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<v Speaker 1>Welcome to Medicine and Health with doctor Paul Anderson. This

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<v Speaker 1>is a show about opening the open, mysterious world of

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<v Speaker 1>how doctors think and how science works. This program exists

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<v Speaker 1>to educate and how are you go? Now? Here's your house,

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<v Speaker 1>Doctor Paul Edison.

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<v Speaker 2>Health with Doctor Paul Anderson, And in our series on

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<v Speaker 2>why Can't I Get Better? This session we're going to

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<v Speaker 2>talk about the effect of one of your hormonal components

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<v Speaker 2>in your body that's fairly important, which is your thyroid.

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<v Speaker 2>And there's of course a lot of hormonal components, but

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<v Speaker 2>in chronic illness, one of the places that kind of

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<v Speaker 2>can go off of the rail, so to speak, and

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<v Speaker 2>not work as well as it used to or not

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<v Speaker 2>work as well as it should is actually the thyroid,

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<v Speaker 2>and so it's worth bringing that up now in this

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<v Speaker 2>series of why Can't I Get Better? What we're talking

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<v Speaker 2>about are people who have usually had an acute infection

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<v Speaker 2>or an acute trauma, or some combination thereof, and then

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<v Speaker 2>at some point in the future, after they never really

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<v Speaker 2>fully recover, they don't get better, or they have one

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<v Speaker 2>of the very difficult to treat and assess chronic illnesses

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<v Speaker 2>such as long COVID or post COVID syndrome, things such

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<v Speaker 2>as chronic fatigue syndrome CFSME, or fibromyalgia or any other

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<v Speaker 2>number of chronic illnesses that go on and so they'll,

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<v Speaker 2>you know, legitimately wonder why they can't get better. Well,

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<v Speaker 2>in this session, we're going to talk about your thyroid.

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<v Speaker 2>In other sessions we talked about like toxins and other

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<v Speaker 2>infections and immune inhibitors and all this other stuff. Well,

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<v Speaker 2>with your thyroid, the thing to keep in mind is

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<v Speaker 2>it is what operates the metabolic rate inside your body.

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<v Speaker 2>So in other sections we talked about the mitochondria and

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<v Speaker 2>how they make your energy. Well, they get their marching

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<v Speaker 2>orders from the thyroid hormone, which tells them at what

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<v Speaker 2>rate to put out energy. Now, go back to the

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<v Speaker 2>cell and mitochondria section that we did. You also know

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<v Speaker 2>that there's other things that can mess with the mitochondria function,

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<v Speaker 2>such as not enough of oxygen and other nutrients going in,

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<v Speaker 2>or too much toxicity and junk. It's not moving out

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<v Speaker 2>of the cells fast enough. So obviously it's not just

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<v Speaker 2>the thyroid, but the thyroid does play a role. So

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<v Speaker 2>your metabolic rate is operated by your thyroid gland ther

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<v Speaker 2>thyroid gland puts out thyroid hormone, and one version, the

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<v Speaker 2>T three version of your thyroid hormone has receptors on

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<v Speaker 2>both the outside of the cell and on the mitochondria

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<v Speaker 2>on the inside of the cell, and so the receptor

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<v Speaker 2>on the outside of the cell turns on the feeding

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<v Speaker 2>system for the cell, half of which goes to the mitochondria,

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<v Speaker 2>and then the internal receptor actually up or down regulates

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<v Speaker 2>your metabolic rate how fast the mitochondria go to do

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<v Speaker 2>their thing. So back in the mitochondria and cell section,

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<v Speaker 2>what we said is if anything slows down the mitochondria,

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<v Speaker 2>your energy production slows down, and you slow down, you

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<v Speaker 2>don't feel right. Well, there's a number of reasons that

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<v Speaker 2>that can go on, and not enough or abnormally functioning

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<v Speaker 2>thyroid hormone can be a piece of that puzzle. So

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<v Speaker 2>when we think about that, we think, well, how, you know,

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<v Speaker 2>the thyroid, like, you're not dead, it didn't stop working.

