my lab survives on donations, 2436 02:00:25.399 --> 02:00:29.399 not on federal government money. Thank you, friends, thank you, 2437 02:00:29.439 --> 02:00:29.760 thank you. 2438 02:00:30.479 --> 02:00:33.760 Well, the thing is, you've accomplished enough where people are like, 2439 02:00:33.840 --> 02:00:36.359 I think he's onto something and I want to live forever. 2440 02:00:36.520 --> 02:00:38.960 Well, I'm lucky. Most scientists can't raise money like that. 2441 02:00:39.159 --> 02:00:41.800 So really, really, it's a blessing, and now I'm raising 2442 02:00:41.840 --> 02:00:46.319 money through a foundation to help other scientists survive. But yeah, 2443 02:00:46.359 --> 02:00:50.079 it's been a blessing. But your question was what do 2444 02:00:50.119 --> 02:00:52.119 I wish I could do? Yeah, I wish I could 2445 02:00:52.159 --> 02:00:55.600 go faster. I wish I could try multiple approaches so 2446 02:00:55.760 --> 02:00:58.600 we don't used to have one shot on goal. It's 2447 02:00:58.640 --> 02:01:01.520 going slower than I would want. With a big injection 2448 02:01:01.600 --> 02:01:03.199 of cash, we could do a lot of trials, a 2449 02:01:03.239 --> 02:01:05.039 lot of different tissues. We could do a whole body 2450 02:01:07.039 --> 02:01:07.960 rejuvenation as well. 2451 02:01:08.000 --> 02:01:09.920 Do you have a website where people can donate? 2452 02:01:11.960 --> 02:01:14.520 I do. It's lifespan dot com. 2453 02:01:14.760 --> 02:01:17.319 So if you go to lifespan dot com, there's a 2454 02:01:17.359 --> 02:01:17.880 link there. 2455 02:01:18.119 --> 02:01:20.640 Yeah, you can do it. A foundation and we're raising 2456 02:01:20.680 --> 02:01:22.000 money for this type of research. 2457 02:01:22.159 --> 02:01:23.840 Is it tax deductible. 2458 02:01:24.800 --> 02:01:28.079 Depends on how big the donation is. For ten dollars, 2459 02:01:28.159 --> 02:01:30.960 you get the new magazine that we're putting out and 2460 02:01:31.000 --> 02:01:34.079 you learn all about how to live longer building. I'm 2461 02:01:34.079 --> 02:01:36.640 hoping to build the world's largest longevity community of millions 2462 02:01:36.640 --> 02:01:39.520 of people who can learn how to really live longer 2463 02:01:39.760 --> 02:01:41.840 and build healthcare from the ground up because top down 2464 02:01:41.920 --> 02:01:44.960 from the government hasn't worked. Yeah. Actually, I have a 2465 02:01:45.000 --> 02:01:45.680 gift for you. 2466 02:01:46.359 --> 02:01:46.760 Where you are. 2467 02:01:47.239 --> 02:01:53.640 I made something for you that's unique. This is for you, Joe, 2468 02:01:53.800 --> 02:01:56.880 as a thanks it's all the support you've given me 2469 02:01:57.119 --> 02:01:58.359 and the science over the years. 2470 02:01:58.439 --> 02:02:03.199 First edition Lifespan Magazine. Ladies and gentlemen, look at that. 2471 02:02:03.760 --> 02:02:04.880 It's written by scientists. 2472 02:02:05.000 --> 02:02:07.680 So it's cover. It's like a velvet cover. What is this? 2473 02:02:07.960 --> 02:02:10.600 I figured it might like that. Inside is the magazine? 2474 02:02:10.880 --> 02:02:11.680 Is this material? 2475 02:02:11.880 --> 02:02:16.479 It's beautiful lure of course, a great expense. No, the 2476 02:02:16.520 --> 02:02:19.000 magazine doesn't come with the lore. That's just special for Joe. 2477 02:02:19.640 --> 02:02:22.399 As a thank you, President, Thank you very much. 2478 02:02:22.560 --> 02:02:25.640 Most most science out there is written by reporters who 2479 02:02:25.640 --> 02:02:28.840 don't know what they're talking about, and so we want 2480 02:02:29.119 --> 02:02:31.560 we wrote this for the public and you can believe 2481 02:02:31.560 --> 02:02:32.359 whatever you read. 2482 02:02:32.159 --> 02:02:35.960 In there, all right beautiful and so you have to 2483 02:02:36.000 --> 02:02:36.399 trust it. 2484 02:02:36.479 --> 02:02:39.520 So that's at lifespan dot com. You can subscribe get 2485 02:02:39.520 --> 02:02:41.319 that every month just for ten bucks. 2486 02:02:41.399 --> 02:02:44.000 I like to take at the bottom, life's too short. 2487 02:02:44.119 --> 02:02:45.359 Let's fix that. 2488 02:02:45.359 --> 02:02:46.119 That's our slogan. 2489 02:02:46.439 --> 02:02:49.640 That's Lifespan slogan. Yeah, it's an awesome slogan. 2490 02:02:50.039 --> 02:02:52.720 So it's it's a it's a community, it's the show 2491 02:02:53.000 --> 02:02:55.520 my show is also called Lifespan on YouTube. But the 2492 02:02:55.560 --> 02:02:57.960 magazine is a passion project. I want to put out 2493 02:02:57.960 --> 02:03:02.439 something that people love. It's beautiful, right, It's like National 2494 02:03:02.439 --> 02:03:07.279 Geographic by the way, just today, This is no joke. 2495 02:03:07.319 --> 02:03:10.800 It seems crazy, but my labs research is on the 2496 02:03:10.800 --> 02:03:12.000 cover of National Geographic. 2497 02:03:12.279 --> 02:03:13.000 Oh that's awesome. 2498 02:03:13.039 --> 02:03:15.760 That just came out today. They heard, by the way, 2499 02:03:16.000 --> 02:03:18.560 at that geo. They said, you're going on Joe Rogan. 