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Speaker 1: The content of this podcast is provided for general informational

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purposes only and is not intended as nor should it

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be considered a substitute for professional medical advice. Hello, this

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is Karen Nickel, family nurse practitioner, and you are listening

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to Itchy and Bitchy, a podcast that provides answers to

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your many unanswered health questions. I have some very exciting

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news to share with my wonderful listeners. For almost nine years,

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I have been the host of Itchy and Bitchy formally

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named Sweaty and pist. It is time for the podcast

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to grow and evolve with new hosts and a slightly

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different format. Growth and change is a good thing. People.

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My dear friends, Stephen Miller and Keith Millica will be

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the future hosts of Itchy and Bitchy. As hosts, they

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will have a comprehensive approach to wellness with a focus

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on connecting human health, animal health, and environmental health. To

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provide a transition period for you, for me, and for

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Stephen and Keith. We have a series of four episodes planned.

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I will introduce Stephen Miller, a fellow nurse practitioner, in

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the first of four episodes. In the next episode, I

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will introduce you to Keith Nilika, a veterinarian. The third

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episode will include all three of us as I interview

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both Stephen and Keith. All three of us will also

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be in the fourth episode, but this time the tables

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will be turned and Keith and Stephen will be interviewing me.

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I'm confident you will enjoy and learn from all that

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they have to share. Stephen Miller is an acute care

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nurse practitioner known for his expertise in diagnosing and treating

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cardiovascular disease. He is highly respected for his patient centered approach,

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consistently ensuring that each individual remains at the heart no

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pun intended of their care. Committed to excellence. Stephen earned

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his Doctor of Nursing Practice from Vanderbilt University, further strengthening

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his clinical knowledge and leadership in advanced nursing practice. Most importantly,

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from my point of view, anyway, we have been friends

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from about twenty five years. Welcome Stephen, High Care. Stephen

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and I are going to chat about something called Takatsubo

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cardiomyopathy because I suspect that many of you have not

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heard about this heart problem. So Stephen, let's first to

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find cardiomyopathy. Let's start there.

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Speaker 2: Yeah, so, cardiomyopathy is anything that decreases the function of

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mild cardial tissue and can lead to weakening of the

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lift and or later more severely congestive heart failure types

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of symptoms.

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Speaker 1: Yeah, not good. So what about Takatsubo cardiomopy? What makes

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that different? What is it? Yeah?

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Speaker 2: So, Tukatsubo is an interesting syndrome. It is otherwise also

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known as broken heart syndrome. It is this temporary condition

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that is triggered by intense emotional or physical stress. It

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mimics something that we call acute coronary syndrome, which can

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come with obstructive coronary artery disease. However, the difference for

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Tucketsubo is that there is no obstructive coronary artery disease

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or blockage in the arteries as the cause for this

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particular event.

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Speaker 1: It's so interesting. So what are the likely symptoms of

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this problem?

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Speaker 2: Most women will experience an intense emotional or intense psychological

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stressor that triggers the events and.

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Speaker 1: It presents a lot of women have those, by the way.

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Speaker 2: Yes they too, and they present with what would be

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like a typical heart attack, so coming in with chest

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pain or unusual shortness of breath. Of course, you always

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have to remember in women's symptoms are also atypical, so

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a lot of those symptoms can present as jaw pain

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or back pain. So some atypical and typical symptoms generally

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examples of triggers for women for these events would be

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some intense event like the death of a family member

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or loved one, and acute illness, a surgery, stroke, and

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sometimes other severe psychological stressors.

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Speaker 1: So, yeah, I had a patient with Takatsubo and she

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was in a very difficult relationship. She was really struggling

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on how to make this relationship work, and the stress

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was so immense that she ended up with Tukatsubo cardiom

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my alpathy. Yeah.

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Speaker 2: Yeah, I've seen a number of cases over the twenty

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six years of practice in cardiology, and all with different

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presentation situations. I have one patient who experienced her husband

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injured himself and she had an episode right there in

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her yard during his event, And so you know, it

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can be. It's real, and the symptoms are real, and

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the and oregon effects of it are very real. It's interesting.

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Has a funny little name. Tucketsubo is something that is

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named after the octopus strap.

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Speaker 1: So something that catches octopus.