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<v Speaker 2>How did it get injured with your you know, whatever

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<v Speaker 2>triggered your chronic illness. Well, there's a couple of things

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<v Speaker 2>to think about. The first thing is that your theory

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<v Speaker 2>could have been totally normal and serving you very well

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<v Speaker 2>for your whole life, and then you get enough stressors

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<v Speaker 2>into your system, and your hormonal system tries to respond,

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<v Speaker 2>tries to bounce back and respond against those stressors because

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<v Speaker 2>your body is ill, and so the thyroid has feedback

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<v Speaker 2>mechanisms that will say, we're creating too much metabolism in

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<v Speaker 2>this person who's sick. And so sometimes with patients, I

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<v Speaker 2>would make the analogy that if your motor is really

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<v Speaker 2>not operating well and you just have to go a

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<v Speaker 2>few blocks to get down to the auto repair shop,

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<v Speaker 2>if you don't put too much of the gas on

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<v Speaker 2>and you don't run your motor too fast, you're going

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<v Speaker 2>to get a little bit more distance out of it

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<v Speaker 2>while it's not running well. Whereas, if you you know,

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<v Speaker 2>floor it put a lot of gas into a motor

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<v Speaker 2>that's very dysfunctional, the motor may break sooner, it may

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<v Speaker 2>have other problems. And your body literally has a version

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<v Speaker 2>of this that it largely regulates through your hormonal system.

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<v Speaker 2>So thyroid is one of those big regulatory areas. Now

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<v Speaker 2>you think, well, how could that go on? It's not

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<v Speaker 2>usually a quick process. It's usually, let's let's say for

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<v Speaker 2>the sake of argument, your thyroid was no problem, and

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<v Speaker 2>then you get knocked down with an illness. And that

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<v Speaker 2>could be you've got pneumonia, you've got lime disease, you've

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<v Speaker 2>got a chronic other problem, you've got a bunch of

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<v Speaker 2>other infections, you got COVID, you got whatever else it happens,

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<v Speaker 2>or you got a trauma, you had a car accident,

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<v Speaker 2>or big surgery, or maybe you know the trifecta. You

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<v Speaker 2>get you know, an accident, a trauma, surgery, then you've

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<v Speaker 2>got recovery going on. So your body, you know, is

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<v Speaker 2>sensing this. So sometimes with a sick body, what the

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<v Speaker 2>hormonal system will do is is it will say, let's

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<v Speaker 2>slow down things. And it's using that sort of logic,

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<v Speaker 2>if you will. It's sort of chemical logic. It's not

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<v Speaker 2>sitting there really thinking about it, we don't believe, but

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<v Speaker 2>it's chemically feeding back and giving this idea that the motor,

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<v Speaker 2>you know, the body is not running well. We don't

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<v Speaker 2>want to put too much energy, too much gas into

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<v Speaker 2>it and make it run fast but ill. Right, So

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<v Speaker 2>you can actually and you see this with people if

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<v Speaker 2>they're real sick, and you upregulate their thyroid by give

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<v Speaker 2>them the thyroid hormone. Though sometimes it'll feel sicker, and

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<v Speaker 2>I tell them, well, it's like having a sick motor

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<v Speaker 2>and then making it run faster. It's going to run fast,

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<v Speaker 2>but not appropriately. So your body has these ways of

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<v Speaker 2>turning down hormonally your your energy production system. Now, one

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<v Speaker 2>way to do that is through the production of antibodies.

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<v Speaker 2>And these are actual autoantibodies, meaning against us, and they

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<v Speaker 2>can turn on during these acute illnesses and chronic illnesses,

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<v Speaker 2>and they can be against our thyroid function. Now, the

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<v Speaker 2>thyroid function is heavily dependent on taking basic things like

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<v Speaker 2>iodine and the amino acid tyrosine and putting them together

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<v Speaker 2>into either a triiodothyronine the T three molecule, or a

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<v Speaker 2>tetra iodothyronine the T four molecule. And so our body

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<v Speaker 2>does this through a bunch of little processes in our

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<v Speaker 2>thyroid gland, which is right in the lower part of

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<v Speaker 2>your throat. And so there are places when you inflame

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<v Speaker 2>the thyroid or the system is backed up, et cetera,

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<v Speaker 2>where the immuneesystem can go start attacking that production system.