2500 02:03:18.600 --> 02:03:20.039 I went yeah, they goes, all right, we'll put it 2501 02:03:20.039 --> 02:03:23.199 out early so you can now read about my lab's 2502 02:03:23.199 --> 02:03:24.800 research on that geo as well today. 2503 02:03:24.880 --> 02:03:27.880 That's very cool. That's very cool. So you would just 2504 02:03:28.039 --> 02:03:32.359 like to do more, have more funding, do more. That's 2505 02:03:32.399 --> 02:03:34.439 the thing that you wish you could be working on now, 2506 02:03:34.600 --> 02:03:39.680 just having more different, more different studies and tests running concurrently. 2507 02:03:39.600 --> 02:03:42.039 We could go so fast with AI because it's spitting 2508 02:03:42.079 --> 02:03:44.479 out new drug candidates all the time that we can't test. 2509 02:03:44.520 --> 02:03:47.279 It takes years to get through. So with money, we 2510 02:03:47.359 --> 02:03:49.920 could do a lot more trials and put these through 2511 02:03:50.119 --> 02:03:51.720 different diseases much faster. 2512 02:03:51.960 --> 02:03:54.239 If you had no regulations, like an Island of Doctor 2513 02:03:54.319 --> 02:03:55.279 Moreau type deal. 2514 02:03:55.520 --> 02:03:58.479 Yeah, well, you know, well, at the risk of getting 2515 02:03:58.560 --> 02:04:05.000 kicked out of my universe. Theoretically we could very safely 2516 02:04:05.199 --> 02:04:09.439 do more animal studies and with those best candidates put 2517 02:04:09.439 --> 02:04:12.960 them into humans quicker. Right now, it takes years. It's 2518 02:04:13.000 --> 02:04:15.520 taken us close to ten years to go from the 2519 02:04:15.600 --> 02:04:19.319 first discovery in my lab in Nature magazine to now. 2520 02:04:19.760 --> 02:04:22.000 But that's too slow. People dying one hundred and fifty 2521 02:04:22.039 --> 02:04:25.399 thousand a day on this planet. It's terrible. So I 2522 02:04:25.439 --> 02:04:28.840 would love to have the resources, you know, like Jeff 2523 02:04:28.840 --> 02:04:31.600 Bezos and others. Yeah, my company, by the way, even 2524 02:04:31.600 --> 02:04:34.439 though we lead the pack of all these guys, we're 2525 02:04:34.479 --> 02:04:39.159 really small. We're a pretty small little outfit in Boston. 2526 02:04:40.079 --> 02:04:42.439 We've raised a lot less money, but we're because I 2527 02:04:42.479 --> 02:04:45.560 think we're focused. We have and we started earlier. We're 2528 02:04:45.560 --> 02:04:46.279 doing pretty well. 2529 02:04:46.279 --> 02:04:48.680 That's the big one. You started earlier, You have a 2530 02:04:48.680 --> 02:04:50.720 lot of momentum on your side. 2531 02:04:50.960 --> 02:04:54.199 But I think we we could have a big impact 2532 02:04:54.199 --> 02:04:58.399 on aging in our lifetime with more money directed in 2533 02:04:58.399 --> 02:05:01.199 general at the field, not just me, but spread it. 2534 02:05:01.359 --> 02:05:03.960 And so the money that we raise from the magazine 2535 02:05:04.000 --> 02:05:08.239 is going to support other labs as well and students 2536 02:05:08.279 --> 02:05:10.319 who can find these medicines quicker. 2537 02:05:10.760 --> 02:05:13.640 So if you in a perfect world and you had 2538 02:05:13.760 --> 02:05:18.079 unlimited resources, you would just run a bunch of different 2539 02:05:18.079 --> 02:05:19.880 clinical trials and studies. 2540 02:05:20.159 --> 02:05:23.359 Concurrently, Yeah, AI is feeding us molecules, We put them 2541 02:05:23.399 --> 02:05:25.239 into mice, we go to monkeys, we go to humans, 2542 02:05:25.239 --> 02:05:29.560 and it'll just be fast. One of my friends, Alex Zakkarnkov, 2543 02:05:29.920 --> 02:05:33.760 he has a similar company, but not on exactly what 2544 02:05:33.800 --> 02:05:36.960 we do, not on reprogramming, but he's able to think 2545 02:05:37.000 --> 02:05:40.760 he's on his thirty fifth drug, but he's driven by 2546 02:05:41.359 --> 02:05:45.680 AI and robots. His whole lab is robots, at least 2547 02:05:45.720 --> 02:05:48.960 he says they are, and then goes into humans and 2548 02:05:49.000 --> 02:05:53.159 his company is worth billions. That approach applied to what 2549 02:05:53.199 --> 02:05:54.439 we do would be incredible. 2550 02:05:54.880 --> 02:06:00.199 Hmm, that's best case scenario. That would be incredible. Well, 2551 02:06:00.239 --> 02:06:03.000 I'm hoping through this conversation that people are going to 2552 02:06:03.039 --> 02:06:05.680 reach out and I'm hoping through this conversation that people 2553 02:06:05.760 --> 02:06:09.439 realizing like, oh, well, so much work has been done 2554 02:06:09.439 --> 02:06:12.840 and so many breakthroughs have been made. If they had 2555 02:06:12.920 --> 02:06:17.880 more access to resources, more access to different whatever you need, 2556 02:06:18.119 --> 02:06:20.359 you know, and that you could run all these different studies, 2557 02:06:21.600 --> 02:06:22.279 we could. 2558 02:06:22.359 --> 02:06:25.279 We were Our budget in my lab is only it's 2559 02:06:25.600 --> 02:06:28.520 almost three three and a bit millions, not much, right, 2560 02:06:28.520 --> 02:06:30.399 compared to what impact it could have on the planet, 2561 02:06:30.399 --> 02:06:34.159 which is trillions of dollars saved just in the US alone. 