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Speaker 2: Yes, that's right. So when we look at echo cardiograms

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and herzations for women who have tacosuba or men more

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rarely men, you see this classic sort of ballooning of

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the apex or bottom part of the heart, and so

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you get this sort of narrow neck at the top

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and ballooning of the ventricle. And that's where it essentially

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gets its name from it and it's very typical and

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very classic presentation. And once you see it on echo

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or cardiac cathization, you know exactly what.

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Speaker 1: It's pretty clear on that imaging that that's what's going on. Yeah,

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oh good. Are there certain people who tend to get

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this or have greater risk of developing takatsubo. Yeah.

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Speaker 2: Ninety percent of the cases are women or female people,

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particularly among postmenopausal women, as there is a strong trigger

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from the hormonal shift that happens at menopause and declines

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in estrogen levels around the age of fifty five, risk

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goes up. And honestly, the majority of the cases that

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I've seen over the years have been women in that

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age group. There are also other sort of pre existing

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conditions that can set someone up for having tucketsubas, so

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like neurologic conditions, stroke, epilepsy, and then of course anxiety

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and depression, and who doesn't have anxiety and depression, so

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lots of people.

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Speaker 1: It's really quite incredible and interesting that we now know

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that estrogen is so heart protective and the lack of

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estrogen is part of the reason women experience this way,

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way way more than men.

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Speaker 2: Sure, and when you take that into account for the

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fact that during these events you get this intense surge

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of fight or flight response, and so all of that

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ramps up and causes this intense vase of constriction in

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the coronary arteries and subsequent lack of blood supply to

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the malcardium or heart muscle. So catecholamines are not our

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friend in this situation.

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Speaker 1: Gotcha, We're going to take a quick break, and after

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this break we will talk about who is the likeliest

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person to come up with the Takatsubo cardiomyopathy. We'll be

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right back. Welcome back. So you mentioned a couple of

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other things that put people at risk, but are there

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other events that could trigger takatsubo.

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Speaker 2: Oh yeah, yeah, so you look at sometimes surgical events,

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people can have intense catecholamine released during surgery. Of course,

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the death of a loved one, relationship breakups, which large

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percentage of people go through divorce in the middle age

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of a life. I've seen a number of cases in

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our office of people who had were having intense arguments

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with a loved one, a husband, or a family member.

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And then of course intense fear can set off these

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events of this surge of ctcola means or ctcolam mediated

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events that people get.

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Speaker 1: So so like if you were hiking and a bear

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started running down the trail right at you and you

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manage to survive.

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Speaker 2: It the bear.

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Speaker 1: Yeah, yeah, if you survive the bear, the fear from

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that experience could trigger this. Yeah.

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Speaker 2: Or if your husband were a bear, well, if.

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Speaker 1: You're marrying a bear, that's a little weird, but hey,

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but hey, to each his out. It happens. So you

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mentioned the echo cardiogram or angiogram that there's clear physical

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findings to help confirm your suspicion of takatsuba. Are there

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any blood tests that you do for that?

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Speaker 2: Yeah, So when someone presents. Say, for example, they come

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in the emergency room and they have the presentation of

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angina a Q cornary syndrome type of thing. We run

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an EKG. So a basic EKG can show some ST

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segment elevation or depression depending on where they are. Additionally,

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you would get now high sensitivity traponents or troponin levels,

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which often are elevated and not always peaked like they

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might be with an acute occlusion of an artery, because

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you have to remember this a transient occlusion. Back to

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EKG again, we see ST segment elevation, ST segment depression,

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T wave inversion, and even QT prolongation. So all of that,

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putting that in English, just EKG changes that might show.

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Speaker 1: Up that are typical for this problem.

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Speaker 2: Pretty typical. Yeah, And then once level of suspicion is

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high and screening testing is indicative, then you would move

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on to something like a heart catherization and or echo cardiogram. Generally,

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in this situation we would end up doing both. The

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cardiac catheterization is particularly helpful because it helps us to

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diagnose coronary disease or flow limiting.

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Speaker 1: Rolling out that part that's right.

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Speaker 2: Ideally and in Takatsubo, you would not see necessarily flow

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limiting coronary disease. And then we also do what it's

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called l V or left ventricula gram shoot die into

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the left centrical and that's where we would see that

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ballooning of the apex of the left fentricle.

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Speaker 1: Interesting, So, say someone gets diagnosed with Takatsubo cardiomyopathy, is

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there hope, what is the treatment for the condition.

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Speaker 2: When the blood flow to the heart is temporarily blocked

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and a patient has an event and then you see

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some weakening of the left fentricle and you don't see

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any flow limiting disease and you've determined it's a takatsubo.