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<v Speaker 2>So it can start attacking in two major places to

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<v Speaker 2>slow down production. And so a lot of times what

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<v Speaker 2>happens is that people will get. You know, they have

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<v Speaker 2>normal thyroid before and they're sick afterwards, and sometimes those

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<v Speaker 2>antibodies don't get checked and you'll see that they went

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<v Speaker 2>up because of the illness. So that has to be

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<v Speaker 2>worked on to get the antibodies to come down, which

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<v Speaker 2>is a long, slow process. But the longer the antibodies

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<v Speaker 2>are elevated, the worst your thyroid function is going to be. Well,

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<v Speaker 2>the other thing that your thyroid will do is it

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<v Speaker 2>will actually start to trigger a mirror image molecule of

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<v Speaker 2>the active T three hormone, and it's called reverse T three,

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<v Speaker 2>and so they both can go sit on the receptor

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<v Speaker 2>sites to turn things on. Right, So your metabolism has

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<v Speaker 2>put T three in your system turned and on works

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<v Speaker 2>faster by the T three binding to the receptor. Well,

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<v Speaker 2>if you have reverse TE three, it will bind to

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<v Speaker 2>the receptors, but it won't turn them on. It's sort

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<v Speaker 2>of a blocking hormone. Now, a lot of folks in

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<v Speaker 2>medicine will say, well, reverse T three is probably meaningless,

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<v Speaker 2>It probably doesn't really help your clinical guidance, etc. And

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<v Speaker 2>I would say for the average human who's healthy, that's

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<v Speaker 2>probably true. Reverse T three is probably not a great

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<v Speaker 2>measurement for healthy people. But because my world is chronically

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<v Speaker 2>ill people or people with cancer, which is chronically ill patient. Also,

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<v Speaker 2>what we see in the chronically ill patients, especially when

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<v Speaker 2>they've had these inciting traumas and stuff, is that the

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<v Speaker 2>reverse T three will go up, and that's your body's

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<v Speaker 2>way of blocking the thyroid from turning on your energy.

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<v Speaker 2>And so what will happen then is your energy production

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<v Speaker 2>doesn't shut off or you'd be dead. It slows way down. Now,

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<v Speaker 2>those symptoms then can be things such as fatigue, usually

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<v Speaker 2>severe tiredness, sleeping too much. You can also have disturbed sleep.

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<v Speaker 2>Sometimes you can gain weight really easy. Your water retention

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<v Speaker 2>can be very bad. A whole number of things happen

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<v Speaker 2>when your metabolism slows down. But another thing that's super

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<v Speaker 2>important there is that the metabolism slowing down will also

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<v Speaker 2>make that mitochondrial problem that we talked about in the

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<v Speaker 2>other segment more magnified. So let's say the mitochondria are

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<v Speaker 2>already kind of sick and they're recovering from your illness,

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<v Speaker 2>they're feeling slow. You're feeling slow if now you're blocking

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<v Speaker 2>your thyroid, either through autoimmune issues or reverse T three

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<v Speaker 2>or whatever, or you're just your levels of T three

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<v Speaker 2>and T four go down, your mitochondria are going to

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<v Speaker 2>be double slow, and so you're going to be double slow.

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<v Speaker 2>So the things that you have to do first is

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<v Speaker 2>realize that even if your thyroid was normal prior, even

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<v Speaker 2>if you didn't have any antibodies to your thyroid or

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<v Speaker 2>reverse T three prior, now your body is in a

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<v Speaker 2>new situation. And so every chronically ill patient on the

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<v Speaker 2>screening side, when we're trying to sort out how many

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<v Speaker 2>problems they have creating their chronic illness, all of those

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<v Speaker 2>patients really need to have the thyroid looked at in

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<v Speaker 2>a multi dimensional way, and so that that would be

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<v Speaker 2>the normal screening of the TSH test, and then usually

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<v Speaker 2>they do a T four that's the primary output hormone,

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<v Speaker 2>and sometimes now they'll do a T three as well.