2562 02:06:34.439 --> 02:06:39.439 So it's a little bit of donation or getting a magazine, 2563 02:06:39.920 --> 02:06:42.479 the impact would be life changing for all of us. 2564 02:06:43.359 --> 02:06:44.680 Who doesn't age, who doesn't get. 2565 02:06:44.600 --> 02:06:46.960 Diseases, right, who doesn't want to feel better? 2566 02:06:47.640 --> 02:06:49.000 Yeah, it's also. 2567 02:06:48.840 --> 02:06:51.800 Like so much you can get so much more done 2568 02:06:51.880 --> 02:06:52.840 if you feel better. 2569 02:06:53.840 --> 02:06:56.159 Well, we take it for granted until we feel sick, 2570 02:06:56.199 --> 02:06:57.880 and it's like, oh right, I forgot what it's like 2571 02:06:57.920 --> 02:07:00.439 to feel well exactly. 2572 02:07:00.560 --> 02:07:02.560 I had a day a week and a half ago 2573 02:07:03.039 --> 02:07:06.680 where I came back from Italy. I was a little 2574 02:07:06.760 --> 02:07:09.800 jet lagged, I didn't sleep right, and I worked out 2575 02:07:09.840 --> 02:07:11.319 really hard a bunch of days in a row, and 2576 02:07:11.359 --> 02:07:13.680 I was working constantly, and then I had one day 2577 02:07:13.720 --> 02:07:16.239 I was like, I kind of feel like shit, like 2578 02:07:16.359 --> 02:07:20.479 I better not do anything today, and I, you know, 2579 02:07:20.960 --> 02:07:24.399 after I was on work, I just watched TV and relaxed. 2580 02:07:24.439 --> 02:07:27.079 I went and I was like, I can't wait to 2581 02:07:27.079 --> 02:07:28.039 feel better again. 2582 02:07:28.199 --> 02:07:31.359 Well, imagine what it's like being old, yes, and frail. 2583 02:07:31.680 --> 02:07:34.079 That's every day or sick, and right now you can't 2584 02:07:34.119 --> 02:07:35.039 do anything about it. 2585 02:07:35.119 --> 02:07:40.439 Yes, yeah, and while you're healthy, you take it for granted, 2586 02:07:40.520 --> 02:07:44.039 and that's the real sin. Like you're like, ah, I'm fine, 2587 02:07:44.119 --> 02:07:46.159 I'm great. I mean, this is what people do when 2588 02:07:46.159 --> 02:07:49.000 they go out drinking, right, They take advantage of the 2589 02:07:49.039 --> 02:07:51.439 fact that it's worth it for a good time. Just 2590 02:07:51.520 --> 02:07:52.760 poison myself for a night. 2591 02:07:53.760 --> 02:07:56.560 Well, it's not worth it because that also accelerates aging 2592 02:07:56.800 --> 02:07:58.640 a big time, Right, is what I tell my kids 2593 02:07:58.640 --> 02:08:02.279 who like alcohol. Like my kids, you know, you might 2594 02:08:02.359 --> 02:08:04.920 feel better in a few days, but the memory of 2595 02:08:04.960 --> 02:08:07.399 that is going to be in your body. Yeah, I 2596 02:08:07.399 --> 02:08:09.159 think you can drink. It's you know, it's fine to 2597 02:08:09.159 --> 02:08:11.399 get drunk once in a while, but not a lot, 2598 02:08:11.560 --> 02:08:14.079 not constantly. I used to drink once a day, and 2599 02:08:14.159 --> 02:08:16.800 I do not do that anymore because the date is 2600 02:08:16.840 --> 02:08:19.560 incontrovertible that it affects the brain, even the size of 2601 02:08:19.560 --> 02:08:21.880 the brain, if you drink constantly consisting. 2602 02:08:21.920 --> 02:08:24.079 I took eight months off of no alcohol at all, 2603 02:08:24.159 --> 02:08:25.239 and I felt a lot better. 2604 02:08:25.319 --> 02:08:25.800 Exactly. 2605 02:08:26.079 --> 02:08:28.560 I started drinking again one night. I went to dinner 2606 02:08:28.560 --> 02:08:30.159 with my wife and had a margarite, and I was like, 2607 02:08:31.000 --> 02:08:31.840 I think I'm back. 2608 02:08:32.760 --> 02:08:36.520 Ah, really, well, I saw I drink now I do 2609 02:08:36.560 --> 02:08:37.239 not get drunk. 2610 02:08:37.279 --> 02:08:39.039 I haven't gotten drunk. This was over a year ago. 2611 02:08:39.079 --> 02:08:41.680 It was when I had a drink again, I think 2612 02:08:41.800 --> 02:08:43.520 I think it was a year I'm not sure, but 2613 02:08:43.840 --> 02:08:47.239 point is I have not been drunk since then. I 2614 02:08:47.279 --> 02:08:49.520 will have a glass of wine with dinner, or I 2615 02:08:49.520 --> 02:08:53.119 will have a like a shot of whiskey before I 2616 02:08:53.159 --> 02:08:56.199 go on stage, like a little bit. But I do 2617 02:08:56.239 --> 02:08:59.199 not get drunk anymore. It's just not worth it. The 2618 02:08:59.319 --> 02:09:03.640 feeling words, is so terrible the morning, and especially for 2619 02:09:03.680 --> 02:09:05.880 me because I work out so much. When I wake up, 2620 02:09:05.920 --> 02:09:08.720 it's like that workout's gonna get done, okay, whether I 2621 02:09:08.720 --> 02:09:11.039 feel like shit or not, that workout is gonna get done. 2622 02:09:11.079 --> 02:09:12.479 And this is gonna be rough, and. 2623 02:09:12.520 --> 02:09:13.880 Then you got the sweats, it's all right. 