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The prognosis is really quite excellent because with medical therapy

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then you can see significant improvements. So prognosis is excellent.

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Outcomes bad outcomes are pretty rare. It's about a mortality

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rate of about one percent to three point two percent,

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and that includes you know, things like life they're threatening,

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a arrhythmias and that kind of thing.

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Speaker 1: And that might happen because the heart's baggy.

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Speaker 2: It's it's boggy, and it's not pumping efficient right right,

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and so when we help people through the acute phase

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of takasuba with medications, and we give medicines to help

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decrease the work of the left ventricle and medications that

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help improve ventricular remodeling, then we start to see the

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heart go back to its normal shape.

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Speaker 1: And so what kind of medications are those? What typically

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would you start?

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Speaker 2: So it's interesting there are treatments considered to be supportive

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because certainly in this situation you would not do any

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kind of intervention. You wouldn't need to do intervention as

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far as stints or angioplasti or anything like that. But

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treatment is tailored to what we call hemodynamic phenotype or

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an English basically the person's hemodynamic presentation and what their

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body can tolerate. As far as adding on GDMT or

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guideline or directed therapy, there are no guidelines currently because

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there aren't any randomized controlled trials looking at standards of

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care for these patients.

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Speaker 1: Maybe because it's mostly women.

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Speaker 2: You know, one can only.

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Speaker 1: But listen my listeners hear me say this all the time. Now, Yeah,

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that didn't get studied because it's a women problem.

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Speaker 2: So yes, the truth of what you're saying is that

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historically when women are under represented in population studies, and

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so the data historically has been skewed to the male population.

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And that's very accurate.

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Speaker 1: But you would use medications you would use often in

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heart failure of other causes, so that like beta blockers and.

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Speaker 2: Yeah yeah, so things like data blockers like matopra law

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in which we would use in acute cornery center ace

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inhibitors ARBs. Those things are helpful. Definitely some type of

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aspirin and or plavix because clearly if that person had

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a tendency toward having a Takatsubo event, you would want

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to make sure they're protected moving forward. They don't need

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another insult. The interesting thing about that is that reoccurrence

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rates are actually pretty low, but they do happen. They're

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about one point five percent.

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Speaker 1: Yeah, so if somebody has this, they can feel it's

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terrible that it, but they can feel pretty good about

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regaining heart function, yes to normalish levels to normal. Yeah.

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Speaker 2: Yeah, So we repeat an echo cardiogram when they come back,

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and as a general rule, their ejection fractions improve and

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mil cardial function returns to normal. So and that usually

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happens somewhere between three to six weeks.

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Speaker 1: Oh, okay, the ejection fraction tells us how well the

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left ventricle, the bottom left chamber is squeezing. Yeah, so

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we're looking to see if they've regained the function that

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we want to see in that left.

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Speaker 2: Bottom Nay, yeah, that's absolutely correct. So the ejection fraction

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is the percent of blood pump from the left ventricle

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with each contraction, and it's normally somewhere between fifty to

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seventy percent, somewhere in that range. A lot of these

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people will see their ejection fractions during their event decline

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into the thirties twenties, but then with proper medication, then

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you can see those that ventricular recovery occur.

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Speaker 1: So it's hopeful for the people who experiences that they'll

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recover function pretty quickly and the chances of it happening

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again are pretty slim. Do you, ever, as a cardiology practitioner,

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do you send them for cognitive behavioral therapy or anything

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that would help avoid another event if an emotional stressor

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especially was one of the triggers for the event.

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Speaker 2: Yes, So a lot of people who have intense emotional

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reaction around events in life benefit may benefit from certain

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medications for their anxiety or you know, if they're bipolar

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or whatever underlying psychiatric issue is going on, and so

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it's a very good idea to get these people connected.

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I've actually historically given a couple of the patients treated

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them with SSRIs and there is a slim amount of

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evidence there serotonin reuptake inhibitors. So yes, behavior those.

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Speaker 1: Are things like prozac, pax paxel lexapro. Yeah, just for

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our listeners, Yeah.

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Speaker 2: That's right, and so yes, a good referral to mental

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health specialty is vital. Cardiac rehab is another really vital

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part of recovery. A lot of people when they have

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this event, feel utterly exhausted. So the heart deconditions really

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rapidly when you have an event, and people will notice

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unusual fatigue for weeks after, shortness of breath for weeks after,

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while the ventricle is recovering and their bodies are having

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get readjusted because they're now new medications on board with

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all kinds of side effects that they have to deal with.

