WEBVTT

1
00:00:00.840 --> 00:00:02.520
<v Speaker 1>I'm sure we all have a little bit of fear

2
00:00:02.640 --> 00:00:05.679
<v Speaker 1>factor as far as Alzheimer's disease goes. We've all seen

3
00:00:05.759 --> 00:00:11.560
<v Speaker 1>patients fall into that category. Relatives, friends, neighbors, and you

4
00:00:11.640 --> 00:00:14.320
<v Speaker 1>get so discouraged even trying to be around those people.

5
00:00:15.279 --> 00:00:16.000
<v Speaker 2>Now, a new.

6
00:00:16.079 --> 00:00:19.480
<v Speaker 1>Report comes out how a neurologist to use what he

7
00:00:19.559 --> 00:00:23.679
<v Speaker 1>called precision lifestyle medicine to reverse early signs of Alzheimer's.

8
00:00:24.199 --> 00:00:27.719
<v Speaker 1>He's suggesting we start much earlier. Stay tuned, we'll talk

9
00:00:27.760 --> 00:00:30.679
<v Speaker 1>about this. Hi, and welcome to Health Talk with Doctor Lynn.

10
00:00:30.719 --> 00:00:33.600
<v Speaker 1>Your daily dose. The information you hear on the show

11
00:00:33.799 --> 00:00:37.200
<v Speaker 1>is informational. It's not meant to diagnose or treat any disease.

12
00:00:38.119 --> 00:00:42.079
<v Speaker 1>Any kind of complete health conditions must be checked out

13
00:00:42.119 --> 00:00:45.039
<v Speaker 1>and discussed with your primary care physicians.

14
00:00:45.759 --> 00:00:47.399
<v Speaker 2>Get ready for the good news of the day.

15
00:00:48.240 --> 00:00:50.240
<v Speaker 1>God bless you, folks, and.

16
00:00:50.200 --> 00:00:51.759
<v Speaker 2>Here is doctor Lynn.

17
00:00:51.840 --> 00:00:54.600
<v Speaker 1>Our daily devotional today comes from the Book of Ephesians,

18
00:00:54.679 --> 00:00:58.880
<v Speaker 1>Chapter five. Find freedom through seeking to please me above

19
00:00:58.880 --> 00:01:02.640
<v Speaker 1>all else. You can have only one master. When you

20
00:01:02.719 --> 00:01:06.519
<v Speaker 1>let others expectations drive you, you scatter your energy to the winds.

21
00:01:06.879 --> 00:01:09.719
<v Speaker 1>Your own desire to look good can also drain your energy.

22
00:01:10.400 --> 00:01:12.640
<v Speaker 1>I am your master, and I do not drive you

23
00:01:12.719 --> 00:01:16.079
<v Speaker 1>to be what you are not. Your pretense displeases me,

24
00:01:16.280 --> 00:01:19.920
<v Speaker 1>especially when it's in my service. Concentrate on staying close

25
00:01:19.959 --> 00:01:23.560
<v Speaker 1>to me at all times. It's impossible to be inauthentic

26
00:01:23.840 --> 00:01:27.680
<v Speaker 1>while you are focusing on my presence. Oh that was good.

27
00:01:28.200 --> 00:02:46.800
<v Speaker 1>Stay tuned, we'll talk about Alzheimer's seven nine one six

28
00:02:46.879 --> 00:02:50.240
<v Speaker 1>four to reach me off air. It's funny because I'm

29
00:02:50.280 --> 00:02:53.199
<v Speaker 1>right now in the middle of writing up an entire

30
00:02:53.240 --> 00:02:57.400
<v Speaker 1>presentation I'll be doing in Pittsburgh for the professional training

31
00:02:57.439 --> 00:03:01.719
<v Speaker 1>event Nutritional Frontiers dealing with brain functionality. I've been given

32
00:03:01.719 --> 00:03:04.000
<v Speaker 1>a whole hour to discuss everything about the brain.