2624 02:09:14.079 --> 02:09:18.039 Versus when I feel great, I love the workout. I'm excited, 2625 02:09:18.479 --> 02:09:20.960 like I look forward to it, even when it's hard. 2626 02:09:21.159 --> 02:09:23.600 When it's over, I'm like, whoo, all right, let's see, 2627 02:09:23.840 --> 02:09:27.000 and I don't feel bad. I feel good, And it's like, 2628 02:09:27.119 --> 02:09:30.760 why am I giving up that for a few hours 2629 02:09:30.800 --> 02:09:34.079 of a You know, it's just not worth it. It's 2630 02:09:34.119 --> 02:09:34.800 not worth it. 2631 02:09:34.920 --> 02:09:37.760 Yeah, well, you're funny even without alcohol. But I'm not so. 2632 02:09:37.800 --> 02:09:41.640 I've lost a lot of my humor. But there's nothing 2633 02:09:41.680 --> 02:09:43.840 better than feeling great. Right. Yes, and you can make 2634 02:09:43.880 --> 02:09:48.560 it your hobby of working on your health and your longevity. Yeah, 2635 02:09:48.640 --> 02:09:51.039 you'll enjoy it. Yes, it shouldn't be a chore. 2636 02:09:51.319 --> 02:09:55.319 It'll also directly affect the other things that you love 2637 02:09:55.399 --> 02:09:58.760 because you will have more energy your life. Energy, your 2638 02:09:58.920 --> 02:10:02.720 vitality is so important for anything you're doing, whether it's 2639 02:10:02.720 --> 02:10:06.479 a creative thing or an intellectual thing, like anything that 2640 02:10:06.520 --> 02:10:08.880 you're doing, if you have more energy, you'll be able 2641 02:10:08.880 --> 02:10:11.479 to apply more energy to that thing. It's that simple. 2642 02:10:11.680 --> 02:10:15.439 You're building a bigger gas tank for yourself. You're building 2643 02:10:15.520 --> 02:10:17.640 a larger engine, and that's what you're. 2644 02:10:17.439 --> 02:10:20.760 Doing exactly mentally, physically, you can do so much. When 2645 02:10:20.760 --> 02:10:22.399 you feel good, you jump out of bed. If you 2646 02:10:22.439 --> 02:10:25.960 wake up and you're tired, woozy, you know your eyes 2647 02:10:25.960 --> 02:10:28.039 are puffy, that's not how it should be when you 2648 02:10:28.079 --> 02:10:31.039 wake up. If you're getting and sleep is important for longevity. 2649 02:10:31.039 --> 02:10:33.760 Of course, if you're getting good deep sleep, then you 2650 02:10:33.760 --> 02:10:36.720 should wake up and you feel great. Yes, yes, you 2651 02:10:36.960 --> 02:10:39.439 don't even necessarily need a cup of coffee, but it's 2652 02:10:39.479 --> 02:10:40.600 not bad if you have one. 2653 02:10:40.760 --> 02:10:43.399 I like coffee. I'm not gonna stop drinking it now. 2654 02:10:43.520 --> 02:10:44.840 I'll give a fuck what anybody says. 2655 02:10:44.960 --> 02:10:45.560 Right, it's good. 2656 02:10:45.640 --> 02:10:48.640 And it's also like conflicting information. Some people say it's 2657 02:10:48.800 --> 02:10:50.720 good for you, there's benefits. 2658 02:10:50.359 --> 02:10:52.920 It's good for you. Come on, that's what I say. Oh, 2659 02:10:52.920 --> 02:10:55.199 it really is. Anyone that says it's not doesn't read 2660 02:10:55.239 --> 02:10:55.840 the well. 2661 02:10:55.840 --> 02:11:00.640 I would imagine. An over abundance of caffeine is not good. 2662 02:11:01.119 --> 02:11:03.800 Too much is not good. But that's true for everything. 2663 02:11:03.800 --> 02:11:06.279 Too much salt of killer, Yeah, exact pound of salt, 2664 02:11:06.319 --> 02:11:07.159 You'll be dead in an hour. 2665 02:11:07.439 --> 02:11:09.680 Right, You can get away with very little sleep, actually 2666 02:11:09.760 --> 02:11:12.359 as long as a deep sleep, because what it's doing 2667 02:11:12.439 --> 02:11:15.279 is clearing out the misfolded proteins in your brain and 2668 02:11:15.279 --> 02:11:18.800 the toxins. We know this the glymphatic system. And if 2669 02:11:18.800 --> 02:11:22.079 you get deep sleep for you know, an hour, you're 2670 02:11:22.119 --> 02:11:27.239 actually going to wake up much cleaner, healthier. And what 2671 02:11:27.279 --> 02:11:30.720 I've been able to do with some work is figure 2672 02:11:30.720 --> 02:11:34.000 out how to get deep sleep every night. Efficiency on 2673 02:11:34.039 --> 02:11:36.520 these rings that say but above ninety Sometimes I like. 2674 02:11:36.479 --> 02:11:42.479 You say rings because you're wearing two aur rings or okay, 2675 02:11:42.520 --> 02:11:45.239 why do you wear two different rings? 2676 02:11:48.039 --> 02:11:50.760 Because when I've got to neither of them is correct. 2677 02:11:51.600 --> 02:11:55.199 Now that the truth is some of them, some of 2678 02:11:55.239 --> 02:11:57.159 them are really good for sleep. The others are good 2679 02:11:57.159 --> 02:12:00.000 for a heart. And so I've this one's my heart, 2680 02:12:00.119 --> 02:12:00.920 this is my sleep. 2681 02:12:01.279 --> 02:12:03.920 What is the difference in the companies? Which one's which? 2682 02:12:04.479 --> 02:12:08.039 Um, you don't mind me saying who they are? This 2683 02:12:08.119 --> 02:12:10.159 is an aura, the one right, and then the thinner 2684 02:12:10.159 --> 02:12:12.399 one is called ultra human ultra human? 2685 02:12:13.199 --> 02:12:14.439 And which one is good for what? 2686 02:12:14.800 --> 02:12:17.439 Well? I find aura really good for sleep, that's their specialty. 