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<v Speaker 2>So those are the hormonal and the feedback parts. But

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<v Speaker 2>then we also add on three other things. So that

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<v Speaker 2>would be the two main thyroid antibodies that are blocking.

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<v Speaker 2>There's others that do other things, but the two main

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<v Speaker 2>blocking antibodies, which would be the antithybroglobulin and the thyroid

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<v Speaker 2>peroxtase antibodies, and then we do a reverse T three

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<v Speaker 2>just to get a three sixty. Look at the thyroid function. Now,

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<v Speaker 2>maybe it's doing great, no problems anywhere there. Then you

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<v Speaker 2>kind of focus on other things. You focus on the

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<v Speaker 2>mitochondria more, You focus on many of these other things

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<v Speaker 2>we talk about, but a lot of times in chronically

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<v Speaker 2>other people, that's one of the factors that comes up. Now,

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<v Speaker 2>the thing you have to keep in mind is that

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<v Speaker 2>that's all you fix, and you've got all this other

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<v Speaker 2>junk in your system, and your mitochondria can't work as

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<v Speaker 2>there's a lot of metabolic toxicity and all that stuff.

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<v Speaker 2>You're going to turn your thyroid on and you're going

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<v Speaker 2>to feel actually worse because your thyroid's working hard in

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<v Speaker 2>a system than sick. So a lot of times in

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<v Speaker 2>chronic illness we have to play a little bit of

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<v Speaker 2>a balancing game of getting the thyroid back online slowly

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<v Speaker 2>so that your body starts to work faster and better,

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<v Speaker 2>and then kind of start to fix the other things

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<v Speaker 2>that are contributing. That's all these other sections that we're doing.

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<v Speaker 2>On one, I can't I get better, and you fix

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<v Speaker 2>all of those kind of at the same time or

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<v Speaker 2>at least in a rotation and then your thyroid can

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<v Speaker 2>get back to being normal. So there's a whole number

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<v Speaker 2>of other things, but that's why the theroid is so critical,

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<v Speaker 2>and that's why it gets feedback to it that slow

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<v Speaker 2>it down. Now, one thing I like to say is,

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<v Speaker 2>wherever you're seeing or hearing this, we're on all the

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<v Speaker 2>pod burners. We're on CTR Radio, Facebook Live, and then

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<v Speaker 2>on YouTube on DRA online, doctor Online, Please like, share

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<v Speaker 2>and subscribe, do the notifications. It really helps. We need

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<v Speaker 2>subscribers on all the platforms, especially over on YouTube where

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<v Speaker 2>there's a really growing community for this sort of information. Also,

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<v Speaker 2>I will put in the show notes some links. There

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<v Speaker 2>will be some links to some information around this, and

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<v Speaker 2>also some links to some provider referral services, etc. That

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<v Speaker 2>may be of help to you. But that's about all

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<v Speaker 2>the time that we have for thyroid. One of the

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<v Speaker 2>things that we usually say is with thyroid, it's because

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<v Speaker 2>it's a hormonal problem and there's all these things to test.

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<v Speaker 2>You really need to work with a healthcare provider who's

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<v Speaker 2>used to looking at chronically old people's thyroid so you

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<v Speaker 2>can do all the testing, but also then they can

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<v Speaker 2>treat you appropriately and that might mean hormonal treatment, it

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<v Speaker 2>might mean non hormonal treatment, but that's really dependent upon

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<v Speaker 2>how you're doing in that respect with your thyroid, how

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<v Speaker 2>your labs are, and how you physically are doing in

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<v Speaker 2>your body. Well, we're going to move on right now

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<v Speaker 2>to our next segment, and I want to thank you

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<v Speaker 2>for listening to this one and why it came better.

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<v Speaker 2>Thybrid addition