33
00:03:04.120 --> 00:03:09.080
<v Speaker 2>Well, good luck with that. This new article that just came.

34
00:03:08.960 --> 00:03:11.800
<v Speaker 1>Out this morning in the Journal of Dementia in Alzheimer's,

35
00:03:12.360 --> 00:03:16.120
<v Speaker 1>said a neurologist used was called precision lifestyle medicine to

36
00:03:16.120 --> 00:03:20.280
<v Speaker 1>reverse early Alzheimer's. A forty nine year old woman's memory

37
00:03:20.319 --> 00:03:22.919
<v Speaker 1>loss had been reached the point where she placed a

38
00:03:22.960 --> 00:03:24.639
<v Speaker 1>sticky note on the steering wheel of her car to

39
00:03:24.759 --> 00:03:27.000
<v Speaker 1>reminder to drive on the right side of the road.

40
00:03:27.919 --> 00:03:30.080
<v Speaker 1>As a jogger, she was used to keeping it left,

41
00:03:30.479 --> 00:03:33.560
<v Speaker 1>and she had begun to confuse the two diagnosed with

42
00:03:33.639 --> 00:03:37.199
<v Speaker 1>Alzheimer's related mild cognitive IMPAIRMID. She asked the neurologist for

43
00:03:37.240 --> 00:03:40.240
<v Speaker 1>her as anything she could do to prevent further decline.

44
00:03:40.319 --> 00:03:44.080
<v Speaker 2>He said, good luck with that.

45
00:03:44.120 --> 00:03:51.400
<v Speaker 1>The idiot response is for most neurologists, it's unbelievable. The

46
00:03:51.439 --> 00:03:54.280
<v Speaker 1>woman wasn't satisfied with that answer. She decided to try

47
00:03:54.280 --> 00:03:57.639
<v Speaker 1>a precision medicine protocol and it worked for her.

48
00:03:57.680 --> 00:03:58.280
<v Speaker 2>Over time or.

49
00:03:58.319 --> 00:04:02.439
<v Speaker 1>Cognitive testing improved from below average the thirty fifth percentile

50
00:04:02.520 --> 00:04:04.520
<v Speaker 1>to far above the ninety eighth percentile.

51
00:04:05.840 --> 00:04:06.360
<v Speaker 2>Did you catch that?

52
00:04:07.639 --> 00:04:09.520
<v Speaker 1>She is one of the patients featured in the case

53
00:04:09.560 --> 00:04:13.400
<v Speaker 1>study published in the Journal of Biomedicines. Many people believe

54
00:04:13.439 --> 00:04:16.399
<v Speaker 1>Alzheimer's disease is simply a matter of bad genes, bad luck,

55
00:04:16.399 --> 00:04:20.800
<v Speaker 1>and inevitable consequences of aging, and once decline begins, nothing

56
00:04:20.879 --> 00:04:23.839
<v Speaker 1>can be done. Doctor Dale Bredson, the lead author of

57
00:04:23.879 --> 00:04:29.319
<v Speaker 1>the study internationally recognized neurologists specializing in neurodegenitive diseases, said

58
00:04:29.360 --> 00:04:31.759
<v Speaker 1>the belief is outdated and that he has built a

59
00:04:31.800 --> 00:04:34.720
<v Speaker 1>career trying to prove it, which more people understood that

60
00:04:34.759 --> 00:04:37.600
<v Speaker 1>Alzheimer's disease is far more common than it needs to be.

61
00:04:40.199 --> 00:04:43.800
<v Speaker 1>He believes precision medicine should be how the disease is approached.