2687 02:12:18.479 --> 02:12:22.079 And then the heart for ultra human my cardiac age. 2688 02:12:22.279 --> 02:12:25.439 Okay, So it's just like giving you data all the time. 2689 02:12:26.039 --> 02:12:28.600 Yeah, and they're getting even better because they I don't 2690 02:12:28.600 --> 02:12:31.000 get paid by these companies, but I do like that 2691 02:12:31.039 --> 02:12:34.760 they pop up with AI information. Now have you noticed 2692 02:12:34.800 --> 02:12:37.439 that data? Da Or I noticed that you ate a 2693 02:12:37.520 --> 02:12:40.800 meal last night that spiked your glucose, you know? And 2694 02:12:41.039 --> 02:12:43.239 this one I have a monitor on right now, so 2695 02:12:43.279 --> 02:12:46.159 I can see what's going on anyway. But yeah, they're becoming. 2696 02:12:45.920 --> 02:12:49.239 Like a fucking monitored bro. I am two rings and 2697 02:12:49.319 --> 02:12:49.880 a patch. 2698 02:12:50.119 --> 02:12:53.000 It's a it's a hobby. It's a hobby, but you 2699 02:12:53.079 --> 02:12:54.439 learn a lot. And I put one of these on 2700 02:12:54.479 --> 02:12:57.359 my son, and he stopped eating bad food for a 2701 02:12:57.840 --> 02:12:58.600 long while. 2702 02:12:58.680 --> 02:13:00.760 Really, because he was just racking the impact of. 2703 02:13:00.760 --> 02:13:02.279 The it's good for kids. 2704 02:13:02.319 --> 02:13:02.399 Now. 2705 02:13:02.439 --> 02:13:07.359 I wouldn't say slap it on a kid without pediatrician recommendation, 2706 02:13:07.479 --> 02:13:10.840 but it was amazing what happened when he could see 2707 02:13:11.079 --> 02:13:13.079 the crap that was going in his mouth was doing 2708 02:13:13.119 --> 02:13:15.880 to his blood sugar. Really, it was amazing. I think 2709 02:13:15.920 --> 02:13:17.800 it's a great learning tool if nothing else. 2710 02:13:18.039 --> 02:13:20.960 Right, just to have actual data. I know a lot 2711 02:13:21.000 --> 02:13:24.079 of people it's changed their opinion on alcohol, particularly the 2712 02:13:24.239 --> 02:13:27.039 or ring when they look at their sleep, because even 2713 02:13:27.199 --> 02:13:29.359 just a couple of drinks before you go to bed, 2714 02:13:29.439 --> 02:13:32.920 like a couple of drinks at dinner, and then you realize, like, 2715 02:13:33.000 --> 02:13:35.720 oh god, my sleep was all fucked up because of 2716 02:13:35.760 --> 02:13:36.640 those drinks. 2717 02:13:37.039 --> 02:13:40.359 Yeah, lay off the medafinil too for me anyway. 2718 02:13:40.840 --> 02:13:43.119 Yeah, yeah, some medafinol fucks with your sleep as well. 2719 02:13:43.199 --> 02:13:46.199 Yeah. I have to work really hard to sleep. Well. 2720 02:13:46.479 --> 02:13:51.680 There's quiet time, there's relaxation, the lights are dimmed. I 2721 02:13:51.680 --> 02:13:55.039 think about a happy place rather than work. I had 2722 02:13:55.039 --> 02:13:56.680 to do that because for fifty years I was burning 2723 02:13:56.720 --> 02:13:59.800 the candle at all ends. I was really burnt out 2724 02:14:00.039 --> 02:14:01.880 and so I've fixed that now I don't worry. 2725 02:14:02.000 --> 02:14:04.079 So are you one of those guys that like dims 2726 02:14:04.119 --> 02:14:06.359 the lights in your house a couple hours before you 2727 02:14:06.399 --> 02:14:09.600 go to bed and prepare it. Stay off your phone? Yeah, 2728 02:14:09.640 --> 02:14:10.279 all that stuff. 2729 02:14:10.359 --> 02:14:12.560 Well, I don't stay off my phone as much as 2730 02:14:12.560 --> 02:14:13.039 I want to. 2731 02:14:13.199 --> 02:14:17.079 But to wear red light glasses or anything like blockers. 2732 02:14:16.720 --> 02:14:19.760 I used to. I haven't found a big difference for myself. 2733 02:14:19.880 --> 02:14:24.159 But interesting fact that isn't well known if you block 2734 02:14:24.199 --> 02:14:27.439 blue light during the day or just stay indoors. There's 2735 02:14:27.479 --> 02:14:31.520 a guy in Japan who says that what happens is 2736 02:14:31.560 --> 02:14:36.920 you get short sightedness, and because the mice that lack 2737 02:14:36.960 --> 02:14:40.760 the ability to sense violet light get myopia short sighted 2738 02:14:41.239 --> 02:14:43.880 and he's got a device that indoors you can shinness. 2739 02:14:43.920 --> 02:14:48.039 But our modern world, the LEDs and being indoors means 2740 02:14:48.039 --> 02:14:50.279 we barely get violet light. And that would be that 2741 02:14:50.279 --> 02:14:53.000 would be so interesting if that's what's causing last half 2742 02:14:53.039 --> 02:14:56.479 I have to wear glasses. Wow. And he claims that 2743 02:14:56.520 --> 02:14:58.359 people that live out in the countryside that see blue 2744 02:14:58.439 --> 02:15:00.600 light all the time because they go out, don't have 2745 02:15:00.640 --> 02:15:02.680 as much need for glasses. 2746 02:15:02.800 --> 02:15:06.760 That actually makes sense. Well, particularly artificial light, and then 2747 02:15:06.920 --> 02:15:10.920 also light that's from a close source. Like one of 2748 02:15:10.960 --> 02:15:14.199 the things that if I do, if I'm tired and 2749 02:15:14.239 --> 02:15:16.319 I lay in bed and I try to read something 2750 02:15:16.359 --> 02:15:20.399 online on my phone, it hurts my eyes. The room's dark, 2751 02:15:20.680 --> 02:15:22.880 and it's like it irritates my eyes, where it never 2752 02:15:23.000 --> 02:15:25.560 irritates my eyes normally, but it's like at the end 2753 02:15:25.560 --> 02:15:28.520 of the day, you know, I guess I'm more fatigued. 