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But certainly cardiac rehab is highly recommended for these folks.

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Speaker 1: Yeah, that's great. I just think this is a really

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interesting subject and one that I don't think gets talked

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about a lot, and so I appreciate you filling in

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all that information that most of us don't know. I

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really appreciate that. Is there anything you would like to

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share about who you are or what you hope to

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bring to the listening audience as a future host?

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Speaker 2: Yeah, I think this will be super fun and exciting.

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I'm definitely after twenty six years of practice, I've got

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lots of experience with all manner of people and on

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multiple levels. And I think the ability to bring that

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rich history of practice into conversation with people and present

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data in an appropriate way, that's another thing through my

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especially through my doctorate work. So we have studied that

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and God spent a lot of money and degrees learning

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how to gather up that data and present it in

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a way that people can understand. And so I think

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the ability to do that should be able to we

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should be able to enhance people well.

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Speaker 1: I think the listeners over the last almost nine years,

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I do talk about studies in most of my episodes.

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I don't go into pee values and all that, but

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I think it's helpful for people to know what's being studied,

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what the results were, you know, how many people were

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in the study, right, that kind.

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Speaker 2: Of thing, helping people tease through that's really important.

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Speaker 1: Yeah, I think so too.

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Speaker 2: And historically, you know, with women, the population of women

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in studies within medicine have been underrepresented, and so maybe

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we have missed the mark on finding pathways for women

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in healthcare.

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Speaker 1: Yeah. I mean the fact that ninety percent of the

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patients who experiences are women and we don't have information

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really on the best way to treat that and we're

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in twenty twenty six is sort of incredible.

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Speaker 2: There are no guidelines.

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Speaker 1: Yeah, yeah, that's yeah. Well, I won't go on my tirade.

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I promise all my listeners are going, oh, thank god. Well,

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I'm so glad you're here. I'm so glad Keith is

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going to be here with us. And I also want

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to point out that you're a musician and Keith is

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an artist, and so they you know, have similar experiences

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that I have as a musician. So they bring that

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to the table as well, which I think is a

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really good fit for this podcast.

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Speaker 2: Sometimes it takes an artistic mind to take something so

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technical and look at different ways of getting across to peace,

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and certainly music being so scientific, but yet so creative

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and colorful, and it taps into our right brain, and

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so it allows us the ability to extend beyond the

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sort of robotic care that I think people really just

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don't want.

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Speaker 1: We love our right brain, Yes, it love it.

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Speaker 2: I am working to preserve mine every day. I know

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it's important and a lessons saying all of that.

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Speaker 1: See, it's so good, Keith painting, painting, My gosh, it's

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so important. Right brain is so good, it is. Well,

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thank you so very much, Stephen. I'm excited that you're

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coming on board, and I appreciate your time and knowledge

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about Takatsubo.

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Speaker 2: Well, thank you, Karen. We love you very much and

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consider you family and we're so excited to do these

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next few episodes with you, and it'll be fun and

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continue to honor your work through this podcast to your listeners.

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I think that's a brain child of yours and we're

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just thrilled to be able to carry it forward.

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Speaker 1: I appreciate that very very much. I appreciate that well,

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MANI thanks to all of you out there for listening,

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and wherever you listen to this podcast, please leave a

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review and rate the podcast. Your reviews and ratings really

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do matter. Also, make sure you follow the show so

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that it will be automatically downloaded. That absolutely matters. I

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00:22:30,079 --> 00:22:33,000
encourage you to visit our Facebook page imb Podcast, where

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you can give us a like or leave comments or

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questions for me. Our website is itchymbitchi dot com, where

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there are blogs with some of our subjects available for

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you to read. Thank you to Forrest winsl my son,

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our producer and composer of our theme music and the

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person who does all the behind the scenes work to

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make this podcast possible. Thank you so much, Forrest. And

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Forrest continues to thrive at Peabody Music Conservatory and is

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finishing up his final semester the Master's program, and he

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has informed us that he has been admitted to the

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Peabody Doctoral Program to receive a Doctor of Musical Arts

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in Composition. His dad and I are so so very

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happy for him. It's fun to see his immense musical

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talents recognized. If you want to listen to what he's creating,

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you can go to his website Forrestwinsle dot com. Remember

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that your health is in your hands.