62
00:04:45.360 --> 00:04:48.720
<v Speaker 1>He describes a biological switch that moves the brain between

63
00:04:48.720 --> 00:04:52.360
<v Speaker 1>what he calls connection mode and protection mode. When the

64
00:04:52.399 --> 00:04:54.720
<v Speaker 1>brain is in connection mode, it can learn adapt in

65
00:04:54.759 --> 00:04:59.279
<v Speaker 1>form memories. Alzheimer's, he said, develops when the brain shifts

66
00:04:59.319 --> 00:05:02.040
<v Speaker 1>into protection mode, a shift that can be triggered by

67
00:05:02.040 --> 00:05:10.199
<v Speaker 1>many different factors, including insulin resistance, sleep apnea, poor energy

68
00:05:10.240 --> 00:05:17.480
<v Speaker 1>production at the cellular level, lack of exercise, chronic inflammation, infections,

69
00:05:17.519 --> 00:05:22.720
<v Speaker 1>and exposure to toxins such as air pollution, heavy metals, microplastics.

70
00:05:22.879 --> 00:05:24.120
<v Speaker 2>But that's all inclusive.

71
00:05:24.800 --> 00:05:28.480
<v Speaker 1>We're addressing network insufficiency, he said, nothing by itself as

72
00:05:28.519 --> 00:05:29.040
<v Speaker 1>a cure.

73
00:05:29.600 --> 00:05:32.199
<v Speaker 2>It's like tuning up a car. You're changing multiple things

74
00:05:32.240 --> 00:05:32.560
<v Speaker 2>to get.

75
00:05:32.480 --> 00:05:34.720
<v Speaker 1>Them working together, so the body no longer needs to

76
00:05:34.720 --> 00:05:37.959
<v Speaker 1>stay in protection mode and can return to connection mode.

77
00:05:38.839 --> 00:05:41.560
<v Speaker 1>One reason why treatment for Alzheimer's disease has not been

78
00:05:41.600 --> 00:05:44.720
<v Speaker 1>successful up till now, is that we have historically approached

79
00:05:44.720 --> 00:05:47.040
<v Speaker 1>to Alzheimer's too narrowly.

80
00:05:46.800 --> 00:05:47.519
<v Speaker 2>And too late.

81
00:05:48.759 --> 00:05:52.000
<v Speaker 1>Focus needs to shift beyond amyloid in a variety of factors,

82
00:05:52.000 --> 00:05:57.000
<v Speaker 1>from insulin resistance to nutrient efficiencies. These are not alternative

83
00:05:57.000 --> 00:06:01.439
<v Speaker 1>medicine questions, but mainstream dementia risk factors. The growing recognition

84
00:06:01.480 --> 00:06:05.199
<v Speaker 1>that Alzheimer's is a multifactorial disease has given rise to

85
00:06:05.279 --> 00:06:09.319
<v Speaker 1>a precision medicine approach to treating it. Instead of giving

86
00:06:09.360 --> 00:06:13.879
<v Speaker 1>everyone the same treatment, precision medicine takes a more personalized approach.

87
00:06:14.439 --> 00:06:17.439
<v Speaker 1>Doctors consider the factors that may be affecting a person's

88
00:06:17.480 --> 00:06:21.079
<v Speaker 1>brain health that put together a plan on that person's needs.

89
00:06:21.920 --> 00:06:25.639
<v Speaker 1>In this study, researchers at wyl Cornell Medicine and New

90
00:06:25.720 --> 00:06:29.439
<v Speaker 1>York Presbyterian used a precision medicine approach with people with

91
00:06:29.519 --> 00:06:34.480
<v Speaker 1>Alzheimer's disease or mild cognitive impairment. Participants received a personalized

92
00:06:34.480 --> 00:06:39.000
<v Speaker 1>program that included changes to their diet, exercise, sleep, stress

93
00:06:39.040 --> 00:06:43.480
<v Speaker 1>management supplements in some cases medication. Most showed improvements or

94
00:06:43.519 --> 00:06:46.399
<v Speaker 1>stabilization and cognitive function over the course of the study,

95
00:06:46.879 --> 00:06:53.839
<v Speaker 1>along with improvements in several Alzheimer's related risk factors. His

96
00:06:53.959 --> 00:06:56.759
<v Speaker 1>protocol is one example of what precision medicine can look

97
00:06:56.800 --> 00:06:59.560
<v Speaker 1>like in practice. The goals to identify as many potential

98
00:06:59.600 --> 00:07:04.160
<v Speaker 1>contribute to cognitive decline as possible. Protocol centers on a

99
00:07:04.199 --> 00:07:09.920
<v Speaker 1>plant rich, mildly ketogenic, high fiber diet, leafy greens, non

100
00:07:10.000 --> 00:07:15.680
<v Speaker 1>starchy vegetables, healthy fats, logallycemic foods. It encourages organic produce,

101
00:07:15.720 --> 00:07:19.319
<v Speaker 1>wild caught, low mercury fish and pasteurized eggs and meat.