2754 02:15:28.039 --> 02:15:30.399 And so then and you're trying to focus on Yeah. 2755 02:15:30.760 --> 02:15:33.319 So like, now, think about that when people are doing 2756 02:15:33.359 --> 02:15:35.000 it all day long. Maybe you're doing it at work 2757 02:15:35.000 --> 02:15:37.239 where you have to start at a computer monitor from 2758 02:15:37.279 --> 02:15:40.199 three feet away or closer, and then you're looking at 2759 02:15:40.199 --> 02:15:41.960 your phone all the time, or you're working from a 2760 02:15:41.960 --> 02:15:45.600 tablet or you're watching television. It's like you're constantly staring 2761 02:15:45.640 --> 02:15:47.359 at these light sources that are artificial. 2762 02:15:48.039 --> 02:15:51.039 Yeah, And also keep in mind that the muscles have 2763 02:15:51.079 --> 02:15:54.079 to focus. It's not naturally you don't naturally look this far. 2764 02:15:54.560 --> 02:15:57.319 Naturally you relax, you see out there right to look here, 2765 02:15:57.359 --> 02:16:00.720 your muscles here have to be straining for hours and 2766 02:16:00.760 --> 02:16:03.800 they get very tired, and I guess eventually they age 2767 02:16:03.800 --> 02:16:06.359 to a point where you cannot keep it up, and 2768 02:16:06.680 --> 02:16:08.239 sometimes I do this to see better though. 2769 02:16:10.760 --> 02:16:13.399 Well, it all makes sense if you think about it, 2770 02:16:13.439 --> 02:16:16.520 particularly like if your eyes are accustomed to only focusing 2771 02:16:16.560 --> 02:16:18.359 on things that are close. I mean, that was what 2772 02:16:18.399 --> 02:16:20.920 they would say about reading when people would have glasses, Oh, 2773 02:16:21.000 --> 02:16:23.920 you fucked up your vision reading, which I used to 2774 02:16:23.920 --> 02:16:27.039 think was nonsense. But I'm like, well, kind of makes sense. 2775 02:16:27.079 --> 02:16:29.560 If you spend all day long focus even though it's 2776 02:16:29.560 --> 02:16:31.800 on a screen, You're spending all day long focusing on 2777 02:16:31.840 --> 02:16:33.639 a book that's only a foot from your face. 2778 02:16:33.760 --> 02:16:37.799 Yeah, it does make sense, and the lens gets really inflexible, right, 2779 02:16:37.920 --> 02:16:39.840 And I'm seeing this with my father. He's otherwise in 2780 02:16:39.840 --> 02:16:42.479 perfect health at eighty seven, which is amazing, but it's 2781 02:16:42.520 --> 02:16:44.440 his eyes that are failing him. 2782 02:16:44.719 --> 02:16:46.440 Maybe you should get him a red light bed. 2783 02:16:46.840 --> 02:16:49.000 That's a great idea. Yeah, I'm gonna do that. He's 2784 02:16:49.079 --> 02:16:51.879 arriving tonight actually from Sydney. 2785 02:16:52.200 --> 02:16:54.239 He's uh, he's gonna get him a red light bed, man, 2786 02:16:54.319 --> 02:16:56.680 because I'm telling you, there's not a thing that I've 2787 02:16:56.680 --> 02:16:59.840 done that's impacted me in a more obvious way than 2788 02:16:59.840 --> 02:17:02.440 that in terms of like something that's. 2789 02:17:02.360 --> 02:17:04.799 Hugely Yeah, I'm going to do it, And I mean 2790 02:17:04.840 --> 02:17:08.639 he's into science. He's been taking and aman resveratrol mid 2791 02:17:08.680 --> 02:17:11.920 foreman exercising. He goes to the gym two or three 2792 02:17:11.920 --> 02:17:15.879 times a week six months. He's a role model at 2793 02:17:15.920 --> 02:17:19.319 eighty seven, with no diseases, no aches or pains. He's 2794 02:17:19.319 --> 02:17:21.719 struggling the world. He was in Japan two weeks ago. Wow, 2795 02:17:22.440 --> 02:17:23.799 coming to the Boston. 2796 02:17:23.600 --> 02:17:27.040 That's so cool. I love hearing about people that are 2797 02:17:27.079 --> 02:17:29.200 older that just keep on top of it and stay 2798 02:17:29.200 --> 02:17:31.680 active and stay alive and enjoy life. 2799 02:17:31.760 --> 02:17:34.600 Yeah, exactly. He's a great role model. And what it 2800 02:17:34.639 --> 02:17:36.399 shows is he was an average guy till he was 2801 02:17:36.399 --> 02:17:39.440 in his sixties, and he figured he was going to 2802 02:17:39.479 --> 02:17:41.719 die in his seventies, probably because everyone in my family 2803 02:17:41.760 --> 02:17:44.319 dies young because we've got pretty bad jeans. But he's 2804 02:17:44.399 --> 02:17:47.120 just taken life by the horns and just is running 2805 02:17:47.120 --> 02:17:51.040 with it and has not physically aged except for his 2806 02:17:51.120 --> 02:17:55.079 eyes in the last twenty years. And that's not an exaggeration. 2807 02:17:55.200 --> 02:17:58.840 Anyone who's seen him knows. He walks, he moves, he travels, 2808 02:17:58.840 --> 02:18:01.559 he does everything he was when he was forty. 2809 02:18:01.920 --> 02:18:05.840 That's where things like resistance exercises are so important because 2810 02:18:05.840 --> 02:18:09.520 it maintains bone density, maintains muscle mass, maintains your ability 2811 02:18:09.559 --> 02:18:11.079 to just get around and do things. 