102
00:07:20.000 --> 00:07:24.560
<v Speaker 1>Processed foods, refined carbs, artificial sweeteners, gluten containing foods, dairy,

103
00:07:24.560 --> 00:07:28.040
<v Speaker 1>and alcohol are discouraged. People are encouraged to fast overnight

104
00:07:28.079 --> 00:07:31.160
<v Speaker 1>for twelve to sixteen hours. This approach helps to support

105
00:07:31.199 --> 00:07:37.000
<v Speaker 1>gut health, insulin sensitivity, metabolic flexibility, and ketone production. The

106
00:07:37.040 --> 00:07:39.040
<v Speaker 1>brain needs a lot of power to function, he said.

107
00:07:40.079 --> 00:07:43.480
<v Speaker 1>They can use gluten coses or ketones. Many people lack

108
00:07:43.519 --> 00:07:47.160
<v Speaker 1>access to either because they're insulin resistant. Like every other

109
00:07:47.199 --> 00:07:50.480
<v Speaker 1>aspect of the protocol, the dietary approach must be individualized,

110
00:07:50.800 --> 00:07:51.160
<v Speaker 1>he said.

111
00:07:51.199 --> 00:07:52.879
<v Speaker 2>For someone who's overweight.

112
00:07:52.800 --> 00:07:55.519
<v Speaker 1>Fasting in ketosis may be easier because they have fat

113
00:07:55.560 --> 00:07:59.000
<v Speaker 1>stores available to make ketones. For some frail however, the

114
00:07:59.000 --> 00:08:04.279
<v Speaker 1>same approach may not be appropriate. Exercises, another core component protocol,

115
00:08:04.319 --> 00:08:07.920
<v Speaker 1>includes aerobic exercise, strength training, balance work and stretching for

116
00:08:07.920 --> 00:08:10.959
<v Speaker 1>at least forty five minutes per day, six days a week.

117
00:08:11.519 --> 00:08:16.920
<v Speaker 1>Hormone levels and nutrient status including vitamin d bs, minerals,

118
00:08:16.959 --> 00:08:20.759
<v Speaker 1>omega threes, thyroid function, and sex hormones are assessed and

119
00:08:20.839 --> 00:08:24.959
<v Speaker 1>corrected where necessary. Stress management through biofeedback and heart rate

120
00:08:25.040 --> 00:08:29.279
<v Speaker 1>variability training is also included. Once the brain's been better nourished,

121
00:08:29.600 --> 00:08:32.720
<v Speaker 1>brain stimulation is also added. The last thing you want

122
00:08:32.759 --> 00:08:34.879
<v Speaker 1>to do is work out with weights if you're malnourished.

123
00:08:34.879 --> 00:08:40.639
<v Speaker 1>The same applies to the brain residence. Trials published in

124
00:08:40.679 --> 00:08:44.679
<v Speaker 1>Journal Ofolzheimer's Disease tested as Precision Medicine approach twenty five

125
00:08:44.679 --> 00:08:48.480
<v Speaker 1>people with mild cognitive impairment or dementia. Each person received

126
00:08:48.519 --> 00:08:52.559
<v Speaker 1>personalized treatment in his most recent randomized controlled trial currently

127
00:08:52.799 --> 00:08:57.039
<v Speaker 1>pending peer review, compared the standard care and people with

128
00:08:57.120 --> 00:09:01.799
<v Speaker 1>mild cognitive impairment or early dementia. Standard care means participants

129
00:09:01.879 --> 00:09:05.519
<v Speaker 1>continue to receive their usual treatment, usually managed with drugs

130
00:09:05.919 --> 00:09:10.600
<v Speaker 1>that simply target symptoms from their healthcare providers. Fifty patients

131
00:09:10.639 --> 00:09:15.559
<v Speaker 1>received the Precision medical protocol, twenty three receives standard care treatment.

132
00:09:17.799 --> 00:09:20.440
<v Speaker 1>Cognitive testing was performed at the beginning of the study

133
00:09:20.840 --> 00:09:25.039
<v Speaker 1>and again at three, six and nine months. Participants following

134
00:09:25.080 --> 00:09:29.440
<v Speaker 1>the Precision Medicine protocol showed significant improvements in overall cognitive

135
00:09:29.480 --> 00:09:33.879
<v Speaker 1>function memory in Alzheimer's symptoms. Severity provens were seen in

136
00:09:33.879 --> 00:09:37.279
<v Speaker 1>blood pressure, body mass index, blood sugar control, lipid profiles,

137
00:09:37.320 --> 00:09:40.759
<v Speaker 1>and other markers. The treatment effects size for overall cognitive

138
00:09:40.799 --> 00:09:43.960
<v Speaker 1>function was calculated to be seven times greater than that

139
00:09:44.080 --> 00:09:47.840
<v Speaker 1>reported in the trials for anti amyloid drugs such as

140
00:09:47.960 --> 00:09:54.399
<v Speaker 1>lacanamap and don add and app got that overall function

141
00:09:55.919 --> 00:09:59.480
<v Speaker 1>seven times greater than those high tech drugs that are

142
00:09:59.519 --> 00:10:00.960
<v Speaker 1>multiple expense.

143
00:10:02.360 --> 00:10:02.559
<v Speaker 2>Well.

144
00:10:02.600 --> 00:10:05.600
<v Speaker 1>They've noted that precision medicine for Alzheimer's disease is an

145
00:10:05.600 --> 00:10:09.159
<v Speaker 1>emerging field. She said that President's work offers an important

146
00:10:09.159 --> 00:10:12.000
<v Speaker 1>shift in how the disease is understood and challenges the

147
00:10:12.039 --> 00:10:16.039
<v Speaker 1>idea that Alzheimer's is a single pathway disease, even among

148
00:10:16.080 --> 00:10:20.120
<v Speaker 1>those sympathetic to the protocol's goal. The practicality that portrays

149
00:10:20.159 --> 00:10:24.960
<v Speaker 1>his questions. A nutritional functional practitioner by the name of

150
00:10:25.000 --> 00:10:29.279
<v Speaker 1>Paul Aerons as a master personal trainer, said it's so

151
00:10:29.399 --> 00:10:31.639
<v Speaker 1>full in regards to xerra azed commitment, and there are

152
00:10:31.720 --> 00:10:35.480
<v Speaker 1>very few people can afford the time or the cost involved.

153
00:10:36.639 --> 00:10:38.240
<v Speaker 2>What a negativity that was.

154
00:10:39.120 --> 00:10:42.200
<v Speaker 1>Bresden acknowledges people don't need to do everything, he said.

155
00:10:43.559 --> 00:10:46.080
<v Speaker 2>Who is this idiot, Paul ERNs.

156
00:10:45.879 --> 00:10:52.279
<v Speaker 1>Ehr e n Forget it. We now have an option

157
00:10:53.039 --> 00:10:55.639
<v Speaker 1>to not worry about Alzheimer's. If we do the right thing,

158
00:10:56.320 --> 00:11:01.559
<v Speaker 1>this will become a scourge of the past. You make

159
00:11:01.600 --> 00:11:04.279
<v Speaker 1>the call, need help with that, Give a call. Have

160
00:11:04.360 --> 00:11:05.159
<v Speaker 1>a great day, folks.

161
00:11:05.200 --> 00:11:05.440
<v Speaker 2>God