2812 02:18:11.920 --> 02:18:14.600 That's the other reason to do that. I mean, you're 2813 02:18:14.639 --> 02:18:16.440 going to be really strong when you're older, and you 2814 02:18:16.479 --> 02:18:18.319 won't fall, and if you do fall, you'll bounce, you 2815 02:18:18.360 --> 02:18:21.280 won't break a bone. And he's like that. He's been 2816 02:18:21.280 --> 02:18:24.280 working out at the gym, mostly strength training, but balance 2817 02:18:24.319 --> 02:18:27.239 as well. It's very important to maintain balance. He's better 2818 02:18:27.280 --> 02:18:28.920 at the gym than me at eighty seven. 2819 02:18:29.120 --> 02:18:29.879 That's incredible. 2820 02:18:30.000 --> 02:18:34.200 That just shows how Yeah, I got to go to 2821 02:18:34.239 --> 02:18:37.000 the gym. How about next time? If you have me on, 2822 02:18:37.639 --> 02:18:40.680 you're gonna be buff. Do you get your trainer. You're 2823 02:18:40.719 --> 02:18:43.120 in Massachusetts. There's a ton of trainers out there. Great, 2824 02:18:44.280 --> 02:18:44.799 it's a deal. 2825 02:18:45.280 --> 02:18:47.559 We'll find you someone. We'll find you someone. Three days 2826 02:18:47.600 --> 02:18:49.760 a week. That's all you need. The other days you 2827 02:18:49.799 --> 02:18:53.959 could do stuff elective, do stuff that you want, you know, 2828 02:18:54.040 --> 02:18:56.520 but three days a week, get a personal trainer and 2829 02:18:56.879 --> 02:18:59.440 work out with them. Right, you're on all right? 2830 02:19:00.120 --> 02:19:02.360 You know when it's going or you help me. I 2831 02:19:02.360 --> 02:19:05.079 can hear though that. There's probably a few million people 2832 02:19:05.120 --> 02:19:07.280 right now screaming David. Just go to the lab. Forget 2833 02:19:07.280 --> 02:19:08.360 about the gym you. 2834 02:19:08.319 --> 02:19:11.600 Need to help your stop work. It'll help everything. It'll 2835 02:19:11.600 --> 02:19:13.879 help the amount of research you're able to do. You'll 2836 02:19:13.920 --> 02:19:16.840 have more energy, you'll be more excited about things. I'm 2837 02:19:16.840 --> 02:19:19.920 sure you've seen those MRI cross sections of people's tissue 2838 02:19:20.239 --> 02:19:22.840 where they take like a seven year old man who's 2839 02:19:22.840 --> 02:19:26.120 sedentary versus seven year old man who's a marathon runner. 2840 02:19:26.840 --> 02:19:28.680 It's fucking extraordinary. 2841 02:19:28.719 --> 02:19:31.280 I've seen my own. There's there's too much fat in 2842 02:19:31.319 --> 02:19:32.479 the muscle. Got to get rid of it. 2843 02:19:32.719 --> 02:19:36.200 Yeah, yeah, it's really extraordinary. When you see those images 2844 02:19:36.239 --> 02:19:37.360 like those, really bring it home. 2845 02:19:37.440 --> 02:19:41.040 And the bone changes, bone turns to fat too, parts 2846 02:19:41.040 --> 02:19:43.680 of the bones. So, yes, you got to have the 2847 02:19:43.680 --> 02:19:45.399 strength training for sure. 2848 02:19:46.559 --> 02:19:51.280 Yeah. One hundred percent strength training is that's mandatory. Yeah. 2849 02:19:51.319 --> 02:19:54.680 And then do you do a lot of aerobic exercises. Yes, yeah, 2850 02:19:54.719 --> 02:19:56.440 I saw the training bike. 2851 02:19:56.639 --> 02:19:59.479 Oh yeah, well you saw my hypoxia machines and you 2852 02:19:59.600 --> 02:20:05.719 just got stalled today. Yeah. The hypoxia thing. What it 2853 02:20:05.760 --> 02:20:10.159 does is it replicates fourteen thousand feet above sea level 2854 02:20:10.559 --> 02:20:13.000 and you train in it. And it also has a 2855 02:20:13.000 --> 02:20:15.000 heat element so you could ramp the heat up to 2856 02:20:15.079 --> 02:20:17.719 one hundred and fifteen degrees. So one hundred and fifteen 2857 02:20:17.760 --> 02:20:20.680 degrees and fourteen thousand feet about. 2858 02:20:21.239 --> 02:20:21.760 Kind of stuff. 2859 02:20:21.920 --> 02:20:24.959 Yeah, you're going to hell, that's what it is. Straight 2860 02:20:25.000 --> 02:20:27.760 to feel like it, but it shouldn't work right. 2861 02:20:27.840 --> 02:20:29.479 Yeah, POxy is great for muscle. 2862 02:20:29.399 --> 02:20:32.760 Yes, and for adaptation, that's the big thing. And my 2863 02:20:32.799 --> 02:20:35.639 friend Roman who installed it, who's owns one of the 2864 02:20:35.680 --> 02:20:39.920 guys from the company, it's a very they're very specific 2865 02:20:39.959 --> 02:20:42.760 with this protocol in terms of monitoring your heart rate, 2866 02:20:42.879 --> 02:20:45.079 when to do it, when to push, how much time 2867 02:20:45.159 --> 02:20:48.000 to spend, and how you do it. And it's very 2868 02:20:48.000 --> 02:20:51.799 scientific in terms of the application on athletes and that's 2869 02:20:51.799 --> 02:20:56.280 a My friend Adam Greentree turned me onto it, fellow Australian, 2870 02:20:57.079 --> 02:21:01.559 and he's a big hunter and does a lot of 2871 02:21:01.600 --> 02:21:04.040 mountain hunting and he said there's nothing he's ever done 2872 02:21:04.239 --> 02:21:06.159 that's had more of an impact on his cardio. So 2873 02:21:06.280 --> 02:21:07.319 it's been phenomenal. 2874 02:21:08.000 --> 02:21:11.239 Sounds wonderful. Actually there's a lot of science behind that. 2875 02:21:11.920 --> 02:21:16.479 You probably know it. The best results are when people 2876 02:21:16.559 --> 02:21:20.959 are either having too much oxygen or not enough. And 2877 02:21:21.000 --> 02:21:23.479 you might say, well that's weird, why does it matter, Well, 2878 02:21:23.520 --> 02:21:26.000 you got to get out of the comfort zone. Hormesis. 2879 02:21:26.040 --> 02:21:30.319 We keep talking about. And there's a big study in 2880 02:21:30.760 --> 02:21:33.079 Israel where they put people in these hyperbaric chambers. 2881 02:21:33.120 --> 02:21:37.079 I've done that protocol. Yeah yeah, sixty sessions of ninety 2882 02:21:37.079 --> 02:21:38.799 minutes over ninety days. 2883 02:21:38.920 --> 02:21:42.120 Yeah yeah, yeah, I have one a loss, you do, Yeah, 2884 02:21:42.159 --> 02:21:46.479 because the data's incontrovertible, better wound healing, better memory. 2885 02:21:46.239 --> 02:21:47.440 Increase in telemar length. 2886 02:21:47.719 --> 02:21:50.239 Yeah, I saw that one. That's the Israel's study. 2887 02:21:50.600 --> 02:21:50.959 Yes. 2888 02:21:51.040 --> 02:21:53.319 What I thought was interesting was when I went over 2889 02:21:53.319 --> 02:21:56.959 there myself and sat in that thing. They made a 2890 02:21:57.040 --> 02:21:58.840 joke over there in Israel. By the way, they said, 2891 02:21:59.239 --> 02:22:01.879 this gas chamber here that were you going into, made 2892 02:22:01.920 --> 02:22:04.040 by Germans. I thought, that's not a funny joke. Don't 2893 02:22:04.079 --> 02:22:07.559 say that again. Anyway, I probably shouldn't have shared that. 2894 02:22:08.920 --> 02:22:12.559 I did go into the chamber, and what I found 2895 02:22:12.559 --> 02:22:14.920 out and was that they believe what I believe, which 2896 02:22:14.959 --> 02:22:17.719 is it's not so much the high pressure that's good 2897 02:22:17.719 --> 02:22:21.079 for you. It's the coming down that mimics hypoxia, which 2898 02:22:21.120 --> 02:22:23.959 your room will mimic. So the lack of oxygen, or 2899 02:22:23.959 --> 02:22:26.719 the perceived lack of oxygen from a high state is 2900 02:22:26.760 --> 02:22:27.319 the benefit. 2901 02:22:27.600 --> 02:22:28.879 Interesting and that makes a lot of sense. 2902 02:22:28.879 --> 02:22:31.799 You're going to grow new blood vessels, just like viagra 2903 02:22:32.479 --> 02:22:34.600 is going to open things up. We actually had a 2904 02:22:34.600 --> 02:22:38.600 paper two thousand and twelve that found that one of 2905 02:22:38.600 --> 02:22:41.479 the supplements that I take, which everyone knows about, Niman, 2906 02:22:42.200 --> 02:22:46.879 could allow animals to grow new blood vessels by getting 2907 02:22:47.000 --> 02:22:50.840 rid of a protein that accumulates with aging. The bottom 2908 02:22:50.840 --> 02:22:55.079 line is we could mimic this lack of blood vessels 2909 02:22:55.159 --> 02:22:59.440 with this pill, but by exercising. It's the same. What 2910 02:23:00.440 --> 02:23:04.000 I really believe is barely talked about in the medical 2911 02:23:04.079 --> 02:23:06.799 establishment is that a major reason we get sick when 2912 02:23:06.840 --> 02:23:10.159 we get older is lack of blood flow. It's really 2913 02:23:10.159 --> 02:23:14.760 talked about, right, Vascular dementia second largest cause of dementia 2914 02:23:14.920 --> 02:23:19.399 in the world. Blood flow, and it's the easiest to reverse. 2915 02:23:19.520 --> 02:23:22.959 You just do exercise, or take one of these PD 2916 02:23:23.159 --> 02:23:26.639 five inhibitors viagra, or you take my stuff which is 2917 02:23:26.680 --> 02:23:28.559 an a man which we think also works. 2918 02:23:28.440 --> 02:23:30.840 Or all the above, which is probably the best approach. 2919 02:23:31.799 --> 02:23:36.399 I'm two out of three, hopefully soon three out of three. 2920 02:23:36.639 --> 02:23:38.920 But yeah, you know, to protect your brain, which is 2921 02:23:39.040 --> 02:23:40.600 the most important because you don't want to be old 2922 02:23:40.639 --> 02:23:44.280 and demented. That's worse than anything. Keep the blood flowing 2923 02:23:44.280 --> 02:23:47.079 in your body. Remember that blood flowing is important. 2924 02:23:47.200 --> 02:23:51.760 Yes, couldn't agree more. David, You're a treasure. I really 2925 02:23:51.760 --> 02:23:53.719 appreciate you. Thank you for being here. 2926 02:23:53.760 --> 02:23:55.520 You've been so kind, and thank you for getting the 2927 02:23:55.559 --> 02:23:57.639 word out here about the great science that's going on. 2928 02:23:57.719 --> 02:24:00.200 Oh my pleasure, dude. I'm so happy there's someone like 2929 02:24:00.479 --> 02:24:03.360 you out there doing this. I mean it's it's such 2930 02:24:03.399 --> 02:24:06.159 an enormous benefit to people that are listening to the 2931 02:24:06.159 --> 02:24:09.680 world and you're doing you're literally doing God's work, and. 2932 02:24:10.000 --> 02:24:10.879 We'll try to do more. 2933 02:24:11.000 --> 02:24:15.559 Thank you very much. Lifespan dot com is the website. 2934 02:24:15.559 --> 02:24:19.079 Please folks, if you're you're so inclined, go donate. It'll 2935 02:24:19.120 --> 02:24:22.399 really help, will change the world. David. I love you 2936 02:24:22.440 --> 02:24:26.840 to Thank you by everybody.